The Volatility Trend of Protosolar and Terrestrial Elemental Abundances

We present new estimates of protosolar elemental abundances based on an improved combination of solar photospheric abundances and CI chondritic abundances. These new estimates indicate CI chondrites and solar abundances are consistent for 60 elements. We compare our new protosolar abundances with our recent estimates of bulk Earth composition (normalized to aluminium), thereby quantifying the devolatilization in going from the solar nebula to the formation of the Earth. The quantification yields a linear trend $\log(f) = \alpha\log(T_C) + \beta$, where $f$ is the Earth-to-Sun abundance ratio and $T_C$ is the 50$\%$ condensation temperature of elements. The best fit coefficients are: $\alpha = 3.676\pm 0.142$ and $\beta = -11.556\pm 0.436$. The quantification of these parameters constrains models of devolatilization processes. For example, the coefficients $\alpha$ and $\beta$ determine a critical devolatilization temperature for the Earth $T_{\mathrm{D}}(\mathrm{E}) = 1391 \pm 15$ K. The terrestrial abundances of elements with $T_{C} < T_{\mathrm{D}}(\mathrm{E})$ are depleted compared with solar abundances, whereas the terrestrial abundances of elements with $T_{C} > T_{\mathrm{D}}(\mathrm{E})$ are indistinguishable from solar abundances. The terrestrial abundance of Hg ($T_C$ = 252 K) appears anomalously high under the assumption that solar and CI chondrite Hg abundances are identical. To resolve this anomaly, we propose that CI chondrites have been depleted in Hg relative to the Sun by a factor of $13\pm7$. We use the best-fit volatility trend to derive the fractional distribution of carbon and oxygen between volatile and refractory components ($f_\mathrm{vol}$, $f_\mathrm{ref}$). We find ($0.91\pm 0.08$, $0.09 \pm 0.08$) for carbon and ($0.80 \pm 0.04$, $0.20 \pm 0.04$) for oxygen.Comment: Accepted for publication in Icarus. 28 pages, 12 figures, 5 tables. Compared to v1, the results and conclusion are the same, while discussion of results and implications is expanded considerabl

Tissue Inhibitor of Metalloproteinase–3 (TIMP-3) induces FAS dependent apoptosis in human vascular smooth muscle cells

Over expression of Tissue Inhibitor of Metalloproteinases-3 (TIMP-3) in vascular smooth muscle cells (VSMCs) induces apoptosis and reduces neointima formation occurring after saphenous vein interposition grafting or coronary stenting. In studies to address the mechanism of TIMP-3-driven apoptosis in human VSMCs we find that TIMP-3 increased activation of caspase-8 and apoptosis was inhibited by expression of Cytokine response modifier A (CrmA) and dominant negative FAS-Associated protein with Death Domain (FADD). TIMP-3 induced apoptosis did not cause mitochondrial depolarisation, increase activation of caspase-9 and was not inhibited by over-expression of B-cell Lymphoma 2 (Bcl2), indicating a mitochondrial independent/type-I death receptor pathway. TIMP-3 increased levels of the First Apoptosis Signal receptor (FAS) and depletion of FAS with shRNA showed TIMP-3-induced apoptosis was FAS dependent. TIMP-3 induced formation of the Death-Inducing Signalling Complex (DISC), as detected by immunoprecipitation and by immunofluorescence. Cellular-FADD-like IL-1 converting enzyme-Like Inhibitory Protein (c-FLIP) localised with FAS at the cell periphery in the absence of TIMP-3 and this localisation was lost on TIMP-3 expression with c-FLIP adopting a perinuclear localisation. Although TIMP-3 inhibited FAS shedding, this did not increase total surface levels of FAS but instead increased FAS levels within localised regions at the cell surface. A Disintegrin And Metalloproteinase 17 (ADAM17) is inhibited by TIMP-3 and depletion of ADAM17 with shRNA significantly decreased FAS shedding. However ADAM17 depletion did not induce apoptosis or replicate the effects of TIMP-3 by increasing localised clustering of cell surface FAS. ADAM17-depleted cells could activate caspase-3 when expressing levels of TIMP-3 that were otherwise sub-apoptotic, suggesting a partial role for ADAM17 mediated ectodomain shedding in TIMP-3 mediated apoptosis. We conclude that TIMP-3 induced apoptosis in VSMCs is highly dependent on FAS and is associated with changes in FAS and c-FLIP localisation, but is not solely dependent on shedding of the FAS ectodomain

The Keck Aperture Masking Experiment: spectro-interferometry of 3 Mira Variables from 1.1 to 3.8 microns

