Early Intervention, Documentation, and Service Delivery: A Review of IFSPs and Service Notes

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Spitzer/IRAC Observations of the Variability of Sgr A* and the Object G2 at 4.5 microns

We present the first detection from the Spitzer Space Telescope of 4.5 micron variability from Sgr A*, the emitting source associated with the Milky Way's central black hole. The >23 hour continuous light curve was obtained with the IRAC instrument in 2013 December. The result characterizes the variability of Sgr A* prior to the closest approach of the G2 object, a putative infalling gas cloud that orbits close to Sgr A*. The high stellar density at the location of Sgr A* produces a background of ~250 mJy at 4.5 microns in each pixel with a large pixel-to-pixel gradient, but the light curve for the highly variable Sgr A* source was successfully measured by modeling and removing the variations due to pointing wobble. The observed flux densities range from the noise level of ~0.7 mJy rms in a 6.4-s measurement to ~10 mJy. Emission was seen above the noise level ~34% of the time. The light curve characteristics, including the flux density distribution and structure function, are consistent with those previously derived at shorter infrared wavelengths. We see no evidence in the light curve for activity attributable to the G2 interaction at the observing epoch, ~100 days before the expected G2 periapsis passage. The IRAC light curve is more than a factor of two longer than any previous infrared observation, improving constraints on the timescale of the break in the power spectral distribution of Sgr A* flux densities. The data favor the longer of the two previously published values for the timescale.Comment: 13 pages, 10 figures, 2 tables, accepted for publication in the Ap

Warm Molecular Hydrogen Emission in Normal Edge-On Galaxies NGC 4565 and NGC 5907

We have observed warm molecular hydrogen in two nearby edge-on disk galaxies, NGC 4565 and NGC 5907, using the Spitzer high-resolution infrared spectrograph. The 0-0 S(0) 28.2 micron and 0-0 S(1) 17.0 micron pure rotational lines were detected out to 10 kpc from the center of each galaxy on both sides of the major axis, and in NGC 4565 the S(0) line was detected at r = 15 kpc on one side. This location lies beyond a steep drop in the radio continuum emission from cosmic rays in the disk. Despite indications that star formation activity decreases with radius, the H2 excitation temperature and the ratio of the H2 line and the far-IR luminosity surface densities, Sigma_L(H2}/Sigma_L(TIR}, change very little as a function of radius, even into the diffuse outer region of the disk of NGC 4565. This suggests that the source of excitation of the H2 operates over a large range of radii, and is broadly independent of the strength and relative location of UV emission from young stars. Although excitation in photodissociation regions is the most common explanation for the widespread H2 emission, cosmic ray heating or shocks cannot be ruled out. The inferred mass surface densities of warm molecular hydrogen in both edge-on galaxies differ substantially, being 4(-60) M_solar/pc^2 and 3(-50) M_solar/pc^2 at r = 10 kpc for NGC 4565 and NGC 5907, respectively. The higher values represent very unlikely point-source upper limits. The point source case is not supported by the observed emission distribution in the spectral slits. These mass surface densities cannot support the observed rotation velocities in excess of 200 km/s. Therefore, warm molecular hydrogen cannot account for dark matter in these disk galaxies, contrary to what was implied by a previous ISO study of the nearby edge-on galaxy NGC 891.Comment: Accepted for publication in the Astronomical Journal (20 pages, 17 figures, 7 tables

Sensitivity analysis of circadian entrainment in the space of phase response curves

Sensitivity analysis is a classical and fundamental tool to evaluate the role of a given parameter in a given system characteristic. Because the phase response curve is a fundamental input--output characteristic of oscillators, we developed a sensitivity analysis for oscillator models in the space of phase response curves. The proposed tool can be applied to high-dimensional oscillator models without facing the curse of dimensionality obstacle associated with numerical exploration of the parameter space. Application of this tool to a state-of-the-art model of circadian rhythms suggests that it can be useful and instrumental to biological investigations.Comment: 22 pages, 8 figures. Correction of a mistake in Definition 2.1. arXiv admin note: text overlap with arXiv:1206.414

Calibration and data quality of warm IRAC

We present an overview of the calibration and properties of data from the IRAC instrument aboard the Spitzer Space Telescope taken after the depletion of cryogen. The cryogen depleted on 15 May 2009, and shortly afterward a two-month- long calibration and characterization campaign was conducted. The array temperature and bias setpoints were revised on 19 September 2009 to take advantage of lower than expected power dissipation by the instrument and to improve sensitivity. The final operating temperature of the arrays is 28.7 K, the applied bias across each detector is 500 mV and the equilibrium temperature of the instrument chamber is 27.55 K. The final sensitivities are essentially the same as the cryogenic mission with the 3.6 μm array being slightly less sensitive (10%) and the 4.5 μm array within 5% of the cryogenic sensitivity. The current absolute photometric uncertainties are 4% at 3.6 and 4.5 μm, and better than milli-mag photometry is achievable for long-stare photometric observations. With continued analysis, we expect the absolute calibration to improve to the cryogenic value of 3%. Warm IRAC operations fully support all science that was conducted in the cryogenic mission and all currently planned warm science projects (including Exploration Science programs). We expect that IRAC will continue to make ground-breaking discoveries in star formation, the nature of the early universe, and in our understanding of the properties of exoplanets

