Identifikasi Tanda Tangan Menggunakan Transformasi Gabor Wavelet Dan Jarak Minkowski

Tanda tangan memiliki beberapa kesulitan untuk di lakukan identifikasi yang disebabkan karena banyaknya variasi tanda tangan yang diperlukan terhadap tanda tangan orang yang sama, hal ini memiliki kecenderungan Perubahan berdasarkan posisi, ukuran, dan kemiringan. Tanda tangan yang akan di identifikasi akan diambil terlebih dahulu ciri-cirinya dengan melakukan proses ekstraksi ciri. Salah satu metode ekstraksi ciri adalah Transformasi Gabor Wavelet (TGW). TGW mampu mendeskripsikan variasi citra tanda tangan menjadi beberapa nilai ekstraksi ciri berdasarkan orientasi dan scale. Untuk itu, dikembangkan perangkat lunak untuk mengekstraksi ciri citra tanda tangan dengan metode TGW serta melakukan identifikasi tanda tangan menggunakan jarak Minkowski. Hasil percobaan memperlihatkan bahwa metode TGW mendapatkan hasil yang baik pada proses ekstraksi ciri, dengan persentase hasil pengujian identifikasi tanda tangan untuk data uji terhadap data latih adalah sebesar 81% yaitu menggunakan jarak Minkowski parameter 2, 74% untuk jarak Minkowski parameter 4, dan 74% untuk jarak Minkowski parameter 6

Faktor-Faktor yang Mempengaruhi Perilaku Agresif Remaja di Smk Negeri 2 Pekanbaru

The purpose of this study was to determine factors associated with aggressive behavior of adolescents at vocational high school 2 Pekanbaru. The method of this study used descriptive correlative with cross sectional approach. The study was conducted in vacational high school 2 Pekanbaru with a sample 94 students. The sampling methode used was proportionate stratified random sampling. The instrument used was questionnaire that has been tested for validity and reliability. An analysis used was univariate and bivariate analisis using Chi-Square test. From the statistic data showed that there was significant relation (p value 0.05) between electronic media (p value= 0,065) with aggressive behaviour of adolescents at vocational high school 2 Pekanbaru. This study suggested to the health institution to give health education about aggressive behavior so adolescent can take the prevention of aggressive behavior

Pemanfaatan Media Teknologi Informasi Dan Komunikasi Tutorial Sebagai Suplemen Eksperimen

The goals of this research were to determine the differences in cognitive learning outcomes, describe the Science Process Skills (SPS), the character, the activities and students’ attitudes toward the use of media ICT tutorial as a supplement experiment in the learning measuring instruments. The research design used One-Shot Case Study. The sample of this research was class VIID of SMPN 2 Way Tenong randomly. The data was analyzed by using pair sample t-test. The researcher concludes by the use of media ICT tutorial as supplement experiment that the differences in cognitive learning outcomes can bring up SPS, to build character, to increase the activity of students and to foster positive attitudes of students toward the use of ICT media tutorial as a supplement experiment in the learning measuring instruments.Tujuan penelitian ini untuk mengetahui hasil belajar ranah kognitif, mendeskripsikan Keterampilan Proses Sains (KPS), karakter, aktivitas dan sikap siswa terhadap pemanfaatan media TIK tutorial sebagai suplemen eksperimen terhadap peningkatan. Desain penelitian menggunakan One-Shot Case Study. Sampel penelitian ini kelas VIID SMPN 2 Way Tenong menggunakan teknik random. Kesimpulan penelitian setelah pemanfaatan media TIK tutorial sebagai suplemen eksperimen terdapat peningkatan hasil belajar ranah kognitif, memunculkan KPS, membentuk karakter, meningkatkan aktivitas siswa serta menumbuhkan sikap positif siswa terhadap pemanfaatan media TIK tutorial sebagai suplemen eksperimen dalam pembelajaran alat ukur

Sintomas de depressão e ansiedade em uma amostra representativa de universitários espanhóis, portugueses e brasileiros

