2,879 research outputs found
Thermal Diffusivities of Functionalized Pentacene Semiconductors
We have measured the interlayer and in-plane (needle axis) thermal
diffusivities of 6,13-bis(triisopropylsilylethynyl) pentacene (TIPS-Pn). The
needle axis value is comparable to the phonon thermal conductivities of
quasi-one dimensional organic metals with excellent pi-orbital overlap, and its
value suggests that a significant fraction of heat is carried by optical
phonons. Furthermore, the interlayer (c-axis) thermal diffusivity is at least
an order of magnitude larger, and this unusual anisotropy implies very strong
dispersion of optical modes in the interlayer direction, presumably due to
interactions between the silyl-containing side groups. Similar values for both
in-plane and interlayer diffusivities have been observed for several other
functionalized pentacene semiconductors with related structures.Comment: 9 pages, including 4 figures; submitted to Applied Physics Letter
The Event Horizon of M87
The 6 billion solar mass supermassive black hole at the center of the giant
elliptical galaxy M87 powers a relativistic jet. Observations at millimeter
wavelengths with the Event Horizon Telescope have localized the emission from
the base of this jet to angular scales comparable to the putative black hole
horizon. The jet might be powered directly by an accretion disk or by
electromagnetic extraction of the rotational energy of the black hole. However,
even the latter mechanism requires a confining thick accretion disk to maintain
the required magnetic flux near the black hole. Therefore, regardless of the
jet mechanism, the observed jet power in M87 implies a certain minimum mass
accretion rate. If the central compact object in M87 were not a black hole but
had a surface, this accretion would result in considerable thermal
near-infrared and optical emission from the surface. Current flux limits on the
nucleus of M87 strongly constrain any such surface emission. This rules out the
presence of a surface and thereby provides indirect evidence for an event
horizon.Comment: 9 pages, 2 figures, submitted to Ap
Diffusion Enhancement in Core-softened fluid confined in nanotubes
We study the effect of confinement in the dynamical behavior of a
core-softened fluid. The fluid is modeled as a two length scales potential.
This potential in the bulk reproduces the anomalous behavior observed in the
density and in the diffusion of liquid water. A series of Molecular
Dynamics simulations for this two length scales fluid confined in a nanotube
were performed. We obtain that the diffusion coefficient increases with the
increase of the nanotube radius for wide channels as expected for normal
fluids. However, for narrow channels, the confinement shows an enhancement in
the diffusion coefficient when the nanotube radius decreases. This behavior,
observed for water, is explained in the framework of the two length scales
potential.Comment: 17 pages, 8 figures, accept for publication at J. Chem. Phy
Laboratory and telescope use of the NICMOS2 128 x 128 HgCdTe array
The second generation of Hubble Space Telescope (HST) instruments will include a near-infrared instrument. This choice has driven the development of near-infrared arrays to larger sizes and lower read noises. Rockwell International has delivered an array for use in the Near Infrared Camera and Multi-Object Spectrometer (NICMOS) instrument; this array has been dubbed NICMOS2. NICMOS2 is a 128x128 array of HgCdTe diodes In-bonded to a switched MOSFET readout. The readout was specifically designed for astronomical use with the HST requirement of low read noise a prime goal. These arrays use detector material which is similar to that used by Rockwell in previous arrays (e.g., HgCdTe produced on a sapphire substrate), but the NICMOS2 devices differ substantially from other 128x128 arrays produced by Rockwell in having a read noise of only 30 electrons when read out using appropriate correlated sampling. NICMOS2 has now been characterized in the laboratory, and it has been used on groundbased telescopes
Learning to Read Better: Training Decoding, Comprehension and Perceptual Skills
The present study is a program evaluation designed to evaluate an elementary school remedial reading instructional program using Carr\u27s model (1982) of reading ability. The Learning to Read Better program evolved from Anes\u27 (1979a, 1979b, 1981) study and experience In teaching children with reading problems. The program is structured according to the components of the reading process, with time in the reading room and teaching responsibility allocated so that learning in each component occurs during every remedial session. Four key components of the reading process emphasized in this program are: visual-perceptual training, decoding, oral reading, and comprehension
IL-15 Activates the Jak3/STAT3 Signaling Pathway to Mediate Glucose Uptake in Skeletal Muscle Cells
