Black Hole Formation and Classicalization in Ultra-Planckian 2 -> N Scattering

We establish a connection between the ultra-Planckian scattering amplitudes in field and string theory and unitarization by black hole formation in these scattering processes. Using as a guideline an explicit microscopic theory in which the black hole represents a bound-state of many soft gravitons at the quantum critical point, we were able to identify and compute a set of perturbative amplitudes relevant for black hole formation. These are the tree-level N-graviton scattering S-matrix elements in a kinematical regime (called classicalization limit) where the two incoming ultra-Planckian gravitons produce a large number N of soft gravitons. We compute these amplitudes by using the Kawai-Lewellen-Tye relations, as well as scattering equations and string theory techniques. We discover that this limit reveals the key features of the microscopic corpuscular black hole N-portrait. In particular, the perturbative suppression factor of a N-graviton final state, derived from the amplitude, matches the non-perturbative black hole entropy when N reaches the quantum criticality value, whereas final states with different value of N are either suppressed or excluded by non-perturbative corpuscular physics. Thus we identify the microscopic reason behind the black hole dominance over other final states including non-black hole classical object. In the parameterization of the classicalization limit the scattering equations can be solved exactly allowing us to obtain closed expressions for the high-energy limit of the open and closed superstring tree-level scattering amplitudes for a generic number N of external legs. We demonstrate matching and complementarity between the string theory and field theory in different large-s and large-N regimes.Comment: 55 pages, 7 figures, LaTeX; v2: typos removed; final version to appear in Nucl. Phys.

New modelling technique for aperiodic-sampling linear systems

A general input-output modelling technique for aperiodic-sampling linear systems has been developed. The procedure describes the dynamics of the system and includes the sequence of sampling periods among the variables to be handled. Some restrictive conditions on the sampling sequence are imposed in order to guarantee the validity of the model. The particularization to the periodic case represents an alternative to the classic methods of discretization of continuous systems without using the Z-transform. This kind of representation can be used largely for identification and control purposes.Comment: 19 pages, 0 figure

Fecal Metaproteomics Reveals Reduced Gut Inflammation and Changed Microbial Metabolism Following Lifestyle-Induced Weight Loss

Gut microbiota-mediated inflammation promotes obesity-associated low-grade inflammation, which represents a hallmark of metabolic syndrome. To investigate if lifestyle-induced weight loss (WL) may modulate the gut microbiome composition and its interaction with the host on a functional level, we analyzed the fecal metaproteome of 33 individuals with metabolic syndrome in a longitudinal study before and after lifestyle-induced WL in a well-defined cohort. The 6-month WL intervention resulted in reduced BMI (−13.7%), improved insulin sensitivity (HOMA-IR, −46.1%), and reduced levels of circulating hsCRP (−39.9%), indicating metabolic syndrome reversal. The metaprotein spectra revealed a decrease of human proteins associated with gut inflammation. Taxonomic analysis revealed only minor changes in the bacterial composition with an increase of the families Desulfovibrionaceae, Leptospiraceae, Syntrophomonadaceae, Thermotogaceae and Verrucomicrobiaceae. Yet we detected an increased abundance of microbial metaprotein spectra that suggest an enhanced hydrolysis of complex carbohydrates. Hence, lifestyle-induced WL was associated with reduced gut inflammation and functional changes of human and microbial enzymes for carbohydrate hydrolysis while the taxonomic composition of the gut microbiome remained almost stable. The metaproteomics workflow has proven to be a suitable method for monitoring inflammatory changes in the fecal metaproteome

Azbade

Pierre Loti'nin Eşref'te yayımlanan Azbade adlı romanının ilk ve son tefrikalarıTefrikanın devamına rastlanmamış, tefrika yarım kalmıştır

High-throughput microfluidic micropipette aspiration device to probe time-scale dependent nuclear mechanics in intact cells