We present results from a spectro-interferometric study of the Miras o Cet, R Leo and W Hya obtained with the Keck Aperture Masking Experiment from 1998 Sep to 2002 Jul. The spectrally dispersed visibility data permit fitting with circularly symmetric brightness profiles such as a simple uniform disk. The stellar angular diameter obtained over up to ~ 450 spectral channels spaning the region 1.1-3.8 microns is presented. Use of a simple uniform disk brightness model facilitates comparison between epochs and with existing data and theoretical models. Strong size variations with wavelength were recorded for all stars, probing zones of H2O, CO, OH, and dust formation. Comparison with contemporaneous spectra extracted from our data show a strong anti-correlation between the observed angular diameter and flux. These variations consolidate the notion of a complex stellar atmosphere consisting of molecular shells with time-dependent densities and temperatures. Our findings are compared with existing data and pulsation models. The models were found to reproduce the functional form of the wavelength vs. angular diameter curve well, although some departures are noted in the 2.8-3.5 micron range.Comment: 10 pages, 10 figures Accepted to Ap

A close halo of large transparent grains around extreme red giant stars

Intermediate-mass stars end their lives by ejecting the bulk of their envelope via a slow dense wind back into the interstellar medium, to form the next generation of stars and planets. Stellar pulsations are thought to elevate gas to an altitude cool enough for the condensation of dust, which is then accelerated by radiation pressure from starlight, entraining the gas and driving the wind. However accounting for the mass loss has been a problem due to the difficulty in observing tenuous gas and dust tens of milliarcseconds from the star, and there is accordingly no consensus on the way sufficient momentum is transferred from the starlight to the outflow. Here, we present spatially-resolved, multi-wavelength observations of circumstellar dust shells of three stars on the asymptotic giant branch of the HR diagram. When imaged in scattered light, dust shells were found at remarkably small radii (<~ 2 stellar radii) and with unexpectedly large grains (~300 nm radius). This proximity to the photosphere argues for dust species that are transparent to starlight and therefore resistant to sublimation by the intense radiation field. While transparency usually implies insufficient radiative pressure to drive a wind, the radiation field can accelerate these large grains via photon scattering rather than absorption - a plausible mass-loss mechanism for lower-amplitude pulsating stars.Comment: 13 pages, 1 table, 6 figure

Witten's Invariants of Rational Homology Spheres at Prime Values of KK and Trivial Connection Contribution

We establish a relation between the coefficients of asymptotic expansion of trivial connection contribution to Witten's invariant of rational homology spheres and the invariants that T.~Ohtsuki extracted from Witten's invariant at prime values of $K$. We also rederive the properties of prime $K$ invariants discovered by H.~Murakami and T.~Ohtsuki. We do this by using the bounds on Taylor series expansion of the Jones polynomial of algebraically split links, studied in our previous paper. These bounds are enough to prove that Ohtsuki's invariants are of finite type. The relation between Ohtsuki's invariants and trivial connection contribution is verified explicitly for lens spaces and Seifert manifolds.Comment: 32 pages, no figures, LaTe

Direct Detection of the Brown Dwarf GJ 802B with Adaptive Optics Masking Interferometry

We have used the Palomar 200" Adaptive Optics (AO) system to directly detect the astrometric brown dwarf GJ 802B reported by Pravdo et al. 2005. This observation is achieved with a novel combination of aperture masking interferometry and AO. The dynamical masses are 0.175$\pm$0.021 M$_\odot$ and 0.064$\pm$0.032 M$_\odot$ for the primary and secondary respectively. The inferred absolute H band magnitude of GJ 802B is M$_H$=12.8 resulting in a model-dependent T$_\mathrm{eff}$ of 1850 $\pm$ 50K and mass range of 0.057--0.074 M$_\odot$.Comment: 4 Pages, 5 figures, emulateapj format, submitted to ApJ

Lung function in South African children with cystic fibrosis

Objective: To determine the pattern of lung function in stable cystic fibrosis (CF) patients and to investigate the relationship of abnormal lung function to demographic variables, CF genotype and pulmonary colonisation with Pseudomonas aeruginosa (PA)Design: A descriptive study done at the CF clinic at Red Cross War Memorial Children's Hospital in Cape Town.Methods: Data were recorded and pulmonary function testing (PFT) was performed in 42 CF patients.Results: 29 patients (69%) had mild disease,. while 11 (26%) and 2 (5%) had moderate and severe disease respectively. Twenty-four patients (57'%) demonstrated lower airway obstruction (LAO). Patients with moderate or severe disease were significantly older than those with mild disease (13.3 (3.7) years (mean (SD)) compared with 11.1 (3.0) years (t =2.1; P =OM)). PA colonisation status differed significantly with the pattern of lung function (X2 =6.6; P = 0.04) and severity of lung disease (X2=12.6; P =0.002.). Nine (35%) of the 26 patients tested before and after broncbodilator therapy showed a positive response.Conclusion: The majority of patients had mildly impaired or normal lung function, with LAO predominating. A minority of patients were bronchodilator-responsive. PA colonisation may be associated with the development of abnormal lung function and more severe pulmonary disease.