The educational value of the rules in handball

The game rules of team sports and the technical and tactical methods applicable to them are indispensable for practicing competitive sports. The correct competition arose from the automatic mechanism of the sanction following the infringement of a game rule which is also aided by the relational dynamics of the individual members of the group who demand the application of the rule to continue playing. The competition can also be self-regulated by the two groups who compete for the victory without even the decisive action of the referee as always happens in training activities. This phenomenon is found only in those contexts where the rule is necessary and alone sufficient to ensure the orderly development of activities. The objective of the study is to identify the significant elements of the handball game rules, and the related technical and tactical behaviours, to identify an inventory of significant behaviours. The method is documentary archival research for the analysis of the game rules of the team sport in question, and a subsequent comparative method between grids of indicators, descriptors and weights that classify rule, technique and tactics. The expected results will focus on the appropriate presence of the significant elements and the commonality or discrepancy between team sports. The data is useful for measuring the quantity of significant behaviours in order to qualitatively elaborate the value of each of them with respect to the other current behaviours of quantitative performance and establish the connections

Removing the division into categories between cycling and para-cycling (Handbike category H) by designing a single performance and training activity

Cycling and all categories of para-cycling including Handbike are cyclical sports, that is, sports characterized using a specific skill, continuous skill. To separate competitions between cyclists and paracyclists, there is a classification system. The study in aims to design one activity performance and training, to eliminate the division into categories between cycling and para-cycling (Handbike), since this does not favour the integration and sporting inclusion of the two groups of athletes. The differences in performance will be identified between: cyclists and paracyclists with spinal cord injury or amputation of the lower limbs (H). Then will proceed to design and verify an activity capable of making the two categories compete and train together, eliminating the differences in performance through the use of a "counterweight" and using a mixed training, HIIT (High Intensity Interval Training) and Endurance. The sample taken into consideration is composed of 5 cyclists and 5 paracyclists (H) aged between 19 and 38 years. To achieve the goal, the study was based on the method of analysing the scientific literature, detecting the various parameters in the race and using mathematical statistical methods, such as Multiple Regression and the T-Test for independent samples. The analysis of the results of this study shows that; between cyclists and para-cyclists who participated, there are substantial differences in performance, thanks to the data obtained from multiple regression, in which we find an R-squared value that is .999975008, also the only positive coefficient among the independent variables is that of power (6.760634791). This means that of all the reported values, it is the only one that directly affects performance

Proactive school and motricity: Key elements for children’s health and psychophysical well-being

The new legal framework of the primary school provides two hours of compulsory physical education teaching from master’s degree specialists in physical education in addition to the PE hours taught by a master’s degree generalist in primary education sciences. The present research aims to analyze critical issues concerning the legislative transition from the current law system to the next. The research investigates how the school community can incorporate educational-didactic and managerial-administrative measures in dedicated platforms for rules application. The results will determine the good practice models to be offered to the primary school education system as an inventory of good teaching practices helpful for teachers, managers, and family members. The overall scientific evidence will also flow into a final document to enhance the construction of teaching plans for the disciplines regarding the methods and didactics of motor and sports activities in light of legislative innovations (Legislative Decree no. 36/2021)

Physical education in secondary higher school

Teaching of motor activities in secondary higher school imposes a prescriptive teaching through unidirectional methodological-didactic decisions: teacher directs and the student performs. Improving performance through skills improvement and the structuring of new skills through exercise requires the adoption of a less prescriptive methodology and allowing the student to express himself with greater freedom and awareness to facilitate heuristic learning according to the motor principle by Bernstein of executive variability. Physical education doesn’t have the scientific basis in knowledge as for other theoretical knowledge because the scientific paradigm of corporeality and movement is based on doing and acting. In agreement with the scientific pedagogical community, we ask ourselves about the most appropriate methodology to educate the body with the movement in a habilitative sense, the person through the body for a training of the person (life skills) and strive for the person's well-being through movement (soft skills). This vision seems to be tempered in the documents of physical education up to the first-grade secondary school and seems to change in secondary higher school, when a higher level of education is required. Alongside this prescription, reasonably useful for raising the levels of motor ability of individual services the problem of individual performance in groups arises to achieve the common goal (sports game), where along with significant skill levels, the best and fastest possible decision is also needed. For this necessity, the methodology of the "Teaching games for understanding" comes to the rescue, which contemplates the tactical part together with the enabling one

Physical education in secondary higher school

Teaching of motor activities in secondary higher school imposes a prescriptive teaching through unidirectional methodological-didactic decisions: teacher directs and the student performs. Improving performance through skills improvement and the structuring of new skills through exercise requires the adoption of a less prescriptive methodology and allowing the student to express himself with greater freedom and awareness to facilitate heuristic learning according to the motor principle by Bernstein of executive variability. Physical education doesn’t have the scientific basis in knowledge as for other theoretical knowledge because the scientific paradigm of corporeality and movement is based on doing and acting. In agreement with the scientific pedagogical community, we ask ourselves about the most appropriate methodology to educate the body with the movement in a habilitative sense, the person through the body for a training of the person (life skills) and strive for the person's well-being through movement (soft skills). This vision seems to be tempered in the documents of physical education up to the first-grade secondary school and seems to change in secondary higher school, when a higher level of education is required. Alongside this prescription, reasonably useful for raising the levels of motor ability of individual services the problem of individual performance in groups arises to achieve the common goal (sports game), where along with significant skill levels, the best and fastest possible decision is also needed. For this necessity, the methodology of the "Teaching games for understanding" comes to the rescue, which contemplates the tactical part together with the enabling one

