101 research outputs found
Great Britain's Energy Vectors and Transmission Level Energy Storage
As an example of the challenges facing many developed countries, the scale of daily energy flows through Great Britain's electrical, gas and transport systems are presented. When this data is expressed graphically it illustrates important differences in the demand characteristics of these different vectors; these include the scale of energy delivered through the networks on a daily basis, and the scale of variability in the different demands over multiple timescales (seasonal, weekly and daily). The paper discusses energy storage in general; the scale of within day stores of energy available to the gas and electrical transmission networks, and suggests Synthetic Natural Gas as an interesting energy carrier that could use existing natural gas infrastructure
Smoking and health-related quality of life in English general population: Implications for economic evaluations
Copyright @ 2012 Vogl et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.This article has been made available through the Brunel Open Access Publishing Fund.Background: Little is known as to how health-related quality of life (HRQoL) when measured by generic instruments such as EQ-5D differ across smokers, ex-smokers and never-smokers in the general population; whether the overall pattern of this difference remain consistent in each domain of HRQoL; and what implications this variation, if any, would have for economic evaluations of tobacco control interventions. Methods: Using the 2006 round of Health Survey for England data (n = 13,241), this paper aims to examine the impact of smoking status on health-related quality of life in English population. Depending upon the nature of the EQ-5D data (i.e. tariff or domains), linear or logistic regression models were fitted to control for biology, clinical conditions, socio-economic background and lifestyle factors that an individual may have regardless of their smoking status. Age- and gender-specific predicted values according to smoking status are offered as the potential 'utility' values to be used in future economic evaluation models. Results: The observed difference of 0.1100 in EQ-5D scores between never-smokers (0.8839) and heavy-smokers (0.7739) reduced to 0.0516 after adjusting for biological, clinical, lifestyle and socioeconomic conditions. Heavy-smokers, when compared with never-smokers, were significantly more likely to report some/severe problems in all five domains - mobility (67%), self-care (70%), usual activity (42%), pain/discomfort (46%) and anxiety/depression (86%) -. 'Utility' values by age and gender for each category of smoking are provided to be used in the future economic evaluations. Conclusion: Smoking is significantly and negatively associated with health-related quality of life in English general population and the magnitude of this association is determined by the number of cigarettes smoked. The varying degree of this association, captured through instruments such as EQ-5D, may need to be fed into the design of future economic evaluations where the intervention being evaluated affects (e.g. tobacco control) or is affected (e.g. treatment for lung cancer) by individual's (or patients') smoking status
People with limiting long-term conditions report poorer experiences and more problems with hospital care
Modelling of JET hybrid scenarios with GLF23 transport model: E × B shear stabilization of anomalous transport
The E × B shear stabilization of anomalous transport in JET hybrid discharges is studied via self-consistent predictive modelling of electron and ion temperature, ion density and toroidal rotation velocity performed with the GLF23 model. The E × B shear stabilization factor (parameter α E in the GLF23 model) is adjusted to predict accurately the four simulated quantities under different experimental conditions, and the uncertainty in α E determined by 15% deviation between simulated and measured quantities is estimated. A correlation of α E with toroidal rotation velocity and E × B shearing rate is found in the low density plasmas, suggesting that the turbulence quench rule may be more complicated than assumed in the GLF23 model with constant α E . For the selected discharges the best predictive accuracy is obtained by using weak/no E × B shear stabilization (i.e. α E ≈ 0) at low toroidal angular frequency (Ω < 60 krad s −1 ), even in the scenarios with the current overshoot, and α E = 0.9 at high frequency (Ω > 100 krad s −1 ). Interestingly, a