Higher Education Exchange:2004

This annual publication serves as a forum for new ideas and dialogue between scholars and the larger public. Essays explore ways that students, administrators, and faculty can initiate and sustain an ongoing conversation about the public life they share.The Higher Education Exchange is founded on a thought articulated by Thomas Jefferson in 1820: "I know no safe depository of the ultimate powers of the society but the people themselves; and if we think them not enlightened enough to exercise their control with a wholesome discretion, the remedy is not to take it from them, but to inform their discretion by education."In the tradition of Jefferson, the Higher Education Exchange agrees that a central goal of higher education is to help make democracy possible by preparing citizens for public life. The Higher Education Exchange is part of a movement to strengthen higher education's democratic mission and foster a more democratic culture throughout American society.Working in this tradition, the Higher Education Exchange publishes interviews, case studies, analyses, news, and ideas about efforts within higher education to develop more democratic societies

Biomass Ashes as Potential Raw Materials for Mineral Wool Manufacture: Initial Studies of Glass Structure and Chemistry

The energy intensive and CO2-generating nature of commercial mineral wool and glass production necessitates advances and changes in materials and processes. The derivation of raw materials from waste products arising from biomass energy generation offers the possibility of a two-fold environmental benefit: partial replacement of carbonate raw minerals in production, leading to lower CO2 release during melting; and the utilisation and valorisation of byproducts which may otherwise be sent to landfill. Glass samples with a basaltic mineral wool composition were produced with additions to the raw materials of 0, 1, 5 and 10 wt% of a fly ash and a bottom ash arising from biomass combustion. The resulting glasses were analysed by x-ray fluorescence (XRF), x-ray diffraction (XRD), dilatometry, 57 Fe Mössbauer and Raman spectroscopies, and their densities, molar volumes and viscosity–temperature profiles were calculated and compared against benchmark glass samples. All biomass ash-containing glasses were closely similar in both composition and properties to the benchmark glass, with up to 10 wt% ash additions to the raw materials. In addition, the use of the biomass fly ash led to a reduction in batch CO2 content estimated to be 1 · 5 kg CO2 per tonne of batch for each 1 wt% addition. These initial results provide evidence supporting the further development of these ash materials as potential value-added raw materials for mineral wool manufacture

A Chemical Analog of Curcumin as an Improved Inhibitor of Amyloid Abeta Oligomerization

Amyloid-like plaques are characteristic lesions defining the neuropathology of Alzheimer's disease (AD). The size and density of these plaques are closely associated with cognitive decline. To combat this disease, the few therapies that are available rely on drugs that increase neurotransmission; however, this approach has had limited success as it has simply slowed an imminent decline and failed to target the root cause of AD. Amyloid-like deposits result from aggregation of the Aβ peptide, and thus, reducing amyloid burden by preventing Aβ aggregation represents an attractive approach to improve the therapeutic arsenal for AD. Recent studies have shown that the natural product curcumin is capable of crossing the blood-brain barrier in the CNS in sufficient quantities so as to reduce amyloid plaque burden. Based upon this bioactivity, we hypothesized that curcumin presents molecular features that make it an excellent lead compound for the development of more effective inhibitors of Aβ aggregation. To explore this hypothesis, we screened a library of curcumin analogs and identified structural features that contribute to the anti-oligomerization activity of curcumin and its analogs. First, at least one enone group in the spacer between aryl rings is necessary for measureable anti-Aβ aggregation activity. Second, an unsaturated carbon spacer between aryl rings is essential for inhibitory activity, as none of the saturated carbon spacers showed any margin of improvement over that of native curcumin. Third, methoxyl and hydroxyl substitutions in the meta- and para-positions on the aryl rings appear necessary for some measure of improved inhibitory activity. The best lead inhibitors have either their meta- and para-substituted methoxyl and hydroxyl groups reversed from that of curcumin or methoxyl or hydroxyl groups placed in both positions. The simple substitution of the para-hydroxy group on curcumin with a methoxy substitution improved inhibitor function by 6-7-fold over that measured for curcumin

Defragmenting the System: Inter-Professional Collaboration for Meeting the Needs of Adolescents with Learning Disabilities and Mental Health Issues in British Columbia

