31 research outputs found
Challenges and opportunities for energy recovery from municipal solid waste in the Russian Federation
Energy recovery from municipal solid waste (MSW) is currently a key factor in waste management in Russia, as can be seen from the corresponding changes in the state regulatory framework. The paper presents a comparative assessment of different waste flow characteristics; it focuses on pre-treatment options and the method of subsequent thermal treatment. It reflects the basic method of untreated MSW incineration and other advanced technologies which have different levels of waste preparation. Step-by-step research has been carried out in a large Russian city in order to determine different technological approaches to recovering energy from MSW. The study included: 1) field studies of the composition and characterization of MSW; 2) laboratory studies of MSW thermal properties, i.e. moisture, ash content and calorific value; 3) several options for waste treatment schemes with equipment of different technical specifications; 4) analysis of material flow, energy flow and key substance flow according to these considered schemes. The research revealed that for all seasons a significant proportion of MSW (almost 40%) is represented by fines (below 50 mm). On average, the energy potential of MSW (the total content of waste paper, polymers, textiles, wood, multilayer packaging, leather, rubber, footwear) amounts to about 40%. It was found that MSW calorific value depends on fraction size, since screening (over 50 mm) is characterized by high moisture and low content of valuable components, compared to MSW greater than 50 mm in size. Pre-processing and treatment of MSW allows solid recovered fuel (SRF) to be obtained with a calorific value similar to brown coal. The energy balance of the process allows the conclusion that 33.8% of initial MSW energy potential is concentrated in residues from the sorting process, since it has a relatively low calorific value of 4.8 MJ/kg, but a high mass fraction of 47.9%. In the process of MSW treatment and solid fuel production, most of the chlorine and mercury (80% and 55% respectively) is removed by the rest of the sorting process. The data obtained in the study can be used in selecting the optimal option for energy recovery from MSW. Β© 2019 WIT PressACKNOWLEDGEMENT The work was supported by Act 211 Government of the Russian Federation, contract β 02.A 03.21.0006
Transmission of the Female Image in the Β«Kurgan and Kurgan InhabitantsΒ» City Newspaper in the 1990s and 2010s: a REgional Aspect
ΠΠ΅Π½Π΄Π΅ΡΠ½ΡΠ΅ ΠΎΠ±ΡΠ°Π·Ρ (Π² ΡΠ°ΡΡΠ½ΠΎΡΡΠΈ, ΡΠ΅ΠΌΠΈΠ½Π½ΡΠ΅) ΡΠ²Π»ΡΡΡΡΡ ΠΎΠ΄Π½ΠΎΠΉ ΠΈΠ· Π²Π°ΠΆΠ½Π΅ΠΉΡΠΈΡ
ΡΠΎΡΡΠ°Π²Π»ΡΡΡΠΈΡ