weak E × B shear stabilization of anomalous transport is found in the medium density strongly rotating discharge. An importance of linear β e stabilization in this discharge is estimated and compared to the low density discharge with equally high β e . The toroidal rotation velocity is well predicted here by assuming that the momentum diffusion coefficient is a fraction of thermal ion diffusivity. Taking into account the α E and Prandtl number with their uncertainties determined in the modelling of JET hybrid discharges, the performance of ITER hybrid scenario with optimized heat mix (33 MW of NBI and 20 MW of ECCD) is estimated showing the importance of toroidal rotation for achieving Q > 5.</p
Fungi Unearthed: Transcripts Encoding Lignocellulolytic and Chitinolytic Enzymes in Forest Soil
BACKGROUND: Fungi are the main organisms responsible for the degradation of biopolymers such as lignin, cellulose, hemicellulose, and chitin in forest ecosystems. Soil surveys largely target fungal diversity, paying less attention to fungal activity. METHODOLOGY/PRINCIPAL FINDINGS: Here we have focused on the organic horizon of a hardwood forest dominated by sugar maple that spreads widely across Eastern North America. The sampling site included three plots receiving normal atmospheric nitrogen deposition and three that received an extra 3 g nitrogen m(2) y(1) in form of sodium nitrate pellets since 1994, which led to increased accumulation of organic matter in the soil. Our aim was to assess, in samples taken from all six plots, transcript-level expression of fungal genes encoding lignocellulolytic and chitinolytic enzymes. For this we collected RNA from the forest soil, reverse-transcribed it, and amplified cDNAs of interest, using both published primer pairs as well as 23 newly developed ones. We thus detected transcript-level expression of 234 genes putatively encoding 26 different groups of fungal enzymes, notably major ligninolytic and diverse aromatic-oxidizing enzymes, various cellulose- and hemicellulose-degrading glycoside hydrolases and carbohydrate esterases, enzymes involved in chitin breakdown, N-acetylglucosamine metabolism, and cell wall degradation. Among the genes identified, 125 are homologous to known ascomycete genes and 105 to basidiomycete genes. Transcripts corresponding to all 26 enzyme groups were detected in both control and nitrogen-supplemented plots. CONCLUSIONS/SIGNIFICANCE: Many of these enzyme groups are known to be important in soil turnover processes, but the contribution of some is probably underestimated. Our data highlight the importance of ascomycetes, as well as basidiomycetes, in important biogeochemical cycles. In the nitrogen-supplemented plots, we have detected no transcript-level gap likely to explain the observed increased carbon storage, which is more likely due to community changes and perhaps transcriptional and/or post-transcriptional down-regulation of relevant genes
Modelling of hybrid scenario: from present-day experiments towards ITER
The ‘hybrid’ scenario is an attractive operating scenario for ITER since it combines long plasma duration with the reliability of the reference H-mode regime. We review the recent European modelling effort carried out within the Integrated Scenario Modelling group which aims at (i) understanding the underlying physics of the hybrid regime in ASDEX-Upgrade and JET and (ii) extrapolating them towards ITER. JET and ASDEX-Upgrade hybrid scenarios performed under different experimental conditions have been simulated in an interpretative and predictive way in order to address the current profile dynamics and its link with core confinement, the relative importance of magnetic shear, s , and E × B flow shear on the core turbulence, pedestal stability and H–L transition. The correlation of the improved confinement with an increased s / q at outer radii observed in JET and ASDEX-Upgrade discharges is consistent with the predictions based on the GLF23 model applied in the simulations of the ion and electron kinetic profiles. Projections to ITER hybrid scenarios have been carried out focusing on optimization of the heating/current drive schemes to reach and ultimately control the desired plasma equilibrium using ITER actuators. Firstly, access condition to the hybrid-like q -profiles during the current ramp–up phase has been investigated. Secondly, from the interpreted role of the s / q ratio, ITER hybrid scenario flat-top performance has been optimized through tailoring the q -profile shape and pedestal conditions. EPED predictions of pedestal pressure and width have been used as constraints in the interpretative modelling while the core heat transport is predicted by GLF23. Finally, model-based approach for real-time control of advanced tokamak scenarios has been applied to ITER hybrid regime for simultaneous magnetic and kinetic profile control.</p