Effects of Musical Classes on Motor Creativity According to Age, Sex, and Weight Status in Young Students: A Music-Oriented versus Conventional Education Plan

Motor creativity can be influenced by the specificity of the school–class environments (music-based education plans) and individual characteristics. This study aimed to investigate the effects of music oriented and conventional education plans on rhythmic perceptive capacity, motor creativity, and skill- and health-related fitness components in young students according to age, sex, and weight status. One hundred sixty-three young Italian students from elementary (second and fourth grade) and middle school (sixth and eighth grade) were enrolled in the study according to their education plan (music oriented or conventional). All participants were tested for rhythmic perceptive capacity (Stambak’s test), motor creativity (Divergent Movement Ability test), skill-related (Körperkoordinationstest Für Kinder), and health-related (Multistage Fitness test) components. Individuals were also considered according to age (elementary and middle school), sex, and weight status. Significant age × education plan and sex × education plan interactions (p < 0.01) were found in motor creativity (locomotor and stability skills) and motor competence (balance and jumping-like activities). No significant weight status × education plan interaction was found. The predominant role of music in the music-oriented education plan appeared to foster the ability to enhance motor creativity in elementary and middle school students compared to the conventional plan. Moreover, music-oriented experience also seems relevant for expressing and exhibiting motor competence (i.e., balance) in relation to sex

Iron Metabolism in Liver Cancer Stem Cells

Cancer stem cells (CSC) which have been identified in several tumors, including liver cancer, represent a particular subpopulation of tumor cells characterized by properties similar to those of adult stem cells. Importantly, CSC are resistant to standard therapies, thereby leading to metastatic dissemination and tumor relapse. Given the increasing evidence that iron homeostasis is deregulated in cancer, here we describe the iron homeostasis alterations in cancer cells, particularly in liver CSC. We also discuss two paradoxically opposite iron manipulation-strategies for tumor therapy based either on iron chelation or iron overload-mediated oxidant production leading to ferroptosis. A better understanding of iron metabolism modifications occurring in hepatic tumors and particularly in liver CSC cells may offer new therapeutic options for this cancer, which is characterized by increasing incidence and unfavorable prognosis

Different ataxin-3 amyloid aggregates induce intracellular Ca2+ deregulation by different mechanisms in cerebellar granule cells

AbstractThis work aims at elucidating the relation between morphological and physicochemical properties of different ataxin-3 (ATX3) aggregates and their cytotoxicity. We investigated a non-pathological ATX3 form (ATX3Q24), a pathological expanded form (ATX3Q55), and an ATX3 variant truncated at residue 291 lacking the polyQ expansion (ATX3/291Δ). Solubility, morphology and hydrophobic exposure of oligomeric aggregates were characterized. Then we monitored the changes in the intracellular Ca2+ levels and the abnormal Ca2+ signaling resulting from aggregate interaction with cultured rat cerebellar granule cells. ATX3Q55, ATX3/291Δ and, to a lesser extent, ATX3Q24 oligomers displayed similar morphological and physicochemical features and induced qualitatively comparable time-dependent intracellular Ca2+ responses. However, only the pre-fibrillar aggregates of expanded ATX3 (the only variant which forms bundles of mature fibrils) triggered a characteristic Ca2+ response at a later stage that correlated with a larger hydrophobic exposure relative to the two other variants. Cell interaction with early oligomers involved glutamatergic receptors, voltage-gated channels and monosialotetrahexosylganglioside (GM1)-rich membrane domains, whereas cell interaction with more aged ATX3Q55 pre-fibrillar aggregates resulted in membrane disassembly by a mechanism involving only GM1-rich areas. Exposure to ATX3Q55 and ATX3/291Δ aggregates resulted in cell apoptosis, while ATX3Q24 was substantially innocuous. Our findings provide insight into the mechanisms of ATX3 aggregation, aggregate cytotoxicity and calcium level modifications in exposed cerebellar cells

Models for the study of inclusion bodies formation as a function of fermentation conditions and protein sequence

on host physiology The organisers would like to thank Novozymes Delta Ltd who generously supported the meeting. Meetin

A Major Role for Side-Chain Polyglutamine Hydrogen Bonding in Irreversible Ataxin-3 Aggregation

The protein ataxin-3 consists of an N-terminal globular Josephin domain (JD) and an unstructured C-terminal region containing a stretch of consecutive glutamines that triggers the neurodegenerative disorder spinocerebellar ataxia type 3, when it is expanded beyond a critical threshold. The disease results from misfolding and aggregation, although the pathway and structure of the aggregation intermediates are not fully understood. In order to provide insight into the mechanism of the process, we monitored the aggregation of a normal (AT3Q24) ataxin-3, an expanded (AT3Q55) ataxin-3, and the JD in isolation. We observed that all of them aggregated, although the latter did so at a much slower rate. Furthermore, the expanded AT3Q55 displayed a substantially different behavior with respect to the two other variants in that at the latest stages of the process it was the only one that did the following: i) lost its reactivity towards an anti-oligomer antibody, ii) generated SDS-insoluble aggregates, iii) gave rise to bundles of elongated fibrils, and iv) displayed two additional bands at 1604 and 1656 cm−1 in FTIR spectroscopy. Although these were previously observed in other aggregated polyglutamine proteins, no one has assigned them unambiguously, yet. By H/D exchange experiments we show for the first time that they can be ascribed to glutamine side-chain hydrogen bonding, which is therefore the hallmark of irreversibly SDS-insoluble aggregated protein. FTIR spectra also showed that main-chain intermolecular hydrogen bonding preceded that of glutamine side-chains, which suggests that the former favors the latter by reorganizing backbone geometry