The Use of Subconjunctival Erythropoietin Injection to Treat Avascular Bleb after Trabeculectomy: A Case Report

Purpose: To report a patient with avascular bleb after trabeculectomy who showed promising results after subconjunctival erythropoietin injection. Case Report: A 45-year-old woman with the diagnosis of primary open-angle glaucoma and history of trabeculectomy three years prior was admitted to our center. The corrected distance visual acuity (CDVA) was 20/20 in both eyes. Her ocular examination revealed an avascular and cystic bleb in the right eye. Seidel test was negative while bleb sweating was observed after fluorescein staining of the bleb area. Intraocular pressure (IOP) was 5 mmHg in the right eye. Erythropoietin (2000 unit in 0.1 ml) was injected subconjuctivally around the bleb area in the temporal quadrant. Six weeks after the injection, the bleb area just superior to the conjunctiva showed an increased fibrosis formation while the IOP remained the same as before injection. &nbsp

Fertility outcomes subsequent to medical and surgical treatment for ectopic pregnancy: A retrospective cohort study in Iran

Background: Ectopic pregnancy (EP) and its treatment methods may affect subsequent fertility outcomes. Objective: To compare methotrexate (MTX), laparoscopic salpingostomy, and salpingectomy methods of EP treatment and their effects on fertility outcomes. Materials and Methods: This retrospective cohort study was performed on women receiving a definitive diagnosis of tubular EP from 2014 to 2017 at Arash Medical Center, Tehran, Iran. In total, 194 women were studied, of which 64 were treated with MTX, 52 underwent salpingostomy, and 78 underwent salpingectomy, depending on their clinical status. Basic information, obstetrics history, and major outcomes of the treatment after an 18-month follow-up, including recurrence of EP, miscarriage, and successful intrauterine pregnancy (IUP), were recorded and variables were compared among the three groups. Results: There was no significant difference in fertility outcomes among the three groups. Among the studied variables, predictors of successful IUP after EP treatment were multiparity (Hazard Ratio (HR): 1.37; 95%CI: 1.06-1.77), no history of miscarriage (HR: 2.37; 95%CI: 1.01-5.56), and a higher number of live births (HR: 1.54; 95%CI: 1.01- 2.37). On the other hand, predictors of EP recurrence included nulliparity (HR: 1.61; 95%CI: 1.02-2.53) and a lower number of live births (HR: 3.84; 95%CI: 1.43-10.98). The effect of other factors, including the utilized therapeutic modalities, was not statistically significant. Conclusion: The current study results demonstrated that after an 18-month follow-up, fertility outcomes, including recurrence of EP and successful IUP, were not significantly different among the subjects with EP treated with MTX, salpingostomy, or salpingectomy. Further studies with long-term follow-ups are recommended. Key words: Ectopic pregnancy, Fertility, Methotrexate, Salpingostomy, Salpingectomy

Determination of the Train Wheel Wear Trend, Comparing with Field Measurements

Abstract In this paper, the train's wheel wear trend is discussed. To test, the second line of Tehran subway was selected, and In order to simulate, both of the tracks and fleet of this line were modeled in ADAMS/RAIL©. In different logged distances, the worn wheel profile was measured by Miniprof© and was used in simulation in order to make the simulation more accurate. After simulation process the wheel wear trend was determined and the accuracy of the results was proved by comparing them with field measurements, measured during three years. Using this method will result in determining the effects of the different model parameters on wheel wear and specifying optimum parameters in order to reduce wear rate. Moreover, it is possible to have better maintenance planning by determining wheel wear trend

