Identification and validation of novel biomarkers and therapeutics for pulpitis using connectivity mapping

International audienceAim To create an irreversible pulpitis gene signature from microarray data of healthy and inflamed dental pulps, followed by a bioinformatics approach using connectivity mapping to identify therapeutic compounds that could potentially treat pulpitis. Methodology The Gene Expression Omnibus (GEO) database, an international public repositor

A stochastic model for proactive risk management decisions

The analysis of stochastic discounting models provides one of the more powerful tools available for decision-making under conditions of uncertainty. This paper is mainly devoted to the establishment of properties and applications of a particular stochastic discounting model. More precisely, the paper investigates some of the theoretical problems encountered in a stochastic discounting model when assessing mutually exclusive options, and establishes the advantages of considering risk retention in proactive risk-management programs

Statistical evaluation of the re-education of pelvic floor musculature using the Bradford Perineometer with biofeedback

SIGLEGBUnited Kingdo

A statistical study of the pressure-time profiles generated by perineometry in the treatment of female genuine stress incontinence

SIGLEGBUnited Kingdo

Statistical assessment of pre-modulated interferential therapy in the treatment of genuine stress incontinence

SIGLEGBUnited Kingdo

A stochastic present-value model for application in situations of financial constraint

SIGLEAvailable from British Library Document Supply Centre-DSC:7673.051(97-78) / BLDSC - British Library Document Supply CentreGBUnited Kingdo

Investigation of mirror-self recognition in ravens (Corvus corax).

Large-brained birds, such as corvids and parrots, tend to fail tests for self-recognition (mirror self-recognition [MSR]), but the limited positive evidence for MSR in these species has been questioned due to methodological limitations. In the present study, we aimed to investigate MSR in ravens by performing three mirror tests: a mirror exposure test, a mirror preference test, and a mark test. Across all three tests, the ravens' behavior was not consistent with MSR. Three out of six ravens infrequently interacted with the mirror and the nonmirror surfaces. Two birds explored the mirror and occasionally displayed contingent behaviors. Finally, the ravens made very few social displays toward the mirror, suggesting that at this stage they did not treat their reflection as a conspecific. These findings, along with the current evidence available, raise further questions on the validity of relying on one test to establish self-recognition and call for the development of methods beyond mirror tests to explore self-recognition in nonhuman animals. (PsycInfo Database Record (c) 2022 APA, all rights reserved)