The Global Financial Crisis and Economic Integration: Evidence on Asean-5 Countries

The ASEAN Charter has been ratified by the ten member countries of ASEAN in 2008. This is to reaffirm the commitment of the member countries to the establishment of the ASEAN free trade area by 2015. The ASEAN members must prepare themselves with the economic and non economics aspects to be ready facing this era. Nevertheless, the global financial crisis could be a major hindrance to the implementation of the ASEAN free tradearea. In this study, we attempt to determine how the global financial crisis could possibly affect the creation of the regional economic integration among ASEAN countries.The study based on Newtonian paradigm on economic regional or namely the gravity model. Gravity model explored the economic relation of the many regions or countries.The core properties of gravity model are export, GDP, population and distance inters countries. This followed by the analysis of the possibility of the economics integrationusing the core gravity model. Next, we will incorporate the Exchange Market Pressure (EMP) as the financial crisis index to the core gravity model, to determine the influence offinancial crisis in ASEAN-5's economic integration. We will use the panel data method to execute the model. The result indicates EMP giving negative effect on ASEAN-5'seconomic integration. In overall result reported here indicate that economic integration is possible to implement on ASEAN-5 countries. But, the global financial crisis will be threat implementation of the economic integration

Peat swamp forest conservation withstands pervasive land conversion to oil palm plantation in North Selangor, Malaysia

Tropical deforestation remains one of the major global challenges of the twenty-first century driven to a large extent by the conversion of land for agricultural purposes, such as palm oil production. Malaysia is one of the world’s largest palm oil producers and has seen widespread conversion to oil palm from primary forest, including peat swamp forest (PSF). This study investigates the rate and extent of pervasive oil palm expansion in and around North Selangor Peat Swamp Forest (NSPSF) over the last three decades, exploring how land conversion has affected the region’s tropical forests, and assessing the relative success of PSF conservation measures. Time-series Landsat imagery was used to assess thematic land cover change and improvement in vegetation condition since NSPSF was given protected status in 1990. The results show a near tripling in oil palm cover throughout North Selangor, from 24,930 ha in 1989 to 70,070 ha in 2016; while at the same time tropical forest cover shrank from 145,570 ha to 88,400 ha. Despite concerns over the sustainability and environmental impact of such rapid oil palm conversion at a regional level, at the local scale, NSPSF represents a relative conservation success story. Effective land stewardship by government and non-governmental organization (NGO) management actors has limited illegal encroachment of oil palm around the reserve boundary. PSF rehabilitation measures have also markedly improved vegetation condition in NSPFS’s interior. These findings have broad significance for how oil palm agriculture is managed and especially for PSF stewardship and conservation, and the approaches described here may be usefully adopted elsewhere in Southeast Asia and around the world

A single-cell atlas of Plasmodium falciparum transmission through the mosquito

Malaria parasites have a complex life cycle featuring diverse developmental strategies, each uniquely adapted to navigate specific host environments. Here we use single-cell transcriptomics to illuminate gene usage across the transmission cycle of the most virulent agent of human malaria - Plasmodium falciparum. We reveal developmental trajectories associated with the colonization of the mosquito midgut and salivary glands and elucidate the transcriptional signatures of each transmissible stage. Additionally, we identify both conserved and non-conserved gene usage between human and rodent parasites, which point to both essential mechanisms in malaria transmission and species-specific adaptations potentially linked to host tropism. Together, the data presented here, which are made freely available via an interactive website, provide a fine-grained atlas that enables intensive investigation of the P. falciparum transcriptional journey. As well as providing insights into gene function across the transmission cycle, the atlas opens the door for identification of drug and vaccine targets to stop malaria transmission and thereby prevent disease

Dissection-independent production of Plasmodium sporozoites from whole mosquitoes

Progress towards a protective vaccine against malaria remains slow. To date, only limited protection has been routinely achieved following immunisation with either whole-parasite (sporozoite) or subunit-based vaccines. One major roadblock to vaccine progress, and to pre-erythrocytic parasite biology in general, is the continued reliance on manual salivary gland dissection for sporozoite isolation from infected mosquitoes. Here, we report development of a multi-step method, based on batch processing of homogenised whole mosquitoes, slurry, and density-gradient filtration, which combined with free -flow electrophoresis rapidly produces a pure, infective sporozoite inoculum. Human-infective Plasmodium falciparum and rodent-infective Plasmodium berghei sporozoites produced in this way are two-to threefold more infective than salivary gland dissection sporozoites in in vitro hepatocyte infection assays. In an in vivo rodent malaria model, the same P. berghei sporozoites confer sterile protection from mosquito-bite challenge when immunisation is delivered intravenously or 60-70% protection when delivered intramuscularly. By improving purity, infectivity, and immunogenicity, this method represents a key advancement in capacity to produce research grade sporozoites, which should impact delivery of a whole parasite based malaria vaccine at scale in the future.Host-parasite interactio

Transmission of Artemisinin-Resistant Malaria Parasites to Mosquitoes under Antimalarial Drug Pressure.

