Re-visioning Science Education

Science education is crucial for shaping the culture of science and its practitioners. Boundaries currently limit ties between natural and social science education structures, exposing the public to a one-dimensional science and its possible ramifications. Believing this to be a “crisis,” I explore a variety of approaches to re-visioning science education and the ensuing forms of resistance that these face. In addition, a more personal accounting of my experience with trying to integrate social and cultural issues into the education of scientists allows me to explore the forms of resistance I faced; bridge the gap between theory and practice; and locate more effective ways of re-visioning science education

Conservation of Distinct Genetically-Mediated Human Cortical Pattern

The many subcomponents of the human cortex are known to follow an anatomical pattern and functional relationship that appears to be highly conserved between individuals. This suggests that this pattern and the relationship among cortical regions are important for cortical function and likely shaped by genetic factors, although the degree to which genetic factors contribute to this pattern is unknown. We assessed the genetic relationships among 12 cortical surface areas using brain images and genotype information on 2,364 unrelated individuals, brain images on 466 twin pairs, and transcriptome data on 6 postmortem brains in order to determine whether a consistent and biologically meaningful pattern could be identified from these very different data sets. We find that the patterns revealed by each data set are highly consistent (p<10−3), and are biologically meaningful on several fronts. For example, close genetic relationships are seen in cortical regions within the same lobes and, the frontal lobe, a region showing great evolutionary expansion and functional complexity, has the most distant genetic relationship with other lobes. The frontal lobe also exhibits the most distinct expression pattern relative to the other regions, implicating a number of genes with known functions mediating immune and related processes. Our analyses reflect one of the first attempts to provide an assessment of the biological consistency of a genetic phenomenon involving the brain that leverages very different types of data, and therefore is not just statistical replication which purposefully use very similar data sets.publishedVersio

The German National Registry of Primary Immunodeficiencies (2012-2017)

Introduction: The German PID-NET registry was founded in 2009, serving as the first national registry of patients with primary immunodeficiencies (PID) in Germany. It is part of the European Society for Immunodeficiencies (ESID) registry. The primary purpose of the registry is to gather data on the epidemiology, diagnostic delay, diagnosis, and treatment of PIDs. Methods: Clinical and laboratory data was collected from 2,453 patients from 36 German PID centres in an online registry. Data was analysed with the software Stata® and Excel. Results: The minimum prevalence of PID in Germany is 2.72 per 100,000 inhabitants. Among patients aged 1–25, there was a clear predominance of males. The median age of living patients ranged between 7 and 40 years, depending on the respective PID. Predominantly antibody disorders were the most prevalent group with 57% of all 2,453 PID patients (including 728 CVID patients). A gene defect was identified in 36% of patients. Familial cases were observed in 21% of patients. The age of onset for presenting symptoms ranged from birth to late adulthood (range 0–88 years). Presenting symptoms comprised infections (74%) and immune dysregulation (22%). Ninety-three patients were diagnosed without prior clinical symptoms. Regarding the general and clinical diagnostic delay, no PID had undergone a slight decrease within the last decade. However, both, SCID and hyper IgE- syndrome showed a substantial improvement in shortening the time between onset of symptoms and genetic diagnosis. Regarding treatment, 49% of all patients received immunoglobulin G (IgG) substitution (70%—subcutaneous; 29%—intravenous; 1%—unknown). Three-hundred patients underwent at least one hematopoietic stem cell transplantation (HSCT). Five patients had gene therapy. Conclusion: The German PID-NET registry is a precious tool for physicians, researchers, the pharmaceutical industry, politicians, and ultimately the patients, for whom the outcomes will eventually lead to a more timely diagnosis and better treatment

The ABC130 barrel module prototyping programme for the ATLAS strip tracker

For the Phase-II Upgrade of the ATLAS Detector, its Inner Detector, consisting of silicon pixel, silicon strip and transition radiation sub-detectors, will be replaced with an all new 100 % silicon tracker, composed of a pixel tracker at inner radii and a strip tracker at outer radii. The future ATLAS strip tracker will include 11,000 silicon sensor modules in the central region (barrel) and 7,000 modules in the forward region (end-caps), which are foreseen to be constructed over a period of 3.5 years. The construction of each module consists of a series of assembly and quality control steps, which were engineered to be identical for all production sites. In order to develop the tooling and procedures for assembly and testing of these modules, two series of major prototyping programs were conducted: an early program using readout chips designed using a 250 nm fabrication process (ABCN-25) and a subsequent program using a follow-up chip set made using 130 nm processing (ABC130 and HCC130 chips). This second generation of readout chips was used for an extensive prototyping program that produced around 100 barrel-type modules and contributed significantly to the development of the final module layout. This paper gives an overview of the components used in ABC130 barrel modules, their assembly procedure and findings resulting from their tests.Comment: 82 pages, 66 figure

