Between revolt and loyalty: Students of the Austrian empire in the 1848 revolution

Introduction. As a social group with its specific features and motivation, students have been long characterized by their active involvement in social and political unrest. However, the behavioral analysis of students in different historical situations has become an independent research topic as late as in the 1960s. Numerous nuances of student activity remain for that reason unexplored. That is true of the process of student politicization and nationalization in the multi-ethnic Austrian empire during the tumultuous year of 1848. In literature, this issue is either pushed aside or based on an image of a radical “Austrian” student helping proletarians to fight against the regime on barricades. The latter is not relevant in view of the diversity of student sentiments and ideas that were present in the vast Habsburg hereditary lands. Methods and materials. This article analyzes students' sympathies and actual participation in the rebellious events of 1848 considering the cases of two universities - that of the capital city of Vienna and the university of provincial Innsbruck. The study is based on students' memoires, pamphlets, letters and newspapers of that time, as well as official documents and appeals by the government. Analysis. The analysis shows that Viennese students had an effective voice in revolutionary events, but their demands were of relatively moderate liberal character, while they largely remained loyal to the emperor. The revolutionary activity of provincial students was much more modest and peaceful than in Vienna. In case of Innsbruck, in particular, an image of a patriotic student fighting with arms for his emperor and fatherland replaced the image of a student fighting for political freedoms. Results. The participation of students in the revolutionary events of 1848 resulted in politicization of the “Austrian” student body and its consolidation as an independent social group. © 2020 Volgograd State University. All rights reserved.Russian Foundation for Basic Research, RFBR: 19-59-23005The reported study was funded by RFBR according to research project no. 19-59-23005 “The Habsburg 0onarchy: New Directions in the Study of the Economic, Socio-Political and National Development of the Composite State of Central Europe”

Between revolt and loyalty: Students of the Austrian empire in the 1848 revolution

Introduction. As a social group with its specific features and motivation, students have been long characterized by their active involvement in social and political unrest. However, the behavioral analysis of students in different historical situations has become an independent research topic as late as in the 1960s. Numerous nuances of student activity remain for that reason unexplored. That is true of the process of student politicization and nationalization in the multi-ethnic Austrian empire during the tumultuous year of 1848. In literature, this issue is either pushed aside or based on an image of a radical “Austrian” student helping proletarians to fight against the regime on barricades. The latter is not relevant in view of the diversity of student sentiments and ideas that were present in the vast Habsburg hereditary lands. Methods and materials. This article analyzes students' sympathies and actual participation in the rebellious events of 1848 considering the cases of two universities - that of the capital city of Vienna and the university of provincial Innsbruck. The study is based on students' memoires, pamphlets, letters and newspapers of that time, as well as official documents and appeals by the government. Analysis. The analysis shows that Viennese students had an effective voice in revolutionary events, but their demands were of relatively moderate liberal character, while they largely remained loyal to the emperor. The revolutionary activity of provincial students was much more modest and peaceful than in Vienna. In case of Innsbruck, in particular, an image of a patriotic student fighting with arms for his emperor and fatherland replaced the image of a student fighting for political freedoms. Results. The participation of students in the revolutionary events of 1848 resulted in politicization of the “Austrian” student body and its consolidation as an independent social group. © 2020 Volgograd State University. All rights reserved.Russian Foundation for Basic Research, RFBR: 19-59-23005The reported study was funded by RFBR according to research project no. 19-59-23005 “The Habsburg 0onarchy: New Directions in the Study of the Economic, Socio-Political and National Development of the Composite State of Central Europe”

Smoking makes Marlboro cowboy 'unfit'

published_or_final_versio

Single microcolony diffusion analysis in Pseudomonas aeruginosa biofilms

© 2019, The Author(s). The influence of the biofilm matrix on molecular diffusion is commonly hypothesized to be responsible for emergent characteristics of biofilms such as nutrient trapping, signal accumulation and antibiotic tolerance. Hence quantifying the molecular diffusion coefficient is important to determine whether there is an influence of biofilm microenvironment on the mobility of molecules. Here, we use single plane illumination microscopy fluorescence correlation spectroscopy (SPIM-FCS) to obtain 3D diffusion coefficient maps with micrometre spatial and millisecond temporal resolution of entire Pseudomonas aeruginosa microcolonies. We probed how molecular properties such as size and charge as well as biofilm properties such as microcolony size and depth influence diffusion of fluorescently labelled dextrans inside biofilms. The 2 MDa dextran showed uneven penetration and a reduction in diffusion coefficient suggesting that the biofilm acts as a molecular sieve. Its diffusion coefficient was negatively correlated with the size of the microcolony. Positively charged dextran molecules and positively charged antibiotic tobramycin preferentially partitioned into the biofilm and remained mobile inside the microcolony, albeit with a reduced diffusion coefficient. Lastly, we measured changes of diffusion upon induction of dispersal and detected an increase in diffusion coefficient inside the biofilm before any loss of biomass. Thus, the change in diffusion is a proxy to detect early stages of dispersal. Our work shows that 3D diffusion maps are very sensitive to physiological changes in biofilms, viz. dispersal. However, this study also shows that diffusion, as mediated by the biofilm matrix, does not account for the high level of antibiotic tolerance associated with biofilms

