Study on baseline characteristics and lipid profile abnormalities among type 2 diabetic patients attending urban diabetic care hospital, Bangladesh

Background: Altered levels of serum glycated hemoglobin (HbA1c) and lipid profile are prevalent in patients having type 2 diabetic mellitus (T2DM). Aim of the study was to investigate the relationship between serum HbA1c and lipid profile in T2DM to predict diabetic dyslipidemia.Methods: A structured questionnaire was filled up by each study subject to collect data according to study protocol including age, gender, BMI, BP, residential status, socio-economic status, educational status, physical activity, dietary habit, smoking and duration of diabetes. We collected blood samples from 270 type-2 diabetes mellitus (T2DM) patients aged 30-65 years after overnight fasting (10-12 hours). Then blood samples collected from T2DM patients were used to measure serum levels of HbA1c, fasting blood glucose (FBG), total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL) and high-density lipoprotein (HDL) were estimated by standard laboratory methods.Results: In this study, increased levels of fasting blood glucose (8.61 mmo/l), HbA1c (7.86%), TC (226.15 mg/dl), TG (193.34 mg/dl) and LDL (147.37 mg/dl), and decreased levels of HDL (40.36 mg/dl) were observed in T2DM patients. Moreover, the strong positive correlation of HbA1c levels with FBG, TC, TG, and LDL levels were found in this study. Besides, a very strong and significant negative correlation (R2=0.1822) between the serum levels of HbA1c and HDL were noted in this study.Conclusions: This study revealed a strong correlation between dyslipidemia and serum levels of HbA1c in T2DM patients

Psilocybin’s Effects on Neuritogenesis in Cancer Associated Neurons

https://openworks.mdanderson.org/sumexp23/1034/thumbnail.jp

Electronic-Banking Services: A Study on Selected Commercial Banks in Bangladesh

E-Banking as the wave of the future, provides enormous benefits to consumers in terms of cost of transactions, either through internet, telephone or other electronic delivery channels. E-Banking is now widely practiced in Bangladesh. There are various types of e-banking services like SMS banking, Tele Banking, Push and Pull services, ATM, Fast Track etc. that have been introduced by the commercial banks in Bangladesh. This study attempts to explore various forms and characteristics of e-banking and finds out the merits and demerits of e-banking in selected commercial banks of our country. The major findings of the study show that all the commercial banks selected for the study have been practicing e-banking successfully and Dutch-Bangla Bank Ltd. is providing electronic banking services more effectively than other commercial banks selected in this study. Besides, there is a positive impact of e-banking on the socio-economic development in Bangladesh. There should be diversification of such activities in rural areas of Bangladesh

Targeting Nociceptive and Cholinergic Nerves in Irradiated Oropharyngeal Cancer Model Reveals Novel Mechanism for Dysphagia

https://openworks.mdanderson.org/sumexp23/1038/thumbnail.jp

Effect of short wave length UV-C irradiation on polyphenols and vitamins in liquid foods: Mechanism and kinetic of degradation

UV-C technology is a novel non-thermal disinfection technique which is being considered as an alternative to pasteurization of liquid foods. This study investigated the effect of UV-C irradiation on the individual polyphenols, vitamins and other nutritional attributes of apple juice. Dose validation was performed through biodosimetry where a challenge organism MS2 was used. Four different polyphenols: chlorogenic acid, phloridzin dehydrate, catechin, epicatechin and ten B vitamins (riboflavin, thiamine hydrochloride, pyridoxal hydrochloride, pyridoxine, pyridoxamine dihydrochloride, cyanocobalamin, choline chloride, biotin, niacin, niacinamide) along with lumichrome were investigated and quantified by LCMS method of determination. The first investigation documented the effect of UV-C irradiation of doses (0-240) mJ.cm-2 on pure apple juices where UV-C doses at lower energy level (0-40 mJ.cm -2) had no significant (p\u3e0.05) effect on major polyphenols, total phenol content, major sugars (glucose and fructose) and antioxidant activities of apple juice. Similar results for polyphenols were found in the second investigation where apple juices were irradiated with doses (0-150) mJ.cm-2, however all vitamins and lumichrome were sensitive to the UV-C exposure, they degraded significantly even at low doses of 20 and 40 mJ.cm-2. Degradation kinetics of vitamins were explained by exponential decline [single first order (SFO)] and sum of biexponential decline functions [double first order in parallel (DFOP)]. Cytotoxicity study showed that UV-C treatment did not cause any harmful cytotoxic effect to normal intestinal cells, and both irradiated and non-irradiated samples exhibited very similar significant inhibitory effects on the growth of human colon cancer cells. The effect of advanced oxidation process using hydrogen peroxide and UV-Irradiation (0-100 mJ˙cm-2) was investigated on polyphenols and in-vitro antioxidant activity including total phenols. Results showed concentration of polyphenols (chlorogenic acid, phloridzin dehydrate, catechin) did not change significantly (p\u3e0.05) as a function of dosage, and also the changes in the content of total phenolics and total antioxidant activities were very minor (\u3c3.0%) at the recommended level of irradiation doses (40 mJ.cm-2). The overall results of this study showed the effectiveness of the UV-C technology at commercially relevant doses for treating highly turbid liquid foods such as apple juice

ITGA2, LAMB3, and LAMC2 may be the potential therapeutic targets in pancreatic ductal adenocarcinoma : an integrated bioinformatics analysis

Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer with an abysmal prognosis rate over the last few decades. Early diagnosis and prevention could effectively combat this malignancy. Therefore, it is crucial to discover potential biomarkers to identify asymptomatic premalignant or early malignant tumors of PDAC. Gene expression analysis is a powerful technique to identify candidate biomarkers involved in disease progression. In the present study, five independent gene expression datasets, including 321 PDAC tissues and 208 adjacent non-cancerous tissue samples, were subjected to statistical and bioinformatics analysis. A total of 20 differentially expressed genes (DEGs) were identified in PDAC tissues compared to non-cancerous tissue samples. Gene ontology and pathway enrichment analysis showed that DEGs were mainly enriched in extracellular matrix (ECM), cell adhesion, ECM–receptor interaction, and focal adhesion signalling. The protein–protein interaction network was constructed, and the hub genes were evaluated. Collagen type XII alpha 1 chain (COL12A1), fibronectin 1 (FN1), integrin subunit alpha 2 (ITGA2), laminin subunit beta 3 (LAMB3), laminin subunit gamma 2 (LAMC2), thrombospondin 2 (THBS2), and versican (VCAN) were identified as hub genes. The correlation analysis revealed that identified hub genes were significantly interconnected. Wherein COL12A1, FN1, ITGA2, LAMB3, LAMC2, and THBS2 were significantly associated with PDAC pathological stages. The Kaplan–Meier survival plots revealed that ITGA2, LAMB3, and LAMC2 expression were inversely correlated with a prolonged patient survival period. Furthermore, the Human Protein Atlas database was used to validate the expression and cellular origins of hub genes encoded proteins. The protein expression of hub genes was higher in pancreatic cancer tissue than in normal pancreatic tissue samples, wherein ITGA2, LAMB3, and LAMC2 were exclusively expressed in pancreatic cancer cells. Pancreatic cancer cell-specific expression of these three proteins may play pleiotropic roles in cancer progression. Our results collectively suggest that ITGA2, LAMB3, and LAMC2 could provide deep insights into pancreatic carcinogenesis molecular mechanisms and provide attractive therapeutic targets.peer-reviewe