Myokines are specialized cytokines that are secreted from skeletal muscle (SKM) in response to metabolic stimuli, such as exercise. Interleukin-15 (IL-15) is a myokine with potential to reduce obesity and increase lean mass through induction of metabolic processes. It has been previously shown that IL-15 acts to increase glucose uptake in SKM cells. However, the downstream signals orchestrating the link between IL-15 signaling and glucose uptake have not been fully explored. Here we employed the mouse SKM C2C12 cell line to examine potential downstream targets of IL-15-induced alterations in glucose uptake. Following differentiation, C2C12 cells were treated overnight with 100 ng/ml of IL-15. Activation of factors associated with glucose metabolism (Akt and AMPK) and known downstream targets of IL-15 (Jak1, Jak3, STAT3, and STAT5) were assessed with IL-15 stimulation. IL-15 stimulated glucose uptake and GLUT4 translocation to the plasma membrane. IL-15 treatment had no effect on phospho-Akt, phospho-Akt substrates, phospho-AMPK, phospho-Jak1, or phospho-STAT5. However, with IL-15, phospho-Jak3 and phospho-STAT3 levels were increased along with increased interaction of Jak3 and STAT3. Additionally, IL-15 induced a translocation of phospho-STAT3 from the cytoplasm to the nucleus. We have evidence that a mediator of glucose uptake, HIF1α, expression was dependent on IL-15 induced STAT3 activation. Finally, upon inhibition of STAT3 the positive effects of IL-15 on glucose uptake and GLUT4 translocation were abolished. Taken together, we provide evidence for a novel signaling pathway for IL-15 acting through Jak3/STAT3 to regulate glucose metabolism
IL-15 Activates the Jak3/STAT3 Signaling Pathway to Mediate Glucose Uptake in Skeletal Muscle Cells
Myokines are specialized cytokines that are secreted from skeletal muscle (SKM) in response to metabolic stimuli, such as exercise. Interleukin-15 (IL-15) is a myokine with potential to reduce obesity and increase lean mass through induction of metabolic processes. It has been previously shown that IL-15 acts to increase glucose uptake in SKM cells. However, the downstream signals orchestrating the link between IL-15 signaling and glucose uptake have not been fully explored. Here we employed the mouse SKM C2C12 cell line to examine potential downstream targets of IL-15-induced alterations in glucose uptake. Following differentiation, C2C12 cells were treated overnight with 100 ng/ml of IL-15. Activation of factors associated with glucose metabolism (Akt and AMPK) and known downstream targets of IL-15 (Jak1, Jak3, STAT3, and STAT5) were assessed with IL-15 stimulation. IL-15 stimulated glucose uptake and GLUT4 translocation to the plasma membrane. IL-15 treatment had no effect on phospho-Akt, phospho-Akt substrates, phospho-AMPK, phospho-Jak1, or phospho-STAT5. However, with IL-15, phospho-Jak3 and phospho-STAT3 levels were increased along with increased interaction of Jak3 and STAT3. Additionally, IL-15 induced a translocation of phospho-STAT3 from the cytoplasm to the nucleus. We have evidence that a mediator of glucose uptake, HIF1α, expression was dependent on IL-15 induced STAT3 activation. Finally, upon inhibition of STAT3 the positive effects of IL-15 on glucose uptake and GLUT4 translocation were abolished. Taken together, we provide evidence for a novel signaling pathway for IL-15 acting through Jak3/STAT3 to regulate glucose metabolism
NICMOS Imaging of the HR 4796A Circumstellar Disk
We report the first near infrared (NIR) imaging of a circumstellar annular
disk around the young (~8 Myr), Vega-like star, HR 4796A. NICMOS coronagraph
observations at 1.1 and 1.6 microns reveal a ring-like symmetrical structure
peaking in reflected intensity 1.05 arcsec +/- 0.02 arcsec (~ 70 AU) from the
central A0V star. The ring geometry, with an inclination of 73.1 deg +/- 1.2
deg and a major axis PA of 26.8 deg +/- 0.6 deg, is in good agreement with
recent 12.5 and 20.8 micron observations of a truncated disk (Koerner, et al.
1998). The ring is resolved with a characteristic width of less than 0.26
arcsec (17 AU) and appears abruptly truncated at both the inner and outer
edges. The region of the disk-plane inward of ~60 AU appears to be relatively
free of scattering material. The integrated flux density of the part of the
disk that is visible (greater than 0.65 arcsec from the star) is found to be
7.5 +/- 0.5 mJy and 7.4 +/- 1.2 mJy at 1.1 and 1.6 microns, respectively.
Correcting for the unseen area of the ring yields total flux densities of 12.8
+/- 1.0 mJy and 12.5 +/- 2.0 mJy, respectively (Vega magnitudes = 12.92 /+-
0.08 and 12.35 +/-0.18). The NIR luminosity ratio is evaluated from these
results and ground-based photometry of the star. At these wavelengths
Ldisk(lambda)/L*(lambda) = 1.4 +/- 0.2E-3 and 2.4 +/- 0.5E-3, giving reasonable
agreement between the stellar flux scattered in the NIR and that which is
absorbed in the visible and re-radiated in the thermal infrared. The somewhat
red reflectance of the disk at these wavelengths implies mean particle sizes in
excess of several microns, larger than typical interstellar grains. The
confinement of material to a relatively narrow annular zone implies dynamical
constraints on the disk particles by one or more as yet unseen bodies.Comment: 14 pages, 1 figure for associated gif file see:
http://nicmosis.as.arizona.edu:8000/AAS99/FIGURE1_HR4796A_ApJL.gif . Accepted
13 January 1999, Astrophyical Journal Letter
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