ΠΊΠΎΠΌΠΌΡΠ½ΠΈΠΊΠ°ΡΠΈΠ²Π½ΠΎ-ΠΊΡΠ»ΡΡΡΡΠ½ΠΎΠΉ ΠΏΠ°ΠΌΡΡΠΈ Π½Π°ΡΠ΅Π»Π΅Π½ΠΈΡ. ΠΡΠΈ ΡΡΠΎΠΌ Π½Π° ΡΠ΅Π³ΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠΌ ΡΡΠΎΠ²Π½Π΅ ΠΎΠ½ΠΈ ΠΌΠΎΠ³ΡΡ ΠΈΠΌΠ΅ΡΡ ΠΎΡΠΎΠ±ΡΠ΅ ΡΠ΅ΡΡΡ, ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½Π½ΡΠ΅ Π³Π΅ΠΎΠ³ΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΠ΅ΠΌ, ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π½ΡΠΌΠΈ ΡΠΎΡΠΈΠ°Π»ΡΠ½ΡΠΌΠΈ ΡΠ΅Π½Π΄Π΅Π½ΡΠΈΡΠΌΠΈ ΠΈ ΡΡΠ°Π΄ΠΈΡΠΈΡΠΌΠΈ. ΠΠ°Π½Π½ΡΠ΅ ΡΠ΅ΡΡΡ ΠΌΠΎΠ³ΡΡ ΠΌΠ΅Π½ΡΡΡΡΡ Ρ ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ΠΌ Π²ΡΠ΅ΠΌΠ΅Π½ΠΈ, ΡΠ°ΠΊ ΠΊΠ°ΠΊ Π² ΡΠ°Π·Π½ΡΡ
ΡΠΎΡΠΈΠ°Π»ΡΠ½ΠΎ-ΡΠΊΠΎΠ½ΠΎΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΡΠ»ΠΎΠ²ΠΈΡΡ
Π°ΠΊΡΡΠ°Π»ΠΈΠ·ΠΈΡΡΡΡΡΡ ΡΠ°Π·Π»ΠΈΡΠ½ΡΠ΅ Π³Π΅Π½Π΄Π΅ΡΠ½ΡΠ΅ ΠΊΠ°ΡΠ΅ΡΡΠ²Π°. ΠΡΠΈ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΠΌΠΎΠΆΠ½ΠΎ ΠΎΡΡΠ»Π΅Π΄ΠΈΡΡ ΠΏΠΎ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Π°ΠΌ ΡΠ΅Π³ΠΈΠΎΠ½Π°Π»ΡΠ½ΡΡ
Π‘ΠΠ. ΠΠ±ΡΠ΅ΠΊΡΠΎΠΌ Π΄Π°Π½Π½ΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΡΠ°Π» ΠΎΠ±ΡΠ°Π· ΠΆΠ΅Π½ΡΠΈΠ½Ρ, Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠ½ΡΠΉ Π΄Π»Ρ Π½Π°ΡΠ΅Π»Π΅Π½ΠΈΡ ΠΡΡΠ³Π°Π½ΡΠΊΠΎΠΉ ΠΎΠ±Π»Π°ΡΡΠΈ Π² Π½Π°ΡΠ°Π»Π΅ 1990-Ρ
ΠΈ Π² ΠΊΠΎΠ½ΡΠ΅ 2010-Ρ
Π³ΠΎΠ΄ΠΎΠ², Π° ΠΏΡΠ΅Π΄ΠΌΠ΅ΡΠΎΠΌ β ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΈ Π² Π³ΠΎΡΠΎΠ΄ΡΠΊΠΎΠΉ Π³Π°Π·Π΅ΡΠ΅ Β«ΠΡΡΠ³Π°Π½ ΠΈ ΠΊΡΡΠ³Π°Π½ΡΡΒ» Π² ΡΠΊΠ°Π·Π°Π½Π½ΡΠ΅ ΠΏΠ΅ΡΠΈΠΎΠ΄Ρ, ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΠ΅ ΠΆΠ΅Π½ΡΠΊΠΈΠ΅ ΠΎΠ±ΡΠ°Π·Ρ. Π Ρ
ΠΎΠ΄Π΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ, ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π½ΠΎΠ³ΠΎ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΊΠΎΠ½ΡΠ΅Π½Ρ-Π°Π½Π°Π»ΠΈΠ·Π° ΠΈ Π΄ΠΈΠ°Ρ
ΡΠΎΠ½Π½ΠΎΠ³ΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ, ΠΌΡ Π²ΡΡΠ²ΠΈΠ»ΠΈ, ΡΡΠΎ ΡΡΠ°Π΄ΠΈΡΠΈΠΎΠ½Π½ΠΎΠΉ Π΄Π»Ρ ΠΡΡΠ³Π°Π½ΡΠΊΠΎΠΉ ΠΎΠ±Π»Π°ΡΡΠΈ ΠΊΠ°ΠΊ ΡΠ΅Π»ΡΡΠΊΠΎΡ
ΠΎΠ·ΡΠΉΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ ΠΈ ΠΏΡΠΎΠΌΡΡΠ»Π΅Π½Π½ΠΎΠ³ΠΎ ΡΠ΅Π³ΠΈΠΎΠ½Π° ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΡΠ°Π½ΡΠ»ΡΡΠΈΡ ΠΆΠ΅Π½ΡΠΊΠΈΡ
ΠΎΠ±ΡΠ°Π·ΠΎΠ², Π΄Π΅ΡΠ΅ΡΠΌΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΡΠ΅ΡΠ΅Π· Π²ΡΠΏΠΎΠ»Π½Π΅Π½ΠΈΠ΅ ΡΠ΅Ρ
ΠΈΠ»ΠΈ ΠΈΠ½ΡΡ
ΠΏΡΠΎΡΠ΅ΡΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΡ
ΡΡΠ½ΠΊΡΠΈΠΉ Π³Π΅ΡΠΎΠΈΠ½ΡΠΌΠΈ ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΉ; Π΄ΡΡΠ³ΠΈΠ΅ ΠΎΠ±ΡΠ°Π·Π½ΡΠ΅ ΡΠ΅Π½Π΄Π΅Π½ΡΠΈΠΈ (Π½Π°ΠΏΡΠΈΠΌΠ΅Ρ, ΡΡΠΎΡΠΈΠ·Π°ΡΠΈΡ ΠΆΠ΅Π½ΡΠΈΠ½Ρ ΠΈΠ»ΠΈ ΠΏΠΎΡΠ²Π»Π΅Π½ΠΈΠ΅ Π±ΠΈΠ·Π½Π΅Ρ-Π»Π΅Π΄ΠΈ Π² 1990-Π΅ Π³Π³. ΠΈ ΡΠΎΡΡ ΠΆΠ΅Π½ΡΠΊΠΎΠΉ ΠΏΡΠ΅ΡΡΡΠΏΠ½ΠΎΡΡΠΈ Π² 2010-Π΅ Π³Π³.) ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½Ρ ΠΊΠΎΠ½ΠΊΡΠ΅ΡΠ½ΡΠΌΠΈ ΡΠΎΡΠΈΠ°Π»ΡΠ½ΠΎ-ΠΈΡΡΠΎΡΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΡΡΠ»ΠΎΠ²ΠΈΡΠΌΠΈ. ΠΡΠΈ ΡΡΠΎΠΌ Π½Π΅ΠΈΠ·ΠΌΠ΅Π½Π½ΡΠΌ ΠΎΡΡΠ°Π΅ΡΡΡ ΠΏΡΠ΅ΠΎΠ±Π»Π°Π΄Π°Π½ΠΈΠ΅ ΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΡΡ
