5 research outputs found
A multiwavelength study of Swift GRB 060111B constraining the origin of its prompt optical emission
In this work, we present the results obtained from a multi-wavelength
campaign, as well as from the public Swift/BAT, XRT, and UVOT data of GRB
060111B for which a bright optical emission was measured with good temporal
resolution during the prompt phase. We identified the host galaxy at R~25 mag;
its featureless spectral continuum and brightness, as well as the non-detection
of any associated supernova 16 days after the trigger and other independent
redshift estimates, converge to z~1-2. From the analysis of the early afterglow
SED, we find that non-negligible host galaxy dust extinction, in addition to
the Galactic one, affects the observed flux in the optical regime. The
extinction-corrected optical-to-gamma-ray spectral energy distribution during
the prompt emission shows a flux density ratio =0.01-0.0001
with spectral index , strongly suggesting a
separate origin of the optical and gamma-ray components. This result is
supported by the lack of correlated behavior in the prompt emission light
curves observed in the two energy domains. The properties of the prompt optical
emission observed during GRB 060111B favor interpretation of this optical light
as radiation from the reverse shock in a thick shell limit and in the slow
cooling regime. The expected peak flux is consistent with the observed one
corrected for the host extinction, likely indicating that the starting time of
the TAROT observations is very near to or coincident with the peak time. The
estimated fireball initial Lorentz factor is >260-360 at z=1-2, similar to the
Lorentz factors obtained from other GRBs. GRB 060111B is a rare, good test case
of the reverse shock emission mechanism in both the X-ray and optical energy
ranges.Comment: Accepted for publication in Astronomy and Astrophysics, 15 pages,10
figures and 7 table
Interstitial lung disease with and without progressive fibrosing phenotype in patients with idiopathic inflammatory myopathies: data from a large multicentric cohort
OBJECTIVES: Patients with connective tissue diseases can develop interstitial lung disease (ILD), leading to a progressive fibrosing ILD (PF-ILD) phenotype in some cases. We aimed to investigate the occurrence of PF-ILD in idiopathic inflammatory myopathies (IIMs), and factors potentially predicting this phenotype. Secondary aims were to assess the radiological pattern and factors associated with IIMs-ILD. METHODS: Patients with IIMs from our multicentric prospective cohort were retrospectively evaluated. Data were recorded at IIMs and ILD diagnosis, and during follow-up. Patients with ILD were classified according to the predominant high-resolution CT (HRCT) pattern: non-specific interstitial pneumonia (NSIP), usual interstitial pneumonia (UIP) and organising pneumonia (OP). PF-ILD was defined according to the 2022 American Thoracic Society (ATS), European Respiratory Society (ERS), Japanese Respiratory Society (JRS) and Latin American Thoracic Society (ALAT) guidelines. Univariate and multivariate analyses were performed to identify factors associated to ILD and to PF-ILD. RESULTS: Of 253 patients with IIMs, 125 (49%) had ILD: 99 (78%) at IIMs diagnosis and 26 (22%) during follow-up (21/26 within 5 years). Multivariate analysis identified anti-Jo-1, anti-MDA5, anti-Ro52, high score on manual muscle test, mechanic's hands and Raynaud's phenomenon as independently associated with ILD. The predominant HRCT pattern was NSIP (50% of patients), followed by UIP (28%) and OP (22%). At 1-year follow-up, PF-ILD occurred in 18% of IIMs-ILD. PF-ILD was predicted by anti-MDA5, heliotropic rash, xerostomia and xerophthalmia at univariate but not at multivariate analysis. CONCLUSION: Patients with IIM should be carefully screened for ILD at IIMs diagnosis and yearly during follow-up. All patients with IIMs-ILD should be carefully monitored to capture ILD progression since a consistent proportion of them are expected to develop PF-ILD