183 research outputs found
AdS2xS2 as an exact heterotic string background
An exact heterotic string theory on an AdS2xS2 background supported by an
electromagnetic flux is found as a marginal deformation of an SL(2,R)xSU(2) WZW
model. Based on a talk given at NATO Advanced Study Institute and EC Summer
School on String Theory: from Gauge Interactions to Cosmology, Cargese,
Corsica, France, 7 Jun - 19 Jun 2004.Comment: 5 page
D-branes in Lorentzian AdS(3)
We study the exact construction of D-branes in Lorentzian AdS(3). We start by
defining a family of conformal field theories that gives a natural Euclidean
version of the SL(2,R) CFT and does not correspond to H(3)+, the analytic
continuation of AdS(3). We argue that one can recuperate the exact CFT results
of Lorentzian AdS(3), upon an analytic continuation in the moduli space of
these conformal field theories. Then we construct exact boundary states for
various symmetric and symmetry-breaking D-branes in AdS(3).Comment: JHEP style;21 pages, no figures; v2:some corrections, comments and
references adde
D-branes in a Big Bang/Big Crunch Universe: Nappi-Witten Gauged WZW Model
We study D-branes in the Nappi-Witten model, which is a gauged WZW model
based on (SL(2,R) x SU(2)) / (U(1) x U(1)). The model describes a four
dimensional space-time consisting of cosmological regions with big bang/big
crunch singularities and static regions with closed time-like curves. The aim
of this paper is to investigate by D-brane probes whether there are pathologies
associated with the cosmological singularities and the closed time-like curves.
We first classify D-branes in a group theoretical way, and then examine DBI
actions for effective theories on the D-branes. In particular, we show that
D-brane metric from the DBI action does not include singularities, and wave
functions on the D-branes are well behaved even in the presence of closed
time-like curves.Comment: 50 pages, 2 figures, minor change
Two Antagonistic MALT1 Auto-Cleavage Mechanisms Reveal a Role for TRAF6 to Unleash MALT1 Activation.
The paracaspase MALT1 has arginine-directed proteolytic activity triggered by engagement of immune receptors. Recruitment of MALT1 into activation complexes is required for MALT1 proteolytic function. Here, co-expression of MALT1 in HEK293 cells, either with activated CARD11 and BCL10 or with TRAF6, was used to explore the mechanism of MALT1 activation at the molecular level. This work identified a prominent self-cleavage site of MALT1 isoform A (MALT1A) at R781 (R770 in MALT1B) and revealed that TRAF6 can activate MALT1 independently of the CBM. Intramolecular cleavage at R781/R770 removes a C-terminal TRAF6-binding site in both MALT1 isoforms, leaving MALT1B devoid of the two key interaction sites with TRAF6. A previously identified auto-proteolysis site of MALT1 at R149 leads to deletion of the death-domain, thereby abolishing interaction with BCL10. By using MALT1 isoforms and cleaved fragments thereof, as well as TRAF6 WT and mutant forms, this work shows that TRAF6 induces N-terminal auto-proteolytic cleavage of MALT1 at R149 and accelerates MALT1 protein turnover. The MALT1 fragment generated by N-terminal self-cleavage at R149 was labile and displayed enhanced signaling properties that required an intact K644 residue, previously shown to be a site for mono-ubiquitination of MALT1. Conversely, C-terminal self-cleavage at R781/R770 hampered the ability for self-cleavage at R149 and stabilized MALT1 by hindering interaction with TRAF6. C-terminal self-cleavage had limited impact on MALT1A but severely reduced MALT1B proteolytic and signaling functions. It also abrogated NF-κB activation by N-terminally cleaved MALT1A. Altogether, this study provides further insights into mechanisms that regulate the scaffolding and activation cycle of MALT1. It also emphasizes the reduced functional capacity of MALT1B as compared to MALT1A
Head-to-head Comparison of Transrectal Ultrasound-guided Prostate Biopsy Versus Multiparametric Prostate Resonance Imaging with Subsequent Magnetic Resonance-guided Biopsy in Biopsy-naive Men with Elevated Prostate-specific Antigen: A Large Prospective Multicenter Clinical Study
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Rolling tachyon in anti-de Sitter space-time
We study the decay of the unstable D-particle in three-dimensional anti-de
Sitter space-time using worldsheet boundary conformal field theory methods. We
test the open string completeness conjecture in a background for which the
phase space available is only field-theoretic. This could present a serious
challenge to the claim. We compute the emission of closed strings in the AdS(3)
x S^3 x T^4 background from the knowledge of the exact corresponding boundary
state we construct. We show that the energy stored in the brane is mainly
converted into very excited long strings. The energy stored in short strings
and in open string pair production is much smaller and finite for any value of
the string coupling. We find no "missing energy" problem. We compare our
