Forensic Toxicology

Forensic toxicology is a broad science that integrates principles and practices about toxicology and legal aspects, which occur in conjunction with medicolegal instances as with homicide, suicide, road traffic and other types of accident and/or disasters. Nowadays, the practitioners of forensic toxicology science have to deal with three chief sections, namely: postmortem, drug testing, and human performance forensic toxicology. Postmortem forensic toxicology is dealing mostly with investigation of abnormal deaths, or when drug intoxication incidence is assumed as a cause of death and no abnormal findings were detected during autopsy

Donor-Acceptor Complexes of N-Substituted Anilines with Aromatic Nitro Compounds Preparation & Infrared Spectroscopic Investigation

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Co-creation in service assemblages for service innovation : an empirical investigation

Co-creation could enhance service innovation (Perks, Gruber, and Edvardsson, 2012). Despite the research conducted on co-creation, the issue concerning how actors could form service system with high density still needs to be addressed (Michel, Vargo and Lusch, 2008). We conceptualized service system as an assemblage and investigated emergence and dynamic process of assemble and dissemble of service assemblages by drawing on theories of co-creation, affordance, task network and modularity and the notion of assemblage (Delanda, 2006). We developed a framework and empirically examined how to map the competences required for actors in a task network and how capacities could be optimally (re)configured as assemblages (clusters) for value co-creation. We demonstrated that the framework developed could be applied to formation, reformation of service assemblages for design of service offerings enabling optimal value co-creation

Spectrophotometric studies on some nitrosonaphthols

1018-1021The UV and visible absorption spectra of some nitrosonaphthol derivatives have been studied in organic solvents of varying polarities. The dependence of the band shift on the nature of substituent, dielectric effect and specific solvation has been studied. The absorption spectra have also been studied in buffer solutions of varying pH values and the acid dissociation constants of the different ionisable groups have been determined using the half-height and the modified limiting absorbance methods. It is found that the nitroso substituent leads to a decrease in ionisation constants of the naphthalenic OH group

A Reduced Nonlinear Model for the Simulation of Two Phase Flow in a Horizontal Pipe.

In the last 10 years many 3D numerical schemes have been developed for the study the flow of a mixture of liquid and gas in a pipeline (Frank, Numerical simulation of slug flow regime for an air-water two-phase flow in horizontal pipes. In: The 11th international topical meeting on nuclear reactor thermal-hydraulics (NURETH-11), Avignon, 2005; Vallée et al., Nucl Eng Des 238(3):637–646, 2008; Höhne, Experiments and numerical simulations of horizontal two-phase flow regimes. In: Proceeding of the seventh international conference on CFD in the minerals and process industries, Melbourne, 2009; Bartosiewicz et al., Nucl Eng Des 240(9):2375–2381, 2010) but although they offer a very good accuracy, they are rarely fit for modelling a long pipe, due to the high computational costs. Then one is usually led to consider 1D models, see e.g. the works of Issa and his group (Issa and Kempf, Int J Multiphase Flow 29(1):69–95, 2003). Such models offer much faster simulations than 3D schemes, on the other hand they almost completely miss the dynamics in the transversal direction. Here we present a model able of representing the full 3D dynamics, but with the computational cost typical of 1D simulation. The main feature of our model consists in describing the dynamical variables in the direction transversal to the pipe by means of a family of functions depending on a set of parameters. The model is then solved by a standard finite volume scheme

Molecular diagnosis in recessive pediatric neurogenetic disease can help reduce disease recurrence in families.

BackgroundThe causes for thousands of individually rare recessive diseases have been discovered since the adoption of next generation sequencing (NGS). Following the molecular diagnosis in older children in a family, parents could use this information to opt for fetal genotyping in subsequent pregnancies, which could inform decisions about elective termination of pregnancy. The use of NGS diagnostic sequencing in families has not been demonstrated to yield benefit in subsequent pregnancies to reduce recurrence. Here we evaluated whether genetic diagnosis in older children in families supports reduction in recurrence of recessive neurogenetic disease.MethodsRetrospective study involving families with a child with a recessive pediatric brain disease (rPBD) that underwent NGS-based molecular diagnosis. Prenatal molecular testing was offered to couples in which a molecular diagnosis was made, to help couples seeking to prevent recurrence. With this information, families made decisions about elective termination. Pregnancies that were carried to term were assessed for the health of child and mother, and compared with historic recurrence risk of recessive disease.ResultsBetween 2010 and 2016, 1172 families presented with a child a likely rPBD, 526 families received a molecular diagnosis, 91 families returned to the clinic with 101 subsequent pregnancies, and 84 opted for fetal genotyping. Sixty tested negative for recurrence for the biallelic mutation in the fetus, and all, except for one spontaneous abortion, carried to term, and were unaffected at follow-up. Of 24 that genotyped positive for the biallelic mutation, 16 were electively terminated, and 8 were carried to term and showed features of disease similar to that of the older affected sibling(s). Among the 101 pregnancies, disease recurrence in living offspring deviated from the expected 25% to the observed 12% ([95% CI 0·04 to 0·20], p = 0·011).ConclusionsMolecular diagnosis in an older child, coupled with prenatal fetal genotyping in subsequent pregnancies and genetic counselling, allows families to make informed decisions to reduce recessive neurogenetic disease recurrence

Ultra-sensitive and selective Hg2+ chemosensors derived from substituted 8-hydroxyquinoline analogues

International audienceNovel analogues of 8-hydroxyquinoline with phosphinate or thiophosphinate functions and styryl fluorophores in the para position to the nitrogen atom were prepared via multi-step syntheses, using phosphorylation and Wittig coupling reactions. A strong affinity between the quinoline analogues and heavy metal ions such as Pb2+, Cd2+ and Hg2+ was highlighted. The interaction of the metal ions with the nitrogen of the styrylquinoline leads to a large red shift of the absorption and emission spectra in agreement with an increase of the photoinduced charge transfer character of the styryl fluorophore. In the presence of metal ions the appearance of a green fluorescence emission is also observed upon excitation at 420 nm or 840 nm, thanks to a significant increase of the two-photon response. Under optimal conditions, a mercury concentration of 15 ppt in a partially aqueous medium can be detected using the thiophosphinate derivative without interference from other metal ions