TANGGUNG JAWAB PELAKU BISNIS ANGKUTAN UMUM BUS LINTAS KOTA LINTAS PROVINSI TERHADAP BARANG BAWAAN PENUMPANG

Permasalahan mengenai hilangnya barang bawaan penumpang angkutan umum bus masih sering terjadi di Indonesia. Perusahaan sebagai penyedia layanan angkutan umum memiliki kewajiban untuk meningkatkan keamanan armada busnya sebagai bentuk tanggung jawab kepada penumpang selaku konsumennya. Penelitian ini bertujuan untuk membahas mengenai tanggung jawab yang seharusnya dimiliki oleh perusahaan angkutan umum bus terutama yang melayani perjalanan lintas kota dan lintas provinsi terhadap barang bawaan penumpangnya. Metode penelitian ini ialah hukum empiris dengan menggunakan sumber data sekunder yang berasal dari sumber hukum dan studi literatur dari berbagai referensi yang kemudian dianalisis secara deskriptif-kualitatif. Hasil dari pembahasan pada studi ini ialah perusahaan dapat menerapkan sejumlah strategi yang berkaitan dengan upaya meningkatkan keamanan armada busnya yakni dengan pemanfaatan teknologi untuk menjaga keamanan barang bawaan penumpang. Penelitian yang membahas efektivitas dan efisiensi pemanfaatan teknologi dalam meningkatkan keamanan barang bawaan penumpang angkutan umum bus diperlukan untuk meninjau lebih jauh dampak yang diterima oleh perusahaan dengan memanfaatkan teknologi tersebu

Pelaksanaan Program Ahlul Qur’an (PRO-AQ) Sebagai Sarana Percepatan Hafalan di Rumah Qur’an Al-Azhar Al-Syarif Kertak Hanyar Kalsel

Based on Sofyan's research entitled Development of the Tahfiz Qur'an Movement in the Reformation Era in Indonesia, tahfizh Al-Qur'an learning is growing. It can be seen from the rapid development of Rumah Tahfizh which was triggered by Daarul Qur'an which was initiated by Yusuf Mansur which reached 300 more branches. The concept of Rumah Tahfizh was adopted by Al-Qur'an educational institutions in Indonesia, instead of the Al-Azhar Al-Syarif Qur'an House which was installed in Manarap Village, Banjar Regency, South Kalimantan Province. Based on the results of observations, learning at Al-Azhar Al-Syarif Qur'an House is carried out in 3 shifts, namely shift 1, shift 2, and the afternoon shift. Each shift was conducted 3 times in the discussion. Expect students to actively study in 1 week 3 times. The target of students to memorize each visit is 2 lines of the Al-Qur'an Standard Mushaf Madinah. But this target failed to be resolved due to several problems, in the approval of students not entering (permission or illness), strengthening memorization that had been deposited, still the process of developing reading improvements, or new students memorizing composting at the Qur'an House not at home. One of the alternatives to maximize the memorization of the Qur'an is the program held by Tahfidzh Quarantine 1 Day at Al-Azhar Al-Syarif Qur'an House. The purpose of quarantine tahfidzh 1 day is to accelerate memorization, and activities at school after quarantine is muroja'ah, which is repetition of memorization that has been completed by compiling quarantine programs, has improved memorization, learning will be efficient, both for improving memorization and reading

The Relationship of Pregnancy-Associated Plasma Protein A and Human Chorionic Gonadotropin with Adverse Pregnancy Outcomes: A Prospective Study

bstract Purpose: This prospective study investigated the relationship between pregnancy-associated plasma protein A (PAPP-A) and human chorionic gonadotropin (hCG) and adverse pregnancy outcomes in the Iranian population. Materials: Overall, 994 singleton pregnant mothers of 18-35-year old were referred for first-trimester screening tests, including PAPP-A and β-hCG, at the age of 6 days and 11-13 weeks, and were followed until the end of their pregnancy. The adverse pregnancy outcomes, PAPP-A, and β-hCG serum levels were recorded and analyzed. The sensitivity and specificity of the test were measured by calculating the area under the curve of receiver operating characteristic curve (ROC). Results: The mean serum level of PAPP-A and β-hCG was 1.10 ± 0.69 and 1.09 ± 0.8 MoM, respectively. Pregnancy-associated plasma protein A, regardless of its percentile, showed a significant relationship with the incidence of preeclampsia, preterm birth, and fetal low birth weight (p 0.05). According to ROC, the results indicated that PAPP-A had a significant relationship with the incidence of preeclampsia, preterm birth, and fetal low birth weight (p < 0.001). However, β-hCG levels showed no significant relationship with adverse pregnancy outcomes. Conclusions: The result of this study revealed that lower level of PAPP-A and β-hCG could be a predictive factor in preterm labor. Also, this study indicated that PAPP-A measurements could be a screening test for adverse pregnancy outcomes, such as preeclampsia, low birth weight and preterm labor

