Manejo del dolor infantil por los profesionales de enfermería

Introducción: La sensación de dolor es subjetiva y en el caso de la infancia se hace más compleja su valoración debido a las dificultades que los niños tienen para comunicarse. Por tanto, se tiende a infravalorar su dolor y el tratamiento es inadecuado. Este artículo está centrado en los profesionales de Enfermería que cuidan a diario a niños que están sometidos a situaciones dolorosas por estar ingresados o padecer alguna alteración de salud. El objetivo es evaluar el grado de conocimiento de los profesionales de Enfermería sobre el dolor infantil. Metodología: Se realizó un estudio cuasiexperimental de tipo pretest-postest, en el que se distinguieron 3 Fases: I: Medida del grado de conocimiento sobre el dolor pediátrico mediante un cuestionario ya validado. II: Intervención formativa para mejorar los conocimientos, la actitud y las habilidades necesarias para el manejo adecuado del dolor. III: Evaluación de la intervención y del nivel de conocimientos tras la misma. Resultados: El resultado global más importante es que el 57% de los profesionales poseen un nivel de conocimientos considerado “Alto” y el 30% posee un nivel “Medio”. Este nivel de conocimientos es mayor en las unidades de Neonatología e inferior en las unidades de Maternidad. Conclusiones: La experiencia y la especialización suponen una cualidad para el conocimiento sobre el manejo del dolor infantil. Los profesionales necesitan más tiempo para la formación especializada y la formación mejora el conocimiento sobre el manejo del dolor infantil.Introduction: The pain sensation is subjective and in the case of the childhood it becomes more complex its valuation due to the difficulties that the children have to communicate. Therefore, he/she couches to undervalue their pain and the treatment is inadequate. This article, it is centered in the professionals of Infirmary that take care to newspaper to children that are subjected to painful situations to be entered or to suffer some alteration of health. The objective is to evaluate the grade of the professionals' of Infirmary knowledge on the infantile pain. Metodology: It is a study pretest-postest cuasiexperimental, in which is distinguished 3 Phases: I: Measured of the grade of knowledge on the pediatric pain by means of a questionnaire already validated. II: formative Intervention to improve the knowledge, the attitude and the abilities necessary for the appropriate handling of the pain. III: Evaluation of the intervention and of the level of knowledge after the same one. Results: The most important global result is that 57% of the professionals possesses a "High" considered level of knowledge and 30% it possesses a "Half" level. This level of knowledge is bigger in the units of Neonatología, and inferior in the of Maternity unidade. Conclusions: The experience and the specialization suppose a quality for the knowledge on the handling of the infantile pain. The professionals need more time for the specialized formation. and the formation improves the knowledge on the handling of the infantile pain

Emotions Detection based on a Single-electrode EEG Device

The study of emotions using multiple channels of EEG represents a widespread practice in the field of research related to brain computer interfaces (Brain Computer Interfaces). To date, few studies have been reported in the literature with a reduced number of channels, which when used in the detection of emotions present results that are less accurate than the rest. To detect emotions using an EEG channel and the data obtained is useful for classifying emotions with an accuracy comparable to studies in which there is a high number of channels, is of particular interest in this research framework. This article uses the Neurosky Maindwave device; which has a single electrode to acquire the EEG signal, Matlab software and IBM SPSS Modeler; which process and classify the signals respectively. The accuracy obtained in the detection of emotions in relation to the economic resources of the hardware dedicated to the acquisition of EEG signal is remarkable

GLP-1 Receptor Agonists and Cardiovascular Disease in Patients with Type 2 Diabetes.

Diabetes mellitus is a chronic disease prevalence of which is high and continually growing. Cardiovascular disease continues to be the leading cause of death in patients with T2DM. The prevention of cardiovascular complications and the cardiovascular safety of treatments should be a primary objective when selecting treatment. Among all the drugs available, the compounds known as glucagon-like peptide-1 receptor agonists (GLP-1 RAs) appear to be not just innocuous in terms of CVD but indeed to be beneficial. GLP-1 RA actions not only translate on an improvement of well-known cardiovascular risk factors such as glycaemic control, dyslipidaemia, weight, or arterial hypertension but also might show benefits on endothelial function, coronary ischaemia, and heart failure. On the other hand, recent clinical trials aimed at studying cardiovascular episodes have been conducted with GLP-1 RAs. Only liraglutide and semaglutide have shown superiority in cardiovascular benefit compared with placebo. Although many of the mechanisms by which liraglutide and semaglutide produce a cardiovascular benefit are still unknown it would be desirable for these benefits to be incorporated into the therapeutic algorithms routinely used in clinical practice. The purpose of this review is to explore GLP-1 RA actions not only in cardiovascular risk factors (glucose, weight, and hypertension) but also the possible effects on established cardiovascular disease

