Assessing the Scholarly Productivity of Allied Health Faculty

No abstract available

Predictors of Job Satisfaction of Nurses and Allied Health Professionals

No abstract available

Intravital microscopy for evaluating tumor perfusion of nanoparticles exposed to non-invasive radiofrequency electric fields

Poor biodistribution and accumulation of chemotherapeutics in tumors due to limitations on diffusive transport and high intra-tumoral pressures (Jain RK, Nat Med. 7(9):987–989, 2001) have prompted the investigation of adjunctive therapies to improve treatment outcomes. Hyperthermia has been widely applied in attempts to meet this need, but it is limited in its ability to reach tumors in deeply located body regions. High-intensity radiofrequency (RF) electric fields have the potential to overcome such barriers enhancing delivery and extravasation of chemotherapeutics. However, due to factors, including tumor heterogeneity and lack of kinetic information, there is insufficient understanding of time-resolved interaction between RF fields and tumor vasculature, drug molecules and nanoparticle (NP) vectors. Intravital microscopy (IVM) provides time-resolved high-definition images of specific tumor microenvironments, overcoming heterogeneity issues, and can be integrated with a portable RF device to enable detailed observation over time of the effects of the RF field on kinetics and biodistribution at the microvascular level. Herein, we provide a protocol describing the safe integration of IVM with a high-powered non-invasive RF field applied to 4T1 orthotopic breast tumors in live mice. Results show increased perfusion of NPs in microvasculature upon RF hyperthermia treatment and increased perfusion, release and spreading of injected reagents preferentially in irregular vessels during RF exposure

DAS Processing Algorithms

This report addresses deliverable D1.5 of the DigiMon project, which covers processing algorithms for Distributed Acoustic Systems (DAS) datasets that are contained within a python library called DASpy. The objective of DigiMon is to develop an early-warning system for Carbon Capture and Storage (CCS) which utilises a broad range of sensor technologies including DAS. While the system is primarily focused on the CCS projects located in shallow offshore environment of the North Sea, it is also intended to be adaptable to onshore settings. Some of the key areas that the systems will monitor include the movement of the plume within the reservoir, well integrity and CO2 leakage into the overburden. A combination of both active and passive seismic methods will be deployed to track the movement of CO2, for example seismic reflection to image seismic velocity changes or microseismics to capture small earthquakes relating to fault activation

戴帽式・祝辞

Splitting iterative methods for the sum of maximal monotone and single-valued monotone operators in a finite-dimensional space are studied: convergence, rate of convergence and optimal iterative parameters are derived. A two-stage iterative method with inner iterations is analysed in the case when both operators are linear, self-adjoint and positive definite. The results are applied for the mesh variational inequalities which are solved using a non-overlapping domain decomposition method and the splitting iterative procedure. Parallel solution of a mesh scheme for continuous casting problem is presented and the dependence of the calculation time on the number of processors is discussed

Predictor-corrector methods for solving continuous casting problem

In this paper we present new numerical approach to solve the continuous casting problem. The main tool is to use IPEC method and DDM similar to Lapin and Pieska [2002] with multilevel domain decomposition. On the subdomains we use multidecomposition of the subdomains. The IPEC is used both in the whole calculation domain and inside the subdomains. The calculation algorithm is presented and numerically tested. Several conclusions are made and discussed