7 research outputs found
SERUM CONCENTRATIONS OF TNF-a AND ITS SOLUBLE RECEPTORS DURING PSYCHOTHERAPY IN GERMAN SOLDIERS SUFFERING FROM COMBAT-RELATED PTSD
Background: Changes in serum concentrations of tumor necrosis factor
Serum concentrations of TNF-α and its soluble receptors during psychotherapy in German soldiers suffering from combat-related PTSD
Background: Changes in serum concentrations of tumor necrosis factor
Serum concentrations of TNF-α, sTNF-R p55 and p75 and post-traumatic stress in German soldiers
Serum Concentrations of Tumor Necrosis Factor-α and its Soluble Receptors in Soldiers with and Without Combat-related Posttraumatic Stress Disorder: Influence of Age and Body Mass Index
SERUM CONCENTRATIONS OF TNF-a AND ITS SOLUBLE RECEPTORS DURING PSYCHOTHERAPY IN GERMAN SOLDIERS SUFFERING FROM COMBAT-RELATED PTSD
Background: Changes in serum concentrations of tumor necrosis factor
Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer
Small-cell lung cancer (SCLC) is an aggressive lung tumor subtype with poor prognosis. We sequenced 29 SCLC exomes, 2 genomes and 15 transcriptomes and found an extremely high mutation rate of 7.4 ± 1 protein-changing mutations per million base pairs. Therefore, we conducted integrated analyses of the various data sets to identify pathogenetically relevant mutated genes. In all cases, we found evidence for inactivation of TP53 and RB1 and identified recurrent mutations in the CREBBP, EP300 and MLL genes that encode histone modifiers. Furthermore, we observed mutations in PTEN, SLIT2 and EPHA7, as well as focal amplifications of the FGFR1 tyrosine kinase gene. Finally, we detected many of the alterations found in humans in SCLC tumors from Tp53 and Rb1 double knockout mice. Our study implicates histone modification as a major feature of SCLC, reveals potentially therapeutically tractable genomic alterations and provides a generalizable framework for the identification of biologically relevant genes in the context of high mutational background