Deuterium on Venus: Observations from Earth

In view of the importance of the deuterium-to-hydrogen ratio in understanding the evolutionary scenario of planetary atmospheres and its relationship to understanding the evolution of our own Earth, we undertook a series of observations designed to resolve previous observational conflicts. We observed the dark side of Venus in the 2.3 micron spectral region in search of both H2O and HDO, which would provide us with the D/H ratio in Venus' atmosphere. We identified a large number of molecular lines in the region, belonging to both molecules, and, using synthetic spectral techniques, obtained mixing ratios of 34 plus or minus 10 ppm and 1.3 plus or minus 0.2 ppm for H2O and HDO, respectively. These mixing ratios yield a D/H ratio for Venus of D/H equals 1.9 plus or minus 0.6 times 10 (exp 12) and 120 plus or minus 40 times the telluric ratio. Although the detailed interpretation is difficult, our observations confirm that the Pioneer Venus Orbiter results and establish that indeed Venus had a period in its early history in which it was very wet, perhaps not unlike the early wet period that seems to have been present on Mars, and that, in contrast to Earth, lost much of its water over geologic time

Hdo And SO2 Thermal Mapping On Venus: Evidence For Strong SO2 Variability

We have been using the TEXES high-resolution imaging spectrometer at the NASA Infrared Telescope Facility to map sulfur dioxide and deuterated water over the disk of Venus. Observations took place on January 10-12, 2012. The diameter of Venus was 13 arcsec, with an illumination factor of 80%. Data were recorded in the 1344-1370 cm(-1) range (around 7.35 mu m) with a spectral resolving power of 80 000 and a spatial resolution of about 1.5 arcsec. In this spectral range, the emission of Venus comes from above the cloud top (z = 60-80 km). Four HDO lines and tens of SO2 lines have been identified in our spectra. Mixing ratios have been estimated from HDO/CO2 and SO2/CO2 line depth ratios, using weak neighboring transitions of comparable depths. The HDO maps, recorded on Jan. 10 and Jan. 12, are globally uniform with no significant variation between the two dates. A slight enhancement of the HDO mixing ratio toward the limb might be interpreted as a possible increase of the D/H ratio with height above the cloud level. The mean H2O mixing ratio is found to be 1.5 +/-0.75 ppm, assuming a D/H ratio of 0.0312 (i.e. 200 times the terrestrial value) over the cloud deck. The SO2 maps, recorded each night from Jan. 10 to Jan. 12, show strong variations over the disk of Venus, by a factor as high as 5 to 10. In addition, the position of the maximum SO2 mixing ratio strongly varies on a timescale of 24 h. The maximum SO2 mixing ratio ranges between 75 +/-25 ppb and 125 +/-50 ppb between Jan. 10 and Jan. 12. The high variability of sulfur dioxide is probably a consequence of its very short photochemical lifetime.NASA NNX-08AE38A, NNX08AW33G S03NSF AST-0607312, AST-0708074Astronom

Near-infrared oxygen airglow from the Venus nightside

Groundbased imaging and spectroscopic observations of Venus reveal intense near-infrared oxygen airglow emission from the upper atmosphere and provide new constraints on the oxygen photochemistry and dynamics near the mesopause (approximately 100 km). Atomic oxygen is produced by the Photolysis of CO2 on the dayside of Venus. These atoms are transported by the general circulation, and eventually recombine to form molecular oxygen. Because this recombination reaction is exothermic, many of these molecules are created in an excited state known as O2(delta-1). The airglow is produced as these molecules emit a photon and return to their ground state. New imaging and spectroscopic observations acquired during the summer and fall of 1991 show unexpected spatial and temporal variations in the O2(delta-1) airglow. The implications of these observations for the composition and general circulation of the upper venusian atmosphere are not yet understood but they provide important new constraints on comprehensive dynamical and chemical models of the upper mesosphere and lower thermosphere of Venus

HDO And SO2 Thermal Mapping On Venus II. The So2 Spatial Distribution Above And Within The Clouds

