546 research outputs found

    Integrated plant monitoring to improve plant operation strategy and results

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    The more and more demanding conditions in the power generation sector requires to apply all the available technologies to optimize processes and reduce costs. An integrated asset management strategy, combining technical analysis and operation and maintenance management can help to improve plant performance, flexibility and reliability. In order to deploy such a model it is necessary to combine plant data and specific equipment condition information, with different systems devoted to analyze performance and equipment condition, and take advantage of the results to support operation and maintenance decisions. This model that has been dealt in certain detail for electricity transmission and distribution networks, is not yet broadly extended in the power generation sector, as proposed in this study for the case of a combined power plant. Its application would turn in direct benefit for the operation and maintenance and for the interaction to the energy marke

    Dispensación de medicamentos con informes médicos

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    INTRODUCCIÓN Diariamente se reciben en la farmacia solicitudes de dispensación apoyadas en informes médicos, pero sin el modelo oficial de receta médica. Se trata de un problema para el farmacéutico ya que, en sentido estricto, al proceder a su dispensación no se cumple la legalidad vigente. El objetivo principal de nuestro estudio ha sido conocer las características de las demandas de medicamentos con informes médicos, sin receta médica oficial, en cinco oficinas de farmacia de la Comunidad de Madrid.MÉTODOS Estudio observacional descriptivo transversal realizado en cinco farmacias comunitarias de la Comunidad de Madrid en diciembre de 2008. Se analizaron los informes médicos presentados para dispensación de los tratamientos reseñados.RESULTADOS Se registraron un total de 272 dispensaciones con informes médicos. Los centros sanitarios que remitían los informes fueron mayoritariamente públicos, 208 (76%), frente a 68 (24%) de privados. El 86% de los pacientes acude el mismo día frente al 14% que no lo hace dicho día. El coste medio del tratamiento fue de 12,56. Los medicamentos más prescritos fueron: antibióticos 78 (29%) y psicótropos 83 (31%), mientras que el resto de grupos registró 111 (40%).DISCUSIÓN Creemos que se debería corregir este problema, aumentando la comunicación entre colectivos, a través de nuestros representantes, y planteando a los médicos de hospital la problemática tanto administrativa como jurídica en la que nos encontramos los farmacéuticos, así como contemplar el desembolso que supone para los pacientes

    Development of the technique of isoelectricfocusing and immunodetection of immunoglobulin A in the healthcare context as support for the diagnosis of Multiple Sclerosis

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    Motivation: Multiple sclerosis (MS) is characterized by demyelination and subsequent degeneration of myelin sheaths that line the axons of neurons, producing multifocal and temporarily dispersed damage to the central nervous system (CNS) [1] that leads to neuronal damage and axonal loss [2]. MS is a complex disease in which the exact etiology remains unknown, although our current understanding of the natural history of MS and its immunopathogenesis points to an immune deregulation resulting from an interaction between genetic predispositions and environmental factors [2]. Given this uncertainty, there is a need for the identification of biomarkers in both cerebrospinal fluid and peripheral blood that help us to have a more complete view of the disease, and at the same time could contribute to a faster and more accurate diagnosis. This project arises from the importance and need to study immunoglobulin A as a biomarker for MS. Methods: Isoelectric focusing is one of the most powerful techniques used to solve complex mixtures of proteins [2]. The main objective of this project is the development of the isoelectroenfocusing and immunodetection technique for oligoclonal bands of immunoglobulin A and the IgA reduction protocol [3][4] to establish a subsequent relationship between patients diagnosed with MS and intrathecal secretion of immunoglobulin A. Results: For the implementation of the technique, a set of cerebrospinal fluid (CSF) samples previously extracted by lumbar puncture were selected, presenting the patient with a diagnostic suspicion of demyelinating disease, and presenting a high quantification of intrathecal secretion of IgA, routinely carried out in the Clinical Biochemistry Unit, immunology laboratory. A total of 23 samples were selected based on IgA concentrations in both CSF and serum. Conclusions: It should be noted that today the CSF remains the most interesting fluid for the study of degenerative neurological diseases. The CSF is the best representative of the clinical manifestations that are confined to the central nervous system, hence its characterization is, increasingly, of high interest for a more accurate diagnosis. With this set-up it is intended to give new information to the clinician to help diagnose the disease. Its value as a marker of the disease will be derived from subsequent observations and studies that clinicians perform in their cohort

    La cotidianeidad del mito en la narrativa de IulĂ­a Iatridi

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    Congreso Internacional: La literatura de los Epirotas, Ioánina-Grecia, del 24 al 28 de junio de 2004

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