116 research outputs found
Positive end-expiratory pressure does not increase intraocular pressure in patients with intracranial pathology
Radon measurement in karstic waters with Lucas cell technique
Based on Lucas cell technique, the portable device named “PRASSI” (SILENA mod. 5S) was used to realise discrete radon measurements in water samples. The calibration factor is (64.766.9) cpmQBq21 and, with the present set-up for measuring radon in water, the detection and the determination limits are, respectively, 0.007 and 0.020 Bq. Thus, the device is well adapted for determining low radon content in karstic waters. Several discrete radon samplings were performed nearly every week in the three main springs of the Bastareny karstic system (Catalonian
Pyrenees, N-E Spain). Thus, it was possible to estimate the reproducibility of the methodology as well as to characterise every spring of the aquifer in relation to
their hydrogeological features. With the portable radon monitor, some useful measurements were achieved to estimate radon loss due to degassing process over short distances, with important consequences for radon studies in karstic waters. Lastly, it was possible to perform intensive sampling during a flood and the results point out the great variability of radon levels, closely related to the flow rate trend. That permitted also an intercomparison with other radon probes installed previously in every spring, for continuous radon measurements
Climate drives community-wide divergence within species over a limited spatial scale: evidence from an oceanic island
Geographic isolation substantially contributes to species endemism on oceanic islands when speciation involves the colonisation of a new island. However, less is understood about the drivers of speciation within islands. What is lacking is a general understanding of the geographic scale of gene flow limitation within islands, and thus the spatial scale and drivers of geographical speciation within insular contexts. Using a community of beetle species, we show that when dispersal ability and climate tolerance are restricted, microclimatic variation over distances of only a few kilometres can maintain strong geographic isolation extending back several millions of years. Further to this, we demonstrate congruent diversification with gene flow across species, mediated by Quaternary climate oscillations that have facilitated a dynamic of isolation and secondary contact. The unprecedented scale of parallel species responses to a common environmental driver for evolutionary change has profound consequences for understanding past and future species responses to climate variation
The XMM Cluster Survey: testing chameleon gravity using the profiles of clusters
The chameleon gravity model postulates the existence of a scalar field that couples with matter to mediate a fifth force. If it exists, this fifth force would influence the hot X-ray emitting gas filling the potential wells of galaxy clusters. However, it would not influence the clusters weak lensing signal. Therefore, by comparing X-ray and weak lensing profiles, one can place upper limits on the strength of a fifth force. This technique has been attempted before using a single, nearby cluster (Coma, z = 0.02). Here we apply the technique to the stacked profiles of 58 clusters at higher redshifts (0.1 < z < 1.2), including 12 new to the literature, using X-ray data from the XMM Cluster Survey and weak lensing data from the Canada-France-Hawaii-Telescope Lensing Survey. Using a multiparameter Markov chain Monte Carlo analysis, we constrain the two chameleon gravity parameters (beta and phi∞). Our fits are consistent with general relativity, not requiring a fifth force. In the special case of f(R) gravity (where beta = &surd;{1/6}), we set an upper limit on the background field amplitude today of |fR0| < 6 × 10-5 (95 per cent CL). This is one of the strongest constraints to date on |fR0| on cosmological scales. We hope to improve this constraint in future by extending the study to hundreds of clusters using data from the Dark Energy Survey
Designed Inhibitors of Insulin-Degrading Enzyme Regulate the Catabolism and Activity of Insulin
