26 research outputs found
Hypocalcaemia as a Reversible Cause of Acute Heart Failure in a Long-Term Survivor of Childhood Cancer
Hypocalcaemia is known for its neuromuscular symptoms, which are rapidly alleviated by intravenous supplementation. Calcium is also essential for both cardiac cell excitability and contraction. We present a case of acute heart failure due to hypocalcaemia in a young male with a complex medical history
A systematic review and bibliometric analysis of wildland fire behavior modeling
Wildland fires have become a major research subject among the national and international research community. Different simulation models have been developed to prevent this phenomenon. Nevertheless, fire propagation models are, until now, challenging due to the complexity of physics and chemistry, high computational requirements to solve physical models, and the difficulty defining the input parameters. Nevertheless, researchers have made immense progress in understanding wildland fire spread. This work reviews the state-of-the-art and lessons learned from the relevant literature to drive further advancement and provide the scientific community with a comprehensive summary of the main developments. The major findings or general research-based trends were related to the advancement of technology and computational resources, as well as advances in the physical interpretation of the acceleration of wildfires. Although wildfires result from the interaction between fundamental processes that govern the combustion at the solid- and gas-phase, the subsequent heat transfer and ignition of adjacent fuels are still not fully resolved at a large scale. However, there are some research gaps and emerging trends within this issue that should be given more attention in future investigations. Hence, in view of further improvements in wildfire modeling, increases in computational resources will allow upscaling of physical models, and technological advancements are being developed to provide near real-time predictive fire behavior modeling. Thus, the development of two-way coupled models with weather prediction and fire propagation models is the main direction of future work.This work was supported by the Portuguese Foundation for Science and Technology (FCT)
within the R&D Units Project Scope UIDB/00319/2020 (ALGORITMI) and R&D Units Project Scope
UIDP/04077/2020 (METRICS) and through project: PCIF/GRF/0141/2019: “O3F—An Optimization
Framework to reduce Forest Fire
Synthesis of aminodiarylamines in the thieno[3,2-b]pyridine series and effects on tumor cell growth inhibition, cell cycle and apoptosis
Several series of compounds that include the
thienopyridine scaffold have been reported as
inhibitors of known cancer therapeutic targets or
as inhibitors of cell proliferation in tumor cell lines
[1,2]. Our research group has already
synthesized several thieno[3,2-b]pyridine
derivatives by Pd-catalyzed C-C (Suzuki and
Sonogashira) and C-N (Buchwald-Hartwig)
couplings and some of them have presented
tumor cell growth inhibitory activity in cell lines [3-
5]
Aminodi(hetero)arylamines in the thieno[3,2-b]pyridine series: synthesis, effects in human tumor cells growth, cell cycle analysis, apoptosis and evaluation of toxicity using non-tumor cells
Three aminodi(hetero)arylamines were prepared via a palladium-catalyzed C-N
Buchwald-Hartwig coupling of methyl 3-aminothieno[3,2-b]pyridine-2-carboxylate with
different bromonitrobenzenes, followed by reduction of the nitro groups of the coupling
products to the corresponding amino compounds. The aminodi(hetero)arylamines thus
obtained were evaluated for their growth inhibitory effect on four human tumor cell lines
MCF-7 (breast adenocarcinoma), A375-C5 (melanoma), NCI-H460 (non-small cell lung
cancer) and HepG2 (hepatocellular carcinoma). The toxicity to non-tumor cells was also
evaluated using a porcine liver primary cell culture (PLP1), established by us. The
aminodi(hetero)arylamine with the NH2 group in the ortho position and an OMe group in the para position to the NH of the di(hetero)arylamine, is the most promising compound
giving the lowest GI50 values (1.30–1.63 μM) in all the tested human tumor cell lines,
presenting no toxicity to PLP1 at those concentrations. The effect of this compound on the
cell cycle and induction of apoptosis was analyzed in the NCI-H460 cell line. It was
observed that it altered the cell cycle profile causing a decrease in the percentage of cells in
the G0/G1 phase and an increase of the apoptosis levels.Foundation for the Science and Technology (FCT–Portugal) for financial support through the NMR Portuguese network (Bruker 400 Avance III-Univ Minho). FCT and FEDER (European Fund for
Regional Development) for financial support through the research centers PEst-C/QUI/UI686/2011and PEst-OE/AGR/UI0690/2011, the research project PTDC/QUI-QUI/111060/2009 and the post-Doctoralgrants attributed to R.C.C. and R.T.L. (SFRH/BPD/68344/2010 and SFRH/BPD/68787/2010, respectively). IPATIMUP is an Associate Laboratory of the Portuguese Ministry of Science,
Technology and Higher Education and is partially supported by FCT
Consequences Of On-Track Competition In Railways By Use Of Simulations
Institute of Transport and Logistics Studies. Faculty of Economics and Business. The University of Sydne
Hiperparatireoidismo primário : caracterização molecular e biomarcadores
Tese de mestrado. Engenharia Biomédica. Faculdade de Engenharia. Universidade do Porto. 200
From Pancreatic β -Cell Gene Networks to Novel Therapies for Type 1 Diabetes
info:eu-repo/semantics/publishe
A Systematic Review and Bibliometric Analysis of Wildland Fire Behavior Modeling
Wildland fires have become a major research subject among the national and international research community. Different simulation models have been developed to prevent this phenomenon. Nevertheless, fire propagation models are, until now, challenging due to the complexity of physics and chemistry, high computational requirements to solve physical models, and the difficulty defining the input parameters. Nevertheless, researchers have made immense progress in understanding wildland fire spread. This work reviews the state-of-the-art and lessons learned from the relevant literature to drive further advancement and provide the scientific community with a comprehensive summary of the main developments. The major findings or general research-based trends were related to the advancement of technology and computational resources, as well as advances in the physical interpretation of the acceleration of wildfires. Although wildfires result from the interaction between fundamental processes that govern the combustion at the solid- and gas-phase, the subsequent heat transfer and ignition of adjacent fuels are still not fully resolved at a large scale. However, there are some research gaps and emerging trends within this issue that should be given more attention in future investigations. Hence, in view of further improvements in wildfire modeling, increases in computational resources will allow upscaling of physical models, and technological advancements are being developed to provide near real-time predictive fire behavior modeling. Thus, the development of two-way coupled models with weather prediction and fire propagation models is the main direction of future work