University students have shown a significant occurrence of depression and anxiety symptoms. This epidemiological work investigated the prevalence of such symptoms in university students in Spain, Portugal, and Brazil, as well as the possible differences according to nationality and gender from a representative sample of three universities (University of Extremadura/Spain, n = 1216; University of Coimbra/Portugal, n = 426, and PUC-Rio, n = 315) in 2015. The results suggest that Brazilian students have a greater manifestation of depression symptoms, especially women, and they also presented greater symptoms of anxiety. No difference was found in the anxiety results between countries. The correlation between depression and anxiety was positive and strong. This study can be of value in social, clinical and political settings.Universitários apresentam sintomas importantes de depressão e ansiedade. Este trabalho epidemiológico investigou a prevalência de tais sintomas em acadêmicos da Espanha, Portugal e Brasil, bem como as possíveis diferenças em função da nacionalidade e do gênero a partir de uma amostra representativa de 3 universidades (Universidade de Extremadura/Espanha = 1216; Universidade de Coimbra/Portugal = 426 e PUC-Rio = 315) em 2015. Análises descritivas e inferências indicaram que estudantes brasileiros, em especial as mulheres, apresentam maior manifestação de sintomas de depressão. Elas também apresentaram maior sintomatologia de ansiedade. A correlação entre depressão e ansiedade foi proporcional e forte e não houve diferença na ansiedade entre os países. Esta pesquisa pode ser utilizada em diversas áreas e auxiliar práticas clínicas e políticas públicas

Plexin-B1 plays a redundant role during mouse development and in tumour angiogenesis

<p>Abstract</p> <p>Background</p> <p>Plexins are a large family of transmembrane receptors for the Semaphorins, known for their role in the assembly of neural circuitry. More recently, Plexins have been implicated in diverse biological functions, including vascular growth, epithelial tissue morphogenesis and tumour development. In particular, PlexinB1, the receptor for Sema4D, has been suggested to play a role in neural development and in tumour angiogenesis, based on in vitro studies. However, the tissue distribution of PlexinB1 has not been extensively studied and the functional relevance of this receptor in vivo still awaits experimental testing. In order to shed light on PlexinB1 function in vivo, we therefore undertook the genomic targeting of the mouse gene to obtain loss of function mutants.</p> <p>Results</p> <p>This study shows that PlexinB1 receptor and its putative ligand, Sema4D, have a selective distribution in nervous and epithelial tissues during development and in the adult. PlexinB1 and Sema4D show largely complementary cell distribution in tissues, consistent with the idea that PlexinB1 acts as the receptor for Sema4D in vivo. Interestingly, PlexinB1 is also expressed in certain tissues in the absence of Sema4D, suggesting Sema4D independent activities. High expression of PlexinB1 was found in lung, kidney, liver and cerebellum.</p> <p>Mutant mice lacking expression of semaphorin receptor PlexinB1 are viable and fertile. Although the axon collapsing activity of Sema4D is impaired in PlexinB1 deficient neurons, we could not detect major defects in development, or in adult histology and basic functional parameters of tissues expressing PlexinB1. Moreover, in the absence of PlexinB1 the angiogenic response induced by orthotopically implanted tumours was not affected, suggesting that the expression of this semaphorin receptor in endothelial cells is redundant.</p> <p>Conclusion</p> <p>Our expression analysis suggests a multifaceted role of PlexinB1 during mouse development and tissue homeostasis in the adult. Nonetheless, the genetic deletion of PlexinB1 does not result in major developmental defects or clear functional abnormalities. We infer that PlexinB1 plays a redundant role in mouse development and it is not strictly required for tumour induced angiogenesis.</p

Targeting EGFR/HER2 pathways enhances the antiproliferative effect of gemcitabine in biliary tract and gallbladder carcinomas

