Scientific Information on Gulf of Mannar - A Bibliography

Gulf of Mannar in the southeast coast of India extends from Rameswaram Island in the north to Kanyakumari in the south. It has a chain of 21 islands stretching from Mandapam to Tuticorin to a distance of 140 km along the coast. Each one of the islands is located anywhere between 2 and 10 km from the mainland. The Gulf of Mannar Biosphere Reserve was set up on 18th February 1989 jointly by the Government of India and the state of Tamilnadu. The government of Tamilnadu in G.O. M.S. No 962 dated 10th September 1986 notified under section 35(1) of the Wildlife (Protection) Act 1972 the intention to declare the 21 islands as Marine National Park for the purpose of protecting marine wildlife and its environment including depths of 3.5 fathoms on the bay side to 5 fathoms on the seaward side. The compilation of all available scientific literature in the form of an annotated bibliography of the Gulf of Mannar biosphere reserve has brought to light the existence of nearly 3,000 publications up to date. This covers the literature published from as early as 1864 to the current year. A large number of publications in the first half of the 20th century have brought out information on the variety of fauna and flora found in the Gulf of Mannar, their biology and ecology. A lot of emphasis on the fish and fisheries research has been given only in the second half of the 20th century. Emphasis is being given on biochemical aspects of flora and fauna in the later part of the 20th century and at present

The effects of the 2004 Tsunami on mainland India and the Andaman and Nicobar Islands

Mortality from the tsunamis was high, with more than 7,000 deaths in the Nicobar group alone (the final number may never be known as many indigenous people on remote islands may have perished). On the mainland, there were a similar number of fatalities ; The greatest losses were in fishing communities although the waves destroyed roads, jetties, other basic infrastructure and entire villages; There was major damage to the coastal resources of southeast India, particularly to mangrove and coastal forests. On the Andaman and Nicobar Islands there was considerable damage to the coral reefs and beaches, as well as the forests; The earthquakes changed the bathymetry of the coral reefs and coasts of the Andaman and Nicobars: reefs in the South Andamans to the Nicobars subsided by 1 - 3 metres; many reefs in the northern Andamans were uplifted out of the water and died; and some beaches have almost disappeared, while new beaches have formed; There was major damage to large areas of coral reefs of the Andamans and Nicobars, particularly due to debris being washed off the land and smothering by sediments; Mainland coral reefs in the Gulf of Mannar and elsewhere suffered very minor, localised damage. Many mainland beaches were seriously eroded; and The affected reefs are expected to recover within 5-10 years, if there is effective resource management and enforcement of legislation controlling destructive fishing, coral mining, over-harvesting of reef resources, coastal development, sedimentation and pollution

Tooth Discoloration in Patients With Neonatal Diabetes After Transfer Onto Glibenclamide: A previously unreported side effect

PublishedJournal ArticleMulticenter StudyResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tOBJECTIVE To assess if tooth discoloration is a novel side effect of sulfonylurea therapy in patients with permanent neonatal diabetes due to mutations in KCNJ11. RESEARCH DESIGN AND METHODS A total of 67 patients with a known KCNJ11 mutation who had been successfully transferred from insulin injections onto oral sulfonylureas were contacted and asked about the development of tooth discoloration after transfer. RESULTS Altered tooth appearance was identified in 5 of the 67 patients. This was variable in severity, ranging from mild discoloration/staining (n = 4) to loss of enamel (n = 1) and was only seen in patients taking glibenclamide (glyburide). CONCLUSIONS These previously unreported side effects may relate to the developing tooth and/or to the high local concentrations in the children who frequently chewed glibenclamide tablets or took it as a concentrated solution. Given the multiple benefits of sulfonylurea treatment for patients with activating KCNJ11 mutations, this association warrants further investigation but should not preclude such treatment.This work was funded by the Welcome Trust (grant 067463/Z/2/Z), National Institutes of Health Grants DK-44752 and DK-20595, and a gift from the Kovler Family Foundation. S.E.F. is the Sir Graham Wilkins, Peninsula Medical School Research Fellow. A.T.H. is a Welcome Trust Research Leave Fellow. O.R.-C. was supported by an “Ayuda para contratos post-Formacio´n Sanitaria Especializada” from the “Instituto de Salud Carlos III” (FIS CM06/00013

A Usability Evaluation of Privacy Add-ons for Web Browsers

The web has improved our life and has provided us with more opportunities to access information and do business. Nonetheless, due to the prevalence of trackers on websites, web users might be subject to profiling while accessing the web, which impairs their online privacy. Privacy browser add-ons, such as DuckDuckGo Privacy Essentials, Ghostery and Privacy Badger, extend the privacy protection that the browsers offer by default, by identifying and blocking trackers. However, the work that focuses on the usability of the privacy add-ons, as well as the users’ awareness, feelings, and thoughts towards them, is rather limited. In this work, we conducted usability evaluations by utilising System Usability Scale and Think-Aloud Protocol on three popular privacy add-ons, i.e., DuckDuckGo Privacy Essentials, Ghostery and Privacy Badger. Our work also provides insights into the users’ awareness of online privacy and attitudes towards the abovementioned privacy add-ons; in particular trust, concern, and control. Our results suggest that the participants feel safer and trusting of their respective add-on. It also uncovers areas for add-on improvement, such as a more visible toolbar logo that offers visual feedback, easy access to thorough help resources, and detailed information on the trackers that have been found

Tackling alcoholism and domestic violence in fisheries - a new opportunity to improve wellbeing for the most vulnerable people in global fisheries

