La crisis del coronavirus y el derecho argentino

Ante una pandemia, todos somos perdedores y el gran desafió es construir la sociedad del futuro y eso depende de cada uno de nosotros. Este pequeño libro es un avance, una colaboración abierta, como otros que se elaboran, del sinnúmero de discusiones que sobrevendrán en el futuro para dirimir el nuevo orden de prelación de los intereses del ser humano a satisfacer.Reflexiones preliminares / Pascual E. Alferillo – La urgencia en el marco de las emergencias / Alejandro Pérez Hualde – El poder de policía del Estado en la crisis sanitaria global / Pascual E. Alferillo – Aproximaciones a las cuestiones de responsabilidad por contagio en la época del COVID-19 / Lidia M. Rosa Garrido Cordobera – Pandemia y tareas de cuidado. Una oportunidad a la perspectiva de género / Mariel F. Molina de Juan – Algunas reflexiones provisorias sobre el COVID- 19 y su impacto en las relaciones jurídicas / Rodrigo Padilla – El impacto de la emergencia por pandemia en las relaciones de consumo / José H. Sahián – Contagio culposo de Coronavirus y función resarcitoria de la responsabilidad civil. Consideraciones acerca de la dificultad probatoria / Julián Emil Jalil – Pandemia COVID-19: trascendencia de los deberes secundarios de conducta / Myriam I. Costilla Duyck – La teoría de la imprevisión frente a la crisis sanitaria global: en camino a las soluciones de equidad basadas en el esfuerzo compartido / Pascual E. Alferillo – Coronavirus (COVID- 19): cuestiones penales y procesales / Pablo Guido Peñasco – El Derecho Internacional en tiempos de pandemia / Enzo Finocchiaro – Algunas reflexiones desde el derecho internacional y el abordaje de grupos vulnerables en contextos de COVID 19 / Christian G. Sommer – El mundo suspendido. Un enfoque psicológico y social sobre la crisis 2020. Pandemia por COVID- 19 / Irene Talarico Pinto – El derecho ambiental frente al Coronavirus. ¿El derecho ambiental subestimado y desestimado? / Dino Luis Bellorio Clabot –Pascual E. Alferillo. Academia Nacional de Derecho y Ciencias Sociales de Córdoba; Argentina.Pérez Hualde, Alejandro. Academia Nacional de Derecho y Ciencias Sociales de Córdoba; Argentina.Garrido Cordobera, Lidia M. Rosa. Academia Nacional de Derecho y Ciencias Sociales de Córdoba; Argentina.Molina de Juan, Mariel F. Academia Nacional de Derecho y Ciencias Sociales de Córdoba; Argentina.Padilla, Rodrigo. Academia Nacional de Derecho y Ciencias Sociales de Córdoba; Argentina.Sahián, José H. Academia Nacional de Derecho y Ciencias Sociales de Córdoba; Argentina.Jalil, Julián Emil. Academia Nacional de Derecho y Ciencias Sociales de Córdoba; Argentina.Costilla Duyck, Myriam I. Academia Nacional de Derecho y Ciencias Sociales de Córdoba; Argentina.Peñasco, Pablo Guido. Academia Nacional de Derecho y Ciencias Sociales de Córdoba; Argentina.Finocchiaro, Enzo. Academia Nacional de Derecho y Ciencias Sociales de Córdoba; Argentina.Sommer, Christian G. Academia Nacional de Derecho y Ciencias Sociales de Córdoba; Argentina.Talarico Pinto, Irene. Academia Nacional de Derecho y Ciencias Sociales de Córdoba; Argentina.Bellorio Clabot, Dino Luis. Academia Nacional de Derecho y Ciencias Sociales de Córdoba; Argentina

Recent results on heavy-ion induced reactions of interest for neutrinoless double beta decay at INFN-LNS

Abstract. The possibility to use a special class of heavy-ion induced direct reactions, such as double charge exchange reactions, is discussed in view of their application to extract information that may be helpful to determinate the nuclear matrix elements entering in the expression of neutrinoless double beta decay halflife. The methodology of the experimental campaign presently running at INFN - Laboratori Nazionali del Sud is reported and the experimental challenges characterizing such activity are describe

