The effect of administration of amodiaquine on some Parameters of neurobehaviour of wistar rats

The effect of administration of Amodiaquine (AQ) on some parameters of neurobehaviour of Wistar rats was carried out. Twenty adult Wistar rats weighing between 160-190g were divided equally into four groups. Group 1 served as the control, while groups 2, 3 and 4 were the experimental groups. The control group received distilled water. Groups 2 and 3 were treated with 8.75mg/kg and 17.50mg/kg respectively of AQ for three days, while group 4 was treated with 8.75mg/kg of AQ for six days. Neurobehaviour test using the open field was carried out twelve hours after the last administrations. There were no significant differences between the control and the experimental groupsin total locomotor activity (TLA), central square duration (CSD), stretch-attend (SA) and defecation. In the central square frequency (CSF), group 3 was significantly (

Correlation of histological and histometric changes in rats testes treated with chloroquine phosphate

Histological and histometric changes in the testes of albino Wistar rats were correlated. Wistar rats weighing between 180-240g were randomly divided into three groups of ten rats each. One group served as control and the rats were given normal saline. The second and third groups received 2mg/kg and 4mg/kg body weights of chloroquine phosphate daily for thirty days respectively. Seminiferous tubules of animals treated with chloroquine phosphate were irregular in shape and werealso isolated compared to control. Marked disruption of the inter-tubular stroma of testes in the treated groups was also observed. Histometric variations in testicular tissue was observed in the experimentalanimals following treatment with chloroquine phosphate. The 2mg/kg body weight and 4mg/kg body weight animals recorded significantly lower (P< 0.05) relative germinal epithelial volume of 43.95%and 32.70% respectively when compared to the control (51.75%). The volume of stroma in the third group (49.33%) was significantly higher (

Atherogenic potentials of some Nigerian meals

The atherogenic potentials of peeled grated cocoyam (Xanthosoma maffafa scot) "ekpang nkukwo", pounded yam (Discorea spp) with plain soup "afia efere", and plantain porridge (Musa paradisiaca) "iwuk ukom" meals were investigated. The three meals were fed to three different groups of albino rats of Wistar strain for a period of twenty eight days. A fourth group which served as control was feed with normal rat pellet. The mean total plasma cholesterol level in the pounded yam with plainsoup fed group was significantly lower (P< 0.05) when compared to the control and peeled grated cocoyam fed groups. The mean total plasma triglyceride (MTPTG) level in the pounded yam with plain soup fed group was significantly lower (P< 0.05) when compared to the control group. However the MTPTG level in the peeled grated cocoyam and plantain porridge fed groups were comparable to control. The mean HDL-cholesterol level in the peeled grated cocoyam and plantain fed groups were comparable control. The mean LDL-cholesterol level in the peeled grated cocoyam and plantain porridge fed groups was significantly lower (