Towards the deformation quantization of linearized gravity

We present a first attempt to apply the approach of deformation quantization to linearized Einstein's equations. We use the analogy with Maxwell equations to derive the field equations of linearized gravity from a modified Maxwell Lagrangian which allows the construction of a Hamiltonian in the standard way. The deformation quantization procedure for free fields is applied to this Hamiltonian. As a result we obtain the complete set of quantum states and its discrete spectrum.Comment: 13 pages, no figures **preliminary entry **

Dumping inflaton energy density out of this world

We argue that a brane world with a warped, infinite extra dimension allows for the inflaton to decay into the bulk so that after inflation, the effective dark energy disappears from our brane. This is achieved by the redshifting of the decay products into infinity of the 5th dimension. As a consequence, all matter and CMB density perturbations could have their origin in the decay of a MSSM flat direction rather than the inflaton. We also discuss a string theoretical model where reheating after inflation may not affect the observable brane.Comment: 16 page

Artritis séptica de rodilla por Streptococcus agalactiae: presentación de un caso y revisión de la literatura

Se describe un caso de artritis séptica de rodilla en un paciente diabético de 69 años. En el momento de la presentación se hallaba sometido a curas locales de una úlcera crónica en el mismo miembro y a antibioterapia oral inespecífica por supuesta infección urinaria. En el cultivo del líquido sinovial se identificó un Streptococcus agalactiae (Estreptococo del grupo B). La infección no remitió con antibioterapia intravenosa electiva e irrigación-aspiración articular repetidas, requiriendo desbridamiento quirúrgico y sinovectomía. A pesar de instaurarse un programa de rehabilitación intensiva la rodilla evolucionó a la rigidez. Se revisa la literatura al respecto, destacando la asociación de artritis por estreptococos del grupo B con pacientes diabéticos portadores de úlceras cutáneas crónicas, así como la potencial gravedad de estas infecciones.This report describes a case of knee septic arthritis in a 69-year-old diabetic patient. At the time of admission he was receiving local treatment for a chronic skin ulcer in the same extremity and inespecific oral antibiotherapy because of an urinary tract infection. Synovial fluid cultures showed a Streptococcus agalactiae (group B streptococcus). The infection had no response to specific parenteral antibiotherapy and repeated joint irrigations-aspirations, and therefore surgical desbridement and synovectomy was required. Despite of an intensive rehabilitation program, the affected knee developed ankylosis. In a review of literature, it is remarkable the association between group B streptococcal arthritis and chronic skin ulcers in diabetic patients and the potential severity of these infections

Fracturas de cadera y diáfisis femoral ipsilaterales

Se aportan 10 casos de fracturas de cadera y diáfisis femoral ipsilaterales tratados quirúrgicamente de forma diferida con un tiempo medio de demora de 12 días (rango: 3 a 22 días). Nueve fracturas diafisarias fueron tratadas con placa AO de fémur, y una, donde la fractura de cadera asociada pasó inicialmente inadvertida, mediante un clavo de Küntscher. Las fracturas de cadera se fijaron con tornillos de esponjosa (8 casos) o clavo-placa de Richards (2 casos). En todos los pacientes se inició un programa de rehabilitación precoz. El seguimiento medio ha sido de 31 meses (rango: 12 a 84 meses). Todas las fracturas consolidaron. Las complicaciones fueron un caso de acortamiento femoral y otro de artrosis coxofemoral post-traumá- tica. En nuestra experiencia, la fijación de la fractura diafisaria con placa AO, combinada con tornillos de esponjosa o clavo-placa de Richards para la síntesis de la fractura de cadera, proporciona resultados satisfactoriosWe review 10 cases of ipsilateral hip and femoral shaft fractures. Operative treatment was performed in all cases, with an average delay of 12 days (range: 3 to 22 days). Nine femoral shaft fractures were stabilizated with an AO plate, and one, where the associated hip fracture was initially missed, with a Küntscher rod. Hip fractures were fixed with cancellous screws (8 cases) or Richards compression screw (2 cases). An early rehabilitation program was carried out in all patients. The average follow-up was 31 months (range: 12 to 84 months). All fractures healed. Complications were a case of femoral shortening an a case of post-traumatic hip osteoarthritis. In our study, the combination of AO plate for the shaft fracture with cancellous screws or Richards compression screw for the hip fracture provides good results

Luxación tibio astragalina posteromedial sin fractura de maleolos: a propósito de un caso

Se describe un caso de luxación tibioastragalina posteromedial abierta sin fractura asociada de maleolos, en un paciente de 28 años. A los dos años del desbridamiento quirúrgico, reducción manual y reparación capsuloligamentosa, el paciente estaba libre de dolor y presentaba una función semejante a la del tobillo contralateral. Se revisa la literatura sobre el tema y se discuten los factores etiopatológicos, complicaciones y principios de tratamiento

The Non-Canonical Wnt/PKC Pathway Regulates Mitochondrial Dynamics through Degradation of the Arm-Like Domain-Containing Protein Alex3

