131 research outputs found
COMPARISON OF SEOI-NAGE TECHNIQUE FOR JUDO ATHLETES OF DIFFERENT SKILL LEVELS
The purpose of the present study was to compare the biomechanics parameters of seoi-nage in judo between highly skilled judo athletes and skilled ones. The motion data of the seoi-nage were collected on three male elite judo athletes and sixteen male student judo athletes using a three-dimensional motion analysis technique. This study found that the anterior-posterior component of the ankle and hip peak velocity of the tori in turning phase were significantly larger in the highly skilled group than the skilled group. In addition, the peak velocities of the ankle and hip were significantly correlated to the peak angular momentum of the tori. The results suggested that it would be useful for judo coaches to pay a greater attention to linear velocity of the lower extremities to evaluate the seoi-nage skill than the knee extension
KINEMATIC COMPARISON OF THE SEOI-NAGE TECHNIQUE BETWEEN ELITE AND COLLEGE JUDO ATHLETES
The purposes of the present study were to compare the biomechanics parameters of seoi-nage between elite and college judo athletes and to produce the standard motion models of elite and college judo athletes. The motion data of the seoi-nage were collected on three male elite judo athletes and nine male student judo athletes using a three-dimensional motion analysis technique and compared. The results demonstrated that the elite judo athletes flexed the knee of the pivot leg and showed less shoulder rotation angle during the latter half of seoi-nage than the college judo athletes. The present study also revealed that the standard motion model seemed to be valid to represent the characteristics of groupsâ motions
COMPARISON OF KINETICS AND KINEMATICS IN SEOI-NAGE BETWEEN JUDO ATHLETES WITH DIFFERENT SKILL LEVELS
The purpose of the present study was to compare the biomechanics parameters of seoi-nage between a skilled group and an unskilled group. The motion data of the seoi-nage were collected on three male elite judo athletes and sixteen male student judo athletes using a three-dimensional motion analysis technique and groups based on skill level were compared. This study found that the anterior-posterior component of the centre of mass velocity of the tori and average anterior-posterior component of the hip velocity of the swing leg in the knee extension phase were significantly larger in the skilled group than those in the unskilled group. The information suggests that it may be more important for judo athletes to maintain the linear velocity towards an opponent than body position of the tori relative to the uke for better seoi-nage performance
Eigenvalue problem for fully nonlinear second-order elliptic PDE on balls, II
This is a continuation of Ikoma and Ishii (Ann Inst H PoincarĂ© Anal Non LinĂ©aire 29:783â812, 2012) and we study the eigenvalue problem for fully nonlinear elliptic operators, positively homogeneous of degree one, on finite intervals or balls. In the multi-dimensional case, we consider only radial eigenpairs. Our eigenvalue problem has a general first-order boundary condition which includes, as a special case, the Dirichlet, Neumann and Robin boundary conditions. Given a nonnegative integer n, we prove the existence and uniqueness, modulo multiplication of the eigenfunction by a positive constant, of an eigenpair whose eigenfunction, as a radial function in the multi-dimensional case, has exactly n zeroes. When an eigenfunction has n zeroes, we call the corresponding eigenvalue of nth order. Furthermore, we establish results concerning comparison of two eigenvalues, characterizations of nth order eigenvalues via differential inequalities, the maximum principle for the boundary value problem in connection with the principal eigenvalue, and existence of a solution having n zeroes, as a radial function in the multi-dimensional case, of the boundary value problem with an inhomogeneous term. © 2015, The Author(s)
The decline of leprosy in Japan: patterns and trends 1964-2008.
OBJECTIVE: Our purpose was to elucidate the patterns and trends of autochthonous leprosy in Japan from 1964 to 2008, to compare them with the findings from other studies of leprosy in decline, and to determine whether M. leprae transmission persists in Japan. DESIGN: Data on registered leprosy cases in Japan in the period 1964-2008 were analysed with reference to trends in case detection, geographical distribution, age at diagnosis, sex, classification, family history and broad correlation with socioeconomic conditions. RESULTS: A consistent decline in leprosy case detection was observed in all areas of the country over the period 1964-2008. Highest incidence was consistently in Okinawa, the southernmost part of Japan. Autochthonous leprosy has not been reported in anyone born in Japan since 1980. Increasing average age and a shift towards lower latitudes were demonstrated throughout the period. There was an inverse association between regional measures of wealth and leprosy incidence. CONCLUSIONS: Leprosy has declined throughout the past century in Japan. Autochthonous transmission has probably stopped in mainland Japan, but may still occur at a low level in Okinawa, the country's southernmost region. Analyses of data on autochthonous cases revealed patterns similar to those reported in other countries with declining leprosy. Detailed comparisons between countries with very low leprosy incidence may help us to better understand the epidemiology of leprosy
Drugs for treating Buruli ulcer (Mycobacterium ulcerans disease)
Background
Buruli ulcer is a necrotizing cutaneous infection caused by infection with Mycobacterium ulcerans bacteria that occurs mainly in tropical and subtropical regions. The infection progresses from nodules under the skin to deep ulcers, often on the upper and lower limbs or on the face. If left undiagnosed and untreated, it can lead to lifelong disfigurement and disabilities. It is often treated with drugs and surgery.
