Fracture Toughness of Composite and Unfilled Restorative Resins

Fracture toughness, critical strain energy release rate, and critical stress intensity factor were determined for experimental and commercial restorative resins. A composite resin had lower resistance to arack initiation than an unfilled acrylic resin. The data were consistent with surface failure observed in single-pass wear studies of these resins.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66920/2/10.1177_00220345770560070801.pd

Extraplanar Dust in Spiral Galaxies: Tracing Outflows in the Disk-Halo Interface

There is now ample evidence that the interstellar thick disks of spiral galaxies are dusty. Although the majority of extraplanar gas in the first few kiloparsecs above the plane of a spiral galaxy is matter that has been expelled from the thin disk, the feedback-driven expulsion does not destroy dust grains altogether (and there is not yet any good measure suggesting it changes the dust-to-gas mass ratio). Direct optical imaging of a majority of edge-on spiral galaxies shows large numbers of dusty clouds populating the thick disk to heights z~2 kpc. These observations are likely revealing a cold, dense phase of the thick disk interstellar medium. New observations in the mid-infrared show emission from traditional grains and polycyclic aromatic hydrocarbons (PAHs) in the thick disks of spiral galaxies. PAHs are found to have large scale heights and to arise both in the dense dusty clouds traced through direct optical imaging and in the diffuse ionized gas. In this contribution, we briefly summarize these probes of dust in the thick disks of spiral galaxies. We also argue that not only can dust can be used to trace extraplanar material that has come from within the thick disk, but that its absence can be a marker for newly accreted matter from the circumgalactic or intergalactic medium. Thus, observations of dust can perhaps provide a quantitative measure of the importance of "outflow versus infall" in spiral galaxies.Comment: 8 pages; Invited review for the proceedings of "The Role of Disk-Halo Interaction in Galaxy Evolution: Outflow vs. Infall?" (Ed. M. de Avillez), in Espinho, Portugal, 18-22 August 2008 ; high resolution version at http://www.nd.edu/~jhowk/Papers/papers.html#conferenc

The influence of Epstein-Barr virus and cytomegalovirus on childhood respiratory health: A population-based prospective cohort study

Background: Epstein-Barr virus (EBV) and cytomegalovirus (CMV) infection are common in early childhood. CMV infection favours a T-helper-1 and EBV infection a T-helper-2 cell response, possibly leading to disbalanced T-helper cell response, and subsequent risk of asthma or atopy. Objective: To study the associations of EBV and CMV with lung function, asthma and inhalant allergic sensitization at school age. Methods: This study among 3546 children was embedded in a population-based prospective cohort. At age 6 years, serum IgG levels against EBV and CMV were measured by ELISA. At age 10 years, lung function was measured by spirometry, asthma by questionnaire and inhalant allergic sensitization by skin prick test. Results: Unadjusted models showed that seropositivity for EBV was associated with a higher FEV1 and FEF75 (Z-score difference (95% CI): 0.09 (0.02, 0.16) and 0.09 (0.02, 0.15)), while seropositivity for CMV was not. Specific combinations of viruses showed that seropositivity for EBV was only associated with FEV1 and FEF75 in the presence of seropositivity for CMV (0.12 (0.04, 0.20)) and 0.08 (0.01, 0.15)). Seropositivity for CMV in the absence of seropositivity for EBV was associated with an increased risk of inhalant allergic sensitization (OR (95% CI): 1.31 (1.02, 1.68)). All effect estimates attenuated into non-significant mainly after adjustment for child's ethnicity. Seropositivity for EBV or CMV was not associated with asthma. Conclusions and Clinical Relevance: Associations of EBV and CMV infections in early childhood with school-age lung function and inhalant allergic sensitization are explained by ethnicity, or sociodemographic and lifestyle-related factors

