Problems and prospects of development of tourism in the Astrakhan region

Features of functioning of tourist business in the Astrakhan region are investigated, problems and prospects of tourist business are defined, ways of increasing the competitiveness and efficiency come to light. On the basis of SWOT the analysis the factors influencing tourist business come to light

Role of Corporate Culture in Model of Logic Levels of Organization

The article deals with the level of corporate culture in a model of logic levels of the organization. The modern organization is influenced by the external factors, and therefore it should have the ability to form and accumulate potential for corporate culture in order to ensure a timely response to the external environment and effectively manage the operation and development of numerous elements and subsystems of the organization

FORMATION OF MANAGEMENT MECHANISMS OF WAREHOUSING LOGISTICS IN UKRAINIAN AIC

The article deals with the main mechanisms of management of storage logistics of AIC at the national level. The system of AIC warehouse management logistics contains five main mechanisms: the organizational mechanism of warehouse management, the mechanism of financial flows management, the mechanism of management of information flows, the mechanism of controlling the processes of storage and the mechanism of risk management. An effective mechanism of warehouse logistics management is introduced. It requires a comprehensive conceptual and methodical approach to its evaluation. In the developed method, based on the system characteristics of the warehouse operation, account was taken: the policy of their use, the coordination and administration of flows, the impact of warehousing risks on economic activity. The analysis of the peculiarities of activity of agroindustrial enterprises, operating on the principles of logistic approach, is carried out, form integrated internal relations between raw material producers and their processors. The developed mechanisms of warehouse logistics management, together with mathematical calculations, create a synergistic effect from their implementation. Further research in this area will make it possible to improve the processes of managing logistics flows at enterprises

Spectral analysis of the blood flow in the foot microvascular bed during thermal testing in patients with diabetes mellitus

Timely diagnostics of microcirculatory system abnormalities, which are the most severe diabetic complications, is one of the major problems facing modern health care. Functional abnormalities manifest themselves earlier than the structural ones, and therefore their assessment is the issue of primary importance. In this study Laser Doppler flowmetry, a noninvasive technique for the cutaneous blood flow monitoring, was utilized together with local temperature tests and wavelet analysis. The study of the blood flow in the microvascular bed of toes was carried out in the control group of 40 healthy subjects and in two groups of 17 type 1 and 23 type 2 diabetic patients. The local temperature tests demonstrated that the diabetic patients have impaired vasodilation in response to local heating. The tendency for impaired low frequency pulsations of the blood flow associated with endothelial and neurogenic activities in both diabetes groups was observed. Local thermal tests induced variations in perfusion and its spectral characteristics, which were different in the groups under study. In our opinion, the obtained preliminary results can be a basis for further research and provide a deeper understanding of pathological processes that drive microvascular abnormalities caused by diabetes mellitus

Роль профессиональной этики и внутреннего аудита в раскрытии информации о предприятии

Потапова Н. В., Приймачук И. В. Роль профессиональной этики и внутреннего аудита в раскрытии информации о предприятииThe issue of disclosure continues to be a challenge for users of financial and non-financial reporting and the accounting standards community. Financial disclosure standards aim to improve the qualitative characteristics, comparability, verifiability, timeliness and understandability of financial statements. Enterprises that implement the principles of the ESG agenda face the problem of disclosing information about the results of socially responsible activities in non-financial reporting. Such reporting is optional and standardized. This is due to the voluntary nature of socially responsible activity. The quality of information disclosure is determined by professional ethical principles and internal audit

Blood flow oscillations as a signature of microvascular abnormalities

Laser Doppler flowmetry (LDF) was utilized for blood ow measurements. Wavelet analysis was used to identify spectral characteristics of the LDF signal in patients with rheumatic diseases and diabetes mellitus. Baseline measurements were applied for both pathological groups. Blood flow oscillations analyses were performed by means of the wavelet transform. Higher baseline perfusion was observed in both pathological groups in comparison to controls. Differences in the spectral properties between the groups studied were revealed. The results obtained demonstrated that spectral properties of the LDF signal collected in basal conditions may be the signature of microvasculature functional state

Spatial heterogeneity of cutaneous blood flow respiratory-related oscillations quantified via laser speckle contrast imaging

LSCI technique provides experimental data which can be considered in the context of spatial blood flow coherency. Analysis of vascular tone oscillations gives additional information to ensure a better understanding of the mechanisms affecting microvascular physiology. The oscillations with different frequencies are due to different physiological mechanisms. The reasons for the generation of peripheral blood flow oscillations in the 0.14–0.6 Hz frequency band are as follows: cardio-respiratory interactions, pressure variations in the venous part of the circulatory system, and the effect of the sympathetic nervous system on the vascular tone. Earlier, we described the spatial heterogeneity of around 0.3 Hz oscillations and this motivated us to continue the research to find the conditions for the occurrence of spatial phase synchronization. For this purpose, a number of physiological tests (controlled respiration, breath holder, and venous occlusion tests) which influence the blood flow oscillations of 0.14–0.6 Hz were considered, an appropriate measurement system and the required data processing algorithms were developed. At spontaneous respiration, the oscillations with frequencies around 0.3 Hz were stochastic, whereas all the performed tests induced an increase in spatial coherence. The protocols and methods proposed here can help to clarify whether the heterogeneity of respiratory-related blood flow oscillations exists on the skin surface

The chemical composition of the three-part beggarticks (Bidens tripartita L.)

In the present article, we have studied the main groups of biologically active substances of the bur-marigold (Bidens tripartita L.) herb using the UPLC method with photodiode array and MS/MS detection. Eighteen compounds have been identified, including the glycosides of luteolin, okaniin, and sulfuretin, polyacetylenes, and hydroxycinnamic acids. The quantitative content of flavonoids (0.7-1.2%) and polysaccharides (4.1-7.5%) was computed by spectrophotometry and gravimetry

Wavelet Analysis of the Temporal Dynamics of the Laser Speckle Contrast in Human Skin

Objective: Spectral analysis of laser Doppler flowmetry (LDF) signals has been widely used in studies of physiological vascular function regulation. An alternative to LDF is the laser speckle contrast imaging method (LSCI), which is based on the same physical principle. In contrast to LDF, LSCI provides non-scanning full-field imaging of a relatively wide skin area and offers high spatial and temporal resolutions, which allows visualization of microvascular structure. This circumstance, together with a large number of works which had shown the effectiveness of temporal LSCI analysis, gave impetus to experimental studies of the relation between LDF and LSCI used to monitor the temporal dynamics of blood flow. Methods: Continuous wavelet transform was applied to construct a time-frequency representation of a signal. Results: Analysis of 10 minute LDF and LSCI output signals recorded simultaneously revealed rather high correlation between oscillating components. It was demonstrated for the first time that the spectral energy of oscillations in the 0.01-2 Hz frequency range of temporal LSCI recordings carries the same information as the conventional LDF recordings and hence it reflects the same physiological vascular tone regulation mechanisms. Conclusion: The approach proposed can be used to investigate speckle pattern dynamics by LSCI in both normal and pathological conditions. Significance: The results of research on the influence of spatial binning and averaging on the spectral characteristics of perfusion monitored by LSCI are of considerable interest for the development of LSCI systems optimized to evaluate temporal dynamics