Resistance to artemisinin-based combination therapy (ACT) in the Plasmodium falciparum parasite is threatening to reverse recent gains in reducing global deaths from malaria. While resistance manifests as delayed parasite clearance in patients, the phenotype can only spread geographically via the sexual stages and mosquito transmission. In addition to their asexual killing properties, artemisinin and its derivatives sterilize sexual male gametocytes. Whether resistant parasites overcome this sterilizing effect has not, however, been fully tested. Here, we analyzed P. falciparum clinical isolates from the Greater Mekong Subregion, each demonstrating delayed clinical clearance and known resistance-associated polymorphisms in the Kelch13 (PfK13var) gene. As well as demonstrating reduced asexual sensitivity to drug, certain PfK13var isolates demonstrated a marked reduction in sensitivity to artemisinin in an in vitro male gamete formation assay. Importantly, this same reduction in sensitivity was observed when the most resistant isolate was tested directly in mosquito feeds. These results indicate that, under artemisinin drug pressure, while sensitive parasites are blocked, resistant parasites continue transmission. This selective advantage for resistance transmission could favor acquisition of additional host-specificity or polymorphisms affecting partner drug sensitivity in mixed infections. Favored resistance transmission under ACT coverage could have profound implications for the spread of multidrug-resistant malaria beyond Southeast Asia

Dissection-independent production of Plasmodium sporozoites from whole mosquitoes.

Progress towards a protective vaccine against malaria remains slow. To date, only limited protection has been routinely achieved following immunisation with either whole-parasite (sporozoite) or subunit-based vaccines. One major roadblock to vaccine progress, and to pre-erythrocytic parasite biology in general, is the continued reliance on manual salivary gland dissection for sporozoite isolation from infected mosquitoes. Here, we report development of a multi-step method, based on batch processing of homogenised whole mosquitoes, slurry, and density-gradient filtration, which combined with free-flow electrophoresis rapidly produces a pure, infective sporozoite inoculum. Human-infective Plasmodium falciparum and rodent-infective Plasmodium berghei sporozoites produced in this way are two- to threefold more infective than salivary gland dissection sporozoites in in vitro hepatocyte infection assays. In an in vivo rodent malaria model, the same P. berghei sporozoites confer sterile protection from mosquito-bite challenge when immunisation is delivered intravenously or 60-70% protection when delivered intramuscularly. By improving purity, infectivity, and immunogenicity, this method represents a key advancement in capacity to produce research-grade sporozoites, which should impact delivery of a whole-parasite based malaria vaccine at scale in the future

Parenting and community engagement factors as predictors of religiosity among muslim adolescents from Malaysia.

Despite the plethora of research on correlates of adolescent religiosity, few studies have examined the contribution of social context to religiosity among non-Western Muslim samples using multidimensional religiosity measures. To address this gap, the current study investigated the influence of community engagement and parenting factors on religiosity among 596 Malaysian Muslim secondary school students (M age = 16.10, SD = .29). After controlling for gender, family structure, family income, and social desirability, the results showed that parental monitoring, mosque involvement, and school engagement significantly predicted religious worldview, whereas parental religious socialization, parental monitoring, mosque involvement, school engagement, and youth organization involvement accounted for a significant amount of the variance in religious personality. Implications for further research on socialization influences on religious development among adolescents are discussed

Monetary policy transmission in an undeveloped South Pacific Island country: a case study of Samoa

Amongst the South Pacific's least developed small island countries, Samoa has emerged as a successful economy. Its achievements of low inflation and high growth rates have been due to sustained fiscal adjustment programmes and appropriate monetary policy measures. This paper undertakes an empirical study of transmission mechanism of monetary policy by adopting a VAR approach and using quarterly data over a 17-year period (1990-2006). The study findings are that money and exchange rate channels are important channels in transmitting monetary impulses to Samoa's output

Monetary and fiscal policies in Fiji: a test of effectiveness

Granger causality tests confirm the results from the bounds-testing approach of the long-run relationships between Fiji?s economic growth and fiscal and monetary policies and exports. Government expenditure, representing fiscal policy, is assessed to have a greater impact than monetary policy and exports on Fiji?s gross domestic product. In the short run, only fiscal policy and exports influenced growth

Implementation of TAGE Method Using Seikkala Derivatives Applied to Two-Point Fuzzy Boundary Value Problems

Iterative methods particularly the Two-Parameter Alternating Group Explicit (TAGE) methods are used to solve system of linear equations generated from the discretization of two-point fuzzy boundary value problems (FBVPs). The formulation and implementation of the TAGE method are also presented. Then numerical experiments are carried out onto two example problems to verify the effectiveness of the method. The results show that TAGE method is superior compared to GS method in the aspect of number of iterations, execution time, and Hausdorff distance