The UN Sustainable Development Goals (SDGs) principle of ‘Leaving no one behind’ focusses global attention on the poorest and most vulnerable people. As different sectors grapple to engage meaningfully with this principle, we posit that greater consideration of social problems in fishing-dependent communities, such as alcoholism and domestic violence, presents an opportunity for fisheries governors to contribute to the SDGs mandate. We further argue that governing marine resources in ignorance of these problems can risk harming some of the most vulnerable people in fisheries. Using subjective wellbeing data from women living in two small-scale fishing communities in India and Sri Lanka, we demonstrate the prevalence and impact of alcoholism and domestic violence in fishing households. We further highlight how policies which restrict access to marine resources can undermine important coping strategies, in particular the ability of women to act as independent income-earners, exacerbating harm to already vulnerable women. A scoping review of the literature reveals that alcoholism and domestic violence are reported in certain fisheries around the world, and we theorise how this may relate to the nature of fishing life, and growing stresses regarding the future of fishing. Tackling the burdens of alcoholism and domestic violence in fisheries, where it is an issue, is an opportunity to improve wellbeing for men, women and their families. The paper concludes with tangible actions which marine resource governors could adopt to contribute to the ‘leave no one behind’ ethos

Stereodivergent Synthesis of Enantioenriched 4-Hydroxy-2- cyclopentenones

Protected 4-hydroxycyclopentenones (4-HCPs) constitute an important class of intermediates in chemical synthesis. A route to this class of compound has been developed. Key steps include Noyori reduction (which establishes the stereochemistry of the product), ring-closing metathesis, and simple functional group conversions to provide a set of substituted 4-HCPs in either enantiomeric form

Attempting to reduce susceptibility to fraudulent computer pop-ups using malevolence cue identification training

People accept a high number of computer pop-ups containing cues that indicate malevolence when they occur as interrupting tasks during a cognitively demanding memory-based task [1, 2], with younger adults spending only 5.5–6-s before making an accept or decline decision [2]. These findings may be explained by at least three factors: pressure to return to the suspended task to minimize forgetting; adopting non-cognitively demanding inspection strategies; and, having low levels of suspicion [3]. Consequences of such behavior could be potentially catastrophic for individuals and organizations (e.g., in the event of a successful cyber breach), and thus it is crucial to develop effective interventions to reduce susceptibility. The current experiment (N = 50) tested the effectiveness of malevolence cue identification training (MCIT) interventions. During phase 1, participants performed a serial recall task with some trials interrupted by pop-up messages with accept or cancel options that either contained cues (e.g., missing company name, misspelt word) to malevolence (malevolent condition) or no cues (non-malevolent condition). In phase 2, participants were allocated to one of three groups: no MCIT/Control, non-incentivized MCIT/N-IMCIT, or incentivized MCIT/IMCIT. Control group participants only had to identify category-related words (e.g., colors). Participants in intervention conditions were explicitly made aware of the malevolence cues in Phase 1 pop-ups before performing trying to identify malevolence cues within adapted passages of text. The N-IMCIT group were told that their detection accuracy was being ranked against other participants, to induce social comparison. Phase 3 was similar to phase 1, although 50% of malevolent pop-ups contained new cues. MCIT did lead to a significant reduction in the number of malevolent pop-ups accepted under some conditions. Incentivized training did not (statistically) improve performance compared to non-incentivized training. Cue novelty had no effect. Ways of further improving the MCIT training protocol used, as well as theoretical implications, are discussed

Generation in vivo of peptide-specific cytotoxic T cells and presence of regulatory T cells during vaccination with hTERT (class I and II) peptide-pulsed DCs

Optimal techniques for DC generation for immunotherapy in cancer are yet to be established. Study aims were to evaluate: (i) DC activation/maturation milieu (TNF-α +/- IFN-α) and its effects on CD8+ hTERT-specific T cell responses to class I epitopes (p540 or p865), (ii) CD8+ hTERT-specific T cell responses elicited by vaccination with class I alone or both class I and II epitope (p766 and p672)-pulsed DCs, prepared without IFN-α, (iii) association between circulating T regulatory cells (Tregs) and clinical responses

A Live-Attenuated HSV-2 ICP0− Virus Elicits 10 to 100 Times Greater Protection against Genital Herpes than a Glycoprotein D Subunit Vaccine

Glycoprotein D (gD-2) is the entry receptor of herpes simplex virus 2 (HSV-2), and is the immunogen in the pharmaceutical industry's lead HSV-2 vaccine candidate. Efforts to prevent genital herpes using gD-2 subunit vaccines have been ongoing for 20 years at a cost in excess of $100 million. To date, gD-2 vaccines have yielded equivocal protection in clinical trials. Therefore, using a small animal model, we sought to determine if a live-attenuated HSV-2 ICP0− virus would elicit better protection against genital herpes than a gD-2 subunit vaccine. Mice immunized with gD-2 and a potent adjuvant (alum+monophosphoryl lipid A) produced high titers of gD-2 antibody. While gD-2-immunized mice possessed significant resistance to HSV-2, only 3 of 45 gD-2-immunized mice survived an overwhelming challenge of the vagina or eyes with wild-type HSV-2 (MS strain). In contrast, 114 of 115 mice immunized with a live HSV-2 ICP0− virus, 0ΔNLS, survived the same HSV-2 MS challenges. Likewise, 0ΔNLS-immunized mice shed an average 125-fold less HSV-2 MS challenge virus per vagina relative to gD-2-immunized mice. In vivo imaging demonstrated that a luciferase-expressing HSV-2 challenge virus failed to establish a detectable infection in 0ΔNLS-immunized mice, whereas the same virus readily infected naïve and gD-2-immunized mice. Collectively, these results suggest that a HSV-2 vaccine might be more likely to prevent genital herpes if it contained a live-attenuated HSV-2 virus rather than a single HSV-2 protein