Evaluación funcional y propuesta de rehabilitación de la Carretera Bagua Grande – Cajaruro – Bagua – Cruce IV Eje Vial – Región Amazonas

La presente tesis propone una rehabilitación en base a una evaluación funcional del pavimento, de la carretera Bagua Grande –Cajaruro –Bagua ubicado en el departamento de Amazonas al Norte del Perú; la vía se encuentra con visibilidad de numerosas fallas como huecos, piel de cocodrilo, grietas de borde, abultamientos y otras fallas, a pesar de tener solo 8 años de haberse inaugurado, siendo la longitud de la carretera de 22+289 km, que comprende varios pueblos entre Bagua Grande y Bagua como distritos y caseríos, la evaluación se hace usando la metodología de la Sociedad Estadounidense para Pruebas y Materiales(ASTM) D6433-07 Índice de condición de pavimento (pavement condition index) PCI, que es la metodología más completa para la evaluación y calificación objetiva de pavimentos flexibles, y que nos brinda un 95 % de confiabilidad del estado de la carretera, además se menciona investigaciones realizadas bajo laboratorio en el comportamiento del asfalto con el agua, con el fin de encontrar las causas por las que se debe la ocurrencia de fallas del pavimento en dicha localidad, evaluando las condiciones de la zona haciéndose estudios de tránsito, de suelos, topográficos, ambiental; y se realiza una propuesta de rehabilitación de la vía

Prevalência de sobrepeso e obesidade em crianças e adolescentes da cidade de Maceió

OBJETIVO: Estabelecer a prevalência de sobrepeso e obesidade em crianças e adolescentes de Maceió (Alagoas, Brasil) e verificar associação destes fatores com gênero, idade e tipo de escola. MÉTODOS: Estudo epidemiológico descritivo, transversal. Avaliou jovens de 7 a 17 anos de idade, sorteados das 396 escolas públicas e particulares de Maceió. Após a randomização, os dados foram coletados por meio de questionário e medidas antropométricas (Índice de Massa Corporal = peso: altura²). Sobrepeso e obesidade foram definidos como Índice de Massa Corporal superior ao percentil 85 e igual ou superior ao percentil 95 para idade e sexo, respectivamente. RESULTADOS: A amostra final foi constituída de 1253 estudantes (706 do gênero feminino). Identificados 116 estudantes com sobrepeso e 56 estudantes com obesidade. Houve associação significante entre obesidade e estudantes com idade de sete a nove anos quando comparados com os de 10 a 13 anos (pOBJECTIVE: To establish prevalence of overweight and obesity in children and adolescents from the city of Maceió, Alagoas, Brazil, and investigate the association of risk of overweight and obesity with gender, age and type of school. METHODS: This was a cross-sectional study. Students between 7 and 17 years of age were selected from 396 public and private schools of Maceió. After randomization, data were collected by questionnaire. Weight and height were measured (body mass index = weight:height2). Overweight and obesity were defined, respectively, as body mass index greater than the 85th percentile and equal or greater than the 95th percentile for age and gender. RESULTS: The final sample included 1253 students (706 females). One hundred sixteen students were overweight and fifty six students were obese. Obesity was significantly associated with students between 7 and 9 years of age, when compared to the 10 and 13 year olds (p<0.04) and the 14 and 17 year olds (p<0.02). Private school students were more likely to be overweight (OR=2.2; CI95%:1.36 - 3.32) and more likely to be obese (OR=4.7; CI95%:2.32 - 9.34) than students CONCLUSION: The prevalence of overweight and obesity were, respectively, 9.3% and 4.5%. Overweight and obesity were significantly more frequent among private school students

European survey on laboratory preparedness, response and diagnostic capacity for crimean-congo haemorrhagic fever, 2012

Crimean-Congo haemorrhagic fever (CCHF) is an infectious viral disease that has (re-)emerged in the last decade in south-eastern Europe, and there is a risk for further geographical expansion to western Europe. Here we report the results of a survey covering 28 countries, conducted in 2012 among the member laboratories of the European Network for Diagnostics of 'Imported' Viral Diseases (ENIVD) to assess laboratory preparedness and response capacities for CCHF. The answers of 31 laboratories of the European region regarding CCHF case definition, training necessity, biosafety, quality assurance and diagnostic tests are presented. In addition, we identifi

Foot-and-Mouth Disease Virus Persists in the Light Zone of Germinal Centres

Foot-and-mouth disease virus (FMDV) is one of the most contagious viruses of animals and is recognised as the most important constraint to international trade in animals and animal products. Two fundamental problems remain to be understood before more effective control measures can be put in place. These problems are the FMDV “carrier state” and the short duration of immunity after vaccination which contrasts with prolonged immunity after natural infection. Here we show by laser capture microdissection in combination with quantitative real-time reverse transcription polymerase chain reaction, immunohistochemical analysis and corroborate by in situ hybridization that FMDV locates rapidly to, and is maintained in, the light zone of germinal centres following primary infection of naïve cattle. We propose that maintenance of non-replicating FMDV in these sites represents a source of persisting infectious virus and also contributes to the generation of long-lasting antibody responses against neutralising epitopes of the virus

Risk factors associated with methicillin-resistant Staphylococcus aureus skin and soft tissue infections in hospitalized patients in Colombia

