Partnerschappen tussen politie en wetenschap in België: fragiele allianties?

20 years of police reform seems to us to be an excellent moment to look back and find out what we can learn about partnerships between police and science in Belgium. Our contribution is based on (inter)national literature on the one hand and observations based on our experiences within the Centre for Policing and Security and the Innovation Network Iungos on the other. Our analysis shows that both partnerships have not been strengthened since the police reform in 1998 but, on the contrary, appear to be weakened. Indeed, both are subject to cultural tensions, a vulnerable institutional setting and fluctuating funding streams. Facing this reality in the Belgian context and naming the partnerships as fragile alliances provides a starting point to further reflect on how partnerships between police and science can be strengthened in our country in the future.Security and Global Affair

Samenwerking tussen politie en wetenschap: lessen uit België

Security and Global Affair

Recessive osteogenesis imperfecta caused by LEPRE1 mutations: clinical documentation and identification of the splice form responsible for prolyl 3-hydroxylation

Abstract: Background: Recessive forms of osteogenesis imperfecta (OI) may be caused by mutations in LEPRE1, encoding prolyl 3-hydroxylase-1 (P3H1) or in CRTAP, encoding cartilage associated protein. These proteins constitute together with cyclophilin B (CyPB) the prolyl 3-hydroxylation complex that hydroxylates the Pro986 residue in both the type I and type II collagen alpha 1-chains. Methods: We screened LEPRE1, CRTAP and PPIB (encoding CyPB) in a European/Middle Eastern cohort of 20 lethal/severe OI patients without a type I collagen mutation. Results: Four novel homozygous and compound heterozygous mutations were identified in LEPRE1 in four probands. Two probands survived the neonatal period, including one patient who is the eldest reported patient (17(7/12) years) so far with P3H1 deficiency. At birth, clinical and radiologic features were hardly distinguishable from those in patients with autosomal dominant (AD) severe/lethal OI. Follow-up data reveal that the longer lived patients develop a severe osteochondrodysplasia that overlaps with, but has some distinctive features from, AD OI. A new splice site mutation was identified in two of the four probands, affecting only one of three LEPRE1 mRNA splice forms, detected in this study. The affected splice form encodes a 736 amino acid (AA) protein with a "KDEL'' endoplasmic reticulum retention signal. While western blotting and immunocytochemical analysis of fibroblast cultures revealed absence of this P3H1 protein, mass spectrometry and SDS-urea-PAGE data showed severe reduction of alpha 1(I) Pro986 3-hydroxylation and overmodification of type I (pro) collagen chains in skin fibroblasts of the patients. Conclusion: These findings suggest that the 3-hydroxylation function of P3H1 is restricted to the 736AA splice form

Estimation of ontogeny functions for renal transporters using a combined population pharmacokinetic and physiology-based pharmacokinetic approach : application to OAT1,3

To date, information on the ontogeny of renal transporters is limited. Here, we propose to estimate the in vivo functional ontogeny of transporters using a combined population pharmacokinetic (popPK) and physiology-based pharmacokinetic (PBPK) modeling approach called popPBPK. Clavulanic acid and amoxicillin were used as probes for glomerular filtration, combined glomerular filtration, and active secretion through OAT1,3, respectively. The predictive value of the estimated OAT1,3 ontogeny function was assessed by PBPK predictions of renal clearance (CLR) of other OAT1,3 substrates: cefazolin and piperacillin. Individual CL(R)post-hoc values, obtained from a published popPK model on the concomitant use of clavulanic acid and amoxicillin in critically ill children between 1 month and 15 years, were used as dependent variables in the popPBPK analysis. CLR was re-parameterized according to PBPK principles, resulting in the estimation of OAT1,3-mediated intrinsic clearance (CLint,OAT1,3,invivo) and its ontogeny. CLint,OAT1,3,invivo ontogeny was described by a sigmoidal function, reaching half of adult level around 7 months of age, comparable to findings based on renal transporter-specific protein expression data. PBPK-based CLR predictions including this ontogeny function were reasonably accurate for piperacillin in a similar age range (2.5 months-15 years) as well as for cefazolin in neonates as compared to published data (%RMSPE of 21.2 and 22.8%, respectively and %PE within +/- 50%). Using this novel approach, we estimated an in vivo functional ontogeny profile for CLint,OAT1,3,invivo that yields accurate CLR predictions for different OAT1,3 substrates across different ages. This approach deserves further study on functional ontogeny of other transporters

Setting a best practice for determining the EGR rate in hydrogen internal combustion engines

Exhaust gas recirculation (EGR) is an effective way to reduce NOx-emissions and increase the efficiency of hydrogen fueled internal combustion engines. Knowledge of the exact amount of EGR is crucial to understand the effects of EGR. As the exhaust gas flow is pulsating and chemically aggressive, the flow rate is typically not measured directly and has to be derived from other quantities. For hydrocarbon fuels, the EGR rate is generally calculated from a molar CO2 balance, but for hydrogen engines this obviously cannot be used as there are no CO2 emissions, and consequently no standard practice has been established. This work considers three methods to calculate the amount of EGR in a hydrogen engine. The first one is based upon a volume balance in the mixing section of exhaust gases and fresh air. The second and third method uses a molar balance of O-2 and H2O respectively in this mixing section. The three methods are developed and tested for their accuracy with an error analysis. Additionally, the methods are applied to an experimental dataset gathered on a single cylinder hydrogen engine. Both the theoretical analysis and the experimental results confirm the method based on an O-2 molar balance as the most accurate one. The least practical method is the one based on an H2O balance as it requires additional relative humidity sensors and is less accurate than the others

