Testing GeoGebra as an effective tool to improve the understanding of the concept of limit on engineering students

The impact GeoGebra on the teaching of the concept of limit was analyzed. Two groups of engineering students, studying differential calculus, served as control and test groups. The traditional teaching, based on examples solved by hand, was given to the control group while a series of activities involving the usage of the mathematical software GeoGebra were applied in an attempt of improving the degree of assimilation on the concept of limits

Learning the concept of integral through the appropriation of the competence in Riemann sums

It is proposed that the difficulty of engineering students into understanding the concept of the integral, as a way for calculating the area under a curve, can be overcame if students are taught how to translate it into the problem of calculating a Riemann sum. A series of applied problems are proposed to provide a frame that required to calculate the area under a curve to two groups of students. For one of these groups, Geogebra was proposed as a tool that could be used to maintain the focus of students into the concepts, by providing ways to easily calculate and visualize the solutions, while the other group reached to the solutions by analytically making all the calculations. Evidence was found that, to a confidence level of 95%, Riemann sums calculated with Geogebra reduce the score difference in context problems requiring the calculation of integrals, helping students to reach a better understanding on the concept of the integral as the area under the curve of a given function

Local perception of ecosystem services offered in agricultural farms in the dry zone north of Tolima, Colombia

La oferta de los servicios ecosistémicos (SE) depende, en gran medida, de la intervención de las familias productoras en sus fincas. Con el objetivo de identificar la percepción de la oferta de 15 SE en sistemas de uso agropecuario y forestal en la zona seca del norte del Tolima, se realizaron 40 encuestas semi-estructuradas a productores agropecuarios locales. La información fue analizada empleando la escala de Likert: 0 a 10 (de menor a mayor). Los productores le dan una alta importancia a los SE, aunque realizan pocas prácticas para mantener o incrementar su oferta. La provisión de agua es el SE más importante que los productores identifican para el manejo de sus cultivos, pero indican que este servicio se afecta negativamente por la intensificación de uso agropecuario y la poca protección de zonas de recarga. Los productores han detectado un aumento de temperatura en la zona en los últimos años y se sienten vulnerables ante el cambio climático y la poca regulación del agua. De la misma forma, se evidencia el nulo conocimiento sobre la huella de carbono de estos sistemas de producción; sin embargo, luego de explicarles el concepto, los productores están interesados en conocer la emisión de gases de efecto invernadero y la fijación de carbono de sus fincas. Lo encontrado en este estudio es importante para generar conciencia ambiental en los productores agropecuarios, promover usos sostenibles y decisiones que impulsen la generación de SE. El estudio muestra que es necesario el diseño de políticas que mejoren la regulación del ciclo hidrológico y contribuyan con programas de reforestación del bosque seco tropical.The offer of ecosystem services (ES) depends, to a large extent, on the intervention of the producer families on their farms. With the aim of identifying the perception of offer of ecosystem services (ES) in agricultural and forestry use systems in the dry zone of north Tolima, 40 semi-structured surveys were carried out to local agricultural producers. The information was analyzed using the Likert scale: 0 to 10 (from lowest to highest). Producers attach high importance to ESs, although they do little to maintain or increase their supply. Water supply is the most important SE that the producers identify for the management of their crops, but they indicate that this service is negatively affected by the intensification of agricultural use and the poor protection of recharge zones. Producers have detected a temperature rise in the area in recent years and they feel vulnerable to climate change and poor water regulation. In the same way, the lack of knowledge about the carbon footprint of these production systems is also evident. However, after explaining the concept, producers are interested in knowing the emission of greenhouse gases and carbon fixation on their farms. The findings of this study are important to generate environmental awareness in agricultural producers, to encourage sustainable practices and decisions that promote ES. This study shows that the design of policies to improve water regulation and to contribute to reforestation programs for the dry forests is necesary

Gauging N=2 Supersymmetric Non-Linear σ\sigma-Models in the Atiyah-Ward Space-Time