ΠΎΠ±ΡΠ°Π·ΠΎΠ² Π½Π°Π΄ ΠΎΡΡΠΈΡΠ°ΡΠ΅Π»ΡΠ½ΡΠΌΠΈ ΠΈ ΠΌΠ°ΡΠΊΡΠ»ΠΈΠ½Π½ΡΡ
Π½Π°Π΄ ΡΠ΅ΠΌΠΈΠ½Π½ΡΠΌΠΈ, ΡΡΠΎ ΠΏΠΎΠ΄ΡΠ΅ΡΠΊΠΈΠ²Π°Π΅Ρ ΠΏΠ°ΡΡΠΈΠ°ΡΡ
Π°Π»ΡΠ½ΡΠΉ Ρ
Π°ΡΠ°ΠΊΡΠ΅Ρ ΠΎΠ±ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ
ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠΉ Π² ΡΠ΅Π³ΠΈΠΎΠ½Π΅.Gender images (in particular, feminine ones) are one of the most important components of the communicative and cultural memory of the population. At the same time, on the regional level they may have special features, caused by the geographical location, social trends and traditions. These features can change over the time, as in different social and economic conditions various gender qualities are actualized. These features are reflected in the regional media. The object of this study was the female image, which was typical for the population of the Kurgan region in the early 1990s and late 2010s, the subject was publications with female images in the βKurgan and Kurgan inhabitantsβ city newspaper in these periods. By the methods of content analysis and diachronic comparison we found that for the agricultural and industrial Kurgan region the transmission of female images determined through the heroines of publications professional functions is considered traditional; other tendencies (for example, erotization of women or the appearance of a business woman in the 1990s and growth of female criminality in the 2010s) are caused by specific social and historical conditions. At the same time the positive images prevail over negative, and masculine images prevail over feminine, which emphasizes the patriarchal nature of social relations in the region
Thermal treatment and disposal of carbon fiber reinforced composites
From the point of view of rational resource management polymer composites treatment is at the same time environmental pollution prevention during their burial and the opportunity to recover valuable resources β fibers and other fillers. This article presents an analysis of the various processes of thermal utilization of carbon fiber reinforced composites. Incineration technologies in specialized installations and in cement production kilns allow to get rid of the significant amounts of a wide variety of wastes, including polymer composites, with useful energy potential, therefore, it is a popular way to solve the problem of such materials in a place where their disposal is prohibited. However, in this case, valuable resources, like carbon fiber, which production is very energy-consuming, are lost. Therefore, the priority is technologies that allow recycled carbon fiber recovery. One of the most widely used methods that meet most requirements is pyrolysis; therefore, investigation of optimal conditions for this process is an urgent task for research