A Hardware/Software Platform to Acquire Bioelectrical Signals. A Case Study: Characterizing Computer Access through Attention

This paper describes a hardware/software platform to acquire human body signals. In the field of physiological computing it is desirable to have a system that allows the synchronized acquisition of signals coming from different sources. Here is described how to unify the whole process of acquiring signals from both customized hardware and low cost commercial devices such as Neurosky’s mindwave. A case study using this platform is also shown: studying the feasibility of using sustained attention to access a computer. In order to do that brain activity was measured using Neurosky’s mindwave. The participants in this study were asked to keep their attention high/low for as long as possible during several trials. Experimentation was performed by 7 normally developed subjects and 3 people with cerebral palsy (CP). Our preliminary work shows that 60% of participants might be potential users of this technology. Eventually, modulating the attention to access a communication board needs a scanning period greater than 5.76s

Colonic content: effect of diet, meals, and defecation

This is the peer reviewed version of the following article: Bendezú, Á., Mego, M., Monclús, E., Merino, X., Accarino, A., Malagelada, J., Navazo, I., Azpiroz, F. Colonic content: effect of diet, meals, and defecation. "Neurogastroenterology and motility", Febrer 2017, vol. 29, núm. 2, which has been published in final form at [http://onlinelibrary.wiley.com.recursos.biblioteca.upc.edu/doi/10.1111/nmo.12930/full]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.The metabolic activity of colonic microbiota is influenced by diet; however, the relationship between metabolism and colonic content is not known. Our aim was to determine the effect of meals, defecation, and diet on colonic content. Methods: In 10 healthy subjects, two abdominal MRI scans were acquired during fasting, 1 week apart, and after 3 days on low- and high-residue diets, respectively. With each diet, daily fecal output and the number of daytime anal gas evacuations were measured. On the first study day, a second scan was acquired 4 hours after a test meal (n=6) or after 4 hours with nil ingestion (n=4). On the second study day, a scan was also acquired after a spontaneous bowel movement. Results: On the low-residue diet, daily fecal volume averaged 145 ± 15 mL; subjects passed 10.6 ± 1.6 daytime anal gas evacuations and, by the third day, non-gaseous colonic content was 479 ± 36 mL. The high-residue diet increased the three parameters to 16.5 ± 2.9 anal gas evacuations, 223 ± 19 mL fecal output, and 616 ± 55 mL non-gaseous colonic content (P<.05 vs low-residue diet for all). On the low-residue diet, non-gaseous content in the right colon had increased by 41 ± 11 mL, 4 hours after the test meal, whereas no significant change was observed after 4-hour fast (-15 ± 8 mL; P=.006 vs fed). Defecation significantly reduced the non-gaseous content in distal colonic segments. Conclusion & inferences: Colonic content exhibits physiologic variations with an approximate 1/3 daily turnover produced by meals and defecation, superimposed over diet-related day-to-day variations.Peer ReviewedPostprint (author's final draft

Real-Time Processing Library for Open-Source Hardware Biomedical Sensors

Applications involving data acquisition from sensors need samples at a preset frequency rate, the filtering out of noise and/or analysis of certain frequency components. We propose a novel software architecture based on open-software hardware platforms which allows programmers to create data streams from input channels and easily implement filters and frequency analysis objects. The performances of the different classes given in the size of memory allocated and execution time (number of clock cycles) were analyzed in the low-cost platform Arduino Genuino. In addition, 11 people took part in an experiment in which they had to implement several exercises and complete a usability test. Sampling rates under 250 Hz (typical for many biomedical applications) makes it feasible to implement filters, sliding windows and Fourier analysis, operating in real time. Participants rated software usability at 70.2 out of 100 and the ease of use when implementing several signal processing applications was rated at just over 4.4 out of 5. Participants showed their intention of using this software because it was percieved as useful and very easy to use. The performances of the library showed that it may be appropriate for implementing small biomedical real-time applications or for human movement monitoring, even in a simple open-source hardware device like Arduino Genuino. The general perception about this library is that it is easy to use and intuitive

Transporters in the Mammary Gland—Contribution to Presence of Nutrients and Drugs into Milk