Sulfur dioxide and water vapor, two key species of Venus photochemistry, are known to exhibit significant spatial and temporal variations above the cloud top. In particular, ground-based thermal imaging spectroscopy at high spectral resolution, achieved on Venus in January 2012, has shown evidence for strong SO2 variations on timescales shorter than a day. We have continued our observing campaign using the TEXES high-resolution imaging spectrometer at the NASA InfraRed Telescope Facility to map sulfur dioxide over the disk of Venus at two different wavelengths, 7 mu m (already used in the previous study) and 19 mu m. The 7 mu m radiation probes the top of the H2SO4 cloud, while the 19 mu m radiation probes a few kilometers below within the cloud. Observations took place on October 4 and 5, 2012. Both HDO and SO2 lines are identified in our 7-mu m spectra and SO2 is also easily identified at 19 mu m. The CO2 lines at 7 and 19 mu m are used to infer the thermal structure. An isothermal/inversion layer is present at high latitudes (above 60 N and S) in the polar collars, which was not detected in October 2012. The enhancement of the polar collar in October 2012 is probably due to the fact that the morning terminator is observed, while the January data probed the evening terminator. As observed in our previous run, the HDO map is relatively uniform over the disk of Venus, with a mean mixing ratio of about 1 ppm. In contrast, the SO2 maps at 19 mu m show intensity variations by a factor of about 2 over the disk within the cloud, less patchy than observed at the cloud top at 7 mu m. In addition, the SO2 maps seem to indicate significant temporal changes within an hour. There is evidence for a cutoff in the SO2 vertical distribution above the cloud top, also previously observed by SPICAV/SOIR aboard Venus Express and predicted by photochemical models.NASA NNX-08AE38AIRTF AST-0607312, AST-0708074Astronom

Urea cycle disorders in Argentine patients: clinical presentation, biochemical and genetic findings

Urea cycle defects; Argininosuccinate synthetase deficiency; HyperammonemiaDefectos del ciclo de la urea; Deficiencia de argininosuccinato sintetasa; HiperamonemiaDefectes del cicle de la urea; Dèficit d’argininosuccinat sintetasa; HiperammonèmiaBACKGROUND: The incidence, prevalence, and molecular epidemiology of urea cycle disorders (UCDs) in Argentina remain underexplored. The present study is the first to thoroughly assess the clinical and molecular profiles of UCD patients examined at a single reference center in Argentina. RESULTS: Forty-nine UCD cases were collected. About half (26/49, 53%) manifested neonatally with classical presentation and had a high mortality (25/26, 96%). Ornithine transcarbamylase deficiency (OTCD) was the most common UCD (26 patients). Argininosuccinate synthetase deficiency (ASSD) was detected in 19 cases, while argininosuccinate lyase deficiency (ASLD) was diagnosed in 4 cases. Molecular genetic analysis revealed 8 private OTC mutations and two large deletion/duplication events in the OTC gene. Most mutations in the ASS1 and ASL genes were recurrent missense changes, and four alterations were novel. The clinical outcome of our UCD cohort was poor, with an overall mortality of 57% (28/49 cases), and a 28% (6/21) disability rate among the survivors. CONCLUSIONS: Most patients in our case series showed severe neonatal onset, with high morbidity/mortality. We detected in total 19 mutations, most of them recurrent and of high frequency worldwide. Noteworthy, we highlight the presence of a geographic cluster with high prevalence of a point mutation in the ASS1 gene. This study suggests that these disorders may be more frequent than commonly assumed, and stresses the need for increased awareness amongst health professionals and greater availability of diagnostic tools for accurate identification, early diagnosis, and timely treatment.This study was supported by grants from the Secretaría de Ciencia y Tecnología, Universidad Nacional de Córdoba and Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina. Work on urea cycle disorders in Zurich is supported by the Swiss National Science Foundation (grant no SNF 310030_153196 to JH)

Models of the SL9 Impacts II. Radiative-hydrodynamic Modeling of the Plume Splashback