The regulation of mitochondrial dynamics is vital in complex cell types, such as neurons, that transport and localize mitochondria in high energy-demanding cell domains. The Armcx3 gene encodes a mitochondrial-targeted protein (Alex3) that contains several arm-like domains. In a previous study we showed that Alex3 protein regulates mitochondrial aggregation and trafficking. Here we studied the contribution of Wnt proteins to the mitochondrial aggregation and dynamics regulated by Alex3. Overexpression of Alex3 in HEK293 cells caused a marked aggregation of mitochondria, which was attenuated by treatment with several Wnts. We also found that this decrease was caused by Alex3 degradation induced by Wnts. While the Wnt canonical pathway did not alter the pattern of mitochondrial aggregation induced by Alex3, we observed that the Wnt/PKC non-canonical pathway regulated both mitochondrial aggregation and Alex3 protein levels, thereby rendering a mitochondrial phenotype and distribution similar to control patterns. Our data suggest that the Wnt pathway regulates mitochondrial distribution and dynamics through Alex3 protein degradation

Cosmology and two-body problem of D-branes

In this paper, we investigate the dynamics and the evolution of the scale factor of a probe Dp-brane which move in the background of source Dp-branes. Action of the probe brane is described by the Born-Infeld action and the interaction with the background R-R field. When the probe brane moves away from the source branes, it expands by power law, whose index depends on the dimension of the brane. If the energy density of the gauge field on the brane is subdominant, the expansion is decelerating irrespective of the dimension of the brane. On the other hand, when the probe brane is a Nambu-Goto brane, the energy density of the gauge field can be dominant, in which case accelerating expansion occurs for $p \leq 4$. The accelerating expansion stops when the brane has expanded sufficiently so that the energy density of the gauge field become subdominant.Comment: 6 pages, 7 figures, reference added, accepted for publication in PR

Staphylococcus aureus nasal colonization in Spanish children. The COSACO nationwide surveillance study

Objective: To assess the prevalence and risk factors for S. aureus and methicillin-resistant S. aureus (MRSA) nasal colonization in Spanish children. Methods: Cross-sectional study of patients <14 years from primary care centers all over Spain. Clinical data and nasal aspirates were collected from March to July 2018. Results: A total of 1876 patients were enrolled. Prevalence of S. aureus and MRSA colonization were 33% (95% CI 30.9–35.1) and 1.44% (95% CI 0.9–2), respectively. Thirtythree percent of the children (633/1876) presented chronic conditions, mainly atopic dermatitis, asthma and/or allergy (524/633). Factors associated with S. aureus colonization were age =5 years (OR 1.10, 95% CI 1.07–1.12), male sex (OR 1.43, 95% CI 1.17–1.76), urban setting (OR 1.46, 95% CI 1.08–1.97) and the presence of asthma, atopic dermatitis or allergies (OR 1.25; 95% CI: 1.093–1.43). Rural residence was the only factor associated with MRSA colonization (OR 3.62, 95% CI 1.57–8.36). MRSA was more frequently resistant than methicillin-susceptible S. aureus to ciprofloxacin [41.2% vs 2.6%; p<0.0001], clindamycin [26% vs 16.9%; p=0.39], and mupirocin [14.3% vs 6.7%; p=0.18]. None of the MRSA strains was resistant to tetracycline, fosfomycin, vancomycin or daptomycin. Conclusions: The main risk factors for S. aureus colonization in Spanish children are being above five years of age, male gender, atopic dermatitis, asthma or allergy, and residence in urban areas. MRSA colonization is low, but higher than in other European countries and is associated with rural settings

Astrophysical and Cosmological Implications of Large Volume String Compactifications

We study the spectrum, couplings and cosmological and astrophysical implications of the moduli fields for the class of Calabi-Yau IIB string compactifications for which moduli stabilisation leads to an exponentially large volume V ~ 10^{15} l_s^6 and an intermediate string scale m_s ~ 10^{11}GeV, with TeV-scale observable supersymmetry breaking. All K\"ahler moduli except for the overall volume are heavier than the susy breaking scale, with m ~ ln(M_P/m_{3/2}) m_{3/2} ~ (\ln(M_P/m_{3/2}))^2 m_{susy} ~ 500 TeV and, contrary to standard expectations, have matter couplings suppressed only by the string scale rather than the Planck scale. These decay to matter early in the history of the universe, with a reheat temperature T ~ 10^7 GeV, and are free from the cosmological moduli problem (CMP). The heavy moduli have a branching ratio to gravitino pairs of 10^{-30} and do not suffer from the gravitino overproduction problem. The overall volume modulus is a distinctive feature of these models and is an M_{planck}-coupled scalar of mass m ~ 1 MeV and subject to the CMP. A period of thermal inflation can help relax this problem. This field has a lifetime ~ 10^{24}s and can contribute to dark matter. It may be detected through its decays to 2\gamma or e^+e^-. If accessible the e^+e^- decay mode dominates, with Br(\chi \to 2 \gamma) suppressed by a factor (ln(M_P/m_{3/2}))^2. We consider the potential for detection of this field through different astrophysical sources and find that the observed gamma-ray background constrains \Omega_{\chi} <~ 10^{-4}. The decays of this field may generate the 511 keV emission line from the galactic centre observed by INTEGRAL/SPI.Comment: 31 pages, 2 figures; v2. refs adde