[EN] A large number of nutrients and bioactive ingredients found in milk play an important role in the nourishment of breast-fed infants and dairy consumers. Some of these ingredients include physiologically relevant compounds such as vitamins, peptides, neuroactive compounds and hormones. Conversely, milk may contain substances—drugs, pesticides, carcinogens, environmental pollutants—which have undesirable effects on health. The transfer of these compounds into milk is unavoidably linked to the function of transport proteins. Expression of transporters belonging to the ATP-binding cassette (ABC-) and Solute Carrier (SLC-) superfamilies varies with the lactation stages of the mammary gland. In particular, Organic Anion Transporting Polypeptides 1A2 (OATP1A2) and 2B1 (OATP2B1), Organic Cation Transporter 1 (OCT1), Novel Organic Cation Transporter 1 (OCTN1), Concentrative Nucleoside Transporters 1, 2 and 3 (CNT1, CNT2 and CNT3), Peptide Transporter 2 (PEPT2), Sodium-dependent Vitamin C Transporter 2 (SVCT2), Multidrug Resistance-associated Protein 5 (ABCC5) and Breast Cancer Resistance Protein (ABCG2) are highly induced during lactation. This review will focus on these transporters overexpressed during lactation and their role in the transfer of products into the milk, including both beneficial and harmful compounds. Furthermore, additional factors, such as regulation, polymorphisms or drug-drug interactions will be described.S

Development and Testing of Motion-Detection Techniques for People with Cerebral Palsy

This paper describes several computer access methods tested by Eva, a woman with choreoathetosic cerebral palsy. This disease prevents her from controlling the peripherals and configurations that normally give access to information and communication technologies, further limiting her independence. To make Eva access a computer, we focused our efforts on the methodologies that Eva could control by just moving her neck and head. These sensors were: Kinect, inertial measurement units (IMU), and video. Kinect, composed of a system of cameras and sensors, gives the option to interact and control the devices contactlessly. The IMU is a device consisting of an accelerometer and a gyroscope that measure velocity, orientation, and gravitational forces. For live image processing, a common webcam was used. During the development of the experiment, Eva must follow a sequence shown on the computer screen that alternates movement of the head with rest. These movements involved moving the head up, down, right, or left. Our results showed that the Kinect system could not be used effectively, while the image-processing algorithm obtained the best performance.Spanish Ministry of Science and Innovation, State Plan 2017–2020: Challenges—R&D&I Projects with grant codes PID2019-104323RB-C3

Ivermectin reduces secretion of meloxicam into milk by inhibition of ABCG2 transporter in sheep

[EN] The ATP-binding cassette transporter G2 (ABCG2) is an efflux protein involved in the bioavailability and secretion into milk of several compounds including anti- inflammatory drugs. The aim of this work was to determine the effect in sheep of an ABCG2 inhibitor, such as the macrocyclic lactone ivermectin, on the secretion into milk of meloxicam, a non-steroidal anti-inflammatory drug widely used in veterinary medicine, and recently reported as an ABCG2 substrate in mice. In vitro meloxicam transport assays in ovine ABCG2-transduced cells have shown that meloxicam is a substrate of ovine ABCG2 and that ivermectin is an efficient inhibitor of in vitro transport of meloxicam mediated by ovine ABCG2. In addition, the role of ovine ABCG2 in secretion into milk of meloxicam was corroborated using Assaf lactating sheep coadministered with ivermectin. Animals were administered subcutaneously with meloxicam (0.5 mg/kg) with or without ivermectin (0.2 mg/kg). A significantly lower concentration of meloxicam in milk was detected when ivermectin was coadministered, revealing a major role of ABCG2 in the secretion into milk of meloxicam and a relevant drug-drug interaction affecting this process. These results will contribute to the understanding of the potential factors that modulate the transfer of anti-inflammatory drugs into milk, opening their potential use in lactating ruminants, and the effect of drug coadministration on the presence of milk residues of these compounds.S

Smart Bracelet for Emotional Enhancement in Children with Autism Spectrum Disorder

People with autism spectrum disorder (ASD) have great difficulties in social interaction and in the management of personal and other people’s emotions. This work aimed at developing an intelligent bracelet, capable of inferring the children’s emotional state, transmitting it to others, and, above all, informing the patients themselves so that they can learn to recognise, control, and work with, as well as to improve their self-knowledge and their relationship with their environment. Electrodermal activity (EDA) and photoplethysmography (PPG) are useful in combined psychophysiological and medical studies to determine the mood of patients. Due to COVID-19, no experiments with subjects could be carried out, although the modules were validated, and a public database was used to test the system’s application. The results concluded that, in general, when an individual is altered or becomes nervous, either positively or negatively (also known as valence) to a stimulus, their heart rate and sweating increase. This is the kind of relationship between physiological signals and external stimuli that the design of these circuits was intended to confirm. Finally, with the indicators of nervous system activity and knowing the behaviour of skin conductance in response to each basic emotion, it can be determined whether the subject is in a situation of pleasure or frustration in response to each reaction.Spanish Ministry of Science and Innovation, State Plan 2017–2020: Challenges—R&D&I Projects PID2019-104323RB-C3