Novel Root-Fungus Symbiosis in Ericaceae: Sheathed Ericoid Mycorrhiza Formed by a Hitherto Undescribed Basidiomycete with Affinities to Trechisporales
Ericaceae (the heath family) are widely distributed calcifuges inhabiting soils with inherently poor nutrient status. Ericaceae overcome nutrient limitation through symbiosis with ericoid mycorrhizal (ErM) fungi that mobilize nutrients complexed in recalcitrant organic matter. At present, recognized ErM fungi include a narrow taxonomic range within the Ascomycota, and the Sebacinales, basal Hymenomycetes with unclamped hyphae and imperforate parenthesomes. Here we describe a novel type of basidiomycetous ErM symbiosis, termed ‘sheathed ericoid mycorrhiza’, discovered in two habitats in mid-Norway as a co-dominant mycorrhizal symbiosis in Vaccinium spp. The basidiomycete forming sheathed ErM possesses clamped hyphae with perforate parenthesomes, produces 1- to 3-layer sheaths around terminal parts of hair roots and colonizes their rhizodermis intracellularly forming hyphal coils typical for ErM symbiosis. Two basidiomycetous isolates were obtained from sheathed ErM and molecular and phylogenetic tools were used to determine their identity; they were also examined for the ability to form sheathed ErM and lignocellulolytic potential. Surprisingly, ITS rDNA of both conspecific isolates failed to amplify with the most commonly used primer pairs, including ITS1 and ITS1F + ITS4. Phylogenetic analysis of nuclear LSU, SSU and 5.8S rDNA indicates that the basidiomycete occupies a long branch residing in the proximity of Trechisporales and Hymenochaetales, but lacks a clear sequence relationship (>90% similarity) to fungi currently placed in these orders. The basidiomycete formed the characteristic sheathed ErM symbiosis and enhanced growth of Vaccinium spp. in vitro, and degraded a recalcitrant aromatic substrate that was left unaltered by common ErM ascomycetes. Our findings provide coherent evidence that this hitherto undescribed basidiomycete forms a morphologically distinct ErM symbiosis that may occur at significant levels under natural conditions, yet remain undetected when subject to amplification by ‘universal’ primers. The lignocellulolytic assay suggests the basidiomycete may confer host adaptations distinct from those provisioned by the so far investigated ascomycetous ErM fungi
Current ramps in tokamaks: from present experiments to ITER scenarios
In order to prepare adequate current ramp-up and ramp-down scenarios for ITER, present experiments from various tokamaks have been analysed by means of integrated modelling in view of determining relevant heat transport models for these operation phases. A set of empirical heat transport models for L-mode (namely, the Bohm-gyroBohm model and scaling based models with a specific fixed radial shape and energy confinement time factors of H(96-L) = 0.6 or H(IPB98) = 0.4) has been validated on a multi-machine experimental dataset for predicting the l(i) dynamics within +/- 0.15 accuracy during current ramp-up and ramp-down phases. Simulations using the Coppi-Tang or GLF23 models (applied up to the LCFS) overestimate or underestimate the internal inductance beyond this accuracy (more than +/- 0.2 discrepancy in some cases). The most accurate heat transport models are then applied to projections to ITER current ramp-up, focusing on the baseline inductive scenario (main heating plateau current of I(p) = 15 MA). These projections include a sensitivity study to various assumptions of the simulation. While the heat transport model is at the heart of such simulations (because of the intrinsic dependence of the plasma resistivity on electron temperature, among other parameters), more comprehensive simulations are required to test all operational aspects of the current ramp-up and ramp-down phases of ITER scenarios. Recent examples of such simulations, involving coupled core transport codes, free-boundary equilibrium solvers and a poloidal field (PF) systems controller are also described, focusing on ITER current ramp-down.</p
Structural basis of genomic RNA (gRNA) dimerization and packaging determinants of mouse mammary tumor virus (MMTV)
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