MANAJEMEN DISIPLIN KERJA PEGAWAI DI BIRO SUMBER DAYA MANUSIA KEMENTERIAN PENDIDIKAN, KEBUDAYAAN, RISET, DAN TEKNOLOGI

Penelitian ini dilaksanakan di Biro Sumber Daya Manusia Kementerian Pendidikan, Kebudayaan, Riset, dan Teknologi. Penelitian ini bertujuan untuk mendeskripsikan manajemen disiplin kerja pegawai di Biro SDM dengan sub fokus penelitian yaitu perencanaan, pelaksanaan, dan pengawasan disiplin kerja pegawai. Peneliti menggunakan pendekatan kualitatif dan metode deskriptif. Pengumpulan data dilakukan melalui wawancara, observasi, dan studi dokumentasi. Berdasarkan observasi peneliti ditemui masalah ketidakdisiplinan pegawai yaitu adanya sejumlah pegawai yang terlambat masuk kantor, Istirahat yang terlalu lama, dan pulang lebih awal dari jadwal yang ditentukan. Hasil dari penelitian ini menunjukkan bahwa: (1) Tahap perencanaan dalam disiplin kerja pegawai dilakukan setiap awal tahun diawali dengan perjanjian kontrak kinerja antara atasan langsung dengan bawahan. Perencanaan dilakukan dengan sosialisasi kegiatan program kerja selama 1 tahun, Negoisasi kegiatan tugas pokok, sasaran kerja yang akan dicapai setiap bulan, target (aspek kuantitas, kualitas dan waktu), Perjanjian setuju atau tidak setuju, dan Tanda tangan perjanjian kontrak kinerja sasaran kerja pegawai. (2) pelaksanaan disiplin kerja pegawai dilakukan sesuai dengan apa yang sudah di rencanakan. Tahap pelaksanaan balik kepada dirinya sendiri, pelaksanaan pemenuhan target bulanan, pelaksanaan kehadiran tepat waktu, komunikasi antara atasan dengan bawahan maupun antara sesama pegawai, sarana dan prasarana yang tersedia, hukuman bagi pelanggar dan apresiasi. (3) Dalam pengawasan disiplin kerja pegawai dilakukan melalui pengawas internal. Pengawas internal yaitu berasal dari atasan langsung. Teknik pengawasan yang digunakan atasan langsung untuk mengawasi disiplin kerja pegawai adalah pengawasan secara langsung dan tidak langsung. Dalam pengawasan selain dilakukan oleh atasan langsung, didukung juga dengan aplikasi perekaman kehadiran pegawai dan untuk kinerja pegawai yaitu aplikasi E-SKP. ******************** This research was conducted at the bureau of human resources ministry of education, culture, research, and technology. This study aims to describe the management of employee work discipline in the HR Bureau with a sub focus of research, namely planning, implementing, and supervising employee work discipline. Researchers used a qualitative approach and descriptive methods. Data was collected through interviews, observations, and documentation studies. Based on the researcher's observations, there were problems with employee indiscipline, namely the presence of a number of employees who were late to the office, took too long a break, and went home earlier than the specified schedule.The results of this study indicate that: (1) The planning stage in employee work discipline is carried out at the beginning of each year starting with a performance contract agreement between direct superiors and subordinates. Planning is carried out by socializing work program activities for 1 year, Negotiating main task activities, work targets to be achieved every month, targets (quantity, quality and time aspects), agreeing or disagreeing agreements, and signing the employee performance target contract agreement. (2) the implementation of employee work discipline is carried out in accordance with what has been planned. The implementation stage is back to himself, the implementation of meeting monthly targets, implementing timely attendance, communication between superiors and subordinates as well as between fellow employees, available facilities and infrastructure, punishment for violators and appreciation. (3) Supervision of employee work discipline is carried out through internal supervisors. Internal supervisors come from direct superiors. Supervision techniques used by direct superiors to supervise employee work discipline are direct and indirect supervision. In addition to supervision carried out by the direct supervisor, it is also supported by an application for recording employee attendance and for employee performance, namely the E-SKP application

