399 research outputs found

    Tau weak dipole moments from azimuthal asymmetries

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    We show that transverse and normal single-tautau polarization of tautau pairs produced at e+e^+ ee^- unpolarized collisions, at the ZZ peak, are sensitive to weak (magnetic and electric) dipole moments of the tautau. We also show how these components of the τ\tau polarization are accessible by measuring appropriate azimuthal asymmetries in the angular distribution of its decay products. Sensitivities of the order of 101810^{-18} ecme\cdot cm, for the weak-electric dipole moment, and 10410^{-4} (10310^{-3}), for the real (imaginary) part of the weak-magnetic dipole moment of τ\tau, may be achieved. Compatible bounds are also presented from spin-spin correlated asymmetries.Comment: Talk given at the TAU'98 Workshop, September 1998, Santander, Spain. 8 pages, 2 figure

    Work-In-Progress Paper: 360-degree immersive storytelling video to create empathetic response

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    Open days are organised by Universities to give potential students the opportunity to visit the University premises, talk to staff and student ambassadors and develop a sense of how it feels to study at a University something difficult to be conveyed via a prospectus. However, visiting open days requires investing time, travelling and can be expensive. The resent years there has been an increasing demand for open days to be delivered online. The social distancing measures imposed by the COVID-19 pandemic enforced this mode of delivery of open days as the only option. Many Universities created VR campuses to help students experience their campuses, but those fail to capture the actual vibe of a place and lack of empathetic response. New tools such as 360-degree immersive storytelling video (VR) and 3D interactive media present new opportunities for effectively delivering open days capturing not only a realistic representation of the place, but the actual feel of a place. This paper presents work-in-progress focusing on studying if 360-degree immersive storytelling video can create empathetic response. It achieves this by creating a 360-degree immersive storytelling video that effectively and realistically captures student life. This paper presents the project motivation, discusses the proposed research methodology, presents the research instruments and finishes with expected contributions to knowledge and future work

    Real-Time Control of a Virtual Human Using Minimal Sensors

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    We track, in real-time, the position and posture of a human body, using a minimal number of 6 DOF sensors to capture full body standing postures. We use 4 sensors to create a good approximation of a human operator\u27s position and posture, and map it on to our articulated computer graphics human model. The unsensed joints are positioned by a fast inverse kinematics algorithm. Our goal is to realistically recreate human postures while minimally encumbering the operator

    Shaping the future of our training

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    A Novel Snf2 Protein Maintains trans-Generational Regulatory States Established by Paramutation in Maize

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    Paramutations represent heritable epigenetic alterations that cause departures from Mendelian inheritance. While the mechanism responsible is largely unknown, recent results in both mouse and maize suggest paramutations are correlated with RNA molecules capable of affecting changes in gene expression patterns. In maize, multiple required to maintain repression (rmr) loci stabilize these paramutant states. Here we show rmr1 encodes a novel Snf2 protein that affects both small RNA accumulation and cytosine methylation of a proximal transposon fragment at the Pl1-Rhoades allele. However, these cytosine methylation differences do not define the various epigenetic states associated with paramutations. Pedigree analyses also show RMR1 does not mediate the allelic interactions that typically establish paramutations. Strikingly, our mutant analyses show that Pl1-Rhoades RNA transcript levels are altered independently of transcription rates, implicating a post-transcriptional level of RMR1 action. These results suggest the RNA component of maize paramutation maintains small heterochromatic-like domains that can affect, via the activity of a Snf2 protein, the stability of nascent transcripts from adjacent genes by way of a cotranscriptional repression process. These findings highlight a mechanism by which alleles of endogenous loci can acquire novel expression patterns that are meiotically transmissible

    Production and Processing of siRNA Precursor Transcripts from the Highly Repetitive Maize Genome

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    Mutations affecting the maintenance of heritable epigenetic states in maize identify multiple RNA–directed DNA methylation (RdDM) factors including RMR1, a novel member of a plant-specific clade of Snf2-related proteins. Here we show that RMR1 is necessary for the accumulation of a majority of 24 nt small RNAs, including those derived from Long-Terminal Repeat (LTR) retrotransposons, the most common repetitive feature in the maize genome. A genetic analysis of DNA transposon repression indicates that RMR1 acts upstream of the RNA–dependent RNA polymerase, RDR2 (MOP1). Surprisingly, we show that non-polyadenylated transcripts from a sampling of LTR retrotransposons are lost in both rmr1 and rdr2 mutants. In contrast, plants deficient for RNA Polymerase IV (Pol IV) function show an increase in polyadenylated LTR RNA transcripts. These findings support a model in which Pol IV functions independently of the small RNA accumulation facilitated by RMR1 and RDR2 and support that a loss of Pol IV leads to RNA Polymerase II–based transcription. Additionally, the lack of changes in general genome homeostasis in rmr1 mutants, despite the global loss of 24 nt small RNAs, challenges the perceived roles of siRNAs in maintaining functional heterochromatin in the genomes of outcrossing grass species

    Real-world evidence of TNF inhibition in axial spondyloarthritis : can we generalise the results from clinical trials?

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    Funding This work was supported by the British Society for Rheumatology (BSR) who funded the BSRBR-AS. The BSR received funding for this from Pfizer, AbbVie and UCB. These companies receive advance copies of manuscripts for comments but have no input in to the topics for analysis in the register nor the work involved in undertaking analysis. Analysis of data was supported by the Versus Arthritis/Medical Research Council Centre for Musculoskeletal Health and Work (grant number 20665).Peer reviewedPostprin

    Introducing mobile fracture prevention services with DXA in Northern Scotland : A comparative study of three rural communities

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    The authors would like to thank the Grampian Osteoporosis Trust for funding the purchase of the mobile DXA scanner and the set-up costs of the service, and the University of Aberdeen Development Trust for funding the project evaluation.Peer reviewedPostprin

    Outcomes and treatment responses, including work productivity, among people with axial spondyloarthritis living in urban and rural areas : a mixed-methods study within a national register

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    ACKNOWLEDGEMENTS We are grateful to the staff of the British Society for Rheumatology Biologics Register in Axial Spondyloarthritis register who at the time of the study were Elizabeth Ferguson-Jones, Maureen Heddle, Nafeesa Nazlee and Barry Morris, and to the recruiting staff at the clinical centres, details of which are available at: https://www.abdn.ac.uk/iahs/research/epidemiology/spondyloarthritis.php#panel1011. FUNDING The BSRBR-AS is funded by the British Society of Rheumatology who have received funding for this, in part, from Pfizer, Abbvie and UCB. These companies receive advance copies of results but have no input in determining the topics for analysis or work involved in undertaking it. This work was conducted within the Versus Arthritis/Medical Research Council Centre for Musculoskeletal Work and Health (Grant No: 20665).Peer reviewedPublisher PD
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