9 research outputs found
Current Understanding of Central Nervous System Drainage Systems: Implications in the Context of Neurodegenerative Diseases
No full textAnterior cingulate GABA levels predict whole-brain cerebral blood flow
No full textThis study examined the relationship of γ-aminobutyric acid (GABA) and glutamate levels from the anterior and posterior cingulates (AC and PC) with cerebral blood flow (CBF) at rest. (1)H magnetic resonance spectroscopy measurements in the AC and PC and pseudo-continuous arterial spin labeling data were acquired from 10 healthy controls. GABA levels from the AC were strongly inversely correlated with global (whole-brain) CBF (r =−0.91, p=0.0015). GABA levels from the PC and glutamate levels from both regions were not significantly correlated with CBF. We hypothesize that GABA-mediated inhibition of AC activation of the locus coeruleus-norepinephrine pathway may influence global CBF
Sleep Disruption Exacerbates and Prolongs the Inflammatory Response to Traumatic Brain Injury
No full textNeuroinflammation is able to downregulate cytochrome P450 epoxygenases 2J3 and 2C11 in the rat brain
No full textPreclinical Study of the Pharmacokinetics of p75ECD-Fc, a Novel Human Recombinant Protein for Treatment of Alzheimer’s Disease, in Sprague Dawley Rats
No full textEffects of corticosterone and testosterone on pituitary gonadotropin content, secretion, bioactivity and messenger RNA levels in the presence or absence of GnRH in male rats
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