Study on determining stability domains for nonlinear dynamical systems Final report 1 May 1966 - 1 Feb. 1967

Numerical procedure for determining stability domains in nonlinear dynamical system

Mitochondrial Membrane Permeability Inhibitors in Acute Myocardial Infarction Still Awaiting Translation

Despite therapeutic advances, acute myocardial infarction (AMI) remains a leading cause of morbidity and mortality worldwide. One potential limitation of the current treatment paradigm is the lack of effective therapies to optimize reperfusion after ischemia and prevent reperfusion-mediated injury. Experimental studies indicate that this process accounts for up to 50% of the final infarct size, lending it importance as a potential target for cardioprotection. However, multiple therapeutic approaches have shown potential in pre-clinical and early phase trials but a paucity of clear clinical benefit when expanded to larger studies. Here we explore this history of trials and errors of the studies of cyclosporine A and other mitochondrial membrane permeability inhibitors, agents that appeared to have a promising pre-clinical record yet provided disappointing results in phase III clinical trials

Study on determining stability domains for nonlinear dynamical systems, II Quarterly progress report, 1 Aug. - 31 Oct. 1966

Stability domain determination for nonlinear dynamical syste

Evolution of the electronic structure across the filling-control and bandwidth-control metal-insulator transitions in pyrochlore-type Ru oxides

We have performed photoemission and soft x-ray absorption studies of pyrochlore-type Ru oxides, namely, the filling-control system Sm$_{2-x}$Ca$_x$Ru$_2$O$_7$ and the bandwidth-control system Sm$_{2-x}$Bi$_x$Ru$_2$O$_7$, which show insulator-to-metal transition with increasing Ca and Bi concentration, respectively. Core levels and the O 2$p$ valence band in Sm$_{2-x}$Ca$_x$Ru$_2$O$_7$ show almost the same amount of monotonous upward energy shifts with Ca concentration, which indicates that the chemical potential is shifted downward due to hole doping. The Ru 4$d$ band in Sm$_{2-x}$Ca$_x$Ru$_2$O$_7$ is also shifted toward the Fermi level ($E_F$) with hole doping and the density of states (DOS) at $E_F$ increases. The core levels in Sm$_{2-x}$Bi$_x$Ru$_2$O$_7$, on the other hand, do not show clear energy shifts except for the Ru 3$d$ core level, whose line shape change also reflects the increase of metallic screening with Bi concentration. We observe pronounced spectral weight transfer from the incoherent to the coherent parts of the Ru 4d $t_{2g}$ band with Bi concentration, which is expected for a bandwidth-control Mott-Hubbard system. The increase of the DOS at $E_F$ is more abrupt in the bandwidth-control Sm$_{2-x}$Bi$_x$Ru$_2$O$_7$ than in the filling-control Sm$_{2-x}$Ca$_x$Ru$_2$O$_7$, in accordance with a recent theoretical prediction. Effects of charge transfer between the Bi 6$sp$ band and the Ru 4$d$ band are also discussed.Comment: 11 pages, 6 figure

Stream programming framework for global ilumination techniques using a GPU

Los procesadores de streams están comenzando a ser una alternativa accesible para implementar técnicas de rendering asistidas por hardware que habitualmente estaban relegadas al uso offline. Nosotros elaboramos un marco de trabajo para procesamiento de streams basado en los conceptos del modelo de Stream Programming, seleccionamos el algoritmo de Photon Mapping y una GPU (Graphics Processing Unit) Nvidia para una implementación de un caso de prueba. Definimos un conjunto de clases en C++ para encapsular los componentes (kernels y streams) de este nuevo paradigma, usando OpenGL y el lenguaje Cg. Nuestra aplicación combina el método de Photon Mapping y una estructura de aceleración BVH (Bounding Volumes Hierarchy) en un pipeline de renderizado basado casi completamente en la GPU. Finalmente, evaluamos su desempeño usando un modelo de caja de Cornell.Stream processors are becoming an affordable alternative to implement hardware assisted rendering techniques which were usually relegated to offline usage. We built a stream processing framework based on the Stream Programming Model concepts, selected the Photon Mapping algorithm and an NVIDIA GPU (Graphics Processing Unit) as a test case implementation of a Global Illumination technique. We defined a set of C++ classes to encapsulate the components (kernels and streams) of this new paradigm, using OpenGL and Cg language. Our application combines the Photon Splatting method and the BVH (Bounding Volumes Hierarchy) acceleration structure into a rendering pipeline relying almost entirely on the GPU. Finally, we evaluated its performance using a Cornell Box model.V Workshop de Computación Gráfica, Imágenes Y VisualizaciónRed de Universidades con Carreras en Informática (RedUNCI

Non linearly induced self waveguiding structure in dye doped nematic liquid crystals confined in capillaries

We report on experiments dealing with the propagation of a collimated laser beam in a dye doped nematic confined in a capillary of optical fiber size. The nematic is aligned in a such a way that the source beam is self focused. The behavior of the beam - focusing, multifocus regime, filamentation and undulation - already observed in larger cylindrical geometry and pure nematic is shown here to be reproduced in the dye doped medium, at much lower powers. Another feature is reported here: a stable regime looking like a waveguide appears in certain conditions, in which the beam to propagate in a narrow tube. This regime is simply modeled in terms of saturated reorientation of the nematic

Interleukin-18 mediates cardiac dysfunction induced by western diet independent of obesity and hyperglycemia in the mouse

Obesity and diabetes are independent risk factors for heart failure and are associated with the consumption of diet rich in saturated fat and sugar, Western diet (WD), known to induce cardiac dysfunction in the mouse through incompletely characterized inflammatory mechanisms. We hypothesized that the detrimental cardiac effects of WD are mediated by interleukin-18 (IL-18), pro-inflammatory cytokine linked to cardiac dysfunction. C57BL/6J wild-type male mice and IL-18 knockout male mice were fed high-saturated fat and high-sugar diet for 8 weeks. We measured food intake, body weight and fasting glycemia. We assessed left ventricular (LV) systolic and diastolic function by Doppler echocardiography and cardiac catheterization. In wild-type mice, WD induced a significant increase in isovolumetric relaxation time, myocardial performance index and left ventricular end-diastolic pressure, reflecting an impairment in diastolic function, paired with a mild reduction in LV ejection fraction. IL-18 KO mice had higher food intake and greater increase in body weight without significant differences in hyperglycemia. Despite displaying greater obesity, IL-18 knockout mice fed with WD for 8 weeks had preserved cardiac diastolic function and higher left ventricular ejection fraction. IL-18 mediates diet-induced cardiac dysfunction, independent of food intake and obesity, thus highlighting a disconnect between the metabolic and cardiac effects of IL-18