Slow stable hybrid stars: a new class of compact stars that fulfills all current observational constraints

We study hybrid stars considering the effects on stellar stability of the hadron-quark conversion speed at the sharp interface. The equation of state is constructed by combining a model-agnostic hadronic description with a constant speed of sound model for quark matter. We show that current LIGO/Virgo, NICER, low-density nuclear and high-density perturbative QCD constraints can be satisfied in two scenarios with low and high transition pressures. If the conversion speed is slow, a new class of hybrid objects is possible and very stiff hadronic equations of state cannot be discarded.Comment: 7 pages, 4 figure

Magnetized hybrid stars: Effects of slow and rapid phase transitions at the quark-hadron interface

We study the influence of strong magnetic fields in hybrid stars, composed by hadrons and a pure quark matter core, and analyse their structure and stability as well as some possible evolution channels due to the magnetic field decay. Using an ad hoc parametrization of the magnetic field strength and taking into account Landau-quantization effects in matter, we calculate hybrid magnetized equations of state and some associated quantities, such as particle abundances and matter magnetization, for different sets of parameters and different magnetic field strengths. Moreover, we compute the magnetized stable stellar configurations, the mass versus radius and the gravitational mass versus central energy density relationships, the gravitational mass versus baryon mass diagram, and the tidal deformability. Our results are in agreement with both, the∼ 2M pulsars and the data obtained from GW170817. In addition, we study the stability of stellar configurations assuming that slow and rapid phase transitions occur at the sharp hadron-quark interface.We find that, unlike in the rapid transition scenario, where ∂M/∂c < 0 is a sufficient condition for instability, in the slow transition scenario there exists a connected extended stable branch beyond the maximum mass star, for which ∂M/∂c < 0. Finally, analysing the gravitational mass versus baryon mass relationship, we have calculated the energy released in transitions between stable stellar configurations. We find that the inclusion of the magnetic field and the existence of new stable branches allows the possibility of new channels of transitions that fulfil the energy requirements to explain gamma-ray bursts.Fil: Mariani, Mauro. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Orsaria, Milva Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas; ArgentinaFil: Ranea Sandoval, Ignacio Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas; ArgentinaFil: Lugones, Germán. Universidad Federal Do Abc; Brasi

Electronic Computer-Based Model of Combined Ventilation Using a New Medical Device

Introduction The increased demand for mechanical ventilation caused by the SARS-CoV-2 pandemic could generate a critical situation where patients may lose access to mechanical ventilators. Combined ventilation, in which two patients are ventilated simultaneously but independently with a single ventilator has been proposed as a life-saving bridge while waiting for new ventilators availability. New devices have emerged to facilitate this task and allow individualization of ventilatory parameters in combined ventilation. In this work we run computer-based electrical simulations of combined ventilation. We introduce an electrical model of a proposed mechanical device which is designed to individualize ventilatory parameters, and tested it under different circumstances. Materials and Methods With an electronic circuit simulator applet, an electrical model of combined ventilation is created using resistor-capacitor circuits. A device is added to the electrical model which is capable of individualizing the ventilatory parameters of two patients connected to the same ventilator. Through computational simulation, the model is tested in different scenarios with the aim of achieving adequate ventilation of two subjects under different circumstances: 1) two identical subjects; 2) two subjects with the same size but different lung compliance; and 3) two subjects with different sizes and compliances. The goal is to achieve the established charge per unit of size on each capacitor under different levels of end-expiratory voltage (as an end-expiratory pressure analog). Data collected included capacitor charge, voltage, and charge normalized to the weight of the simulated patient. Results Simulations show that it is possible to provide the proper charge to each capacitor under different circumstances using an array of electrical components as equivalents to a proposed mechanical device for combined ventilation. If the pair of connected capacitors have different capacitances, adjustments must be made to the source voltage and/or the resistance of the device to provide the appropriate charge for each capacitor under initial conditions. In pressure control simulation, increasing the end-expiratory voltage on one capacitor requires increasing the source voltage and the device resistance associated with the other simulated patient. On the other hand, in the volume control simulation, it is only required to intervene in the device resistance. Conclusions Under simulated conditions, this electrical model allows individualization of combined mechanical ventilation.Facultad de Ingenierí

Actualización ecocardiográfica en canal auriculoventricular disbalanceado derecho

