Background: Changes in serum concentrations of tumor necrosis factor

Bühler, Antje H

Dalton, Bethan

Himmerich, Hubertus

Holdt, Lesca M.

Kirkby, Kenneth C

Teupser, Daniel

Wesemann, Ulrich

Willmund, Gerd D

Wolf, Jörg-Egbert

Zimmermann, Peter

BACKGROUND: Changes in serum concentrations of tumor necrosis factor-α (TNF-α) and its soluble receptors (sTNF-R) p55 and p75 have been shown to be associated with various psychiatric treatments.SUBJECTS AND METHODS: Before and after treatment, serum levels of TNF-α, sTNF-R p55 and sTNF-R p75 were measured in 38 German soldiers who had been deployed abroad and suffered from combat-related post-traumatic stress disorder (PTSD). Patients were randomized either to inpatient psychotherapy (N=21) including eye movement desensitization and reprocessing (EMDR) or to outpatient clinical management (N=17). Symptoms of PTSD were measured using the Post-traumatic Stress Diagnostic Scale (PDS).RESULTS: The PDS score significantly decreased across time in both groups. Serum concentrations of TNF-α increased, while sTNF-R p55 and sTNF-R p75 levels decreased significantly. After the treatment period, we could not detect any significant difference regarding TNF-α, sTNF-R p55 or sTNF-R p75 levels between the inpatient psychotherapy group and the outpatient clinical management control group.CONCLUSIONS: This relatively small clinical study suggests that specific inpatient psychotherapy but also non-specific supportive outpatient treatment for PTSD are associated with changes in the TNF-α system. This may represent an immunological effects or side effects of psychotherapy

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Serum concentrations of TNF-α and its soluble receptors during psychotherapy in German soldiers suffering from combat-related PTSD

Hubertus Himmerich

Gerd D. Willmund

Peter Zimmermann

Jörg-Egbert Wolf

Antje H. Bühler

Kenneth C. Kirkby

Bethan Dalton

Lesca M. Holdt

Daniel Teupser

Ulrich Wesemann

Hrčak - Portal of scientific journals of Croatia

SERUM CONCENTRATIONS OF TNF-a AND ITS SOLUBLE RECEPTORS DURING PSYCHOTHERAPY IN GERMAN SOLDIERS SUFFERING FROM COMBAT-RELATED PTSD

https://kclpure.kcl.ac.uk/portal/files/57599759/Serum_concentrations_of_TNF_HIMMERICH_Accepted_1Sept2016_GREEN_AAM.pdf

Serum concentrations of TNF-α and its soluble receptors during psychotherapy in German soldiers suffering from combat-related PTSD

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