Mortality of midlife women with surgically verified endometriosis-a cohort study including 2.5 million person-years of observation

STUDY QUESTION Is all-cause and cause-specific mortality increased among women with surgically verified endometriosis? SUMMARY ANSWER The all-cause and cause-specific mortality in midlife was lower throughout the follow-up among women with surgically verified endometriosis compared to the reference cohort. WHAT IS KNOWN ALREADY Endometriosis has been associated with an increased risk of comorbidities such as certain cancers and cardiovascular diseases. These diseases are also common causes of death; however, little is known about the mortality of women with endometriosis. STUDY DESIGN, SIZE, DURATION A nationwide retrospective cohort study of women with surgically verified diagnosis of endometriosis was compared to the reference cohort in Finland (1987-2012). Follow-up ended at death or 31 December 2014. During the median follow-up of 17years, 2.5 million person-years accumulated. PARTICIPANTS/MATERIALS, SETTING, METHODS Forty-nine thousand nine hundred and fifty-six women with at least one record of surgically verified diagnosis of endometriosis in the Finnish Hospital Discharge Register between 1987 and 2012 were compared to a reference cohort of 98824 age- and municipality-matched women. The age (meanstandard deviation) of the endometriosis cohort was 36.49.0 and 53.612.1years at the beginning and at the end of the follow-up, respectively. By using the Poisson regression models the crude and adjusted all-cause and cause-specific mortality rate ratios (MRR) and 95% confidence intervals (CI) were assessed. Calendar time, age, time since the start of follow-up, educational level, and parity adjusted were considered in the multivariate analyses. MAIN RESULTS AND THE ROLE OF CHANCE A total of 1656 and 4291 deaths occurred in the endometriosis and reference cohorts, respectively. A lower all-cause mortality was observed for the endometriosis cohort (adjusted MRR, 0.73 [95% CI 0.69 to 0.77])-there were four deaths less per 1000 women over 10years. A lower cause-specific mortality contributed to this: the adjusted MRR was 0.88 (95% CI 0.81 to 0.96) for any cancer and 0.55 (95% CI 0.47 to 0.65) for cardiovascular diseases, including 0.52 (95% CI 0.42 to 0.64) for ischemic heart disease and 0.60 (95% CI 0.47 to 0.76) for cerebrovascular disease. Mortality due to alcohol, accidents and violence, respiratory, and digestive disease-related causes was also decreased. LIMITATIONS, REASONS FOR CAUSATION These results are limited to women with endometriosis diagnosed by surgery. In addition, the study does not extend into the oldest age groups. The results might be explained by the characteristics and factors related to women's lifestyle, and/or increased medical attention and care received, rather than the disease itself. WIDER IMPLICATIONS OF THE FINDINGS These reassuring data are valuable to women with endometriosis and to their health care providers. Nonetheless, more studies are needed to address the causality. STUDY FUNDING/COMPETING INTEREST This research was funded by the Hospital District of Helsinki and Uusimaa and The Finnish Medical Foundation. None of the authors report any competing interest in relation to the present work; all the authors have completed the disclosure form.Peer reviewe

Commentaar bij artikel 121 Grondwet: openbaarheid terechtzittingen [Editie september 2020]

The Legitimacy and Effectiveness of Law & Governance in a World of Multilevel Jurisdiction

Modified Gravity via Spontaneous Symmetry Breaking

We construct effective field theories in which gravity is modified via spontaneous breaking of local Lorentz invariance. This is a gravitational analogue of the Higgs mechanism. These theories possess additional graviton modes and modified dispersion relations. They are manifestly well-behaved in the UV and free of discontinuities of the van Dam-Veltman-Zakharov type, ensuring compatibility with standard tests of gravity. They may have important phenomenological effects on large distance scales, offering an alternative to dark energy. For the case in which the symmetry is broken by a vector field with the wrong sign mass term, we identify four massless graviton modes (all with positive-definite norm for a suitable choice of a parameter) and show the absence of the discontinuity.Comment: 5 pages; revised versio