Unbalanced atrioventricular canal can be a challenging pathology when making a surgical decision, especially in patients with moderate left ventricular hypoplasia. Therefore, the approach is complex and must be fully evaluated and possibly with a multi-imaging modality. The aim of this paper is present an echocardiographic update for evaluation of right unbalanced atrioventricular septal defect, as a useful tool for cardiologist in making surgical decisions in front of this complex pathology.El canal atrioventricular disbalanceado puede ser una patología desafiante al momento de tomar una decisión quirúrgica, especialmente en los pacientes con moderada hipoplasia del ventrículo izquierdo. Es por ello que su abordaje es complejo y deben evaluarse anatómica y hemodinámicamente en forma completa y posiblemente con una modalidad multi-imagen. El presente trabajo brinda una actualización ecocardiográfica para la valoración del canal atrioventricular disbalanceado derecho, con el objetivo de dar al cardiólogo una herramienta para la toma de decisiones quirúrgicas frente a esta compleja patología

A New Medical Device to Provide Independent Ventilation to Two Subjects Using a Single Ventilator: Evaluation in Lung-Healthy Pigs

Background: The global crisis situation caused by SARS-CoV-2 has created an explosive demand for ventilators, which cannot be met even in developed countries Designing a simple and inexpensive device with the ability to increase the number of patients that can be connected to existing ventilators would have a major impact on the number of lives that could be saved We conducted a study to determine whether two pigs with significant differences in size and weight could be ventilated simultaneously using a single ventilator connected to a new medical device called DuplicARⓇ. Methods: Six pigs (median weight 12 kg, range 9-25 kg) were connected in pairs to a single ventilator using the new device for 6 hours Both the ventilator and the device were manipulated throughout the experiment according to the needs of each animal Tidal volume and positive end-expiratory pressure were individually controlled with the device Primary and secondary outcome variables were defined to assess ventilation and hemodynamics in all animals throughout the experiment. Results: Median difference in weight between the animals of each pair was 67% (range: 11-108) All animals could be successfully oxygenated and ventilated for 6 hours through manipulation of the ventilator and the DuplicARⓇ device, despite significant discrepancies in body size and weight Mean PaCO(2) in arterial blood was 42 1 ± 4 4 mmHg, mean PaO(2) was 162 8 ± 46 8 mmHg, and mean oxygen saturation was 98 ± 1 3% End-tidal CO(2) values showed no statistically significant difference among subjects of each pair Mean difference in arterial PaCO(2) measured at the same time in both animals of each pair was 4 8 ± 3 mmHg, reflecting the ability of the device to ventilate each animal according to its particular requirements Independent management of PEEP was achieved by manipulation of the device controllers. Conclusion: It is possible to ventilate two lung-healthy animals with a single ventilator according to each one's needs through manipulation of both the ventilator and the DuplicARⓇ device This gives this device the potential to expand local ventilators surge capacity during disasters or pandemics until emergency supplies can be delivered from central stockpilesFacultad de Ciencias Veterinaria

Long-Term Effectiveness of a Smartphone App and a Smart Band on Arterial Stiffness and Central Hemodynamic Parameters in a Population with Overweight and Obesity (Evident 3 Study): Randomised Controlled Trial

Background: mHealth technologies could help to improve cardiovascular health; however, their effect on arterial stiffness and hemodynamic parameters has not been explored to date. Objective: To evaluate the effect of a mHealth intervention, at 3 and 12 months, on arterial stiffness and central hemodynamic parameters in a sedentary population with overweight and obesity. Methods: Randomised controlled clinical trial (Evident 3 study). 253 subjects were included: 127 in the intervention group (IG) and 126 in the control group (CG). The IG subjects were briefed on the use of the Evident 3 app and a smart band (Mi Band 2, Xiaomi) for 3 months to promote healthy lifestyles. All measurements were recorded in the baseline visit and at 3 and 12 months. The carotid-femoral pulse wave velocity (cfPWV) and the central hemodynamic parameters were measured using a SphigmoCor System® device, whereas the brachial-ankle pulse wave velocity (baPWV) and the Cardio Ankle Vascular Index (CAVI) were measured using a VaSera VS-2000® device. Results: Of the 253 subjects who attended the initial visit, 237 (93.7%) completed the visit at 3 months of the intervention, and 217 (85.3%) completed the visit at 12 months of the intervention. At 12 months, IG showed a decrease in peripheral augmentation index (PAIx) (−3.60; 95% CI −7.22 to −0.00) and ejection duration (ED) (−0.82; 95% CI −1.36 to −0.27), and an increase in subendocardial viability ratio (SEVR) (5.31; 95% CI 1.18 to 9.44). In CG, cfPWV decreased at 3 months (−0.28 m/s; 95% CI −0.54 to −0.02) and at 12 months (−0.30 m/s, 95% CI −0.54 to −0.05), central diastolic pressure (cDBP) decreased at 12 months (−1.64 mm/Hg; 95% CI −3.19 to −0.10). When comparing the groups we found no differences between any variables analyzed. Conclusions: In sedentary adults with overweight or obesity, the multicomponent intervention (Smartphone app and an activity-tracking band) for 3 months did not modify arterial stiffness or the central hemodynamic parameters, with respect to the control group. However, at 12 months, CG presented a decrease of cfPWV and cDBP, whereas IG showed a decrease of PAIx and ED and an increase of SEVR