Objectives
To summarize the evidence of drug treatments for treating Buruli ulcer.
Search methods
We searched the Cochrane Infectious Diseases Group Specialized Register; the Cochrane Central Register of Controlled Trials (CENTRAL), published in the Cochrane Library; MEDLINE (PubMed); Embase (Ovid); and LILACS (Latin American and Caribbean Health Sciences Literature; BIREME). We also searched the US National Institutes of Health Ongoing Trials Register (clinicaltrials.gov) and the World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP) (www.who.int/ictrp/search/en/). All searches were run up to 19 December 2017. We also checked the reference lists of articles identified by the literature search, and contacted leading researchers in this topic area to identify any unpublished data.
Selection criteria
We included randomized controlled trials (RCTs) that compared antibiotic therapy to placebo or alternative therapy such as surgery, or that compared different antibiotic regimens. We also included prospective observational studies that evaluated different antibiotic regimens with or without surgery.
Data collection and analysis
Two review authors independently applied the inclusion criteria, extracted the data, and assessed methodological quality. We calculated the risk ratio (RR) for dichotomous data with 95% confidence intervals (CI). We assessed the certainty of the evidence using the GRADE approach.
Main results
We included a total of 18 studies: five RCTs involving a total of 319 participants, ranging from 12 participants to 151 participants, and 13 prospective observational studies, with 1665 participants. Studies evaluated various drugs usually in addition to surgery, and were carried out across eight countries in areas with high Buruli ulcer endemicity in West Africa and Australia. Only one RCT reported adequate methods to minimize bias. Regarding monotherapy, one RCT and one observational study evaluated clofazimine, and one RCT evaluated sulfamethoxazole/trimethoprim. All three studies had small sample sizes, and no treatment effect was demonstrated. The remaining studies examined combination therapy.
Rifampicin combined with streptomycin
We found one RCT and six observational studies which evaluated rifampicin combined with streptomycin for different lengths of treatment (2, 4, 8, or 12 weeks) (941 participants). The RCT did not demonstrate a difference between the drugs added to surgery compared with surgery alone for recurrence at 12 months, but was underpowered (RR 0.12, 95% CI 0.01 to 2.51; 21 participants; very lowâcertainty evidence).
An additional five singleâarm observational studies with 828 participants using this regimen for eight weeks with surgery (given to either all participants or to a select group) reported healing rates ranging from 84.5% to 100%, assessed between six weeks and one year. Four observational studies reported healing rates for participants who received the regimen alone without surgery, reporting healing rates ranging from 48% to 95% assessed between eight weeks and one year.
Rifampicin combined with clarithromycin
Two observational studies administered combined rifampicin and clarithromycin. One study evaluated the regimen alone (no surgery) for eight weeks and reported a healing rate of 50% at 12 months (30 participants). Another study evaluated the regimen administered for various durations (as determined by the clinicians, durations unspecified) with surgery and reported a healing rate of 100% at 12 months (21 participants).
Rifampicin with streptomycin initially, changing to rifampicin with clarithromycin in consolidation phase
One RCT evaluated this regimen (four weeks in each phase) against continuing with rifampicin and streptomycin in the consolidation phase (total eight weeks). All included participants had small lesions, and healing rates were above 90% in both groups without surgery (healing rate at 12 months RR 0.94, 95% CI 0.87 to 1.03; 151 participants; lowâcertainty evidence). One singleâarm observational study evaluating the substitution of streptomycin with clarithromycin in the consolidation phase (6 weeks, total 8 weeks) without surgery given to a select group showed a healing rate of 98% at 12 months (41 participants).
Novel combination therapy
Two large prospective studies in Australia evaluated some novel regimens. One study evaluating rifampicin combined with either ciprofloxacin, clarithromycin, or moxifloxacin without surgery reported a healing rate of 76.5% at 12 months (132 participants). Another study evaluating combinations of two to three drugs from rifampicin, ciprofloxacin, clarithromycin, ethambutol, moxifloxacin, or amikacin with surgery reported a healing rate of 100% (90 participants).
Adverse effects were reported in only three RCTs (158 participants) and eight prospective observational studies (878 participants), and were consistent with what is already known about the adverse effect profile of these drugs. Paradoxical reactions (clinical deterioration after treatment caused by enhanced immune response to M ulcerans) were evaluated in six prospective observational studies (822 participants), and the incidence of paradoxical reactions ranged from 1.9% to 26%.