Long-Term Health-Related Quality of Life (HRQoL) After Redo-Fundoplication

Background We aim to shed light on long-term subjective outcomes after re-operations for failed fundoplication. Methods 1809 patients were operated on for hiatal hernia and/or gastroesophageal reflux disease (GERD) at the Helsinki University Hospital between 2000 and 2017. 111 (6%) of these had undergone a re-operation for a failed antireflux operation. Overall, HRQoL was assessed in 89 patients at the latest follow-up using the generic 15D (c) instrument. The results were compared to a sample of the general population, weighted to reflect the age and gender distribution of patients. Disease-specific HRQoL was assessed using the GERD-HRQoL questionnaire. We studied variation in the overall HRQoL with respect to disease-specific HRQoL and known patients' parameters using univariate and multivariable linear regression models. Results The median postoperative follow-up period was 9.3 years. All patients were operated on laparoscopically (6% conversion rate), and 87% were satisfied with the re-operation. Postoperative complications were minimal (5%). Twelve patients (11%) underwent a second re-operation. The median GERD-HRQoL score was nine. In multivariable analysis, four variables were independently associated with the 15D score, suggesting a decrease in the 15D score with increasing GERD-HRQoL score, increasing Charlson Comorbidity Index (CCI) and the presence of chronic pain syndrome (CPS) and depression. Conclusion Re-do LF is a safe procedure in experienced hands and may offer acceptable long-term alleviation in patients with recurring symptoms after antireflux surgery. Decreased HRQoL in the long run is related to recurring GERD and co-morbidities.Peer reviewe

Temperature-driven single-valley Dirac fermions in HgTe quantum wells

We report on temperature-dependent magnetospectroscopy of two HgTe/CdHgTe quantum wells below and above the critical well thickness $d_c$. Our results, obtained in magnetic fields up to 16 T and temperature range from 2 K to 150 K, clearly indicate a change of the band-gap energy with temperature. The quantum well wider than $d_c$ evidences a temperature-driven transition from topological insulator to semiconductor phases. At the critical temperature of 90 K, the merging of inter- and intra-band transitions in weak magnetic fields clearly specifies the formation of gapless state, revealing the appearance of single-valley massless Dirac fermions with velocity of $5.6\times10^5$ m$\times$s$^{-1}$. For both quantum wells, the energies extracted from experimental data are in good agreement with calculations on the basis of the 8-band Kane Hamiltonian with temperature-dependent parameters.Comment: 5 pages, 3 figures and Supplemental Materials (4 pages

Correlation of liver stiffness and histological features in healthy persons and in patients with occult hepatitis B, chronic active hepatitis B, or hepatitis B cirrhosis

OBJECTIVES: Liver stiffness measurement using transient elastography has become a popular tool to assess liver fibrosis. The aim of this study was to determine liver stiffness values and histological features in healthy subjects and in patients with chronic hepatitis B (CHB).METHODS: A total of 157 people were included (28 healthy subjects and 18 patients with occult hepatitis B infection, 102 with active CHB, and 9 with end-stage hepatitis B cirrhosis). Histology and liver stiffness measurements were obtained from all patients.RESULTS: The median liver stiffness in healthy subjects and in occult hepatitis B, active hepatitis B, and end-stage cirrhosis patients was 4.6, 4.2, 8.7, and 33.8 kPa, respectively. In healthy subjects and in patients with occult hepatitis B infection, none had significant fibrosis on histology, and all had liver stiffness 7.2 kPa. In patients with active CHB, 32 (31%) had liver stiffness 11.0 kPa, but only four (12%) had cirrhosis on histology. Using liver stiffness to predict cirrhosis in this group had a sensitivity of 100%, a specificity of 69%, a positive predictive value of 10%, and a negative predictive value of 100%. All nine patients with end-stage liver cirrhosis had liver stiffness 11.0 kPa. The overall area under the ROC curve (AUROC) for diagnosing cirrhosis using a cutoff of 11.3 kPa was 0.89.CONCLUSIONS: Liver stiffness measurement has an overall good diagnostic accuracy with excellent negative predictive value. However, in active CHB with elevated alanine aminotransferase (ALT) levels, the positive predictive value for diagnosing cirrhosis is poor, and further studies are needed to optimize the use of transient elastography in this important group. © 2010 by the American College of Gastroenterology.postprin