New results from the NUMEN project

NUMEN aims at accessing experimentally driven information on Nuclear Matrix Elements (NME) involved in the half-life of the neutrinoless double beta decay (0νββ), by high-accuracy measurements of the cross sections of Heavy Ion (HI) induced Double Charge Exchange (DCE) reactions. First evidence about the possibility to get quantitative information about NME from experiments is found for the (18O,18Ne) and (20Ne,20O) reactions. Moreover, to infer the neutrino average masses from the possible measurement of the half-life of 0νββ decay, the knowledge of the NME is a crucial aspect. The key tools for this project are the high resolution Superconducting Cyclotron beams and the MAGNEX magnetic spectrometer at INFN Laboratori Nazionali del Sud in Catania (Italy). The measured cross sections are extremely low, limiting the present exploration to few selected isotopes of interest in the context of typically low-yield experimental runs. A major upgrade of the LNS facility is foreseen in order to increase the experimental yield of at least two orders of magnitude, thus making feasible a systematic study of all the cases of interest. peerReviewe

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts

Erratum: Balconi, M.; et al. Evidences from Rewarding System, FRN and P300 Effect in Internet-Addiction in Young People SHORT TITLE: Rewarding System and EEG in Internet-Addiction Brain Sciences 2017, 7, 81

We would like to submit the following erratum to our recently published paper [1] due to the error in the title.[...

Brain oscillations, inhibitory control mechanisms and rewarding bias in web addiction. Two opposite young subjects\u2019 clusters?

Internet Addiction (IA) is considered a subtype of impulse control disorder, and a behavior related to rewarding system deficits. However whether and how impulse control deficits are related to in rewarding mechanisms is actually unexplored. The present research aims to examine the neural correlates of deficits in inhibitory control and the rewarding mechanisms in IA in a sample of young people. Internet Addiction Inventory (IAT) was applied to a sub-clinical sample. Secondly, cortical oscillations (frequency bands) and personality trait (Behavioral Inhibition System, BIS; Behavioral Activation System, BAS) were considered to explain IA. Oscillatory brain activity (delta, theta, alpha, beta and gamma) and response times (RTs) were monitored during the performance of a Go/NoGo task in response online gambling videos, videogames or neutral stimuli. BAS, BAS-R (BAS-Reward subscale), BIS and IAT predicted the low-frequency band variations, although in an opposite direction: reduced delta and theta and RTs values were found for higher BAS, BAS-R and IAT, in the case of NoGo for gambling and videogames stimuli; in contrast increased delta and theta and RTs values were observed for higher BIS. Two potential different young subjects\u2019 clusters were suggested: with low inhibitory impulse control and rewarding bias (higher BAS and IAT); and with impulse hyper-control (higher BIS)

Evidences from rewarding system, FRN and P300 effect in internet-addiction in young people

The present research explored rewarding bias and attentional de\uef\uac\u81cits in Internet addiction (IA) based on the IAT (Internet Addiction Test) construct, during an attentional inhibitory task (Go/NoGo task). Event-related Potentials (ERPs) effects (Feedback Related Negativity (FRN) and P300) were monitored in concomitance with Behavioral Activation System (BAS) modulation. High-IAT young participants showed speci\uef\uac\u81c responses to IA-related cues (videos representing online gambling and videogames) in terms of cognitive performance (decreased Response Times, RTs, and Error Rates, ERs) and ERPs modulation (decreased FRN and increased P300). Consistent reward and attentional biases was adduced to explain the cognitive \ue2\u80\u9cgain\ue2\u80\u9d effect and the anomalous response in terms of both feedback behavior (FRN) and attentional (P300) mechanisms in high-IAT. In addition, BAS and BAS-Reward subscales measures were correlated with both IAT and ERPs variations. Therefore, high sensitivity to IAT may be considered as a marker of dysfunctional reward processing (reduction of monitoring) and cognitive control (higher attentional values) for speci\uef\uac\u81c IA-related cues. More generally, a direct relationship among reward-related behavior, Internet addiction and BAS attitude was suggested

Integrated Intensified Chemoradiation in the Setting of Total Neoadjuvant Therapy (TNT) in Patients with Locally Advanced Rectal Cancer: A Retrospective Single-Arm Study on Feasibility and Efficacy

While surgery is considered the main treatment for early-stage rectal cancer, locally advanced rectal cancer needs to be handled with a multidisciplinary approach. Based on literature data suggesting promising advantages of total neoadjuvant therapy (TNT), we performed a retrospective, single-arm, single-center study on 45 patients affected by histologically and radiologically proven locally advanced rectal cancer, with the aim of analyzing the feasibility and short-term efficacy of an integrated intensified treatment in the setting of TNT. Each analyzed patient performed three cycles of FOLFOX4 or De Gramont induction chemotherapy (iCT), followed by concurrent chemoradiotherapy (CRT) with long course radiotherapy (LCRT) plus concomitant boost and continuous 5-FU infusion, followed by three cycles of FOLFOX4 or De Gramont consolidation chemotherapy (conCT) and then surgery with total mesorectal excision. At a median follow-up of 30 months, this strategy has shown to be feasible and effective in terms of pathological complete response (pCR) and short-term disease-free survival (DFS)

