3,144 research outputs found
Notorious places: image, reputation, stigma: the role of newspapers in area reputations for social housing estates
This paper reviews work in several disciplines to distinguish between image, reputation and stigma. It also shows that there has been little research on the process by which area reputations are established and sustained through transmission processes. This paper reports on research into the portrayal of two social housing estates in the printed media over an extended period of time (14 years). It was found that negative and mixed coverage of the estates dominated, with the amount of positive coverage being very small. By examining the way in which dominant themes were used by newspapers in respect of each estate, questions are raised about the mode of operation of the press and the communities' collective right to challenge this. By identifying the way regeneration stories are covered and the nature of the content of positive stories, lessons are drawn for programmes of area transformation. The need for social regeneration activities is identified as an important ingredient for changing deprived-area reputations
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A study protocol for a randomised crossover study evaluating the effect of diets differing in carbohydrate quality on ileal content and appetite regulation in healthy humans
A major component of the digesta reaching the colon from the distal ileum is carbohydrate. This carbohydrate is subject to microbial fermentation and can radically change bacterial populations in the colon and the metabolites they produce, particularly short-chain fatty acids (SCFA). However, very little is currently known about the forms and levels of carbohydrate in the ileum and the composition of the ileal microbiota in humans. Most of our current understanding of carbohydrate that is not absorbed by the small intestine comes from ileostomy models, which may not reflect the physiology of an intact gastrointestinal tract. We will investigate how ileal content changes depending on diet using a randomised crossover study in healthy humans. Participants will be inpatients at the research facility for three separate 4-day visits. During each visit, participants will consume one of three diets, which differ in carbohydrate quality: 1) low-fibre refined diet; 2) high-fibre diet with intact cellular structures; 3) high-fibre diet where the cellular structures have been disrupted (e.g. milling, blending). On day 1, a nasoenteric tube will be placed into the distal ileum and its position confirmed under fluoroscopy. Ileal samples will be collected via the nasoenteric tube and metabolically profiled, which will determine the amount and type of carbohydrate present, and the composition of the ileal microbiota will be measured. Blood samples will be collected to assess circulating hormones and metabolites. Stool samples will be collected to assess faecal microbiota composition. Subjective appetite measures will be collected using visual analogue scales. Breath hydrogen will be measured in real-time as a marker of intestinal fermentation. Finally, an continuous fermentation model will be inoculated with ileal fluid in order to understand the shift in microbial composition and SCFA produced in the colon following the different diets. ISRCTN11327221. [Abstract copyright: Copyright: © 2019 Byrne CS et al.
A Study of Lyman-Alpha Quasar Absorbers in the Nearby Universe
Spectroscopy of ten quasars obtained with the Goddard High Resolution
Spectrograph (GHRS) of the Hubble Space Telescope (HST) is presented. A
clustering analysis reveals an excess of nearest neighbor line pairs on
velocity scales of 250-750 km/s at a 95-98% confidence level. The hypothesis
that the absorbers are randomly distributed in velocity space can be ruled out
at the 99.8% confidence level. No two-point correlation power is detected (xi <
1 with 95% confidence). Lyman-alpha absorbers have correlation amplitudes on
scales of 250-500 km/s at least 4-5 times smaller than the correlation
amplitude of bright galaxies. A detailed comparison between absorbers in nearby
galaxies is carried out on a limited subset of 11 Lyman- alpha absorbers where
the galaxy sample in a large contiguous volume is complete to M_B = -16.
Absorbers lie preferentially in regions of intermediate galaxy density but it
is often not possible to uniquely assign a galaxy counterpart to an absorber.