Mental health issues and learning disabilities are common problems faced by adolescents. The intersection of mental illness and learning disabilities leads to multiple complex problems that cannot be easily addressed by any single professional or agency. This report focuses on how schools and educators can play a role in improving cooperation for meeting the needs of these students. Many policies need to go into creating a well-established inter-professional collaboration framework. In-depth interviews and review of best practice documents resulted in recommendations of a handbook and community service directory as well as steering committees to be formed in each school district in order to create a better foundation for inter-professional collaboration in the communities in BC

Prolonged biologically active colonic tissue levels of curcumin achieved after oral administration--a clinical pilot study including assessment of patient acceptability.

Curcumin, the main constituent of turmeric, is suspected to possess cancer chemopreventive properties. Pharmacokinetic and pharmacodynamic parameters have been reported, but few data exist describing whether methodologies are suitably robust for curcuminoid detection in colonic biopsy specimens. Information on the acceptability of prolonged administration of daily curcumin is not available. This is of vital importance to implement chemoprevention strategies. This study aimed to quantify levels of curcuminoids in colorectal mucosa of patients undergoing colorectal endoscopy or surgical resection and to obtain information on the acceptability and compliance with daily curcumin. Curcumin C3 complex (2.35 g) was administered to patients once daily for 14 days before endoscopic biopsy or colonic resection. Safety and tolerance were monitored. Analysis of curcuminoids in plasma, urine, and colonic mucosa was conducted by ultraperformance liquid chromatography (UPLC)-UV with characterization by liquid chromatography/tandem mass spectrometry (LC/MS-MS). Twenty-four of 26 patients commencing curcumin completed the course. Six patients reported mild gastrointestinal adverse events. Curcuminoids were detectable in nine of 24 plasma samples, 24 of 24 urine samples, and in the colonic mucosa of all 23 biopsied participants. Mean tissue levels were 48.4 μg/g (127.8 nmol/g) of parent curcuminoids. The major conjugate, curcumin glucuronide, was detectable in 29 of 35 biopsies. High levels of topical curcumin persisted in the mucosa for up to 40 hours postadministration. Sixteen participants (67%) stated that they would take curcumin long-term should it be of proven benefit. In summary, pharmacologically active levels of curcumin were recovered from colonic mucosa. The regimen used here seems safe, and patients support its use in long-term trials

Synthesis of science: findings on Canadian Prairie wetland drainage

This is an Accepted Manuscript of an article published by Taylor & Francis in Canadian Water Resources Journal on 13 Oct 2021, available at: https://doi.org/10.1080/07011784.2021.1973911.Canada First Research Excellence Fund, via Global Water Futures and the research program Prairie Water (grant no. 418474), Canada Research Chairs and Canada Excellence Research Chairs programs, and the University of Saskatchewan through a Centennial Enhancement Chair to HMBPeer ReviewedExtensive wetland drainage has occurred across the Canadian Prairies, and drainage activities are ongoing in many areas (Prairie Habitat Joint Venture 2014; Dahl 1990; Watmough and Schmoll 2007; Bartzen et al. 2010; Dahl 2014; Dumanski et al. 2015; Waz and Creed 2017). In 2017 the Global Water Futures program funded the Prairie Water project, with the broad goal of helping to foster improved water security in the region (Spence et al. 2018). Throughout the duration of this project, it has been clear that a diverse group of stakeholders (including river basin organizations, government agencies, and landowners) is seeking the same information — a synthesis of what is known and not known about the effects of wetland drainage. This synthesis of the state of the science on wetland drainage in the Canadian Prairies is aimed at assembling current knowledge based on western scientific methods to articulate what is known about the variability of drainage effects across the region. Traditional knowledge, which represents a different but complementary way of knowing the functioning of prairie watersheds (sometimes also termed catchments, or basins), and the processes driving change within them, is not discussed here. Instead, this synthesis is presented in the spirit of building such collaborations. It summarizes current western scientific knowledge on surface hydrology, groundwater interactions, nutrient export, biodiversity, carbon storage and greenhouse gas dynamics, and wetland conservation socioeconomics. The implications to water security now and in the future are also discussed