Phonon Self-energy Effects Due To Superconductivity In Bi2sr2cacu2o8+δ

Raman scattering of A1g phonons in Bi2Sr2CaCu2O8+δ single crystals (δ=0.13, Tc=86 K) has been measured as a function of temperature. We report an anomalous softening in the frequency and a decrease in the linewidth of the A1g phonon at 290 cm-1 (O1,2 c-axis in-phase vibration) below Tc. We also confirm a smaller anomalous softening in the frequency of the A1g phonon at 465 cm-1 (O3 c-axis vibration), but for this phonon mode no linewidth anomaly has been found. We compare the anomalous softening and linewidth behavior in the superconducting state with theoretical calculations for isotropic s-wave, planar d-wave, and dx 2 -y 2 gap symmetries and as for a layered superconductor model.561384268431Thomsen, C., Cardona, M., Gegenheimer, B., Liu, R., Simon, A., (1988) Phys. Rev. B, 37, p. 9860Heynen, E.T., Cardona, M., Karpinski, J., Kaldis, E., Rusiecki, S., (1991) Phys. Rev. B, 43, p. 12958Kendizora, C., Kelley, R.J., Onellion, M., (1996) Phys. Rev. Lett., 77, p. 727Macfarlane, R.M., Rosen, H., Seki, H., (1987) Solid State Commun., 63, p. 831Ruf, T., Thomsen, C., Liu, R., Cardona, M., (1988) Phys. Rev. B, 38, p. 11985Burns, G., Chandrashekhar, G.V., Dacol, F.H., Strobel, P., (1989) Phys. Rev. B, 39, p. 775Bokholt, M., Erie, A., Splittgerber-Hünnekes, P.C., Güntherodt, G., (1990) Solid State Commun., 74, p. 1107Leach, D.H., Thomsen, C., Cardona, M., (1993) Solid State Commun., 88, p. 457Martin, A.A., Lee, M.J.G., (1995) Physica C, 254, p. 222Liu, R., Klein, M., Han, P.D., Payne, D.A., (1992) Phys. Rev. B, 45, p. 7392Menéndez, J., Cardona, M., (1984) Phys. Rev. B, 29, p. 2051Litvinchuk, A.P., Thomsen, C., Cardona, M., (1992) Solid State Commun., 83, p. 343Zeyher, R., Zwicknagl, G., (1990) Z. Phys. B, 78, p. 175Nicol, E.J., Jiang, C., Carbotte, J.P., (1993) Phys. Rev. B, 47, p. 8131Devereaux, T.P., (1994) Phys. Rev. B, 50, p. 10287Kendziora, C., Rosenberg, A., (1995) Phys. Rev. B, 52, pp. R986

Ceramides: A potential therapeutic target in pulmonary emphysema

Background: The aim of this manuscript was to characterize airway ceramide profiles in a rodent model of elastase-induced emphysema and to examine the effect of pharmacological intervention directed towards ceramide metabolism.Methods: Adult mice were anesthetized and treated with an intratracheal instillation of elastase. Lung function was measured, broncho-alveolar lavage fluid collected and histological and morphometrical analysis of lung tissue performed within 3 weeks after elastase injection, with and without sphingomyelinase inhibitors or serine palmitoyltransferase inhibitor. Ceramides in broncho-alveolar lavage (BAL) fluid were quantified by tandem mass spectrometry.Results: BAL fluid showed a transient increase in total protein and IgM, and activated macrophages and neutrophils. Ceramides were transiently upregulated at day 2 after elastase treatment. Histology showed persistent patchy alveolar destruction at day 2 after elastase installation. Acid and neutral sphingomyelinase inhibitors had no effect on BAL ceramide levels, lung function or histology. Addition of a serine palmitoyltransferase inhibitor ameliorated lung function changes and reduced ceramides in BAL.Conclusions: Ceramides were increased during the acute inflammatory phase of elastase-induced lung injury. Since addition of a serine palmitoyltransferase inhibitor diminished the rise in ceramides and ameliorated lung function, ceramides likely contributed to the early phase of alveolar destruction and are a potential therapeutic target in the elastase model of lung emphysema

Prospective longitudinal evaluation of lung function during the first year of life after repair of congenital diaphragmatic hernia

OBJECTIVE: To evaluate lung function and respiratory morbidity prospectively during the first year of life in patients with congenital diaphragmatic hernia and to study the effect of extracorporeal membrane oxygenation therapy. DESIGN: Prospective longitudinal cohort study. SETTING: Outpatient clinic of a tertiary-level pediatric hospital. PATIENTS: The cohort of 43 infants included 12 patients treated with extracorporeal membrane oxygenation. Evaluation was at 6 and 12 months; 33 infants were evaluated at both time points. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Maximal expiratory flow at functional residual capacity and functional residual capacity were measured with Masterscreen Babybody. Z-scores were calculated for maximal expiratory flow at functional residual capacity. Mean maximal expiratory flow at functional residual capacity values at 6 and 12 months were significantly below the expected values (mean z-score -1.4 and -1.5, respectively) without a significant change between both time points. Values did not significantly differ between extracorporeal membrane oxygenation and nonextracorporeal membrane oxygenation-treated patients. Functional residual capacity values were generally high, 47% were above the suggested normal range, and did not change significantly over time. Mean functional residual capacity values in extracorporeal membrane oxygenation-treated patients were significantly higher than in nonextracorporeal membrane oxygenation-treated patients (p = .006). The difference (5.1 mL/kg ± 1.8 SE) did not change significantly between the two time points. Higher mean airway pressure and longer duration of ventilation were associated with higher functional residual capacity. None of the perinatal characteristics was associated with maximal expiratory flow at functional residual capacity. Mean weight z-scores were significantly below zero at both time points (p < .001). Mean weight z-score in extracorporeal membrane oxygenation-treated patients were lower than in nonextracorporeal membrane oxygenation-treated patients (p = .046). CONCLUSIONS: Infants with congenital diaphragmatic hernia have decreased expiratory flows and increased functional residual capacity within the first year of life. Extracorporeal membrane oxygenation-treated patients with congenital diaphragmatic hernia may have more respiratory morbidity and concomitant growth impairment. Close follow-up beyond the neonatal period is therefore required. Copyrigh

A new look at energy release rates for quasistatically propagating cracks in inelastic materials