results to those obtained for a decay in flat space-time and to a background in
the presence of a linear dilaton. Some remarks on holographic aspects of the
problem are made.Comment: JHEP style, 45 pages, one figure; v2: typos corrected, references
added, version to appear in JHE
Orientifolds in N=2 Liouville Theory and its Mirror
We consider unoriented strings in the supersymmetric SL(2,R)/U(1) coset,
which describes the two-dimensional Euclidean black hole, and its mirror dual
N=2 Liouville theory. We analyze the orientifolds of these theories from
several complementary points of view: the parity symmetries of the worldsheet
actions, descent from known AdS_3 parities, and the modular bootstrap method
(in some cases we can also check our results against known constraints coming
from the conformal bootstrap method). Our analysis extends previous work on
orientifolds in Liouville theory, the AdS_3 and SU(2) WZW models and minimal
models. Compared to these cases, we find that the orientifolds of the two
dimensional Euclidean black hole exhibit new intriguing features. Our results
are relevant for the study of orientifolds in the neighborhood of NS5-branes
and for the engineering of four-dimensional chiral gauge theories and gauge
theories with SO and Sp gauge groups with suitable configurations of D-branes
and orientifolds. As an illustration, we discuss an example related to a
configuration of D4-branes and O4-planes in the presence of two parallel
fivebranes.Comment: 47 pages, 2 figures; v2 typos fixed, refs added, improved discussion
of Hanany-Witten setup
Lattice models and Landau theory for type II incommensurate crystals
Ground state properties and phonon dispersion curves of a classical linear
chain model describing a crystal with an incommensurate phase are studied. This
model is the DIFFOUR (discrete frustrated phi4) model with an extra
fourth-order term added to it. The incommensurability in these models may arise
if there is frustration between nearest-neighbor and next-nearest-neighbor
interactions. We discuss the effect of the additional term on the phonon
branches and phase diagram of the DIFFOUR model. We find some features not
present in the DIFFOUR model such as the renormalization of the
nearest-neighbor coupling. Furthermore the ratio between the slopes of the soft
phonon mode in the ferroelectric and paraelectric phase can take on values
different from -2. Temperature dependences of the parameters in the model are
different above and below the paraelectric transition, in contrast with the
assumptions made in Landau theory. In the continuum limit this model reduces to
the Landau free energy expansion for type II incommensurate crystals and it can
be seen as the lowest-order generalization of the simplest Lifshitz-point
model. Part of the numerical calculations have been done by an adaption of the
Effective Potential Method, orginally used for models with nearest-neighbor
interaction, to models with also next-nearest-neighbor interactions.Comment: 33 pages, 7 figures, RevTex, submitted to Phys. Rev.
String Theory on Warped AdS_3 and Virasoro Resonances
We investigate aspects of holographic duals to time-like warped AdS_3
space-times--which include G\"odel's universe--in string theory. Using
worldsheet techniques similar to those that have been applied to AdS_3
backgrounds, we are able to identify space-time symmetry algebras that act on
the dual boundary theory. In particular, we always find at least one Virasoro
algebra with computable central charge. Interestingly, there exists a dense set
of points in the moduli space of these models in which there is actually a
second commuting Virasoro algebra, typically with different central charge than
the first. We analyze the supersymmetry of the backgrounds, finding related
enhancements, and comment on possible interpretations of these results. We also
perform an asymptotic symmetry analysis at the level of supergravity, providing
additional support for the worldsheet analysis.Comment: 24 pages + appendice
ESUR/ESUI consensus statements on multi-parametric MRI for the detection of clinically significant prostate cancer: quality requirements for image acquisition, interpretation and radiologists’ training
Objectives: This study aims to define consensus-based criteria for acquiring and reporting prostate MRI and establishing prerequisites for image quality. Methods: A total of 44 leading urologists and urogenital radiologists who are experts in prostate cancer imaging from the European Society of Urogenital Radiology (ESUR) and EAU Section of Urologic Imaging (ESUI) participated in a Delphi consensus process. Panellists completed two rounds of questionnaires with 55 items under three headings: image quality assessment, interpretation and reporting, and radiologists’ experience plus training centres. Of 55 questions, 31 were rated for agreement on a 9-point scale, and 24 were multiple-choice or open. For agreement items, there was consensus agreement with an agreement ≥ 70% (score 7–9) and disa
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