Analisis Tingkat Pengetahuan Guru PAUD tentang Manajemen Bencana Banjir di Kecamatan Tembilahan Kabupaten Indragiri Hilir

Penelitian ini bertujuan untuk mengetahui bagaimana tingkat pengetahuan guru PAUD tentang manajemen bencana banjir di Kecamatan Tembilahan Kabupaten Indragiri Hilir. Penelitian ini menggunakan pendekatan kuantitatif dengan metode deskriptif. Populasi penelitian adalah 50 Guru PAUD di Kecamatan Tembilahan Kabupaten Indragiri Hilir, sampel yang digunakan keseluruhan jumlah populasi yaitu 50 orang guru.  Penelitian ini menggunakan metode deskriptif dengan pendekatan kuantitatif. Berdasarkan hasil penelitian yang telah dilakukan, peneliti menyimpulkan bahwa analisis tingkat pengetahuan guru PAUD tentang manajemen bencana banjir secara keseluruhan memiliki persentase 84%, yang terdiri dari 4 indikator yang pertama pada indikator mitigasi yang terdiri dari 6 pernyataan memiliki persentase 84%, kedua indikator kesiapsiagaan yang terdiri dari 6 pernyataan  memiliki persentase 84%, ketiga pada indikator tanggap darurat  yang terdiri dari 6 pernyataan memiliki persentase 76,67%, dan yang keempat pada indikator pemulihan terdiri dari 4 pernyataan memiliki persentase 89,50%. Teknik pengumpulan data yang dilakukan yaitu melalui data primer yaitu dilakukan secara langsung oleh peneliti dengan menggunakan tes angket

Teenager Value in Mark Twain's the Adventure of Tom Sawyer

This research aimed to find out the kind of values in the teenager characters of Mark Twain’s The Adventure of Tom Sawyer as well as to find out its similarities with the character of Indonesian teenager. Library research (documentation) and descriptive qualitative method were used to conduct the research. The data findings were identified by using Peterson and Seligman's virtues and character strengths (2004) then the researcher found out the similarities with the characters of Indonesian teenager based on Indonesia Ministry of Education’s Character Education using checklist and simple tabulation. The results showed that: 1) There were 22 type of values found in the teenager characters of Mark Twain’s The Adventure of Tom Sawyer namely curiosity, creativity, open-mindedness, love of learning, wisdom, bravery, honesty, persistence, vitality, love, kindness, social intelligence, fairness, leadership, humility, prudence, self-regulation, appreciation of beauty and excellence, gratitude, hope, humor, and spirituality; 2) There were six similar traits that are presented in 22 type of values found in the teenager characters and characters of Indonesian teenager (Character Education) namely religious, honest, creative, curiosity, love to read, and care about social. To conclude, there were two points about this research as follows. 1) Teenager characters of Mark Twain’s The Adventure of Tom Sawyer dominantly had good personality based on Peterson and Seligman’s virtue and character strengths. 2) There were six similar values (religious, honest, creative, curiosity, love to read, and care about social) between the characters of Indonesian teenager and teenager values from Mark Twain’s The Adventure of Tom Sawyer

Teenager Value in Mark Twain's the Adventure of Tom Sawyer

This research aimed to find out the kind of values in the teenager characters of Mark Twain’s The Adventure of Tom Sawyer as well as to find out its similarities with the character of Indonesian teenager. Library research (documentation) and descriptive qualitative method were used to conduct the research. The data findings were identified by using Peterson and Seligman's virtues and character strengths (2004) then the researcher found out the similarities with the characters of Indonesian teenager based on Indonesia Ministry of Education’s Character Education using checklist and simple tabulation. The results showed that: 1) There were 22 type of values found in the teenager characters of Mark Twain’s The Adventure of Tom Sawyer namely curiosity, creativity, open-mindedness, love of learning, wisdom, bravery, honesty, persistence, vitality, love, kindness, social intelligence, fairness, leadership, humility, prudence, self-regulation, appreciation of beauty and excellence, gratitude, hope, humor, and spirituality; 2) There were six similar traits that are presented in 22 type of values found in the teenager characters and characters of Indonesian teenager (Character Education) namely religious, honest, creative, curiosity, love to read, and care about social. To conclude, there were two points about this research as follows. 1) Teenager characters of Mark Twain’s The Adventure of Tom Sawyer dominantly had good personality based on Peterson and Seligman’s virtue and character strengths. 2) There were six similar values (religious, honest, creative, curiosity, love to read, and care about social) between the characters of Indonesian teenager and teenager values from Mark Twain’s The Adventure of Tom Sawyer

