Flexible Birnbaum-Saunders distribution

In this paper, we propose a bimodal extension of the Birnbaum–Saunders model by including an extra parameter. This new model is termed flexible Birnbaum–Saunders (FBS) and includes the ordinary Birnbaum–Saunders (BS) and the skew Birnbaum–Saunders (SBS) model as special cases. Its properties are studied. Parameter estimation is considered via an iterative maximum likelihood approach. Two real applications, of interest in environmental sciences, are included, which reveal that our proposal can perform better than other competing models.Ministerio de Economía y Competitividad (MINECO). Españ

Generalized modified slash Birnbaum–Saunders distribution

In this paper, a generalization of the modified slash Birnbaum-Saunders (BS) distribution is introduced. The model is defined by using the stochastic representation of the BS distribution, where the standard normal distribution is replaced by a symmetric distribution proposed by Reyes et al. It is proved that this new distribution is able to model more kurtosis than other extensions of BS previously proposed in the literature. Closed expressions are given for the pdf (probability density functio), along with their moments, skewness and kurtosis coefficients. Inference carried out is based on modified moments method and maximum likelihood (ML). To obtain ML estimates, two approaches are considered: Newton-Raphson and EM-algorithm. Applications reveal that it has potential for doing well in real problems

Scale Mixture of Rayleigh Distribution

In this paper, the scale mixture of Rayleigh (SMR) distribution is introduced. It is proven that this new model, initially defined as the quotient of two independent random variables, can be expressed as a scale mixture of a Rayleigh and a particular Generalized Gamma distribution. Closed expressions are obtained for its pdf, cdf, moments, asymmetry and kurtosis coefficients. Its lifetime analysis, properties and Rényi entropy are studied. Inference based on moments and maximum likelihood (ML) is proposed. An Expectation-Maximization (EM) algorithm is implemented to estimate the parameters via ML. This algorithm is also used in a simulation study, which illustrates the good performance of our proposal. Two real datasets are considered in which it is shown that the SMR model provides a good fit and it is more flexible, especially as for kurtosis, than other competitor models, such as the slashed Rayleigh distribution

Extended Half-Power Exponential Distribution with Applications to COVID-19 Data

In this paper, the Extended Half-Power Exponential (EHPE) distribution is built on the basis of the Power Exponential model. The properties of the EHPE model are discussed: the cumulative distribution function, the hazard function, moments, and the skewness and kurtosis coefficients. Estimation is carried out by applying maximum likelihood (ML) methods. A Monte Carlo simulation study is carried out to assess the performance of ML estimates. To illustrate the usefulness and applicability of EHPE distribution, two real applications to COVID-19 data in Chile are discussed

Desarrollo del repertorio de equivalencia y de razonamiento analógico en población infantil: revisión conceptual

El presente trabajo presenta una revisión, desde una perspectiva contextual funcional, de los estudios dirigidos a delimitar las condiciones necesarias para el desarrollo de comportamientos simbólicos como las relaciones de equivalencia y el razonamiento analógico desde edades tempranas. Centrándonos en los estudios con población infantil, se ofrece una síntesis de las habilidades que se consideran relacionadas con dichos comportamientos simbólicos a distintos niveles y los procedimientos de evaluación y entrenamiento analizados, de cara a desarrollar programas de enseñanza normalizados o planes individuales de tratamiento para aquellos niños que muestren dificultades en su desarrollo.

Statistical Inference for a General Family of Modified Exponentiated Distributions

In this paper, a modified exponentiated family of distributions is introduced. The new model was built from a continuous parent cumulative distribution function and depends on a shape parameter. Its most relevant characteristics have been obtained: the probability density function, quantile function, moments, stochastic ordering, Poisson mixture with our proposal as the mixing distribution, order statistics, tail behavior and estimates of parameters. We highlight the particular model based on the classical exponential distribution, which is an alternative to the exponentiated exponential, gamma and Weibull. A simulation study and a real application are presented. It is shown that the proposed family of distributions is of interest to applied areas, such as economics, reliability and finances