The mechanical properties of the cell nucleus are increasingly recognized as critical in many biological processes. The deformability of the nucleus determines the ability of immune and cancer cells to migrate through tissues and across endothelial cell layers, and changes to the mechanical properties of the nucleus can serve as novel biomarkers in processes such as cancer progression and stem cell differentiation. However, current techniques to measure the viscoelastic nuclear mechanical properties are often time consuming, limited to probing one cell at a time, or require expensive, highly specialized equipment. Furthermore, many current assays do not measure time-dependent properties, which are characteristic of viscoelastic materials. Here, we present an easy-to-use microfluidic device that applies the well-established approach of micropipette aspiration, adapted to measure many cells in parallel. The device design allows rapid loading and purging of cells for measurements, and minimizes clogging by large particles or clusters of cells. Combined with a semi-automated image analysis pipeline, the microfluidic device approach enables significantly increased experimental throughput. We validated the experimental platform by comparing computational models of the fluid mechanics in the device with experimental measurements of fluid flow. In addition, we conducted experiments on cells lacking the nuclear envelope protein lamin A/C and wild-type controls, which have well-characterized nuclear mechanical properties. Fitting time-dependent nuclear deformation data to power law and different viscoelastic models revealed that loss of lamin A/C significantly altered the elastic and viscous properties of the nucleus, resulting in substantially increased nuclear deformability. Lastly, to demonstrate the versatility of the devices, we characterized the viscoelastic nuclear mechanical properties in a variety of cell lines and experimental model systems, including human skin fibroblasts from an individual with a mutation in the lamin gene associated with dilated cardiomyopathy, healthy control fibroblasts, induced pluripotent stem cells (iPSCs), and human tumor cells. Taken together, these experiments demonstrate the ability of the microfluidic device and automated image analysis platform to provide robust, high throughput measurements of nuclear mechanical properties, including time-dependent elastic and viscous behavior, in a broad range of applications.This work was supported by awards from the National Institutes of Health [R01 HL082792 and U54 CA210184 to JL], the Department of Defense Breast Cancer Research Program [Breakthrough Award BC150580 to JL], the National Science Foundation [CBET-1254846 and MCB-1715606 to JL; GRFP- 2014163403 to GRF], La Ligue contre le cancer [REMX17751 to PMD] the Fondation ARC [PDF20161205227 to PMD], and a ministerial doctoral fellowship of Paris Saclay University to SDM. This work was performed in part at Cornell NanoScale Facility (CNF), an NNCI member supported by NSF Grant NNCI- 1542081. The authors thank Elisa di Pasquale and Gianluigi Condorelli for the human iPSCs and laminopathy patient fibroblasts, Colin Stewart for the lamin A/C-deficient and wild- type MEFs. The authors thank Karine Guevorkian and Francoise Brochard for helpful discussions

Yang-Mills amplitude relations at loop level from non-adjacent BCFW shifts

This article studies methods to obtain relations for scattering amplitudes at the loop level, with concrete examples at one loop. These methods originate in the analysis of large so-called Britto-Cachazo-Feng-Witten shifts of tree level amplitudes and loop level integrands. In particular BCFW shifts for particles which are not color adjacent and some particular generalizations of this situation are analyzed in some detail in four and higher dimensions. For generic non-adjacent shifts our results are independent of loop order for integrands and hold for generic minimally coupled gauge theories with possible scalar potential and Yukawa terms. By a standard argument this result indicates a generalization of the Bern-Carrasco-Johansson relations for tree level amplitudes exists to the integrand at all loop levels. A concrete relation is presented at one loop. Furthermore, inspired by results in QED it is shown that the results on generalized BCFW shifts of tree level amplitudes imply relations for the so-called rational, bubble and triangle terms of one loop amplitudes in pure Yang-Mills theory. Bubble and triangle terms for instance are shown to obey a five photon decoupling identity, while a three photon decoupling identity is demonstrated for the rational terms. Along the same lines recently conjectured relations for helicity equal amplitudes at one loop are shown to generalize to helicity independent relations for the massive box coefficient of the rational terms.Comment: 69 pages, 27 figure