Gabapentin Determination in Human Plasma and Capsule by Coupling of Solid Phase Extraction, Derivatization Reaction, and UV-Vis Spectrophotometry

Abstract Gabapentin is an anticonvulsant widely used in the treatment of epilepsy. No peculiar chromophore is available on the gabapentin moiety for direct analysis by absorption spectrophotometry. A sensitive spectrophotometric method for the determination of gabapentin in bulk, pharmaceutical formulations and human plasma has been developed. In this method, gabapentin directly derivatized with vanillin and analyzed without any extraction in bulk and pharmaceutical dosage form and in plasma samples, it was extracted with a reversed-phase solid-phase extraction (SPE) cartridge followed by derivatization with vanillin. Analysis was performed by a spectrophotometer system. The quantitation limit of gabapentin in human plasma was 0.8 mg/L. The method was linear over the concentration range of 10.0-90.0 mg/L and 0.8-10.0 mg/L for pharmaceutical dosage form and plasma, respectively. The method was precise (relative standard deviation, RSD &lt;1.20%) and accurate (relative mean error &lt;5.5%) for both pharmaceutical dosage form and plasma samples. Mean absolute recoveries were 94.5% for plasma

Effect of Vaginal Progesterone and Dydrogesterone on Pregnancy Outcomes in patients with Threatened Abortion: A Randomized Clinical Trial

Introduction: Despite the positive evidence on the effect of progesterone on protection of pregnancy in patients with threatened abortion, the results of studies regarding its drug type have been controversial. This study was performed with aim to compare the effect of vaginal progesterone and dydrogesterone on pregnancy outcome in cases with threatened abortion. Methods: In this single-blind randomized clinical trial, 160 pregnant women with threatened abortion who referred to Qazvin Kowsar Hospital in 2018 were randomly assigned to receive dydrogesterone (Duphaston) 10 mg twice daily or vaginal progesterone (Cyclogest) 400 mg daily. Finally, pregnancy outcomes were compared between the two groups. Data were analyzed by SPSS software (version 18) and Chi-square, independent t-test and Mann-Whitney tests. P<0.05 was considered statistically significant. Results: Frequency of cesarean section was 27 (33.7%) in the dydrogesterone group and 25 (31.2%) in the vaginal progesterone group (P = 0.736). In general, the incidence of preterm labor was 97 (60.6%) and there was no significant difference between the two groups (P >0.05). In addition, incidence of preeclampsia, gestational diabetes mellitus, placenta previa and intrauterine fetal death as well as neonatal weight were not significantly different between the two groups (P >0.05). Finally, maternal and neonatal complications showed no significant difference between the two groups (P = 0.675). Conclusion: Pregnancy outcomes after administration of dydrogesterone are not different with vaginal progesterone in the treatment of threatened abortion

Comparing the Efficacy of NCPAP and NIPPV in Infants with RDS after Extubation; A Randomized Clinical Trial

peer reviewe

An overview of multi-ingredient kidney stone dissolving formulations from Traditional Persian Pharmacy

Kidney stone, as a third important urinary tract disease, is a common disease affecting 10-15% of the world population. Effective medical treatment for the disease is not yet well established. On the other hand, there is an increasing global demand to manage and control various diseases with natural medicine and medicaments originating from Complementary and Alternative Medicine (CAM). Traditional Persian medicine (TPM), as one of the most popular schools in CAM, suggests numerous clinical interventions for kidney stones. This review provides various related compound formulations for kidney/bladder stones from the standpoints of Persian scholars. These remedies have been cited in a series of traditional pharmaceutical manuscripts of Persian medicine, namely Qarābādin or prescription. More than fifty multi-ingredient formulations for kidney/bladder stones have been found by reviewing five main Persian pharmacopeias. Various dosage forms have been reported for the management of kidney/bladder stones, such as Majoon (confection), Sharāb (syrup), Jawārish (semisolid confection), Qors (Tablet), and Safoof (oral powder). Considering the positive pharmacological or biological activities of the constituents of filtered formulations, many of those can be re-formulated and either experimentally or clinically evaluated to be introduced as new natural remedies in this field