This sample provides no explicit support for the hypothesis that absorbers are
preferentially associated with the halos of luminous galaxies. We have made a
preliminary comparison of the absorption line properties and environments with
the results of hydrodynamic simulations. The results suggest that the
Lyman-alpha absorbers represent diffuse or shocked gas in the IGM that traces
the cosmic web of large scale structure. (abridged)Comment: 36 pages of text, 15 figures, 4 tables, 36 file
Quantum mechanics and geodesic deviation in the brane world
We investigate the induced geodesic deviation equations in the brane world
models, in which all the matter forces except gravity are confined on the
3-brane. Also, the Newtonian limit of induced geodesic deviation equation is
studied. We show that in the first Randall-Sundrum model the Bohr-Sommerfeld
quantization rule is as a result of consistency between the geodesic and
geodesic deviation equations. This indicates that the path of test particle is
made up of integral multiples of a fundamental Compton-type unit of length
.Comment: 5 pages, no figure
Polysaccharide utilization loci and nutritional specialization in a dominant group of butyrate-producing human colonic Firmicutes
Acknowledgements The Rowett Institute of Nutrition and Health (University of Aberdeen) receives financial support from the Scottish Government Rural and Environmental Sciences and Analytical Services (RESAS). POS is a PhD student supported by the Scottish Government (RESAS) and the Science Foundation Ireland, through a centre award to the APC Microbiome Institute, Cork, Ireland. Data Summary The high-quality draft genomes generated in this work were deposited at the European Nucleotide Archive under the following accession numbers: 1. Eubacterium rectale T1-815; CVRQ01000001âCVRQ0100 0090: http://www.ebi.ac.uk/ena/data/view/PRJEB9320 2. Roseburia faecis M72/1; CVRR01000001âCVRR010001 01: http://www.ebi.ac.uk/ena/data/view/PRJEB9321 3. Roseburia inulinivorans L1-83; CVRS01000001âCVRS0 100 0151: http://www.ebi.ac.uk/ena/data/view/PRJEB9322Peer reviewedPublisher PD
Ruminococcal cellulosome systems from rumen to human
This article is protected by copyright. All rights reserved. The authors appreciate the kind assistance of Miriam Lerner (ImmunArray Ltd. Company, Rehovot, Israel) with experiments involving the MicroGrid II arrayer. This research was supported by a grant (No. 1349) to EAB also from the Israel Science Foundation (ISF) and a grant (No. 24/11) issued to RL by The Sidney E. Frank Foundation also through the ISF. Additional support was obtained from the establishment of an Israeli Center of Research Excellence (I-CORE Center No. 152/11) managed by the Israel Science Foundation, from the United States-Israel Binational Science Foundation (BSF), Jerusalem, Israel, by the Weizmann Institute of Science Alternative Energy Research Initiative (AERI) and the Helmsley Foundation. The authors also appreciate the support of the European Union, Area NMP.2013.1.1-2: Self-assembly of naturally occurring nanosystems: CellulosomePlus Project number: 604530 and an ERA-IB Consortium (EIB.12.022), acronym FiberFuel. HF and SHD acknowledge support from the Scottish Government Food Land and People programme and from BBSRC grant no. BB/L009951/1. In addition, EAB is grateful for a grant from the F. Warren Hellman Grant for Alternative Energy Research in Israel in support of alternative energy research in Israel administered by the Israel Strategic Alternative Energy Foundation (I-SAEF). E.A.B. is the incumbent of The Maynard I. and Elaine Wishner Chair of Bio-organic ChemistryPeer reviewedPostprin
Detection of somatic changes in human cancer DNA by DNA fingerprint analysis.
Minisatellite DNA probes which can detect a large number of autosomal loci dispersed throughout the human genome were used to examine the constitutional and tumour DNA of 35 patients with a variety of cancers of which eight were of gastrointestinal origin. Somatic changes were seen in the tumour DNA in ten of the 35 cases. The changes included alterations in the relative intensities of hybridising DNA fragments, and, in three cases of cancers of gastrointestinal origin, the appearance of novel minisatellite fragments not seen in the corresponding constitutional DNA. The results of this preliminary study suggests that DNA fingerprint analysis provides a useful technique for identifying somatic changes in cancers
Gauge Theories with Cayley-Klein and Gauge Groups
Gauge theories with the orthogonal Cayley-Klein gauge groups and
are regarded. For nilpotent values of the contraction
parameters these groups are isomorphic to the non-semisimple Euclid,
Newton, Galilei groups and corresponding matter spaces are fiber spaces with
degenerate metrics. It is shown that the contracted gauge field theories
describe the same set of fields and particle mass as gauge
theories, if Lagrangians in the base and in the fibers all are taken into
account. Such theories based on non-semisimple contracted group provide more
simple field interactions as compared with the initial ones.Comment: 14 pages, 5 figure
Development of light weight magnesium alloys for low temperature applications Annual progress report, Jun. 19, 1965 - Mar. 20, 1966
Lightweight magnesium alloys for cryogenic application
Casimir Energy for a Spherical Cavity in a Dielectric: Applications to Sonoluminescence
In the final few years of his life, Julian Schwinger proposed that the
``dynamical Casimir effect'' might provide the driving force behind the
puzzling phenomenon of sonoluminescence. Motivated by that exciting suggestion,
we have computed the static Casimir energy of a spherical cavity in an
otherwise uniform material. As expected the result is divergent; yet a
plausible finite answer is extracted, in the leading uniform asymptotic
approximation. This result agrees with that found using zeta-function
regularization. Numerically, we find far too small an energy to account for the
large burst of photons seen in sonoluminescence. If the divergent result is
retained, it is of the wrong sign to drive the effect. Dispersion does not
resolve this contradiction. In the static approximation, the Fresnel drag term
is zero; on the mother hand, electrostriction could be comparable to the
Casimir term. It is argued that this adiabatic approximation to the dynamical
Casimir effect should be quite accurate.Comment: 23 pages, no figures, REVTe
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