Anti-metastatic Activity of Curcumin Analog Pentagamaboronon-0-Sorbitol Against HER2-overexpressed MCF-7 Breast Cancer Cells

Breast cancer with Human Epidermal Growth Factor Receptor (HER)2 overexpression increases tumor progession and lead to metastasis, which is primarily cause of mortality in breast cancer. Pentagamaboronon-0 Sorbitol (PGB-0-So) is an aquoeous formulation of curcumin analog, PGB-0, with sorbitol. This compound has been developed as an anti-cancer chemotherapeutic agent and a boron carrying pharmaceutical for boron neutron capture therapy (BNCT). The aims of this study are to investigate antimetastatic activities of PGB-0-So against HER2-overexpressed MCF-7 breast cancer (MCF-7/HER2) cells. The MTT cytotoxicity assay of PGB-0-So exhibited cytotoxic effect with an IC50 value of 35 μM. The testing of anti-migration activity using the scratch wound healing assay demonstrated that PGB-0-So inhibited the closure of the wound on MCF-7/HER2 cells compare to the control. Furthermore, PGB-0-So was able to suppress matrix metalloproteinase (MMP)-9 activities, based on the gelatin zymography assay. In conclusion, PGB-0-So has potency to be developed as an anti-cancer agent against metastatic breast cancer.Keywords : PGB-0-So, anti-metastatsis, cell migration, MMP-9, MCF-7/HER

Pentagamaboronon-0 Fructose Inhibited Migration and Overexpression of Matrix Metalloproteinases 9 on MCF-7/HER2 Breast Cancer Cells

The incidence of Breast Cancer Metastasis (MBC) can be categorized in stage IV as well as being the leading cause of death in cases of breast cancer. MBC prognosis is known to be weak, frequent recurrent, and MBC patients have only a survival rate of about 5 years. One of the proteins that causes breast cancer metastasis is Human Epidermal Growth Factor 2 (HER2). Pentagamaboron-0 (PGB-0), a newly curcumin analogue performed cytotoxic effect on HER2-positive breast cancer cells but it is practically water-insoluble. The aims of this study are to determine anti-metastatic activity of a more soluble form of PGB-0 namely PGB-0 fructose complex (PGB-0-F) toward HER2 positive cancer (MCF-7/HER2) cells. PGB-0-F was obtained from Cancer Chemoprevention Research Centre Faculty of Pharmacy Universitas Gadjah Mada. Based on scratch wound healing assay result, PGB-0-F inhibited cell migration especially in combination with doxorubicin at the concentration 15 μM. Under gelatin zymography assay, PGB-0-F in combination with doxorubicin decreased Matrix Metalloproteinases 9 (MMP-9) expression compare to the doxorubicin. Hence, PGB-0-F has a potency to be developed as anti-metastatic agent on HER2 overexpression breast cancer.Keywords : HER2, MCF-7/HER2, PGB-0-F, Metastasi

The THE DESCRIPTION AND THE IMPACT OF PLAYING ONLINE GAME ON PHARMACY STUDENTS IN SAMARINDA

Online game is a game that can be accessed by the community using internet access. Online games are known to have a fun and addictive effect on their use. Indonesia is the 16th most online game user in the world. This study aims to provide an overview and the impact of the habit of playing online games on Pharmacy students in Samarinda. The method used in this study was using questionnaires distributed to at least 57 respondents of Pharmacy students in Samarinda. The results show that at least 80% of students have played online games with an average playing time of 1-2 hours in one day. The results of the questionnaire also showed an impact in the form of decreasing students' sensitivity to the surrounding environment and the tendency to speak harshly due to playing online games. Based on the results, it can be concluded that the habit of playing online games can reduce students' sensitivity to their environment and can encourage negative behavior, especially in verbal matters. This research can be used as a preliminary description of behavior changes towards the negative of students due to the habit of playing online games