Structure and Colors of Diffuse Emission in the Spitzer Galactic First Look Survey

We investigate the density structure of the interstellar medium using new high-resolution maps of the 8 micron, 24 micron, and 70 micron surface brightness towards a molecular cloud in the Gum Nebula, made as part of the Spitzer Space Telescope Galactic First Look Survey. The maps are correlated with 100 micron images measured with IRAS. At 24 and 70 micron, the spatial power spectrum of surface brightness follows a power law with spectral index -3.5. At 24 micron, the power law behavior is remarkably consistent from the 0.2 degree size of our maps down to the 5 arcsecond spatial resolution. Thus, the structure of the 24 micron emission is self-similar even at milliparsec scales. The combined power spectrum produced from Spitzer 24 micron and IRAS 25 micron images is consistent with a change in the power law exponent from -2.6 to -3.5. The decrease may be due to the transition from a two-dimensional to three-dimensional structure. Under this hypothesis, we estimate the thickness of the emitting medium to be 0.3 pc.Comment: 13 Pages, 3 Figures, to be published in Astrophysical Journal Supplement Series (Spitzer Special Issue), volume 154. Uses aastex v5.

A Study of Heating and Cooling of the ISM in NGC 1097 with Herschel-PACS and Spitzer-IRS

NGC 1097 is a nearby Seyfert 1 galaxy with a bright circumnuclear starburst ring, a strong large-scale bar and an active nucleus. We present a detailed study of the spatial variation of the far infrared (FIR) [CII]158um and [OI]63um lines and mid-infrared H2 emission lines as tracers of gas cooling, and of the polycyclic aromatic hydrocarbon (PAH) bands as tracers of the photoelectric heating, using Herschel-PACS, and Spitzer-IRS infrared spectral maps. We focus on the nucleus and the ring, and two star forming regions (Enuc N and Enuc S). We estimated a photoelectric gas heating efficiency ([CII]158um+[OI]63um)/PAH in the ring about 50% lower than in Enuc N and S. The average 11.3/7.7um PAH ratio is also lower in the ring, which may suggest a larger fraction of ionized PAHs, but no clear correlation with [CII]158{\mu}m/PAH(5.5 - 14um) is found. PAHs in the ring are responsible for a factor of two more [CII]158um and [OI]63um emission per unit mass than PAHs in the Enuc S. SED modeling indicates that at most 25% of the FIR power in the ring and Enuc S can come from high intensity photodissociation regions (PDRs), in which case G0 ~ 10^2.3 and nH ~ 10^3.5 cm^-3 in the ring. For these values of G0 and nH PDR models cannot reproduce the observed H2 emission. Much of the the H2 emission in the starburst ring could come from warm regions in the diffuse ISM that are heated by turbulent dissipation or shocks.Comment: 17 pages, 14 figures, 5 tables; accepted for publication in Ap

Membranes, molecules and biophysics: enhancing monocyte derived dendritic cell (MDDC) immunogenicity for improved anti-cancer therapy

Despite great medical advancement in the treatment of cancer, cancer remains a disease of global significance. Chemotherapeutics can be very expensive and drain medical resources at a national level and in some cases the cost of treatment is so great that it prohibits their use by local health authorities. Drug resistance is also a major limiting factor to the successful treatment of cancer with many patients initially responding well but then becoming refractory to treatment with the same drug and in some case may become multi-drug resistant. The immune system is known to be important in the prevention of tumors by eliminating pre-cancerous or cancerous cells. This concept of immune surveillance has largely been super-ceded by the concept of immunoediting whereby the immune system imposes a selective pressure on tumor cells which may either control tumor growth or inadvertently select for tumor cells which have evolved to escape the immune response and which may induce tumor development. Stimulation of the immune system by vaccination offers many benefits in the treatment of cancer. It is highly cost effective and vaccines can be manipulated to include multi-antigens which in some cases may overcome equilibrium (and selective pressure) while also preventing the establishment of reactivated cancer cells, since cancer antigen-specific memory would be induced following the initial vaccination/booster phase. To date studies using vaccination as a treatment for cancer have been a little disappointing, probably due to insufficient level of immunogenicity. In this review we will discuss methods of manipulation of the immune system to increase the anti-cancer activity of dendritic cells in vivo and how monocyte derived dendritic cells may be manipulated ex vivo to provide more robust, patient-specific treatments

The infrared spectrograph on the Spitzer Space Telescope

The Infrared Spectrograph (IRS) is one of three science instruments on the Spitzer Space Telescope. The IRS comprises four separate spectrograph modules covering the wavelength range from 5.3 to 38 μm with spectral resolutions, R~90 and 650, and it was optimized to take full advantage of the very low background in the space environment. The IRS is performing at or better than the pre-launch predictions. An autonomous target acquisition capability enables the IRS to locate the mid-infrared centroid of a source, providing the information so that the spacecraft can accurately offset that centroid to a selected slit. This feature is particularly useful when taking spectra of sources with poorly known coordinates. An automated data reduction pipeline has been developed at the Spitzer Science Center