865 research outputs found
65 Cybele in the thermal infrared: Multiple observations and thermophysical analysis
We investigated the physical and thermal properties of 65 Cybele}, one of the
largest main-belt asteroids. Based on published and recently obtained thermal
infrared observations, including ISO measurements, we derived through
thermophysical modelling (TPM) a size of 302x290x232 km (+/- 4 %) and an
geometric visible albedo of 0.050+/-0.005. Our model of a regolith covered
surface with low thermal inertia and "default" roughness describes the
wavelengths and phase angle dependent thermal aspects very well. Before/after
opposition effect and beaming behaviour can be explained in that way. We found
a constant emissivity of 0.9 at wavelengths up to about 100 micron and lower
values towards the submillimetre range, indicating a grain size distribution
dominated by 200 micron particle sizes. The spectroscopic analysis revealed an
emissivity increase between 8.0 and 9.5 micron. We compared this emissivity
behaviour with the Christiansen features of carbonaceous chondrite meteorites,
but a conclusive identification was not possible. A comparison between the
Standard Thermal Model (STM) and the applied TPM clearly demonstrates the
limitations and problems of the STM for the analysis of multi-epoch and
-wavelengths observations. While the TPM produced a unique diameter/albedo
solution, the calculated STM values varied by +/-30 % and showed clear trends
with wavelength and phase angle. Cybele can be considered as a nice textbook
case for the thermophysical analysis of combined optical and thermal infrared
observations.Comment: 11 pages, 8 figures, accepted for publication by A&
The retinoid-related orphan receptor RORα promotes keratinocyte differentiation via FOXN1.
RORα is a retinoid-related orphan nuclear receptor that regulates inflammation, lipid metabolism, and cellular differentiation of several non-epithelial tissues. In spite of its high expression in skin epithelium, its functions in this tissue remain unclear. Using gain- and loss-of-function approaches to alter RORα gene expression in human keratinocytes (HKCs), we have found that this transcription factor functions as a regulator of epidermal differentiation. Among the 4 RORα isoforms, RORα4 is prominently expressed by keratinocytes in a manner that increases with differentiation. In contrast, RORα levels are significantly lower in skin squamous cell carcinoma tumors (SCCs) and cell lines. Increasing the levels of RORα4 in HKCs enhanced the expression of structural proteins associated with early and late differentiation, as well as genes involved in lipid barrier formation. Gene silencing of RORα impaired the ability of keratinocytes to differentiate in an in vivo epidermal cyst model. The pro-differentiation function of RORα is mediated at least in part by FOXN1, a well-known pro-differentiation transcription factor that we establish as a novel direct target of RORα in keratinocytes. Our results point to RORα as a novel node in the keratinocyte differentiation network and further suggest that the identification of RORα ligands may prove useful for treating skin disorders that are associated with abnormal keratinocyte differentiation, including cancer
Real topological Hochschild homology
Funding Information: Acknowledgments. The authors would like to thank the Hausdorff Research Institute for Mathematics in Bonn for their hospitality during the Junior Trimester Program in Topology in 2016. Much of the work on this paper was carried out during that program. The authors also acknowledge the support of the Danish National Research Foundation through the Centre for Symmetry and Deformation (DNRF92). The second author was supported by the Max Planck institute for Mathematics and thanks the Mittag-Leffler Institute for their hospitality. The third author was supported by the German Research Foundation Schwerpunktprogramm 1786. The fourth author was supported by Independent Research Fund Denmark’s Sapere Aude program (DFF–4002-00224) and by the Max Planck Institute for Mathematics. Publisher Copyright: © European Mathematical Society 2021 Copyright: Copyright 2021 Elsevier B.V., All rights reserved.Peer reviewedPostprin
Low delta-V near-Earth asteroids: A survey of suitable targets for space missions
In the last decades Near-Earth Objects (NEOs) have become very important
targets to study, since they can give us clues to the formation, evolution and
composition of the Solar System. In addition, they may represent either a
threat to humankind, or a repository of extraterrestrial resources for suitable
space-borne missions. Within this framework, the choice of next-generation
mission targets and the characterisation of a potential threat to our planet
deserve special attention. To date, only a small part of the 11,000 discovered
NEOs have been physically characterised. From ground and space-based
observations one can determine some basic physical properties of these objects
using visible and infrared spectroscopy. We present data for 13 objects
observed with different telescopes around the world (NASA-IRTF, ESO-NTT, TNG)
in the 0.4 - 2.5 um spectral range, within the NEOSURFACE survey
(http://www.oa-roma.inaf.it/planet/NEOSurface.html). Objects are chosen from
among the more accessible for a rendez-vous mission. All of them are
characterised by a delta-V (the change in velocity needed for transferring a
spacecraft from low-Earth orbit to rendez-vous with NEOs) lower than 10.5 km/s,
well below the Solar System escape velocity (12.3 km/s). We taxonomically
classify 9 of these objects for the first time. 11 objects belong to the
S-complex taxonomy; the other 2 belong to the C-complex. We constrain the
surface composition of these objects by comparing their spectra with meteorites
from the RELAB database. We also compute olivine and pyroxene mineralogy for
asteroids with a clear evidence of pyroxene bands. Mineralogy confirms the
similarity with the already found H, L or LL ordinary chondrite analogues.Comment: 9 pages, 7 figures, to be published in A&A Minor changes by language
edito
Spitzer Observations of Spacecraft Target 162173 (1999 JU3)
Near-Earth asteroid 162173 (1999 JU3) is the primary target of the Hayabusa-2
sample return mission, and a potential target of the Marco Polo sample return
mission. Earth-based studies of this object are fundamental to these missions.