IDENTIFIKASI DAN MOLECULAR DOCKING KOMPONEN UTAMA MINYAK KULIT BUAH JERUK NIPIS SEBAGAI AGEN ANTIKANKER

Kanker  merupakan penyakit penyebab kematian tertinggi di dunia. Penyakit ini diketahui memiliki regulasi yang berbeda  dari penyakit lainnya.  Pengembangan obat dewasa ini adalah dengan mentargetkan obat antikanker pada situs regulasi kanker yang ada pada hallmark of cancer. Jeruk nipis (Citrus aurantifolia) merupakan salah satu jenis Citrus (jeruk) yang mengandung unsur-unsur senyawa kimia yang memiliki aktivitas sebagai agen antikanker. Kulit jeruk nipis diketahui memiliki kandungan bioaktif  berupa minyak atsiri dan flavonoid seperti hesperidin dan hesperitin. Kandungan senyawa ini erat hubungannya dengan aktivitas antikanker. Penelitian ini bertujuan untuk mengidentifikasi kandungan senyawa pada minyak kulit buah jeruk nipis dan kajian in silico molecular docking senyawa tersebut pada protein yang berperan dalam regulasi sel kanker. Minyak kulit buah jeruk nipis didapatkan dengan menggunakan metode distilasi uap kemudian dianalisis dengan menggunakan GC-MS untuk mengetahui komponen  penyusunnya untuk selanjutnya dianalisis in silico menggunakan software YASARA 10.1.8, MarvinSketch 15.4.20, PLANTS. Hasil menunjukkan komponen utama minyak kulit buah jeruk nipis adalah senyawa d-limonen dan beta-pinen dengan persentase 59,71% dan 36,81%. Analisis in silico menunjukkan masing-masing senyawa ini memiliki afinitas yang lebih besar dari pada ligan native pada protein caspase-8 yang ada pada regulasi apoptosis. Berdasarkan hasil ini dapat disimpulkan, bahwa minyak kulit buah jeruk nipis memiliki potensi untuk dikembangkan sebagai agen antikanker

Cytotoxic Activity, Anti-Migration and In Silico Study of Black Ginger (Kaempferia parviflora) Extract against Breast Cancer Cell

Metastatic breast cancer remains the leading cause of death in women worldwide. This condition necessitates extensive research to find an effective treatment, one of which is the natural medicine approach. Kaempferia parviflora (KP) is a plant believed to possess anticancer properties. Therefore, this study aims to determine KP’s bioactive compound, cytotoxic, and anti-migration activity in the highly metastatic breast cancer cell line model 4T1, also in the breast cancer cell model MCF-7 and noncancerous cell line NIH-3T3. Maceration with ethanol (EEKP) and infusion with distilled water (EWKP) was used for extraction. The MTT assay was used to test for cytotoxicity, and the scratch wound healing assay was used to test for the inhibition of migration. Phytochemical profiling of EEKP was performed using UHPLC-MS, and the results were studied for in silico molecular docking. Result showed that EEKP had a better cytotoxic activity than EWKP with an IC50 value of 128.33 µg/mL (24 h) and 115.09 µg/mL (48 h) on 4T1 cell line, and 138.43 µg/mL (24 h) and 124.81 µg/mL (48 h) on MCF-7 cell line. Meanwhile, no cytotoxic activity was observed at concentrations ranging from 3–250 µg/mL in NIH-3T3. EEKP also showed anti-migration activity in a concentration of 65 µg/mL. Mass Spectrophotometer (MS) structures from EEKP are 5-Hydroxy-7,40 -dimethoxyflavanone (HDMF), 5-Hydro-7,8,20 -trimethoxyflavanone (HTMF), Retusine, and Denbinobin. The in silico docking was investigated for receptors Bcl-2, Bcl-XL, ERK2, and FAK, as well as their activities. In silico result indicates that HTMF and denbinobin are bioactive compounds responsible for EEKP’s cytotoxic and anti-migration activity. These two compounds and standardized plant extract can be further studied as potential breast cancer treatment candidates