1,846 research outputs found
Shuttle orbiter boundary layer transition at flight and wind tunnel conditions
Hypersonic boundary layer transition data obtained on the windward centerline of the Shuttle orbiter during entry for the first five flights are presented and analyzed. Because the orbiter surface is composed of a large number of thermal protection tiles, the transition data include the effects of distributed roughness arising from tile misalignment and gaps. These data are used as a benchmark for assessing and improving the accuracy of boundary layer transition predictions based on correlations of wind tunnel data taken on both aerodynamically rough and smooth orbiter surfaces. By comparing these two data bases, the relative importance of tunnel free stream noise and surface roughness on orbiter boundary layer transition correlation parameters can be assessed. This assessment indicates that accurate predications of transition times can be made for the orbiter at hypersonic flight conditions by using roughness dominated wind tunnel data. Specifically, times of transition onset and completion is accurately predicted using a correlation based on critical and effective values of a roughness Reynolds number previously derived from wind tunnel data
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Sociocultural Approaches to Analyzing Cognitive Development in Interdisciplinary Teams
This paper considers whether a sociocultural theory of cognition can supply a suitable perspective for analyzing the nature of interdisciplinary collaboration within groups in the National Institute for Science Education (NISE). We discuss the metaphors of apprenticeship and voice in conversation to identify relevant elements of analysis in group discourse. The NISE group shows evidence of cognitive apprenticeship and of multiple voicedness, but the theories do not fully explain the impact of interdisciplinary interaction on group cognitive development. Although both the apprenticeship metaphor and the voice metaphor provide useful tools for analysis, it would be useful to have a metaphor that deals more directly with interaction among members of equal status from mature communities of practice
Resolving candidate genes of mouse skeletal muscle QTL via RNA-Seq and expression network analyses
Peer reviewedPublisher PD
Spectral and dynamic characteristics of buried-heterostructure single quantum well (Al,Ga)As lasers
We demonstrate that, as predicted, (Al,Ga)As single quantum well (SQW) lasers have substantially narrower spectral linewidths than bulk double-heterostructure lasers. We have observed a further major reduction (>3×) in the linewidth of these SQW lasers when the facet reflectivities are enhanced. This observation is explained theoretically on the basis of the very low losses in coated SQW lasers and the value of the spontaneous emission factor at low threshold currents. We also report on the modulation frequency response parameter of these SQW lasers
RAFT dispersion polymerization of glycidyl methacrylate for the synthesis of epoxy-functional block copolymer nanoparticles in mineral oil
Epoxy-functional poly(stearyl methacrylate)-poly(glycidyl methacrylate) (PSMA-PGlyMA) diblock copolymer nanoparticles are synthesized via reversible addition–fragmentation chain transfer (RAFT) dispersion polymerization of glycidyl methacrylate (GlyMA) in mineral oil at 70 °C. This efficient polymerization-induced self-assembly (PISA) formulation yields well-defined spheres of tunable diameter as confirmed by dynamic light scattering (DLS) and transmission electron microscopy (TEM) studies. 1H NMR spectroscopy and gel permeation chromatography (GPC) studies indicate that such non-polar dispersions exhibit greater stability during their long-term storage at 20 °C compared to related epoxy-functional nanoparticles prepared via RAFT aqueous emulsion polymerization. Model epoxy-amine ring-opening reactions using N-methylaniline demonstrate the potential for post-polymerization functionalization of such spherical nanoparticles
Sensitive Chemical Compass Assisted by Quantum Criticality
The radical-pair-based chemical reaction could be used by birds for the
navigation via the geomagnetic direction. An inherent physical mechanism is
that the quantum coherent transition from a singlet state to triplet states of
the radical pair could response to the weak magnetic field and be sensitive to
the direction of such a field and then results in different photopigments in
the avian eyes to be sensed. Here, we propose a quantum bionic setup for the
ultra-sensitive probe of a weak magnetic field based on the quantum phase
transition of the environments of the two electrons in the radical pair. We
prove that the yield of the chemical products via the recombination from the
singlet state is determined by the Loschmidt echo of the environments with
interacting nuclear spins. Thus quantum criticality of environments could
enhance the sensitivity of the detection of the weak magnetic field.Comment: 4 pages, 3 figure
What is educationally worthwhile knowledge? Revisiting the case for powerful knowledge
For all the talk of ‘the Knowledge Age’, the nature of knowledge in the context of formal education remains a neglected area. Michael Young is one of few sociologists who responds to this neglect and puts the question of knowledge squarely back into discussions of why formal education matters. In the context of ongoing disputes around the curriculum, concerned with factual knowledge and access to multiple ways of meaning making as means for individual realisation, attention to the question of knowledge is ever more urgent. Young asks, “What is educationally worthwhile knowledge?” His response goes to the heart of what is distinctive about humans. Drawing on the work of Durkheim and Vygotsky, Young provides a rich account of ‘powerful knowledge’. This chapter combines his insights with developments in contemporary philosophy. It aims to respond to misconstrued readings of Young’s work which takes his emphasis on ‘powerful knowledge’ to be at odds with a concern for pedagogy and human flourishing
Freshwater ecosystems are becoming increasingly salty. Here’s why this is a concern
Although it has been considerably less studied than other environmental problems, salinization presents major challenges for biodiversity in freshwater and coastal areas
Faecal blood loss with aspirin, nonsteroidal anti-inflammatory drugs and cyclo-oxygenase-2 selective inhibitors: systematic review of randomized trials using autologous chromium-labelled erythrocytes
INTRODUCTION: Faecal blood loss has been measured using autologous erythrocytes labelled with radioactive chromium for several decades, using generally similar methods. We conducted a systematic review of studies employing this technology to determine the degree of blood loss associated with use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs) and cyclo-oxygenase-2 selective inhibitors (coxibs). METHODS: A systematic search of PubMed and the Cochrane Library (to December 2006) was conducted to identify randomized trials in which treatment with aspirin, NSAIDs, or coxibs was continued for at least 7 days, and with at least 7 days of washout for crossover trials. Rates of faecal blood loss associated with these agents were determined in the randomized trials identified. Comparators were placebo, active, or no treatment. Outcomes of interest were mean daily faecal blood loss, and the number or proportion of individuals recording faecal blood above 5 ml/day and above 10 ml/day. RESULTS: Forty-five reports of 47 trials were included, including 1,162 individuals, mostly healthy volunteers and predominantly young men. Only 136 patients (as opposed to healthy volunteers; 12%) were included, and these were mostly older people with an arthritic condition. Most NSAIDs and low-dose (325 mg) aspirin resulted in a small average increase in faecal blood loss of 1 to 2 ml/day from about 0.5 ml/day at baseline. Aspirin at full anti-inflammatory doses resulted in much higher average levels of blood loss of about 5 ml/day. Some individuals lost much more blood than average, at least for some of the time, with 5% of those taking NSAIDs having daily blood loss of 5 ml or more and 1% having daily blood loss of 10 ml or more; rates of daily blood loss of 5 ml/day or 10 ml/day were 31% and 10%, respectively, for aspirin at daily doses of 1,800 mg or greater. CONCLUSION: At baseline, or with placebo, faecal blood loss is measured at 1 ml/day or below. With low-dose aspirin and some NSAIDs, average values may be two to four times this, and anti-inflammatory doses of aspirin result in much higher average losses. A small proportion of individuals respond to aspirin or NSAIDs with much higher faecal blood loss of above 5 ml/day or 10 ml/day. There are significant limitations regarding the quality and validity of reporting of these studies, such as limited size and inclusion of inappropriate participants. The potential for blood loss and consequent anaemia requires more study
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