Low-energy excitations in the three-dimensional random-field Ising model

The random-field Ising model (RFIM), one of the basic models for quenched disorder, can be studied numerically with the help of efficient ground-state algorithms. In this study, we extend these algorithm by various methods in order to analyze low-energy excitations for the three-dimensional RFIM with Gaussian distributed disorder that appear in the form of clusters of connected spins. We analyze several properties of these clusters. Our results support the validity of the droplet-model description for the RFIM.Comment: 10 pages, 9 figure

Environmental inequality in four European cities : a study combining household survey and geo-referenced data

Combining individual-level survey data and geo-referenced administrative noise data for four European cities (Bern, Zurich, Hanover, and Mainz; n = 7,450), we test the social gradient hypothesis, which states that exposure to residential noise is higher for households in a lower socioeconomic position (measured by income and migration background). In addition, we introduce and test the ‘environmental shielding hypothesis’, which states that, given environmental ‘bads’ in the neighbourhood, privileged social groups have better opportunities to shield themselves against them. Our results show that, for many residents of the four cities, observed road traffic and aircraft noise levels are above World Health Organization limits. Estimates of spatial error regression models only partly support the social gradient hypothesis. While we find significant but relatively small income effects and somewhat stronger effects of having a (non-Western) migration background, these effects are not significant in all cities. However, especially high-income households are more capable of avoiding exposure to indoor noise. Due to their residence characteristics and having the resources to maintain high standards of noise protection, these households have more capabilities to shield themselves against environmental bads in their neighbourhood. This supports the environmental shielding hypothesis

Frenkel and charge transfer excitons in C60

We have studied the low energy electronic excitations of C60 using momentum dependent electron energy-loss spectroscopy in transmission. The momentum dependent intensity of the gap excitation allows the first direct experimental determination of the energy of the 1Hg excitation and thus also of the total width of the multiplet resulting from the gap transition. In addition, we could elucidate the nature of the following excitations - as either Frenkel or charge transfer excitons.Comment: RevTEX, 3 Figures, to appear in Phys. Rev.

Critical aspects of three-dimensional anisotropic spin-glass models

We study the $\pm J$ three-dimensional Ising model with a longitudinal anisotropic bond randomness on the simple cubic lattice. The random exchange interaction is applied only in the $z$ direction, whereas in the other two directions, $xy$ - planes, we consider ferromagnetic exchange. By implementing an effective parallel tempering scheme, we outline the phase diagram of the model and compare it to the corresponding isotropic one, as well as to a previously studied anisotropic (transverse) case. We present a detailed finite-size scaling analysis of the ferromagnetic - paramagnetic and spin glass - paramagnetic transition lines, and we also discuss the ferromagnetic - spin glass transition regime. We conclude that the present model shares the same universality classes with the isotropic model, but at the symmetric point has a considerably higher transition temperature from the spin-glass state to the paramagnetic phase. Our data for the ferromagnetic - spin glass transition line are supporting a forward behavior in contrast to the reentrant behavior of the isotropic model.Comment: 10 pages, 9 eps figures, 1 table, corrected symbolis

Percutaneous transhepatic or endoscopic ultrasound-guided biliary drainage in malignant distal bile duct obstruction using a self-expanding metal stent: Study protocol for a prospective European multicenter trial (PUMa trial)

Background Endoscopic ultrasound-guided biliary drainage (EUS-BD) was associated with better clinical success and a lower rate of adverse events (AEs) than fluoroscopy-guided percutaneous transhepatic biliary drainage (PTBD) in recent single center studies with mainly retrospective design and small case numbers (< 50). The aim of this prospective European multicenter study is to compare both drainage procedures using ultrasound-guidance and primary metal stent implantation in patients with malignant distal bile duct obstruction (PUMa Trial). Methods The study is designed as a non-randomized, controlled, parallel group, non-inferiority trial. Each of the 16 study centers performs the procedure with the best local expertise (PTBD or EUS-BD). In PTBD, bile duct access is performed by ultrasound guidance. EUS-BD is performed as an endoscopic ultrasound (EUS)-guided hepaticogastrostomy (EUS-HGS), EUS-guided choledochoduodenostomy (EUS-CDS) or EUS-guided antegrade stenting (EUS-AGS). Insertion of a metal stent is intended in both procedures in the first session. Primary end point is technical success. Secondary end points are clinical success, duration pf procedure, AEs graded by severity, length of hospital stay, re-intervention rate and survival within 6 months. The target case number is 212 patients (12 calculated dropouts included). Discussion This study might help to clarify whether PTBD is non-inferior to EUS-BD concerning technical success, and whether one of both interventions is superior in terms of efficacy and safety in one or more secondary endpoints. Randomization is not provided as both procedures are rarely used after failed endoscopic biliary drainage and study centers usually prefer one of both procedures that they can perform best