Influence of postcoid syndrome on the quality of training of students of the medical-preventive faculty
The article presents the influence of postcovid syndrome on the quality of education of students of the medical-prophylactic faculty.Π ΡΡΠ°ΡΡΠ΅ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½ΠΎ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΠΏΠΎΡΡΠΊΠΎΠ²ΠΈΠ΄Π½ΠΎΠ³ΠΎ ΡΠΈΠ½Π΄ΡΠΎΠΌΠ° Π½Π° ΠΊΠ°ΡΠ΅ΡΡΠ²ΠΎ ΠΎΠ±ΡΡΠ΅Π½ΠΈΡ ΡΡΡΠ΄Π΅Π½ΡΠΎΠ² Π»Π΅ΡΠ΅Π±Π½ΠΎ-ΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠ°ΠΊΡΠ»ΡΡΠ΅ΡΠ°
Assessment of the quality of education of graduates of medical-prophylactic faculty
This article presents and analyzes the survey data on the quality of education of graduates of the treatment-and-prophylactic faculty, which are necessary to improve the learning process.Π Π΄Π°Π½Π½ΠΎΠΉ ΡΡΠ°ΡΡΠ΅ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Ρ ΠΈ ΠΏΡΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Ρ Π΄Π°Π½Π½ΡΠ΅ ΠΎΠΏΡΠΎΡΠ° ΠΏΠΎ ΠΊΠ°ΡΠ΅ΡΡΠ²Ρ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ Π²ΡΠΏΡΡΠΊΠ½ΠΈΠΊΠΎΠ² Π»Π΅ΡΠ΅Π±Π½ΠΎ-ΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠ°ΠΊΡΠ»ΡΡΠ΅ΡΠ°, Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΡΠ΅ Π΄Π»Ρ ΡΠ»ΡΡΡΠ΅Π½ΠΈΡ ΠΏΡΠΎΡΠ΅ΡΡΠ° ΠΎΠ±ΡΡΠ΅Π½ΠΈΡ
Π ΠΏΡΠΎΠ±Π»Π΅ΠΌΠ΅ Π²ΡΠ±ΠΎΡΠ° ΡΠ°ΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΡ Π²Π°ΡΠΈΠ°Π½ΡΠΎΠ² Π΄ΠΈΠ²Π΅ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ½ΠΎΠΉ ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΈ
The necessity of using of heuristic methods take account of uncertainties in each of the transport company activities when choosing a rational variant of the vector control of dynamic processes related to performance indicators, built on the basis of poly-criteria evaluation.Π ΡΡΠ°ΡΡΠ΅ ΠΎΠ±ΠΎΡΠ½ΠΎΠ²ΡΠ²Π°Π΅ΡΡΡ Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎΡΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ ΡΠ²ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΡΡΠ΅ΡΠ° Π½Π΅ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π½ΠΎΡΡΠ΅ΠΉ Π² ΠΊΠ°ΠΆΠ΄ΠΎΠΌ ΠΈΠ· Π²ΠΈΠ΄ΠΎΠ² Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ½ΠΎΠΉ ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΈ ΠΏΡΠΈ Π²ΡΠ±ΠΎΡΠ΅ ΡΠ°ΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ Π²Π°ΡΠΈΠ°Π½ΡΠ° Π²Π΅ΠΊΡΠΎΡΠ° ΡΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡ Π΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΠΏΡΠΎΡΠ΅ΡΡΠ°ΠΌΠΈ Ρ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠΌΠΈ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ, ΠΏΠΎΡΡΡΠΎΠ΅Π½Π½ΡΠΌΠΈ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΏΠΎΠ»ΠΈΠΊΡΠΈΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΡΡ
ΠΎΡΠ΅Π½ΠΎΠΊ
Mechanisms of metformin action