We build up a class of N=2 supersymmetric non-linear $\sigma$-models in an N=1 superspace based on the Atiyah-Ward space-time of (2+2)-signature metric. We also discuss the gauging of isometries of the associated hyper-K\"ahlerian target spaces and present the resulting gauge-covariant supersymmetric action functional.Comment: 12 pages, latex, no figure

Differences in response to antiretroviral therapy in HIV-positive patients being treated for tuberculosis in Eastern Europe, Western Europe and Latin America

BACKGROUND: Efavirenz-based antiretroviral therapy (ART) regimens are preferred for treatment of adult HIV-positive patients co-infected with tuberculosis (HIV/TB). Few studies have compared outcomes among HIV/TB patients treated with efavirenz or non-efavirenz containing regimens. METHODS: HIV-positive patients aged ≥16 years with a diagnosis of tuberculosis recruited to the TB:HIV study between Jan 1, 2011, and Dec 31, 2013 in 19 countries in Eastern Europe (EE), Western Europe (WE), and Latin America (LA) who received ART concomitantly with TB treatment were included. Patients either received efavirenz-containing ART starting between 15 days prior to, during, or within 90 days after starting tuberculosis treatment, (efavirenz group), or other ART regimens (non-efavirenz group). Patients who started ART more than 90 days after initiation of TB treatment, or who experienced ART interruption of more than 15 days during TB treatment were excluded. We describe rates and factors associated with death, virological suppression, and loss to follow up at 12 months using univariate, multivariate Cox, and marginal structural models to compare the two groups of patients. RESULTS: Of 965 patients (647 receiving efavirenz-containing ART, and 318 a non-efavirenz regimen) 50% were from EE, 28% from WE, and 22% from LA. Among those not receiving efavirenz-containing ART, regimens mainly contained a ritonavir-boosted protease inhibitor (57%), or raltegravir (22%). At 12 months 1.4% of patients in WE had died, compared to 20% in EE: rates of virological suppression ranged from 21% in EE to 61% in WE. After adjusting for potential confounders, rates of death (adjusted Hazard Ratio; aHR, 95%CI: 1.13, 0.72–1.78), virological suppression (aHR, 95%CI: 0.97, 0.76–1.22), and loss to follow up (aHR, 95%CI: 1.17, 0.81–1.67), were similar in patients treated with efavirenz and non-efavirenz containing ART regimens. CONCLUSION: In this large, prospective cohort, the response to ART varied significantly across geographical regions, whereas the ART regimen (efavirenz or non-efavirenz containing) did not impact on the proportion of patients who were virologically-suppressed, lost to follow up or dead at 12 months

Durabilidad del Concreto en Ambiente Urbanos y Urnbano/Marinos de México y España

Trabajo presentado en el III Congreso Nacional ALCONPAT (Asociación Latinoamericana de Control de Calidad, Patología y Recuperación de la Construcción), celebrado en Caracas (Venezuela), en noviembre de 200

A survey of zoonotic pathogens carried by house mouse and black rat populations in Yucatan, Mexico

The house mouse (Mus musculus) and the black rat (Rattus rattus) are reservoir hosts for zoonotic pathogens, several of which cause neglected tropical diseases (NTDs). Studies of the prevalence of these NTD-causing zoonotic pathogens, in house mice and black rats from tropical residential areas are scarce. Three hundred and two house mice and 161 black rats were trapped in 2013 from two urban neighbourhoods and a rural village in Yucatan, Mexico, and subsequently tested for Trypanosoma cruzi, Hymenolepis diminuta and Leptospira interrogans. Using the polymerase chain reaction we detected T. cruzi DNA in the hearts of 4.9% (8/165) and 6.2% (7/113) of house mice and black rats, respectively. We applied the sedimentation technique to detect eggs of H. diminuta in 0.5% (1/182) and 14.2% (15/106) of house mice and black rats, respectively. Through the immunofluorescent imprint method, L. interrogans was identified in 0.9% (1/106) of rat kidney impressions. Our results suggest that the black rat could be an important reservoir for T. cruzi and H. diminuta in the studied sites. Further studies examining seasonal and geographical patterns could increase our knowledge on the epidemiology of these pathogens in Mexico and the risk to public health posed by rodents.Centro de Estudios Parasitológicos y de Vectore