A mapping technique is used to derive an integral expression for the energy release rate for a quasistatically propagating crack. The derivation does not depend on any assumptions in regard to the contitutive behavior of the material. It leads to a contour integral around the crack tip, plus an area integral over the region enclosed by this contour. Only the stress and displacement fields appear in the integrands. Although for stationary crack solutions known to the authors the area integral is not convergent, for propagating crack solutions in elastoplastic material, the integrals are convergent, and lead to zero energy release rate. This confirms conclusions by Rice from an independent point of view.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/42773/1/10704_2004_Article_BF00012388.pd

Raman phonons as a probe of disorder, fluctuations and local structure in doped and undoped orthorhombic and rhombohedral manganites

We present a rationalization of the Raman spectra of orthorhombic and rhombohedral, stoichiometric and doped, manganese perovskites. In particular we study RMnO3 (R= La, Pr, Nd, Tb, Ho, Er, Y and Ca) and the different phases of Ca or Sr doped RMnO3 compounds as well as cation deficient RMnO3. The spectra of manganites can be understood as combinations of two kinds of spectra corresponding to two structural configurations of MnO6 octahedra and independently of the average structure obtained by diffraction techniques. The main peaks of compounds with regular MnO6 octahedra, as CaMnO3, highly Ca doped LaMnO3 or the metallic phases of Ca or Sr doped LaMnO3, are bending and tilt MnO6 octahedra modes which correlate to R-O(1) bonds and Mn-O-Mn angles respectively. In low and optimally doped manganites, the intensity and width of the broad bands are related to the amplitude of the dynamic fluctuations produced by polaron hopping in the paramagnetic insulating regime. The activation energy, which is proportional to the polaron binding energy, is the measure of this amplitude. This study permits to detect and confirm the coexistence, in several compounds, of a paramagnetic matrix with lattice polaron together with regions without dynamic or static octahedron distortions, identical to the ferromagnetic metallic phase. We show that Raman spectroscopy is an excellent tool to obtain information on the local structure of the different micro or macro-phases present simultaneously in many manganites.Comment: Submitted to PR

Associations of Plasma Fatty Acid Patterns during Pregnancy with Respiratory and Allergy Outcomes at School Age

Fatty acids might play a role in asthma and allergy development as they can modulate immune responses. We examined among 4260 mother-child pairs participating in a population-based cohort the associations of maternal plasma fatty acid patterns during pregnancy with a child’s respiratory and allergy outcomes at school-age. In mid-pregnancy, 22 individual fatty acids were measured from maternal blood. Three patterns were previously identified by principal component analysis: A ‘high n-6 polyunsaturated fatty acid (PUFA)’, a ‘monounsaturated and saturated fatty acid’, and a ‘high n-3 PUFA’ pattern. At the age of 10 years, a child’s lung function was assessed by spirometry, current asthma and physician-diagnosed inhalant allergy by questionnaire, and inhalant allergic sensitization by skin prick tests. A higher ‘high n-6 PUFA’ pattern was associated with a higher forced expiratory volume in 1 s/forced vital capacity and forced expiratory flow after exhaling 75% of forced vital capacity (Z-score difference (95% CI) 0.04 (0, 0.07) and 0.04 (0.01, 0.07), respectively, per SD increase in the fatty acid pattern). We observed no associations of maternal fatty acid patterns with a child’s asthma or allergy outcomes. Our results showed limited associations of maternal patterns of high n-6 PUFA concentrations in pregnancy with a better lung function in school-aged children

Parental psychological distress during pregnancy and the risk of childhood lower lung function and asthma: a population-based prospective cohort study

Background Although maternal psychological distress during pregnancy is associated with increased risks of respiratory morbidity in preschool children, it is unknown whether this association persists into later childhood. Objective To examine the association between parental psychological distress during pregnancy and lung function and asthma in children of school age. Methods This study of 4231 children was embedded in a population-based prospective cohort. Parental psychological distress was assessed by the Brief Symptom Inventory during and 3 years after pregnancy, and in mothers also at 2 and 6 months after pregnancy. At age 10 years, lung function was obtained by spirometry and asthma by questionnaire. Results The prevalence of asthma was 5.9%. Maternal overall psychological distress during pregnancy was associated with a lower forced vital capacity (FVC) (z-score difference −0.10 (95% CI −0.20 to –0.01) per 1-unit increase), maternal depressive symptoms during pregnancy with a lower forced expiratory volume in the first second (FEV1 ) and FVC (−0.13 (95% CI −0.24 to –0.01) and −0.13 (95% CI −0.24 to –0.02) when using clinical cut-offs) in their children. All maternal psychological distress measures during pregnancy were associated with an increased risk of asthma (range OR: 1.46 (95% CI 1.12 to 1.90) to 1.91 (95% CI 1.26 to 2.91)). Additional adjustment for paternal psychological distress during pregnancy and parental psychological distress after pregnancy did not materially change the associations. Paternal psychological distress during pregnancy was not associated with childhood respiratory morbidity. Conclusion Maternal, but not paternal, psychological distress during pregnancy is associated with an increased risk of asthma and partly lower lung function in children. This suggests intrauterine programming for the risk of later-life respirator