We model the plume "splashback" phase of the SL9 collisions with Jupiter using the ZEUS-3D hydrodynamic code. We modified the Zeus code to include gray radiative transport, and we present validation tests. We couple the infalling mass and momentum fluxes of SL9 plume material (from paper I) to a jovian atmospheric model. A strong and complex shock structure results. The modeled shock temperatures agree well with observations, and the structure and evolution of the modeled shocks account for the appearance of high excitation molecular line emission after the peak of the continuum light curve. The splashback region cools by radial expansion as well as by radiation. The morphology of our synthetic continuum light curves agree with observations over a broad wavelength range (0.9 to 12 microns). A feature of our ballistic plume is a shell of mass at the highest velocities, which we term the "vanguard". Portions of the vanguard ejected on shallow trajectories produce a lateral shock front, whose initial expansion accounts for the "third precursors" seen in the 2-micron light curves of the larger impacts, and for hot methane emission at early times. Continued propagation of this lateral shock approximately reproduces the radii, propagation speed, and centroid positions of the large rings observed at 3-4 microns by McGregor et al. The portion of the vanguard ejected closer to the vertical falls back with high z-component velocities just after maximum light, producing CO emission and the "flare" seen at 0.9 microns. The model also produces secondary maxima ("bounces") whose amplitudes and periods are in agreement with observations.Comment: 13 pages, 9 figures (figs 3 and 4 in color), accepted for Ap.J. latex, version including full figures at: http://oobleck.tn.cornell.edu/jh/ast/papers/slplume2-20.ps.g

Detection of interstellar CH_3

Observations with the Short Wavelength Spectrometer (SWS) onboard the {\it Infrared Space Observatory} (ISO) have led to the first detection of the methyl radical ${\rm CH_3}$ in the interstellar medium. The $\nu_2$ $Q-$branch at 16.5 $\mu$m and the $R$(0) line at 16.0 $\mu$m have been unambiguously detected toward the Galactic center SgrA$^*$. The analysis of the measured bands gives a column density of (8.0$\pm$2.4)$\times10^{14}$ cm$^{-2}$ and an excitation temperature of $(17\pm 2)$ K. Gaseous ${\rm CO}$ at a similarly low excitation temperature and ${\rm C_2H_2}$ are detected for the same line of sight. Using constraints on the ${\rm H_2}$ column density obtained from ${\rm C^{18}O}$ and visual extinction, the inferred ${\rm CH_3}$ abundance is $(1.3{{+2.2}\atop{-0.7}}) \times 10^{-8}$. The chemically related ${\rm CH_4}$ molecule is not detected, but the pure rotational lines of ${\rm CH}$ are seen with the Long Wavelength Spectrometer (LWS). The absolute abundances and the ${\rm CH_3/CH_4}$ and ${\rm CH_3/CH}$ ratios are inconsistent with published pure gas-phase models of dense clouds. The data require a mix of diffuse and translucent clouds with different densities and extinctions, and/or the development of translucent models in which gas-grain chemistry, freeze-out and reactions of ${\rm H}$ with polycyclic aromatic hydrocarbons and solid aliphatic material are included.Comment: 2 figures. ApJL, Accepte

D/H Ratios on Saturn and Jupiter from Cassini CIRS

We present new measurements of the deuterium abundance on Jupiter and Saturn, showing evidence that Saturn's atmosphere contains less deuterium than Jupiter's. We analyzed far-infrared spectra from the Cassini Composite Infrared Spectrometer to measure the abundance of HD on both giant planets. Our estimate of the Jovian D/H = (2.95 ± 0.55) × 10−5 is in agreement with previous measurements by ISO/SWS: (2.25 ± 0.35) × 10−5, and the Galileo probe: (2.6 ± 0.7) × 10−5. In contrast, our estimate of the Saturn value of (2.10 ± 0.13) × 10−5 is somewhat lower than on Jupiter (by a factor of ${0.71}_{-0.15}^{+0.22}$), contrary to model predictions of a higher ratio: Saturn/Jupiter = 1.05–1.20. The Saturn D/H value is consistent with estimates for hydrogen in the protosolar nebula (2.1 ± 0.5) × 10−5, but its apparent divergence from the Jovian value suggests that our understanding of planetary formation and evolution is incomplete, which is in agreement with previous work.The US-based authors: J.E.D.P., C.A.N., G.L.B., R.K.A., B.E.H., and F.M.F. were supported by the NASA Cassini Mission during the period when this research was conducted. L.N.F. was supported by a Royal Society Research Fellowship at the University of Leicester. P.G.J.I. was supported by the United Kingdom Science and Technology Facilities Council.Peer-reviewedPublisher Versio

Basic Science in Movement Disorders: Fueling the Engine of Translation into Clinical Practice

\ua9 2024 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. Basic Science is crucial for the advancement of clinical care for Movement Disorders. Here, we provide brief updates on how basic science is important for understanding disease mechanisms, disease prevention, disease diagnosis, development of novel therapies and to establish the basis for personalized medicine. We conclude the viewpoint by a call to action to further improve interactions between clinician and basic scientists. \ua9 2024 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society