Increased Protein Stability and Interleukin-2 Production of a LAT(G131D)Variant With Possible Implications for T Cell Anergy

The adaptor LAT plays a crucial role in the transduction of signals coming from the TCR/CD3 complex. Phosphorylation of some of its tyrosines generates recruitment sites for other cytosolic signaling molecules. Tyrosine 132 in human LAT is essential for PLC-gamma activation and calcium influx generation. It has been recently reported that a conserved glycine residue preceding tyrosine 132 decreases its phosphorylation kinetics, which constitutes a mechanism for ligand discrimination. Here we confirm that a LAT mutant in which glycine 131 has been substituted by an aspartate (LAT(G131D)) increases phosphorylation of Tyr132, PLC-gamma activation and calcium influx generation. Interestingly, the LAT(G131D)mutant has a slower protein turnover while being equally sensitive to Fas-mediated protein cleavage by caspases. Moreover, J.CaM2 cells expressing LAT(G131D)secrete greater amounts of interleukin-2 (IL-2) in response to CD3/CD28 engagement. However, despite this increased IL-2 secretion, J.CaM2 cells expressing the LAT(G131D)mutant are more sensitive to inhibition of IL-2 production by pre-treatment with anti-CD3, which points to a possible role of this residue in the generation of anergy. Our results suggest that the increased kinetics of LAT Tyr132 phosphorylation could contribute to the establishment of T cell anergy, and thus constitutes an earliest known intracellular event responsible for the induction of peripheral tolerance

Bases de la respuesta inflamatoria en la forma respiratoria del PRRS

El Síndrome Reproductivo y Respiratorio Porcino (PRRS) es una enfermedad de distribución mundial que causa graves pérdidas económicas al sector porcino. Este virus no sólo es importante como agente causal del PRRS sino también por su participación en el desarrollo del Complejo Respiratorio Porcino. Su interacción con las defensas pulmonares, la alteración de la respuesta inmune y su persistencia en los órganos linfoides conlleva a que los cerdos tengan dificultades para luchar contra la enfermedad.Porcine Reproductive and Respiratory Syndrome (PRRS) is considered as the most economically important disease of the modern swine industry. The importance of this virus lies in not only being the causative agent of PRRSV, but also due to its implication in the onset of the Porcine Respiratory Disease Complex. The interaction of the virus with pulmonary defenses, the impairment of the immune response as well as the viral persistence in lymphoid organs make overcoming the disease diffi cult to infected pigs

Activation of T-bet, FOXP3, and EOMES in Target Organs From Piglets Infected With the Virulent PRRSV-1 Lena Strain

Transcription factors (TFs) modulate genes involved in cell-type-specific proliferative and migratory properties, metabolic features, and effector functions. Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most important pathogen agents in the porcine industry; however, TFs have been poorly studied during the course of this disease. Therefore, we aimed to evaluate the expressions of the TFs T-bet, GATA3, FOXP3, and Eomesodermin (EOMES) in target organs (the lung, tracheobronchial lymph node, and thymus) and those of different effector cytokines (IFNG, TNFA, and IL10) and the Fas ligand (FASL) during the early phase of infection with PRRSV-1 strains of different virulence. Target organs from mock-, virulent Lena-, and low virulent 3249-infected animals humanely euthanized at 1, 3, 6, 8, and 13 days post-infection (dpi) were collected to analyze the PRRSV viral load, histopathological lesions, and relative quantification through reverse transcription quantitative PCR (RT-qPCR) of the TFs and cytokines. Animals belonging to both infected groups, but mainly those infected with the virulent Lena strain, showed upregulation of the TFs T-bet, EOMES, and FOXP3, together with an increase of the cytokine IFN-g in target organs at the end of the study (approximately 2 weeks post-infection). These results are suggestive of a stronger polarization to Th1 cells and regulatory T cells (Tregs), but also CD4+ cytotoxic T lymphocytes (CTLs), effector CD8+ T cells, and gdT cells in virulent PRRSV-1-infected animals; however, their biological functionality should be the object of further studies