The relationship of the atlantic diet with cardiovascular risk factors and markers of arterial stiffness in adults without cardiovascular disease

[EN]Abstract: Background: Studying the adherence of the population to the Atlantic Diet (AD) could be simplified by an easy and quickly applied dietary index. The aim of this study is to analyse the relationship of an index measuring compliance with recommendations regarding the Atlantic diet and physical activity with cardiovascular disease risk factors, cardiovascular risk factors, obesity indexes and arterial stiffness markers. Methods: We included 791 individuals from the EVIDENT study (lifestyles and arterial ageing), (52.3 ± 12 years, 61.7% women) without cardiovascular disease. Compliance with recommendations on AD was collected through the responses to a food frequency questionnaire, while physical activity was measured by accelerometer. The number of recommendations being met was estimated using a global scale between 0 and 14 points (a higher score representing greater adherence). Blood pressure, plasma lipid and glucose values and obesity rates were measured. Cardiovascular risk was estimated with the Framingham equation. Results: In the overall sample, 184 individuals (23.3%) scored between 0–3 on the 14-point index we created, 308 (38.9%) between 4 and 5 points, and 299 (37.8%) 6 or more points. The results of multivariate analysis yield a common tendency in which the group with an adherence score of at least 6 points shows lower figures for total cholesterol (p = 0.007) and triglycerides (p = 0.002). Similarly, overall cardiovascular risk in this group is the lowest (p < 0.001), as is pulse wave velocity (p = 0.050) and the mean values of the obesity indexes studied (p < 0.05 in all cases). Conclusion: The rate of compliance with the Atlantic diet and physical activity shows that greater adherence to these recommendations is linked to lower cardiovascular risk, lower total cholesterol and triglycerides, lower rates of obesity and lower pulse wave velocity values.This study was funded by the Spanish Ministry of Science and Innovation (MICINN) and the Carlos III Health Institute/European Regional Development Fund (ERDF) (FIS: PI13/00618, PI13/01526, PI13/00058, PI13/01635, PI13/02528, PI12/01474; RETICS: RD12/0005, RD16/0007), the Regional Health Administration of Castilla and León (GRS 1191/B/15, GRS 909/B/14, GRS 770/B/13) and the Infosalud Foundation. None of the funders were involved in the design, implementation, analysis or interpretation of the data

Effectiveness of a multiple health-behaviour-change intervention in increasing adherence to the Mediterranean Diet in adults (EIRA study): a randomized controlled hybrid trial

Background: The present study describes the efectiveness of a complex intervention that addresses multiple lifestyles to promote healthy behaviours in increasing adherence to the Mediterranean diet (MD). Methods: Cluster-randomised, hybrid clinical trial controlled with two parallel groups. The study was carried out in 26 primary Spanish healthcare centres. People aged 45–75 years who presented at least two of the following crite‑ ria were included: smoker, low adherence to the MD or insufcient level of physical activity. The intervention group (IG) had three diferent levels of action: individual, group, and community, with the aim of acting on the behaviours related to smoking, diet and physical activity at the same time. The individual intervention included personalised recommendations and agreements on the objectives to attain. Group sessions were adapted to the context of each healthcare centre. The community intervention was focused on the social prescription of resources and activities performed in the environment of the community of each healthcare centre. Control group (CG) received brief advice given in the usual visits to the doctor’s ofce. The primary outcome was the change, after 12 months, in the number of participants in each group with good adherence to the MD pattern. Secondary outcomes included the change in the total score of the MD adherence score (MEDAS) and the change in some cardiovascular risk factors. Results: Three thousand sixty-two participants were included (IG=1,481, CG=1,581). Low adherence to the MD was present in 1,384 (93.5%) participants, of whom 1,233 initiated the intervention and conducted at least one individual visit with a healthcare professional. A greater increase (13.7%; 95% CI, 9.9–17.5; p<0.001) was obtained by IG in the number of participants who reached 9 points or more (good adherence) in the MEDAS at the fnal visit. Moreover, the efect attributable to the intervention obtained a greater increase (0.50 points; 95% CI, 0.35 to 0.66; p<0.001) in IG. Conclusions: A complex intervention modelled and carried out by primary healthcare professionals, within a real clinical healthcare context, achieved a global increase in the adherence to the MD compared to the brief advice