Authors' conclusions
While the antibiotic combination treatments evaluated appear to be effective, we found insufficient evidence showing that any particular drug is more effective than another. How different sizes, lesions, and stages of the disease may contribute to healing and which kind of lesions are in need of surgery are unclear based on the included studies. Guideline development needs to consider these factors in designing practical treatment regimens. Forthcoming trials using clarithromycin with rifampicin and other trials of new regimens that also address these factors will help to identify the best regimens
Immunologic Characterization of HIV-Specific DNA Vaccine
We developed a method for applying HIV-1 DNA vaccine topically in mice. Topical application of DNA vaccine to the skin is useful against infections. To find a less expensive and less cumbersome vaccination method, we administered HIV-1 DNA vaccine to the skin of mice after elimination of keratinocytes using a fast-acting adhesive. HIV-1 DNA vaccine induced high levels of both humoral and cell-mediated immune activity against HIV-1 envelope antigen. A high level of HIV-1-specific cytotoxic T lymphocyte response was also observed, and a high level of IFN-Îł and IL-4 production was induced by the improved skin application of DNA vaccine. High levels of both HIV-specific cytotoxic T lymphocyte and delayed type hypersensitivity in topical application were induced by coadministration of the DNA vaccine with IL-12 expression plasmids and granulocyte-macrophage colony-stimulating factor expression plasmids. These immune responses were inhibited by intradermal injection of anti-CD11c or anti-I-A/I-E antibody. Therefore, topical administration of DNA vaccine is an effective route, and may be very useful for the prevention of infectious diseases
A Case of Mycobacterial Skin Disease Caused by Mycobacterium peregrinum, and a Review of Cutaneous Infection
An 83-year-old Japanese man presented with a 2-month history of symptomatic nodules on the left hand. He was not in an immunocompromised condition and reported no causal events. A biopsy specimen demonstrated granulomatous tissue with mixed cell infiltration consisting of neutrophils, histiocytes, lymphocytes, and multinuclear giant cells. No bacillus was detected by PAS, acid-fast stain, immunofluorescent stain or polymerase chain reaction analysis. The isolate was found to be a rapidly growing mycobacterium after 4 weeks of incubation at 25°C on an Ogawa egg slant. Mycobacterium peregrinum was isolated by DNA-DNA hybridization analysis, 16S rRNA gene sequence, and by its production of 3-day arylsulfatase. The patient received 200 mg oral minocycline for 28 weeks. The lesion disappeared after 10 weeks of this treatment
Pseudocapacitance of zeolite-templated carbon in organic electrolytes
Carbon and graphene-based materials often show some amount of pseudocapacitance due to their oxygen-functional groups. However, such pseudocapacitance is generally negligible in organic electrolytes and has not attracted much attention. In this work, we report a large pseudocapacitance of zeolite-templated carbon (ZTC) based on the oxygen-functional groups in 1 M tetraethylammonium tetrafluoroborate dissolved in propylene carbonate (Et4NBF4/PC). Due to its significant amount of active edge sites, a large amount of redox-active oxygen functional groups are introduced into ZTC, and ZTC shows a high specific capacitance (330 F gâ1). Experimental results suggest that the pseudocapacitance could be based on the formation of anion and cation radicals of quinones and ethers, respectively. Moreover, ZTC shows pseudocapacitance also in 1 M lithium hexafluorophosphate dissolved with a mixture of ethylene carbonate and diethyl carbonate (LiPF6/EC+DEC) which is used for lithium-ion batteries and lithium-ion capacitors.This research was partially supported by the Strategic International Cooperative Program, Japan Science and Technology Agency (T.K.); a Grant-in-Aid for Scientific Research (A), 15H01999 (T.K.); a Grant-in-Aid for Scientific Research (B), 26286020 (H.N.); and the Spanish MINECO, FEDER funds (Project MAT2013-42007-P and PRI-PIBJP-2011-0766). This research was supported also by Nano-Macro Materials, Devices and System Research Alliance and by Network Joint Research Center for Materials and Devices
Hansen\u27s disease (leprosy) in Japan, 1947-2020: an epidemiologic study during the declining phase to elimination
Objectives: Leprosy, or Hansenâs disease was a major public health problem in Japan in the early 20th century. Today, the number of new cases has decreased significantly. We aimed to investigate the trends of leprosy in Japan over the past 73 years and the challenges faced in recent years. Methods: We assessed the data on newly registered cases of leprosy from 1947 to 2020. Results: A total of 10,796 newly registered cases of leprosy were reported during the study period, of which 7573 were registered in mainland Japan, 2962 in Okinawa, and 250 were of foreign origin. Most autochthonous cases were born before 1950 in mainland Japan and before 1975 in Okinawa. The number of nonautochthonous cases surpassed that of autochthonous cases in 1992. Nonautochthonous cases orig- inated from 26 countries, particularly Brazil and the Philippines. Three cases of antimicrobial resistance have been detected among nonautochthonous cases since 2004. Conclusion: Our data suggest that ongoing transmission of leprosy likely ceased in the 1940s in mainland Japan and in the 1970s in Okinawa. With the recent rise of nonautochthonous cases with globalization, continuous surveillance and effort s to maint ain leprosy services within the country are necessary even after reaching the state of elimination
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