294 research outputs found
TREX-DM: a low background Micromegas-based TPC for low-mass WIMP detection
Dark Matter experiments are recently focusing their detection techniques in
low-mass WIMPs, which requires the use of light elements and low energy
threshold. In this context, we describe the TREX-DM experiment, a low
background Micromegas-based TPC for low-mass WIMP detection. Its main goal is
the operation of an active detection mass 0.3 kg, with an energy
threshold below 0.4 keVee and fully built with previously selected radiopure
materials. This work describes the commissioning of the actual setup situated
in a laboratory on surface and the updates needed for a possible physics run at
the Canfranc Underground Laboratory (LSC) in 2016. A preliminary background
model of TREX-DM is also presented, based on a Geant4 simulation, the
simulation of the detector's response and two discrimination methods: a
conservative muon/electron and one based on a neutron source. Based on this
background model, TREX-DM could be competitive in the search for low-mass
WIMPs. In particular it could be sensitive, e.g., to the low-mass WIMP
interpretation of the DAMA/LIBRA and other hints in a conservative scenario.Comment: Proceedings of the XIV International Conference on Topics in
Astroparticle and Underground Physics (TAUP 2015), 7-11 September 2015,
Torino, Ital
TREX-DM: a low background Micromegas-based TPC for low mass WIMP detection
Dark Matter experiments are recently focusing their detection techniques in
low-mass WIMPs, which requires the use of light elements and low energy
threshold. In this context, we present the TREX-DM experiment, a low background
Micromegas-based TPC for low-mass WIMP detection. Its main goal is the
operation of an active detection mass 0.300 kg, with an energy threshold
below 0.4 keVee and fully built with previously selected radiopure materials.
This article describes the actual setup, the first results of the comissioning
in Ar+2\%iCH at 1.2 bar and the future updates for a possible
physics run at the Canfranc Underground Laboratory in 2016. A first background
model is also presented, based on Geant4 simulations and a muon/electron
discrimination method. In a conservative scenario, TREX-DM could be sensitive
to DAMA/LIBRA and other hints of positive WIMPs signals, with some space for
improvement with a neutron/electron discrimination method or the use of other
light gases.Comment: Proceedings of the 7th Symposium on Large TPCs for Low-Energy Rare
Event Detectio
Metabolic engineering of folate and its precursors in Mexican common bean (Phaseolus vulgaris L.).
4-1BBL as a Mediator of Cross-Talk between Innate, Adaptive, and Regulatory Immunity against Cancer
The ability of tumor cells to evade the immune system is one of the main challenges we confront in the fight against cancer. Multiple strategies have been developed to counteract this situation, including the use of immunostimulant molecules that play a key role in the anti-tumor immune response. Such a response needs to be tumor-specific to cause as little damage as possible to healthy cells and also to track and eliminate disseminated tumor cells. Therefore, the combination of immunostimulant molecules and tumor-associated antigens has been implemented as an antitumor therapy strategy to eliminate the main obstacles confronted in conventional therapies. The immunostimulant 4-1BBL belongs to the tumor necrosis factor (TNF) family and it has been widely reported as the most effective member for activating lymphocytes. Hence, we will review the molecular, pre-clinical, and clinical applications in conjunction with tumor-associated antigens in antitumor immunotherapy, as well as the main molecular pathways involved in this association
Randomized clinical trial to evaluate the effect of fecal microbiota transplant for initial Clostridium difficile infection in intestinal microbiome
Objective The aim of this study was to evaluate the impact of fecal donor-unrelated donor mix (FMT-FURM) transplantation as first-line therapy for C. difficile infection (CDI) in intestinal microbiome. Methods We designed an open, two-arm pilot study with oral vancomycin (250mg every 6 h for 10–14 days) or FMT-FURM as treatments for the first CDI episode in hospitalized adult patients in Hospital Universitario “Dr. Jose Eleuterio Gonzalez”. Patients were randomized by a closed envelope method in a 1: 1 ratio to either oral vancomycin or FMT-FURM. CDI resolution was considered when there was a reduction on the Bristol scale of at least 2 points, a reduction of at least 50% in the number of bowel movements, absence of fever, and resolution of abdominal pain (at least two criteria). From each patient, a fecal sample was obtained at days 0, 3, and 7 after treatment. Specimens were cultured to isolate C. difficile, and isolates were characterized by PCR. Susceptibility testing of isolates was performed using the agar dilution method. Fecal samples and FMT-FURM were analyzed by 16S rRNA sequencing. Results We included 19 patients; 10 in the vancomycin arm and 9 in the FMT-FURM arm. However, one of the patients in the vancomycin arm and two patients in the FMT-FURM arm were eliminated. Symptoms resolved in 8/9 patients (88.9%) in the vancomycin group, while symptoms resolved in 4/7 patients (57.1%) after the first FMT-FURM dose (P = 0.26) and in 5/7 patients (71.4%) after the second dose (P = 0.55). During the study, no adverse effects attributable to FMT-FURM were observed in patients. Twelve isolates were recovered, most isolates carried tcdB, tcdA, cdtA, and cdtB, with an 18-bp deletion in tcdC. All isolates were resistant to ciprofloxacin and moxifloxacin but susceptible to metronidazole, linezolid, fidaxomicin, and tetracycline. In the FMT-FURM group, the bacterial composition was dominated by Firmicutes, Bacteroidetes, and Proteobacteria at all-time points and the microbiota were remarkably stable over time. The vancomycin group showed a very different pattern of the microbial composition when comparing to the FMT-FURM group over time. Conclusion The results of this preliminary study showed that FMT-FURM for initial CDI is associated with specific bacterial communities that do not resemble the donors’ sample.Peer reviewedFinal Published versio
CAST solar axion search with 3^He buffer gas: Closing the hot dark matter gap
The CERN Axion Solar Telescope (CAST) has finished its search for solar
axions with 3^He buffer gas, covering the search range 0.64 eV < m_a <1.17 eV.
This closes the gap to the cosmological hot dark matter limit and actually
overlaps with it. From the absence of excess X-rays when the magnet was
pointing to the Sun we set a typical upper limit on the axion-photon coupling
of g_ag < 3.3 x 10^{-10} GeV^{-1} at 95% CL, with the exact value depending on
the pressure setting. Future direct solar axion searches will focus on
increasing the sensitivity to smaller values of g_a, for example by the
currently discussed next generation helioscope IAXO.Comment: 5 pages, 2 figures. Last version uploade
Bovine lactoferrin and lactoferrin-derived peptides inhibit the growth of Vibrio cholerae and other Vibrio species
Bovine lactoferrin and lactoferrin-derived peptides inhibit the growth of Vibrio cholerae and other Vibrio species
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