Short-term health effects in the general population following a major train accident with acrylonitrile in Belgium

Background: Following a train derailment, several tons of acrylonitrile (ACN) exploded, inflamed and part of the ACN ended up in the sewage system of the village of Wetteren. More than 2000 residents living in the close vicinity of the accident and along the sewage system were evacuated. A human biomonitoring study of the adduct N-2-cyanoethylvaline (CEV) was carried out days 14-21 after the accident. Objectives: (1) To describe the short-term health effects that were reported by the evacuated residents following the train accident, and (2) to explore the association between the CEV concentrations, extrapolated at the time of the accident, and the self-reported short-term health effects. Methods: Short-term health effects were reported in a questionnaire (n=191). An omnibus test of independence was used to investigate the association between the CEV concentrations and the symptoms. Dose-response relationships were quantified by Generalized Additive Models (GAMs). Results: The most frequently reported symptoms were local symptoms of irritation. In non-smokers, dose-dependency was observed between the CEV levels and the self-reporting of irritation (p=0.007) and nausea (p=0.007). Almost all non-smokers with CEV concentrations above 100 pmol/g globin reported irritation symptoms. Both absence and presence of symptoms was reported by non-smokers with CEV concentrations below the reference value and up to 10 times the reference value. Residents who visited the emergency services reported more symptoms. This trend was seen for the whole range of CEV concentrations, and thus independently of the dose. Discussion and conclusion: The present study is one of the first to relate exposure levels to a chemical released during a chemical incident to short-term (self-reported) health effects. A dose-response relation was observed between the CEV concentrations and the reporting of short-term health effects in the non-smokers. Overall, the value of self-reported symptoms to assess exposure showed to be limited. The results of this study confirm that a critical view should be taken when considering self-reported health complaints and that ideally biomarkers are monitored to allow an objective assessment of exposure

Experimental investigation of solidification in metal foam enhanced phase change material

A major challenge for the use of phase change materials (PCMs) in thermal energy storage (TES) is overcoming the low thermal conductivity of PCM’s. The low conductivity gives rise to limited power during charging and discharging TES. Impregnating metal foam with PCM, however, has been found to enhance the heat transfer. On the other hand, the effect of foam parameters such as porosity, pore size and material type has remained unclear. In this paper, the effect of these foam parameters on the solidification time is investigated. Different samples of PCM-impregnated metal foam were experimentally tested and compared to one without metal foam. The samples varied with respect to choice of material, porosity and pore size. They were placed in a rectangular cavity and cooled from one side using a coolant flowing through a cold plate. The other sides of the rectangular cavity were Polymethyl Methacrylate (PM) walls exposed to ambient. The temperature on the exterior walls of the cavity was monitored as well as the coolant flow rate and its temperature. The metal foam inserts reduced the solidification times by at least 25 %. However, the difference between the best performing and worst performing metal foam is about 28 %. This shows a large potential for future research.This study has received funding from European Union’s Horizon 2020 research and innovation programme under grant agreement Nº 657466 (INPATH-TES)

On the design and advantages of a vapor chamber for battery packs and the discrepancy in vertical channel boiling correlations at small gap spacing

The recent trend of increasing demand for rechargeable energy storage systems leads to the possibility of high power and energy electrical batteries. Especially for mobile applications, minimizing size and weight of the batteries is important, hereby increasing the power and energy density. This leads to higher heat losses, created by the internal resistance of the battery. During discharge, the chemical reactions in most batteries are exothermic which causes an even greater increase in heat generation. To avoid excessive temperatures, which can lead to lower efficiency, reduced lifetime and battery failure, adequate thermal management is needed. This paper introduces battery thermal management for prismatic cells through a vapor chamber. The battery cells are immersed in a non-conducting liquid, contained in a closed vessel. By absorbing heat from the battery, the liquid evaporates at the surface of the battery. The evaporated gas is condensed at the top of the vessel, by releasing heat to the environment. A lumped parameter model is made to simulate the response of a vapor chamber system on several load cycles and to compare with air cooling. Due to the evaporating heat transfer at the battery surface, the local heat transfer coefficient can be increased up to a factor 10 compared to air cooling. Load cycles of batteries often consist of peak currents being drawn for short times. This can cause a temporary increase in battery temperature. To avoid these peak temperatures, thermal buffering has been studied, for example by using the latent heat of melting PCMs. However this also results in an increase of the thermal resistance of the battery system. In a vapor chamber, the latent heat of evaporating refrigerant is used as a thermal buffer, without having a significant increase in thermal resistance. Analysis shows that peak temperature differences between the battery and the environment can be reduced by a factor up to 2 compared to air cooled batteries. The most important factor in modelling and designing the vapor chamber is the heat transfer coefficient of nucleate boiling in vertical rectangular channels and the influence of the distance between the cells on the heat transfer coefficient. Measurements and experimental correlations from literature do not correspond for small channels, where some perceive or predict increased heat transfer while others do not. An experimental setup is designed and being built to experimentally test the heat transfer coefficient for narrow vertical rectangular channels.Papers presented at the 13th International Conference on Heat Transfer, Fluid Mechanics and Thermodynamics, Portoroz, Slovenia on 17-19 July 2017 .International centre for heat and mass transfer.American society of thermal and fluids engineers