Liver injury in non-alcoholic fatty liver disease is associated with urea cycle enzyme dysregulation

The main aim was to evaluate changes in urea cycle enzymes in NAFLD patients and in two preclinical animal models mimicking this entity. Seventeen liver specimens from NAFLD patients were included for immunohistochemistry and gene expression analyses. Three-hundred-and-eighty-two biopsy-proven NAFLD patients were genotyped for rs1047891, a functional variant located in carbamoyl phosphate synthetase-1 (CPS1) gene. Two preclinical models were employed to analyse CPS1 by immunohistochemistry, a choline deficient high-fat diet model (CDA-HFD) and a high fat diet LDLr knockout model (LDLr −/−). A significant downregulation in mRNA was observed in CPS1 and ornithine transcarbamylase (OTC1) in simple steatosis and NASH-fibrosis patients versus controls. Further, age, obesity (BMI > 30 kg/m), diabetes mellitus and ALT werefound to be risk factors whereas A-allele from CPS1 was a protective factor from liver fibrosis. CPS1 hepatic expression was diminished in parallel with the increase of fibrosis, and its levels reverted up to normality after changing diet in CDA-HFD mice. In conclusion, liver fibrosis and steatosis were associated with a reduction in both gene and protein expression patterns of mitochondrial urea cycle enzymes. A-allele from a variant on CPS1 may protect from fibrosis development. CPS1 expression is restored in a preclinical model when the main trigger of the liver damage disappears.The research leading to these results has received funding from the Consejería de Salud de la Junta de Andalucía under grant agreement PC-0148-2016-0148 and PE-0451-2018 and Instituto de Salud Carlos III under grant agreements CD21/00095, PI16/01842, PI19/01404, PI19/00589, IFI18/00041, FI20/00201, CD18/00126 and EHD18PI04/2021. Rocío Gallego-Durán has received the Andrew K Burroughs Fellowship from European Association for the Study of the Liver (EASL), Aprendizaje de Nuevas Tecnologías fellowship from Asociación Española para el Estudio del Hígado (AEEH) and CIBERehd Grant to support researcher’s mobility

Liver injury in non-alcoholic fatty liver disease is associated with urea cycle enzyme dysregulation

The main aim was to evaluate changes in urea cycle enzymes in NAFLD patients and in two preclinical animal models mimicking this entity. Seventeen liver specimens from NAFLD patients were included for immunohistochemistry and gene expression analyses. Three-hundred-and-eighty-two biopsy-proven NAFLD patients were genotyped for rs1047891, a functional variant located in carbamoyl phosphate synthetase-1 (CPS1) gene. Two preclinical models were employed to analyse CPS1 by immunohistochemistry, a choline deficient high-fat diet model (CDA-HFD) and a high fat diet LDLr knockout model (LDLr −/−). A significant downregulation in mRNA was observed in CPS1 and ornithine transcarbamylase (OTC1) in simple steatosis and NASH-fibrosis patients versus controls. Further, age, obesity (BMI > 30 kg/m2), diabetes mellitus and ALT werefound to be risk factors whereas A-allele from CPS1 was a protective factor from liver fibrosis. CPS1 hepatic expression was diminished in parallel with the increase of fibrosis, and its levels reverted up to normality after changing diet in CDA-HFD mice. In conclusion, liver fibrosis and steatosis were associated with a reduction in both gene and protein expression patterns of mitochondrial urea cycle enzymes. A-allele from a variant on CPS1 may protect from fibrosis development. CPS1 expression is restored in a preclinical model when the main trigger of the liver damage disappears