The article discusses modern hypotheses regarding the mechanisms of metformin action. Metformin has been shown to affect not only carbohydrate metabolism, but also many other cell functionsΠ ΡΡΠ°ΡΡΠ΅ ΡΠ°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°ΡΡΡΡ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΠ΅ Π³ΠΈΠΏΠΎΡΠ΅Π·Ρ ΠΎ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΠ°Ρ
Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΌΠ΅ΡΡΠΎΡΠΌΠΈΠ½Π°. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΠΌΠ΅ΡΡΠΎΡΠΌΠΈΠ½ Π²Π»ΠΈΡΠ΅Ρ Π½Π΅ ΡΠΎΠ»ΡΠΊΠΎ Π½Π° ΡΠ³Π»Π΅Π²ΠΎΠ΄Π½ΡΠΉ ΠΎΠ±ΠΌΠ΅Π½, Π½ΠΎ ΡΠ°ΠΊΠΆΠ΅ ΠΈ Π½Π° ΠΌΠ½ΠΎΠ³ΠΈΠ΅ Π΄ΡΡΠ³ΠΈΠ΅ ΡΡΠ½ΠΊΡΠΈΠΈ ΠΊΠ»Π΅ΡΠΎΠΊ
Efficiency results of the project to attract applicants to the medical-preventive faculty
The article describes the result of organizing medical quests and quizzes for students from specialized biomedical classes by students of the Ural State Medical University to increase the motivation for choosing the profession of a medical doctor.Π ΡΡΠ°ΡΡΠ΅ ΠΎΠΏΠΈΡΠ°Π½Ρ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΈΡ
ΠΊΠ²Π΅ΡΡΠΎΠ² ΠΈ ΠΊΠ²ΠΈΠ·ΠΎΠ² Π΄Π»Ρ Π°Π±ΠΈΡΡΡΠΈΠ΅Π½ΡΠΎΠ² ΠΈΠ· ΠΏΡΠΎΡΠΈΠ»ΡΠ½ΡΡ
ΠΌΠ΅Π΄ΠΈΠΊΠΎ-Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΊΠ»Π°ΡΡΠΎΠ² ΡΡΡΠ΄Π΅Π½ΡΠ°ΠΌΠΈ Π£ΡΠ°Π»ΡΡΠΊΠΎΠ³ΠΎ Π³ΠΎΡΡΠ΄Π°ΡΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΎΠ³ΠΎ ΡΠ½ΠΈΠ²Π΅ΡΡΠΈΡΠ΅ΡΠ° Π΄Π»Ρ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΡ ΠΌΠΎΡΠΈΠ²Π°ΡΠΈΠΈ Π²ΡΠ±ΠΎΡΠ° ΠΏΡΠΎΡΠ΅ΡΡΠΈΠΈ Π²ΡΠ°ΡΠ°-Π»Π΅ΡΠ΅Π±Π½ΠΈΠΊΠ°
Changes associated with Ebola virus adaptation to novel species.
Motivation: Ebola viruses are not pathogenic but can be adapted to replicate and cause disease in rodents. Here, we used a structural bioinformatics approach to analyze the mutations associated with Ebola virus adaptation to rodents to elucidate the determinants of host-specific Ebola virus pathogenicity.
Results: We identified 33 different mutations associated with Ebola virus adaptation to rodents in the proteins GP, NP, L, VP24, and VP35. Only VP24, GP and NP were consistently found mutated in rodent-adapted Ebola virus strains. Fewer than five mutations in these genes seem to be required for the adaptation of Ebola viruses to a new species. The role of mutations in GP and NP is not clear. However, three VP24 mutations located in the protein interface with karyopherin 5 may enable VP24 to inhibit karyopherins and subsequently the host interferon response. Three further VP24 mutations change hydrogen bonding or cause conformational changes. Hence, there is evidence that few mutations including crucial mutations in VP24 enable Ebola virus adaptation to new hosts. Since Reston virus, the only non-human pathogenic Ebolavirus species circulates in pigs in Asia, this raises concerns that few mutations may result in novel human pathogenic Ebolaviruses