104 research outputs found

    Understanding the enhanced synchronization of delay-coupled networks with fluctuating topology

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    We study the dynamics of networks with coupling delay, from which the connectivity changes over time. The synchronization properties are shown to depend on the interplay of three time scales: the internal time scale of the dynamics, the coupling delay along the network links and time scale at which the topology changes. Concentrating on a linearized model, we develop an analytical theory for the stability of a synchronized solution. In two limit cases the system can be reduced to an “effective” topology: In the fast switching approximation, when the network fluctuations are much faster than the internal time scale and the coupling delay, the effective network topology is the arithmetic mean over the different topologies. In the slow network limit, when the network fluctuation time scale is equal to the coupling delay, the effective adjacency matrix is the geometric mean over the adjacency matrices of the different topologies. In the intermediate regime the system shows a sensitive dependence on the ratio of time scales, and specific topologies, reproduced as well by numerical simulations. Our results are shown to describe the synchronization properties of fluctuating networks of delay-coupled chaotic maps

    Making translation work: Harmonizing cross-species methodology in the behavioural neuroscience of Pavlovian fear conditioning

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    Translational neuroscience bridges insights from specific mechanisms in rodents to complex functions in humans and is key to advance our general understanding of central nervous function. A prime example of translational research is the study of cross-species mechanisms that underlie responding to learned threats, by employing Pavlovian fear conditioning protocols in rodents and humans. Hitherto, evidence for (and critique of) these cross-species comparisons in fear conditioning research was based on theoretical viewpoints. Here, we provide a perspective to substantiate these theoretical concepts with empirical considerations of cross-species methodology. This meta-research perspective is expected to foster cross-species comparability and reproducibility to ultimately facilitate successful transfer of results from basic science into clinical applications

    Aussagekraft des 18F-FDG-PETs im Restaging nach neoadjuvanter Therapie des Ösophaguskarzinoms

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    The Lunar Lander Neutron & Dosimetry (LND) Experiment on Chang’E4

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    Introduction: Chang'E 4 is the next Chinese mission to the Moon and is planned to land on the far side of the Moon in the South Pole Aitken Basin. The mission consists of a lander, a rover, and a communication relay. Here we describe the Lunar Lander Neutrons & Dosimetry experiment (LND) which will be placed on the lander. It consists of a stack of 10 segmented Si solid-state detectors (SSDs) which forms a particle telescope to measure charged particles (electrons 150-500 keV, protons 12-30 MeV, and heavier nuclei 15-30 MeV/nuc). A special geometrical arrangement allows observations of fast neutrons (and γ-rays) which are also important for dosimetry and cosmic-ray exposure of lunar soils. Thermal neutrons are measured using a very thin Gd conversion foil which is sandwiched between two SSDs. Thermal neutrons are sensitive to subsurface water and important to understand lunar surface mixing processes
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