Acute cholecystitis – early laparoskopic surgery versus antibiotic therapy and delayed elective cholecystectomy: ACDC-study

<p>Abstract</p> <p>Background</p> <p>Acute cholecystitis occurs frequently in the elderly and in patients with gall stones. Most cases of severe or recurrent cholecystitis eventually require surgery, usually laparoscopic cholecystectomy in the Western World. It is unclear whether an initial, conservative approach with antibiotic and symptomatic therapy followed by delayed elective surgery would result in better morbidity and outcome than immediate surgery. At present, treatment is generally determined by whether the patient first sees a surgeon or a gastroenterologist. We wish to investigate whether both approaches are equivalent. The primary endpoint is the morbidity until day 75 after inclusion into the study.</p> <p>Design</p> <p>A multicenter, prospective, randomized non-blinded study to compare treatment outcome, complications and 75-day morbidity in patients with acute cholecystitis randomized to laparoscopic cholecystectomy within 24 hours of symptom onset or antibiotic treatment with moxifloxacin and subsequent elective cholecystectomy. For consistency in both arms moxifloxacin, a fluorquinolone with broad spectrum of activity and high bile concentration is used as antibiotic. Duration: October 2006 – November 2008</p> <p>Organisation/Responsibility</p> <p>The trial was planned and is being conducted and analysed by the Departments of Gastroenterology and General Surgery at the University Hospital of Heidelberg according to the ethical, regulatory and scientific principles governing clinical research as set out in the Declaration of Helsinki (1989) and the Good Clinical Practice guideline (GCP).</p> <p>Trial Registration</p> <p>ClinicalTrials.gov NCT00447304</p

Genomic deletion and promoter methylation status of Hypermethylated in Cancer 1 (HIC1) in mantle cell lymphoma

Mantle cell lymphomas (MCL), characterized by the t(11;14)(q13;q32), frequently carry secondary genetic alterations such as deletions in chromosome 17p involving the TP53 locus. Given that the association between TP53-deletions and concurrent mutations of the remaining allele is weak and based on our recent report that the Hypermethylated in Cancer 1 (HIC1) gene, that is located telomeric to the TP53 gene, may be targeted by deletions in 17p in diffuse large B-cell lymphoma (DLBCL), we investigated whether HIC1 inactivations might also occur in MCL. Monoallelic deletions of the TP53 locus were detected in 18 out of 59 MCL (31%), while overexpression of p53 protein occurred in only 8 out of 18 of these MCL (44%). In TP53-deleted MCL, the HIC1 gene locus was co-deleted in 11 out of 18 cases (61%). However, neither TP53 nor HIC1 deletions did affect survival of MCL patients. In most analyzed cases, no hypermethylation of the HIC1 exon 1A promoter was observed (17 out of 20, 85%). However, in MCL cell lines without HIC1-hypermethylation, the mRNA expression levels of HIC1 were nevertheless significantly reduced, when compared to reactive lymph node specimens, pointing to the occurrence of mechanisms other than epigenetic or genetic events for the inactivation of HIC1 in this entity

Strong-disorder paramagnetic-ferromagnetic fixed point in the square-lattice +- J Ising model

We consider the random-bond +- J Ising model on a square lattice as a function of the temperature T and of the disorder parameter p (p=1 corresponds to the pure Ising model). We investigate the critical behavior along the paramagnetic-ferromagnetic transition line at low temperatures, below the temperature of the multicritical Nishimori point at T*= 0.9527(1), p*=0.89083(3). We present finite-size scaling analyses of Monte Carlo results at two temperature values, T=0.645 and T=0.5. The results show that the paramagnetic-ferromagnetic transition line is reentrant for T<T*, that the transitions are continuous and controlled by a strong-disorder fixed point with critical exponents nu=1.50(4) and eta=0.128(8), and beta = 0.095(5). This fixed point is definitely different from the Ising fixed point controlling the paramagnetic-ferromagnetic transitions for T>T*. Our results for the critical exponents are consistent with the hyperscaling relation 2 beta/nu - eta = d - 2 = 0.Comment: 32 pages, added refs and a discussion on hyperscalin