We present a mid-infrared spectrum (5-38 microns) of 1999 JU3 obtained with
NASA's Spitzer Space Telescope in May 2008. These observations place new
constraints on the surface properties of this asteroid. To fit our spectrum we
used the near-Earth asteroid thermal model (NEATM) and the more complex
thermophysical model (TPM). However, the position of the spin-pole, which is
uncertain, is a crucial input parameter for constraining the thermal inertia
with the TPM; hence, we consider two pole orientations. In the extreme case of
an equatorial retrograde geometry we derive a lower limit to the thermal
inertia of 150 J/m^2/K/s^0.5. If we adopt the pole orientation of Abe et al.
(2008a) our best-fit thermal model yields a value for the thermal inertia of
700+/-200 J/m^2/K/s^0.5 and even higher values are allowed by the uncertainty
in the spectral shape due to the absolute flux calibration. The lower limit to
the thermal inertia, which is unlikely but possible, would be consistent with a
fine regolith similar to wthat is found for asteroid 433 Eros. However, the
thermal inertia is expected to be higher, possibly similar to or greater than
that on asteroid 25143 Itokawa. Accurately determining the spin-pole of
asteroid 162173 will narrow the range of possible values for its thermal
inertia.Comment: 4 pages, 2 figures; to be published as a Letter in Astronomy and
Astrophysic
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Marco Polo: near Earth object sample return mission
Marco Polo is a joint European-Japanese mission of sample return from a Near Earth Object. The Marco Polo proposal was submitted to ESA on July 2007 in the framework of the Cosmic Vision 2015-2025 context, and on October 2007 passed the first evaluation process. The primary objectives of this mission is to visit a primitive NEO, belonging to a class that cannot be related to known meteorite types, to characterize it at multiple scales, and to bring samples back to Earth. Marco Polo will give us the first opportunity for detailed laboratory study of the most primitive materials that formed the planets. This will allow us to improve our knowledge on the processes which governed the origin and early evolution of the Solar System, and possibly of the life on Earth
School Choice, Youth Voice: How Diverse Student Policy Actors Experience High School Choice Policy
School choice research is abundant, but rarely incorporates students’ experiences or perspectives. This study investigates a diverse group of students’ school choice experiences as they applied to, gained admission to and enrolled in high school in Chicago Public Schools, which offers over 130 options. Adapting Ball and colleagues’ (2012) concept of policy actor positionality, we analyzed the role of students’ developmental and social statuses in students’ school choice experiences. Students’ policy encounters were developmentally consistent, but their admissions results and subsequent academic trajectories diverged by their socioeconomic status. We discuss these findings’ developmental and equity implications for school choice policy
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Marco Polo: A near Earth object sample return mission
From Introduction:
MARCO POLO is a joint European-Japanese sample return mission to a Near-Earth Object. In late 2007 this mission was selected by ESA, in the framework of COSMIC VISION 2015-2025, for an assessment scheduled to last until mid 2009.
This Euro-Asian mission will go to a primitive Near-Earth Object (NEO), such as a C or D type asteroid. The spacecraft will rendezvous with the object, and over an extended period scientifically characterize it at multiple scales and bring samples back to Earth for detailed scientific investigation
Genome-Wide Analysis of leafbladeless1-Regulated and Phased Small RNAs Underscores the Importance of the TAS3 ta-siRNA Pathway to Maize Development
Maize leafbladeless1 (lbl1) encodes a key component in the trans-acting short-interfering RNA (ta-siRNA) biogenesis pathway. Correlated with a great diversity in ta-siRNAs and the targets they regulate, the phenotypes conditioned by mutants perturbing this small RNA pathway vary extensively across species. Mutations in lbl1 result in severe developmental defects, giving rise to plants with radial, abaxialized leaves. To investigate the basis for this phenotype, we compared the small RNA content between wild-type and lbl1 seedling apices. We show that LBL1 affects the accumulation of small RNAs in all major classes, and reveal unexpected crosstalk between ta-siRNA biogenesis and other small RNA pathways regulating transposons. Interestingly, in contrast to data from other plant species, we found no evidence for the existence of phased siRNAs generated via the one-hit model. Our analysis identified nine TAS loci, all belonging to the conserved TAS3 family. Information from RNA deep sequencing and PARE analyses identified the tasiR-ARFs as the major functional ta-siRNAs in the maize vegetative apex where they regulate expression of AUXIN RESPONSE FACTOR3 (ARF3) homologs. Plants expressing a tasiR-ARF insensitive arf3a transgene recapitulate the phenotype of lbl1, providing direct evidence that deregulation of ARF3 transcription factors underlies the developmental defects of maize ta-siRNA biogenesis mutants. The phenotypes of Arabidopsis and Medicago ta-siRNA mutants, while strikingly different, likewise result from misexpression of the tasiR-ARF target ARF3. Our data indicate that diversity in TAS pathways and their targets cannot fully account for the phenotypic differences conditioned by ta-siRNA biogenesis mutants across plant species. Instead, we propose that divergence in the gene networks downstream of the ARF3 transcription factors or the spatiotemporal pattern during leaf development in which these proteins act constitute key factors underlying the distinct contributions of the ta-siRNA pathway to development in maize, Arabidopsis, and possibly other plant species as well
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