Q2Q160-66Pacientes hospitalizadosObjectives: Methicillin-resistant Staphylococcus aureus (MRSA) skin and soft tissue infections (SSTIs) represent a major clinical problem in Colombia. The aim of this study was to evaluate the risk factors associated with MRSA SSTI in Colombia. Methods: A multicenter cohort study with nested case–control design was performed. Patients with an SSTI with at least 48 h of inpatient care were included. Patients with an MRSA SSTI were considered the case group and patients with either a non-MRSA SSTI or with an Methicillin-susceptible S. aureus (MSSA) SSTI were the control groups. A multivariate logistic regression approach was used to evaluate risk factors associated with MRSA SSTI with two different statistical models. Results: A total 1134 patients were included. Cultures were positive for 498 patients, of which 52% (n = 259) were Staphylococcus aureus. MRSA was confirmed in 68.3% of the S. aureus cultures. In the first model, independent risk factors for MRSA SSTI were identified as the presence of abscess (P<0.0001), cellulitis (P = 0.0007), age 18–44 years (P = 0.001), and previous outpatient treatment in the previous index visit (P = 0.003); surgical site infection was a protective factor (P = 0.008). In the second model, the main risk factor found was previous outpatient treatment in the previous index visit (P = 0.013). Conclusions: Community-acquired SSTIs in Colombia are commonly caused by MRSA. Therefore, clinicians should consider MRSA when designing the initial empirical treatment for purulent SSTI in Colombia, although there seems to be low awareness of this fact

The OpenMolcas Web: A Community-Driven Approach to Advancing Computational Chemistry

The developments of the open-source OpenMolcas chemistry software environment since spring 2020 are described, with a focus on novel functionalities accessible in the stable branch of the package or via interfaces with other packages. These developments span a wide range of topics in computational chemistry and are presented in thematic sections: electronic structure theory, electronic spectroscopy simulations, analytic gradients and molecular structure optimizations, ab initio molecular dynamics, and other new features. This report offers an overview of the chemical phenomena and processes OpenMolcas can address, while showing that OpenMolcas is an attractive platform for state-of-the-art atomistic computer simulations

A comparative study of teledermatoscopy and face-to-face examination of pigmented skin lesions

We examined the agreement between diagnoses of pigmented skin lesions based on an in-person (face-to-face) dermatological examination and diagnoses based on the study of medical records and images transferred through the web (teledermatoscopy). Two experienced dermatologists examined and diagnosed 64 pigmented skin lesions, which had been surgically excised and undergone histopathology examination. Two years later, the same cases were studied and diagnosed once again by the same dermatologists via the web. There was 72% agreement between the in-person diagnoses and the biopsy results (the gold standard), and 66% agreement between the telediagnoses and the biopsy results. Telemedicine had high sensitivity (87%) and specificity (73%), although there were 4 false-negative diagnoses. A web-based dermatoscopic diagnostic service appears to be feasible and would meet the needs for access to specialized services in rural areas. However, further work is required to decrease the number of false negative cases.Universidade Federal de São Paulo, Dept Dermatol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Hlth Informat, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Pathol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Dermatol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Hlth Informat, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Pathol, São Paulo, BrazilWeb of Scienc

A randomized controlled trial of a transdiagnostic cognitive-behavioral intervention for Afro-descendants' survivors of systemic violence in Colombia.

BackgroundExposure to violence has negative consequences on mental health. Armed-conflict in Colombia has widely affected Afro-descendants in the Pacific region. Evidence regarding effectiveness of mental health interventions is lacking in low-income settings, especially in areas with active conflict. The objective of this study is to evaluate an individualized Common Elements Treatment Approach (CETA), a transdiagnostic psychotherapy model based on Cognitive-Behavioral Therapy, for adult trauma survivors.Methods and findingsA referred sample of 521 adult Afro-descendants from Buenaventura and Quibdó, Colombia, experiencing significant sadness, suffering or fear (score>0.77 in Total Mental Health Symptoms), with history of traumatic experiences, and with associated functional impairment were randomly allocated to CETA intervention, standby group without intervention, but under monthly monitoring, or a Narrative Community-Based Group Therapy. CETA was provided by trained Lay Psychosocial Community Workers without previous mental health experience, supervised by psychologists, during 12-14 weekly, 1.5-hour sessions. Symptoms were assessed with a locally validated survey built based on the Hopkins Symptom Checklist, the Harvard Trauma Questionnaire, the PTSD CheckList-Civilian Version, a qualitative study for additional general symptoms and a gender-specific functional impairment scale. CETA was compared with the control group and the intervention effects were calculated with mixed models using intention to treat analysis. Participant completion of follow-up was 75.1% and 13.2% voluntarily withdrew. Reduction in post-traumatic stress symptoms was significant in both municipalities when comparing intervention and control groups (mean difference), with a with a moderate effect size in Buenaventura (Cohen's d  =  0.70) and a small effect size in Quibdó (d = 0.31). In Buenaventura, the intervention also had significant effects on depression (large effect size d = 1.03), anxiety (large effect size d = 0.80) and functional impairment (moderate effect size d = 0.70). In Quibdó, it had no significant effect on these outcomes. Changes in Total Mental Health Symptoms were not significant in neither city.ConclusionsThis trial suggests that CETA, can be effective in improving depression, anxiety, post-traumatic stress and function among victims of systematized violence in low-income and active conflict settings. Nonetheless, the difference of effectiveness between the two cities of intervention may indicate that we cannot assume that a mental health intervention known to be effective in one setting will be effective in another, even in similar circumstances and population. This may have special importance when implementing and reproducing these types of intervention in non-controlled circumstances. Further research should address these concerns. Results can be of use by governmental decision-makers when defining mental health programs for survivors.Trial registrationClinicalTrials.gov NCT01856673 (https://clinicaltrials.gov/ct2/show/NCT01856673)