<p>Abstract</p> <p>Background</p> <p>Advanced biliary tract carcinomas (BTCs) have poor prognosis and limited therapeutic options. Therefore, it is crucial to combine standard therapies with molecular targeting. In this study EGFR, HER2, and their molecular transducers were analysed in terms of mutations, amplifications and over-expression in a BTC case series. Furthermore, we tested the efficacy of drugs targeting these molecules, as single agents or in combination with gemcitabine, the standard therapeutic agent against BTC.</p> <p>Methods</p> <p>Immunohistochemistry, FISH and mutational analysis were performed on 49 BTC samples of intrahepatic (ICCs), extrahepatic (ECCs), and gallbladder (GBCs) origin. The effect on cell proliferation of different EGFR/HER2 pathway inhibitors as single agents or in combination with gemcitabine was investigated on BTC cell lines. Western blot analyses were performed to investigate molecular mechanisms of targeted drugs.</p> <p>Results</p> <p>EGFR is expressed in 100% of ICCs, 52.6% of ECCs, and in 38.5% of GBCs. P-MAPK and p-Akt are highly expressed in ICCs (>58% of samples), and to a lower extent in ECCs and GBCs (<46%), indicating EGFR pathway activation. HER2 is overexpressed in 10% of GBCs (with genomic amplification), and 26.3% of ECCs (half of which has genomic amplification). EGFR or its signal transducers are mutated in 26.5% of cases: 4 samples bear mutations of PI3K (8.2%), 3 cases (6.1%) in K-RAS, 4 (8.2%) in B-RAF, and 2 cases (4.1%) in PTEN, but no loss of PTEN expression is detected. EGI-1 cell line is highly sensitive to gemcitabine, TFK1 and TGBC1-TKB cell lines are responsive and HuH28 cell line is resistant. In EGI-1 cells, combination with gefitinib further increases the antiproliferative effect of gemcitabine. In TFK1 and TGBC1-TKB cells, the efficacy of gemcitabine is increased with addiction of sorafenib and everolimus. In TGBC1-TKB cells, lapatinib also has a synergic effect with gemcitabine. HuH28 becomes responsive if treated in combination with erlotinib. Moreover, HuH28 cells are sensitive to lapatinib as a single agent. Molecular mechanisms were confirmed by western blot analysis.</p> <p>Conclusion</p> <p>These data demonstrate that EGFR and HER2 pathways are suitable therapeutic targets for BTCs. The combination of gemcitabine with drugs targeting these pathways gives encouraging results and further clinical studies could be warranted.</p

Quantitative analysis of a footwall‐scarp degradation complex and syn‐rift stratigraphic architecture, Exmouth Plateau, NW Shelf, offshore Australia

Interactions between footwall‐, hangingwall‐ and axial‐derived depositional systems make syn‐rift stratigraphic architecture difficult to predict, and preservation of net‐erosional source landscapes is limited. Distinguishing between deposits derived from fault‐scarp degradation (consequent systems) and those derived from long‐lived catchments beyond the fault block crest (antecedent systems) is also challenging, but important for hydrocarbon reservoir prospecting. We undertake geometric and volumetric analysis of a fault‐scarp degradation complex and adjacent hangingwall‐fill associated with the Thebe‐2 fault block on the Exmouth Plateau, NW Shelf, offshore Australia, using high resolution 3D seismic data. Vertical and headward erosion of the complex and fault throw are measured. Seismic‐stratigraphic and seismic facies mapping allow us to constrain the spatial and architectural variability of depositional systems in the hangingwall. Footwall‐derived systems interacted with hangingwall‐ and axial‐derived systems, through diversion around topography, interfingering or successive onlap. We calculate the volume of footwall‐sourced hangingwall fans (VHW) for nine quadrants along the fault block, and compare this to the volume of material eroded from the immediately up‐dip fault‐scarp (VFW). This analysis highlights areas of sediment bypass (VFW > VHW) and areas fed by sediment sources beyond the degraded fault scarp (VHW > VFW). Exposure of the border fault footwall and adjacent fault terraces produced small catchments located beyond the fault block crest that fed the hangingwall basin. One source persisted throughout the main syn‐rift episode, and its location coincided with: (a) an intra‐basin topographic high; (b) a local fault throw minimum; (c) increased vertical and headward erosion within the fault‐scarp degradation complex; and (d) sustained clinoform development in the immediate hangingwall. Our novel quantitative volumetric approach to identify through‐going sediment input points could be applied to other rift basin‐fills. We highlight implications for hydrocarbon exploration and emphasize the need to incorporate interaction of multiple sediment sources and their resultant architecture in tectono‐stratigraphic models for rift basins