Hamburg's warehouse district in Martin tom Dieck's "hundert Ansichten der Speicherstadt"

Most texts that deal with Martin tom Dieck’s black-and-white comic "hundert Ansichten der Speicherstadt" (Zürich: Arrache Cœur, 1997, French title: Vortex) claim that it depicts the eponymous warehouse district (Speicherstadt) in Hamburg. As this paper shows, this claim is inaccurate: although the architecture in tom Dieck’s drawings clearly refers to buildings in the warehouse district, the differences in the details are so obvious, that to speak of a straightforward depiction of the Speicherstadt is oversimplifying. After a brief comparison with Christoph Schäfer’s picture book "Die Stadt ist unsere Fabrik" (Leipzig: Spector Books, 2010), the paper concludes with a discussion of the depiction of urban environments in general and in tom Dieck's book in particular

Art History, Japanese Popular Culture and the Tokyo 2020 Olympics

Spectators of the 2020/21 Olympic Games were frequently confronted with references to Japanese popular culture, particularly at the opening and closing ceremonies. However, these references to anime, manga, video games and other visual media were often so subtle that they were easy to miss unless pointed out and explained by television commentators. Art historians should not shy away from engaging with such objects and images

From Entity Description to Semantic Analysis: The Case of Theodor Fontane’s Notebooks

Within the last few decades, TEI has become a major instrument for philologists in the digital age, particularly since a set of mechanisms has recently been incorporated which facilitates the encoding of genetic editions. Editors use the XML syntax while aiming to preserve the quantity and quality of old books and manuscripts and publish many more of them online, mostly under free licenses. Scholars all over the world are now able to use huge datasets for further research. There are now many digital editions available, but only a few tools to analyze them. This article explores how web technologies (XML and related technologies as well as JavaScript) can be used to enrich the forthcoming edition of Theodor Fontane’s notebooks with data-driven visualizations of named entities and how at the same time applications can be built on these visualizations which are reusable for other edition projects in the TEI world. Because of the density and historical scope of references to named entities and the variety of entity types, Fontane’s notebooks lend themselves to advanced methods of semantic analysis

Akira and Ghost in the Shell (Case Study)

This chapter discusses the animated films, Katsuhiro Ōtomo’s Akira (1988) and Mamoru Oshii’s Ghost in the Shell (1995), in relation to cyberpunk

A method for automatically extracting infectious disease-related primers and probes from the literature

BACKGROUND: Primer and probe sequences are the main components of nucleic acid-based detection systems. Biologists use primers and probes for different tasks, some related to the diagnosis and prescription of infectious diseases. The biological literature is the main information source for empirically validated primer and probe sequences. Therefore, it is becoming increasingly important for researchers to navigate this important information. In this paper, we present a four-phase method for extracting and annotating primer/probe sequences from the literature. These phases are: (1) convert each document into a tree of paper sections, (2) detect the candidate sequences using a set of finite state machine-based recognizers, (3) refine problem sequences using a rule-based expert system, and (4) annotate the extracted sequences with their related organism/gene information. RESULTS: We tested our approach using a test set composed of 297 manuscripts. The extracted sequences and their organism/gene annotations were manually evaluated by a panel of molecular biologists. The results of the evaluation show that our approach is suitable for automatically extracting DNA sequences, achieving precision/recall rates of 97.98% and 95.77%, respectively. In addition, 76.66% of the detected sequences were correctly annotated with their organism name. The system also provided correct gene-related information for 46.18% of the sequences assigned a correct organism name. CONCLUSIONS: We believe that the proposed method can facilitate routine tasks for biomedical researchers using molecular methods to diagnose and prescribe different infectious diseases. In addition, the proposed method can be expanded to detect and extract other biological sequences from the literature. The extracted information can also be used to readily update available primer/probe databases or to create new databases from scratch.The present work has been funded, in part, by the European Commission through the ACGT integrated project (FP6-2005-IST-026996) and the ACTION-Grid support action (FP7-ICT-2007-2-224176), the Spanish Ministry of Science and Innovation through the OntoMineBase project (ref. TSI2006-13021-C02-01), the ImGraSec project (ref. TIN2007-61768), FIS/AES PS09/00069 and COMBIOMED-RETICS, and the Comunidad de Madrid, Spain.S

Evaluation of chronic toxicity and carcinogenesis in rodents with the synthetic analgesic, tilidine fumarate

The carcinogenic potential of tilidine fumarate, a synthetic analgesic, was studied for 80 and 104 weeks in mice and rats, respectively. Groups of 50 albino CF1 mice and 65 albino Wistar rats of each sex received tilidine fumarate-lactose blend (1:1) at doses of 100, 40 and 16 mg/kg. The control groups consisted of 100 mice and 115 rats of each sex and received the lactose vehicle only. Treatment-related non-neoplastic changes consisted of reversible, increased cytoplasmic eosinophilia of hepatocytes in high and mid dose rats corresponding to areas of proliferating smooth endoplasmic reticulum; and an increased in high dose rats of proliferative or cystic lesions of the biliary epithelium. Adequate survival rates allowed stringent statistical analysis of neoplasia. Tilidine did not evoke increased tumor incidences or changes in teh average latency or onset of tumors in either species. The most frequent tumors represented spontaneous neoplasia characteristic of historical background incidence in these strains. In mice, the only statistically significant (P P < 0.01) decreased incidences of mammary fibroadenoma and pituitary adenoma. From these data, it was concluded that the synthetic analgesic tilidine does not possess tumorigenic potential in rodents.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/26174/1/0000253.pd

Nanoinformatics: a new area of research in nanomedicine

Over a decade ago, nanotechnologists began research on applications of nanomaterials for medicine. This research has revealed a wide range of different challenges, as well as many opportunities. Some of these challenges are strongly related to informatics issues, dealing, for instance, with the management and integration of heterogeneous information, defining nomenclatures, taxonomies and classifications for various types of nanomaterials, and research on new modeling and simulation techniques for nanoparticles. Nanoinformatics has recently emerged in the USA and Europe to address these issues. In this paper, we present a review of nanoinformatics, describing its origins, the problems it addresses, areas of interest, and examples of current research initiatives and informatics resources. We suggest that nanoinformatics could accelerate research and development in nanomedicine, as has occurred in the past in other fields. For instance, biomedical informatics served as a fundamental catalyst for the Human Genome Project, and other genomic and ?omics projects, as well as the translational efforts that link resulting molecular-level research to clinical problems and findings