大学祭

写真あり大学祭の展示＆クイズ : 小根山 桃子(日本語日本文学科)ブックカバー作り: 今井 舞菜(国際交流学科

2015年度読書運動プロジェクト活動報告書

活動資料 p.(1)～p.(5)はじめに : 藤本 朝巳 p.1新入生勧誘イベント : 中藤 祥子 p.2読書会 : 匿名、森園 佳子、藏田 香織 p.3-p.5コンテスト・コンクール : 森園 佳子 p.6-p.7展示 : 秋葉 祐子 p.8-p.10コラボランチ : 秋葉 祐子 p.11選書ツアーとPOP講座 : 匿名 p.12文学散歩 : 吉満 みなみ p.13大学祭 : 小根山 桃子、今井 舞菜 p.14-p.16高校訪問 : 森園 佳子 p.17読み聞かせレッスン : 森園 佳子 p.18サマースクールプログラム朗読発表 : 鈴木 珠友 p.19小学校朗読会 : 森園 佳子 p.20朗読会 : 森園 佳子、阿部 果鈴 p.21-p.22朗読チームの活動を振り返って : 高橋 里奈、匿名 p.23-p.24プロフィール p.25-p.31おわりに : 森園 佳子 p.32写真あり表あ

マラリア原虫感染において、抗原特異的CD8+ T細胞の活性化と疲弊は、脾臓の異なる領域で惹起される

The spleen is the major organ in which T cells are primed during infection with malaria parasites. However, little is known regarding the dynamics of the immune responses and their localization within the splenic tissue during malaria infection. We examined murine CD8+ T cell responses during infection with Plasmodium berghei using recombinant parasites expressing a model antigen ovalbumin (OVA) protein and compared the responses with those elicited by Listeria monocytogenes expressing the same antigen. OVA-specific CD8+ T cells were mainly activated in the white pulp of the spleen during malaria infection, as similarly observed during Listeria infection. However, the fates of these activated CD8+ T cells were distinct. During infection with malaria parasites, activated CD8+ T cells preferentially accumulated in the red pulp and/or marginal zone, where cytokine production of OVA-specific CD8+ T cells decreased, and the expression of multiple inhibitory receptors increased. These cells preferentially underwent apoptosis, suggesting that T cell exhaustion mainly occurred in the red pulp and/or marginal zone. However, during Listeria infection, OVA-specific CD8+ T cells only transiently expressed inhibitory receptors in the white pulp and maintained their ability to produce cytokines and become memory cells. These results highlighted the distinct fates of CD8+ T cells during infection with Plasmodium parasites and Listeria, and suggested that activation and exhaustion of specific CD8+ T cells occurred in distinct spleen compartments during infection with malaria parasites.長崎大学学位論文 学位記番号:博(医歯薬)甲第958号 学位授与年月日:平成29年3月21日Author: Ganchimeg Bayarsaikhan, Mana Miyakoda, Kazuo Yamamoto, Daisuke Kimura, Masoud Akbari, Masao Yuda, Katsuyuki YuiCitation: Parasitology International, 66(3), pp.227-235; 2017Nagasaki University (長崎大学)課程博