Upgrade of the MAGNEX spectrometer toward the high-intensity phase of NUMEN

The NUMEN experimental activity with accelerated beams is performed at INFN–Laboratori Nazionali del Sud (LNS) in Catania using the Superconducting Cyclotron and the MAGNEX magnetic spectrometer. The scientific motivation of NUMEN is to extract experiment-driven information on the nuclear matrix elements entering in the expression of the 0νββ decay half-life. The reaction cross sections involved, especially for the double charge exchange process, are very low, thus limiting the present exploration to a few selected isotopes of interest in the context of typically low-yield experimental runs. In order to make feasible a systematic study of all the candidate nuclei, a major upgrade of the LNS facility is foreseen to increase the experimental yield by more than two orders of magnitude. To this purpose, frontier technologies are being developed for the accelerator and the detection systems. An updated description of the choices derived from the recent R&D activity on the target system and MAGNEX focal plane detector is given

La crisis del coronavirus y el derecho argentina

Ante una pandemia, todos somos perdedores y el gran desafió es construir la sociedad del futuro y eso depende de cada uno de nosotros. Este pequeño libro es un avance, una colaboración abierta, como otros que se elaboran, del sinnúmero de discusiones que sobrevendrán en el futuro para dirimir el nuevo orden de prelación de los intereses del ser humano a satisfacer.Reflexiones preliminares / Pascual E. Alferillo – La urgencia en el marco de las emergencias / Alejandro Pérez Hualde – El poder de policía del Estado en la crisis sanitaria global / Pascual E. Alferillo – Aproximaciones a las cuestiones de responsabilidad por contagio en la época del COVID-19 / Lidia M. Rosa Garrido Cordobera – Pandemia y tareas de cuidado. Una oportunidad a la perspectiva de género / Mariel F. Molina de Juan – Algunas reflexiones provisorias sobre el COVID- 19 y su impacto en las relaciones jurídicas / Rodrigo Padilla – El impacto de la emergencia por pandemia en las relaciones de consumo / José H. Sahián – Contagio culposo de Coronavirus y función resarcitoria de la responsabilidad civil. Consideraciones acerca de la dificultad probatoria / Julián Emil Jalil – Pandemia COVID-19: trascendencia de los deberes secundarios de conducta / Myriam I. Costilla Duyck – La teoría de la imprevisión frente a la crisis sanitaria global: en camino a las soluciones de equidad basadas en el esfuerzo compartido / Pascual E. Alferillo – Coronavirus (COVID- 19): cuestiones penales y procesales / Pablo Guido Peñasco – El Derecho Internacional en tiempos de pandemia / Enzo Finocchiaro – Algunas reflexiones desde el derecho internacional y el abordaje de grupos vulnerables en contextos de COVID 19 / Christian G. Sommer – El mundo suspendido. Un enfoque psicológico y social sobre la crisis 2020. Pandemia por COVID- 19 / Irene Talarico Pinto – El derecho ambiental frente al Coronavirus. ¿El derecho ambiental subestimado y desestimado? / Dino Luis Bellorio Clabot –Pascual E. Alferillo. Academia Nacional de Derecho y Ciencias Sociales de Córdoba; Argentina.Pérez Hualde, Alejandro. Academia Nacional de Derecho y Ciencias Sociales de Córdoba; Argentina.Garrido Cordobera, Lidia M. Rosa. Academia Nacional de Derecho y Ciencias Sociales de Córdoba; Argentina.Molina de Juan, Mariel F. Academia Nacional de Derecho y Ciencias Sociales de Córdoba; Argentina.Padilla, Rodrigo. Academia Nacional de Derecho y Ciencias Sociales de Córdoba; Argentina.Sahián, José H. Academia Nacional de Derecho y Ciencias Sociales de Córdoba; Argentina.Jalil, Julián Emil. Academia Nacional de Derecho y Ciencias Sociales de Córdoba; Argentina.Costilla Duyck, Myriam I. Academia Nacional de Derecho y Ciencias Sociales de Córdoba; Argentina.Peñasco, Pablo Guido. Academia Nacional de Derecho y Ciencias Sociales de Córdoba; Argentina.Finocchiaro, Enzo. Academia Nacional de Derecho y Ciencias Sociales de Córdoba; Argentina.Sommer, Christian G. Academia Nacional de Derecho y Ciencias Sociales de Córdoba; Argentina.Talarico Pinto, Irene. Academia Nacional de Derecho y Ciencias Sociales de Córdoba; Argentina.Bellorio Clabot, Dino Luis. Academia Nacional de Derecho y Ciencias Sociales de Córdoba; Argentina