Modelling vehicles acceleration during overtaking manoeuvres

[EN] Abstract: Overtaking manoeuvre is a key issue for two-lane rural roads. These roads should provide sufficient overtaking sight distance (OSD) at certain locations to allow faster vehicles to pass slower ones. However, overtaking requires occupying the opposing lane, which represents a serious safety concern. Severity of overtaking related crashes is very high, compared with other manoeuvres. The development of advanced driver assistance systems (ADAS) for overtaking is being a complex task. Only few systems have been developed, but are not still in use. This research incorporated accurate data of real manoeuvres to improve the knowledge of the phenomenon. The trajectory of the overtaking vehicles on the left lane was observed. An instrumented vehicle measured the overtaking time and distance, the abreast position, and the initial and final speed of 180 drivers that passed it during a field experiment. Six different kinematic models (such as uniform acceleration or linear variation of acceleration) were calibrated. Generally, drivers started to accelerate before changing to the opposing lane. These models may be applied to ADAS, to estimate OSD and to improve microsimulation models.Part of this research was included in the project 'Desarrollo de modelos de distancias de visibilidad de adelantamiento', with reference code TRA2010-21736 and subsidised by the Spanish Ministery of Economy and Competitivity. The authors also thank Prof Dr Sayed, from University of British Columbia, for his valuable review.Llorca Garcia, C.; Moreno, AT.; García García, A. (2016). Modelling vehicles acceleration during overtaking manoeuvres. IET Intelligent Transport Systems. 10(3):206-215. https://doi.org/10.1049/iet-its.2015.0035S206215103Gray, R., & Regan, D. M. (2005). Perceptual Processes Used by Drivers During Overtaking in a Driving Simulator. 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Transportation Research Record: Journal of the Transportation Research Board, 1899(1), 11-18. doi:10.3141/1899-02Rakha, H., Ahn, K., & Trani, A. (2004). Development of VT-Micro model for estimating hot stabilized light duty vehicle and truck emissions. Transportation Research Part D: Transport and Environment, 9(1), 49-74. doi:10.1016/s1361-9209(03)00054-3Polus, A., Livneh, M., & Frischer, B. (2000). Evaluation of the Passing Process on Two-Lane Rural Highways. Transportation Research Record: Journal of the Transportation Research Board, 1701(1), 53-60. doi:10.3141/1701-07Harwood, D. W., Gilmore, D. K., & Richard, K. R. (2010). Criteria for Passing Sight Distance for Roadway Design and Marking. Transportation Research Record: Journal of the Transportation Research Board, 2195(1), 36-46. doi:10.3141/2195-05Hegeman, G., Tapani, A., & Hoogendoorn, S. (2009). Overtaking assistant assessment using traffic simulation. Transportation Research Part C: Emerging Technologies, 17(6), 617-630. doi:10.1016/j.trc.2009.04.010Milanés, V., Llorca, D. F., Villagrá, J., Pérez, J., Fernández, C., Parra, I., … Sotelo, M. A. (2012). Intelligent automatic overtaking system using vision for vehicle detection. Expert Systems with Applications, 39(3), 3362-3373. doi:10.1016/j.eswa.2011.09.024Isermann, R., Mannale, R., & Schmitt, K. (2012). Collision-avoidance systems PRORETA: Situation analysis and intervention control. Control Engineering Practice, 20(11), 1236-1246. doi:10.1016/j.conengprac.2012.06.003Petrov, P., & Nashashibi, F. (2014). Modeling and Nonlinear Adaptive Control for Autonomous Vehicle Overtaking. IEEE Transactions on Intelligent Transportation Systems, 15(4), 1643-1656. doi:10.1109/tits.2014.2303995Llorca, C., & García, A. (2011). Evaluation of Passing Process on Two-Lane Rural Highways in Spain with New Methodology Based on Video Data. Transportation Research Record: Journal of the Transportation Research Board, 2262(1), 42-51. doi:10.3141/2262-05Llorca, C., Moreno, A. T., García, A., & Pérez-Zuriaga, A. M. (2013). Daytime and Nighttime Passing Maneuvers on a Two-Lane Rural Road in Spain. Transportation Research Record: Journal of the Transportation Research Board, 2358(1), 3-11. doi:10.3141/2358-01Llorca, C., Moreno, A. T., Pérez-Zuriaga, A. M., & García, A. (2013). Influence of age, gender and delay on overtaking dynamics. IET Intelligent Transport Systems, 7(2), 174-181. doi:10.1049/iet-its.2012.0147Khoury, J. E., & Hobeika, A. (2007). Incorporating Uncertainty into the Estimation of the Passing Sight Distance Requirements. Computer-Aided Civil and Infrastructure Engineering, 22(5), 347-357. doi:10.1111/j.1467-8667.2007.00491.xRakha, H., Snare, M., & Dion, F. (2004). Vehicle Dynamics Model for Estimating Maximum Light-Duty Vehicle Acceleration Levels. 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