Research and Design of a Routing Protocol in Large-Scale Wireless Sensor Networks

无线传感器网络，作为全球未来十大技术之一，集成了传感器技术、嵌入式计算技术、分布式信息处理和自组织网技术，可实时感知、采集、处理、传输网络分布区域内的各种信息数据，在军事国防、生物医疗、环境监测、抢险救灾、防恐反恐、危险区域远程控制等领域具有十分广阔的应用前景。 本文研究分析了无线传感器网络的已有路由协议，并针对大规模的无线传感器网络设计了一种树状路由协议，它根据节点地址信息来形成路由，从而简化了复杂繁冗的路由表查找和维护，节省了不必要的开销，提高了路由效率，实现了快速有效的数据传输。 为支持此路由协议本文提出了一种自适应动态地址分配算——ADAR（AdaptiveDynamicAddre...As one of the ten high technologies in the future, wireless sensor network, which is the integration of micro-sensors, embedded computing, modern network and Ad Hoc technologies, can apperceive, collect, process and transmit various information data within the region. It can be used in military defense, biomedical, environmental monitoring, disaster relief, counter-terrorism, remote control of haz...学位：工学硕士院系专业：信息科学与技术学院通信工程系_通信与信息系统学号：2332007115216

Leaf Size and Biomass Allocation in Thelypteris dentata, Woodwardia virginica, and Osmunda regalis in Central Florida

Volume: 87Start Page: 71End Page: 7

Neue Muster der Migration : Auf dem Weg nach Deutschland

Brücker H, Tucci I, Bartsch S, Kroh M, Trübswetter P, Schupp J. Neue Muster der Migration : Auf dem Weg nach Deutschland. Institut für Arbeitsmarkt- und Berufsforschung; 2014.Über die Migrationsbiografien, -wege und -erfahrungen der in Deutschland lebenden Zuwanderer gibt es bislang nur wenig gesicherte wissenschaftliche Erkenntnisse. Eine im Jahr 2013 begonnene Längsschnittstudie soll diese Lücke schließen: Für die neue IAB-SOEP-Migrationsstichprobe werden künftig jedes Jahr 5.000 Personen mit Migrationshintergrund und ihre Familienangehörigen befragt. So lässt sich nachvollziehen, wann die Befragten in Deutschland, in ihren Geburtsländern und in anderen Ländern gelebt haben und auf welchen Wegen sie gewandert sind. Traditionelle Muster der Migration, in denen Zuwanderer nach dem Zuzug dauerhaft ihren Lebensmittelpunkt in ein neues Zielland verlagern, werden zunehmend durch neue Muster abgelöst: Insbesondere seit der Wirtschafts- und Finanzkrise sowie der EU-Osterweiterung ist zu beobachten, dass Menschen wiederholt migrieren und Lebenserfahrungen in verschiedenen Ländern sammeln

Neue Muster der Migration

Brücker H, Tucci I, Bartsch S, Kroh M, Trübswetter P, Schupp J. Neue Muster der Migration. Vol 81. Deutsches Institut für Wirtschaftsforschung; 2014.Über die Migrationsbiografien, -wege und -erfahrungen der in Deutschland lebenden Zuwanderer gibt es bislang nur wenig gesicherte wissenschaftliche Erkenntnisse. Eine im Jahr 2013 begonnene Längsschnittstudie soll diese Lücke schließen: Für die neue IAB-SOEP-Migrationsstichprobe werden künftig jedes Jahr 5 000 Personen mit Migrationshintergrund und ihre Familienangehörigen befragt. So lässt sich nachvollziehen, wann die Befragten in Deutschland, in ihren Geburtsländern und in anderen Ländern gelebt haben und auf welchen Wegen sie gewandert sind. Traditionelle Muster der Migration, in denen Zuwanderer nach dem Zuzug dauerhaft ihren Lebensmittelpunkt in ein neues Zielland verlagern, werden zunehmend durch neue Muster abgelöst: Insbesondere seit der Wirtschafts- und Finanzkrise sowie der EU-Osterweiterung ist zu beobachten, dass Menschen wiederholt migrieren und Lebenserfahrungen in verschiedenen Ländern sammeln.There is as yet little scientific knowledge about the migration biographies, routes, and experiences of immigrants living in Germany. But a longitudinal study started in 2013 is to close this gap. Each year, 5,000 people with a migration background and their family members are surveyed for the new IAB-SOEP Migration Sample. Thus, it can be verified when the respondents have lived in Germany, in their countries of birth, and in other countries, and which routes they migrated along. Traditional migration patterns in which migrants permanently spend their lives in a new destination country after moving there are increasingly being replaced by new patterns: particularly since the economic and financial crisis and the EU’s eastern enlargement, it has been observed that people migrate repeatedly and gain life experiences in different countries