Background: Insulin is a vital peptide hormone that is a central regulator of glucose homeostasis, and impairments in insulin signaling cause diabetes mellitus. In principle, it should be possible to enhance the activity of insulin by inhibiting its catabolism, which is mediated primarily by insulin-degrading enzyme (IDE), a structurally and evolutionarily distinctive zinc-metalloprotease. Despite interest in pharmacological inhibition of IDE as an attractive anti-diabetic approach dating to the 1950s, potent and selective inhibitors of IDE have not yet emerged. Methodology/Principal Findings: We used a rational design approach based on analysis of combinatorial peptide mixtures and focused compound libraries to develop novel peptide hydroxamic acid inhibitors of IDE. The resulting compounds are ∼106 times more potent than existing inhibitors, non-toxic, and surprisingly selective for IDE vis-à-vis conventional zinc-metalloproteases. Crystallographic analysis of an IDE-inhibitor complex reveals a novel mode of inhibition based on stabilization of IDE's “closed,” inactive conformation. We show further that pharmacological inhibition of IDE potentiates insulin signaling by a mechanism involving reduced catabolism of internalized insulin. Conclusions/Significance: The inhibitors we describe are the first to potently and selectively inhibit IDE or indeed any member of this atypical zinc-metalloprotease superfamily. The distinctive structure of IDE's active site, and the mode of action of our inhibitors, suggests that it may be possible to develop inhibitors that cross-react minimally with conventional zinc-metalloproteases. Significantly, our results reveal that insulin signaling is normally regulated by IDE activity not only extracellularly but also within cells, supporting the longstanding view that IDE inhibitors could hold therapeutic value for the treatment of diabetes
Eco-friendly one-pot synthesis of Prussian blue-embedded magnetic hydrogel beads for the removal of cesium from water
A simple one-step approach to fabricating Prussian blue-embedded magnetic hydrogel beads (PBMHBs) was fabricated for the effective magnetic removal of radioactive cesium (Cs-137) from water. Through the simple dropwise addition of a mixed aqueous solution of iron salts, commercial PB and polyvinyl alcohol (PVA) to an ammonium hydroxide (NH4OH) solution, the formation of hydrogel beads and the encapsulation of PB in beads were achieved in one pot through the gelation of PVA with in situ-formed iron oxide nanoparticles as the cross-linker. The obtained PB-MHBs, with 43.77 weight %of PB, were stable without releasing PB for up to 2 weeks and could be effectively separated from aqueous solutions by an external magnetic field, which is convenient for the large-scale treatment of Cs-contaminated water. Detailed Cs adsorption studies revealed that the adsorption isotherms and kinetics could be effectively described by the Langmuir isotherm model and the pseudo-second-order model, respectively. Most importantly, the PB-MHBs exhibited excellent selectivity for Cs-137 in (137)Cscontaminated simulated groundwater (55 Bq/g) with a high removal efficiency (>99.5%), and the effective removal of Cs-137 from real seawater by these PB-MHBs demonstrated the excellent potential of this material for practical application in the decontamination of Cs-137-contaminated seawate
The XMM Cluster Survey: New evidence for the 3.5-keV feature in clusters is inconsistent with a dark matter origin
There have been several reports of a detection of an unexplained excess of X-ray emission at 3.5 keV in astrophysical systems. One interpretation of this excess is the decay of sterile neutrino dark matter. The most influential study to date analysed 73 clusters observed by the XMM-Newton satellite. We explore evidence for a â 3.5-keV excess in the XMM-PN spectra of 117 redMaPPer galaxy clusters (0.1 < z < 0.6). In our analysis of individual spectra, we identify three systems with an excess of flux at 3.5 keV. In one case (XCS J0003.3+0204), this excess may result from a discrete emission line. None of these systems are the most dark matter dominated in our sample. We group the remaining 114 clusters into four temperature (TX) bins to search for an increase in â 3.5-keV flux excess with TX-a reliable tracer of halo mass. However, we do not find evidence of a significant excess in flux at â 3.5 keV in any TX bins. To maximize sensitivity to a potentially weak dark matter decay feature at â 3.5 keV, we jointly fit 114 clusters. Again, no significant excess is found at â 3.5 keV. We estimate the upper limit of an undetected emission line at â 3.5 keV to be 2.41 × 10-6 photons cm-2 s-1, corresponding to a mixing angle of sin 2(2θ) = 4.4 × 10-11, lower than previous estimates from cluster studies. We conclude that a flux excess at â 3.5 keV is not a ubiquitous feature in clusters and therefore unlikely to originate from sterile neutrino dark matter decay. © 2020 The Author(s) Published by Oxford University Press on behalf of the Royal Astronomical Society
The XMM cluster survey: exploring scaling relations and completeness of the dark energy survey year 3 redMaPPer cluster catalogue
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